[Ringborg U, Bergqvist D, Brorsson B, Cavallin-Ståhl E, Ceberg J, Einhorn N, et al. The Swedish Council on Technology Assessment in Health Care (SBU) systematic overview of radiotherapy for cancer including a prospective survey of radiotherapy practice in Sweden 2001—summary and conclusions. Acta Oncol 2003; 42: 357-65.10.1080/02841860310010826]Search in Google Scholar
[McGinn CJ, Shewach, DS, Lawrence TS. Radiosensitizing nucleosides. J Natl Cancer Inst 1996; 88: 1193-203.10.1093/jnci/88.17.1193]Search in Google Scholar
[Wachsberger P, Burd R, Dicker AP. Improving tumor response to radiotherapy by targeting angiogenesis signaling pathways. Hematol Oncol Clin North Am 2004; 18: 1039-57.10.1016/j.hoc.2004.06.007]Search in Google Scholar
[Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-6.10.1056/NEJM197111182852108]Search in Google Scholar
[Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249-57.10.1038/35025220]Search in Google Scholar
[Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64.10.1016/S0092-8674(00)80108-7]Search in Google Scholar
[Los M, Voest EE. The potential role of antivascular therapy in the adjuvant and neoadjuvant treatment of cancer. Semin Oncol 2001; 28: 93-105.10.1016/S0093-7754(01)90047-8]Search in Google Scholar
[Ferrara N, Gerber HP. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol 2001; 106: 148-56.10.1159/00004661011815711]Search in Google Scholar
[Jain RK. Molecular regulation of vessel maturation. Nat Med 2003; 9: 685-93.10.1038/nm0603-68512778167]Search in Google Scholar
[Risau W. Mechanisms of angiogenesis. Nature 1997; 386: 671-4.10.1038/386671a09109485]Search in Google Scholar
[Liu W, Ahmad SA, Reinmuth N, Shaheen RM, Jung YD, Fan F, et al. Endothelial cell survival and apoptosis in the tumor vasculature. Apoptosis 2000; 5: 323-8.10.1023/A:1009679307513]Search in Google Scholar
[Byrne AM, Bouchier-Hayes DJ, Harmey JH. Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF). J Cell Moll Med 2005; 9: 777-94.10.1111/j.1582-4934.2005.tb00379.x674009816364190]Search in Google Scholar
[Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-9.10.1126/science.24799862479986]Search in Google Scholar
[Nicosia RF, Tchao R, Leighton J. Interactions between newly formed endothelial channels and carcinoma cells in plasma clot culture. Clin Exp Metastasis 1986; 4: 91-104.10.1007/BF001190762424658]Search in Google Scholar
[Camphausen K, Moses MA, Beecken WD, Khan MK, Folkman J, O'Reilly MS. Radiation therapy to a primary tumor accelerates metastatic growth in mice. Cancer Res 2001; 61: 2207-11.]Search in Google Scholar
[O'Reilly MS. Antiangiogenesis: basic principles. In: Rosenberg SA, editor. Principles and practice of the biologic therapy of cancer. 3rd edition. Philadelphia: Lippincott Williams & Wilkins; 2000. p. 827-43.]Search in Google Scholar
[Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001; 7: 987-9.10.1038/nm0901-98711533692]Search in Google Scholar
[Jain RK. Determinants of tumor blood flow: a review. Cancer Res 1988; 48: 2641-58.]Search in Google Scholar
[Jain RK. Transport of molecules, particles, and cells in solid tumors. Annu Rev Biomed Eng1999; 1: 241-63.10.1146/annurev.bioeng.1.1.24111701489]Search in Google Scholar
[Wouters BG, Koritzinsky M. The tumor microenvironment and cellular hypoxia responses. In: Joiner M, van der Kogel AJ, editors. Basic Clinical Radiobiology. 4th edition. London: A Hodder Arnold Publication; 2009. p. 217-32.10.1201/b13224-17]Search in Google Scholar
[Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653-60.10.1038/nm0603-65312778163]Search in Google Scholar
[Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23: 1011-27.10.1200/JCO.2005.06.08115585754]Search in Google Scholar
[Harris AL. Hypoxia - a key regulatory factor in tumor growth. Nat Rev Cancer 2002; 2: 38-47.10.1038/nrc70411902584]Search in Google Scholar
[Moeller BJ, Cao Y, Li CY, Dewhirst MW. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004; 5: 429-41.10.1016/S1535-6108(04)00115-1]Search in Google Scholar
[Gu J, Yamamoto H, Ogawa M, Ngan CY, Danno K, Hemmi H, et al. Hypoxiainduced up-regulation of angiopoietin-2 in colorectal cancer. Oncol Rep 2006; 15: 779-83.]Search in Google Scholar
[Kuwabara K, Ogawa S, Matsumoto M, Koga S, Clauss M, Pinsky DJ, et al. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl Acad Sci USA 1995; 92: 4606-10.10.1073/pnas.92.10.4606]Search in Google Scholar
[Koukourakis MI, Giatromanolaki A, Sivridis E, Simopoulos K, Pissakas G, Gatter KC, et al. Squamous cell head and neck cancer: evidence of angiogenic regeneration during radiotherapy. Anticancer Res 2001; 21: 4301-9.]Search in Google Scholar
[Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, et al. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 1999; 59: 3374-8.]Search in Google Scholar
[Chapman JD, Dugle DL, Reuvers AP, Meeker BE, Borsa J. Studies on the radiosensitizing effect of oxygen in Chinese hamster cells. Int J Radiat Biol Relat Stud Phys Chem Med 1974; 26: 383-9.10.1080/09553007414551361]Search in Google Scholar
[Patterson DM, Rustin GJ. Vascular damaging agents. Clin Oncol 2007; 19: 443-56.10.1016/j.clon.2007.03.014]Search in Google Scholar
[Giaccia AJ. Hypoxic stress proteins: survival of the fittest. Semin Radiat Oncol 1996; 6: 46-58.10.1016/S1053-4296(96)80035-X]Search in Google Scholar
[Jung YD, Ahmad SA, Liu W, Reinmuth N, Parikh A, Stoeltzing O, et al. The role of the microenvironment and intercellular cross-talk in tumor angiogenesis. Semin Cancer Biol 2002; 12: 105-12.10.1006/scbi.2001.041812027582]Search in Google Scholar
[Siemann DW, Bibby MC, Dark GG, Dicker AP, Eskens FA, Horsman MR, et al. Differentiation and definition of vascular-targeted therapies. Clin Cancer Res 2005; 11: 416-20.10.1158/1078-0432.416.11.2]Search in Google Scholar
[Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumor activity. Nat Rev Cancer 2008; 8: 579-91.10.1038/nrc240318596824]Search in Google Scholar
[Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 2005; 24: 2647-53.10.1038/sj.onc.120824615735759]Search in Google Scholar
[Wu W, Onn A, Isobe T, Itasaka S, Langley RR, Shitani T, et al. Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade. Mol Cancer Ther 2007; 6: 471-83.10.1158/1535-7163.MCT-06-041617308046]Search in Google Scholar
[Kamensek U, Sersa G. Targeted gene therapy in radiotherapy. Radiol Oncol 2008; 42: 115-35.10.2478/v10019-008-0009-1]Search in Google Scholar
[Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-42.10.1056/NEJMoa032691]Search in Google Scholar
[Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355: 2542-50.10.1056/NEJMoa061884]Search in Google Scholar
[Miller KD, Chap LI, Holmes FA, Cobleigh MA, Marcom PK, Fehrenbacher L, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005; 23: 792-9.10.1200/JCO.2005.05.098]Search in Google Scholar
[Escudier B, Pluzanska A, Koralewski P, Ravaud A, Bracarda S, Szczylik C, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomized double-blind phase III trial. Lancet 2007; 370: 2103-11.10.1016/S0140-6736(07)61904-7]Search in Google Scholar
[Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-24.10.1056/NEJMoa065044]Search in Google Scholar
[Huang J, Soffer SZ, Kim ES, McCrudden KW, Huang J, New T, et al. Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis. Mol Cancer Res 2004; 2: 36-42.10.1158/1541-7786.36.2.1]Search in Google Scholar
[Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004; 10: 415-27.10.1158/1078-0432.CCR-0642-03]Search in Google Scholar
[Baguley BC. Antivascular therapy of cancer: DMXAA. Lancet Oncol 2003; 4: 141-8.10.1016/S1470-2045(03)01018-0]Search in Google Scholar
[Tozer GM, Prise VE, Wilson J, Cemazar M, Shan S, Dewhirst MW, et al. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res 2001; 61: 6413-22.]Search in Google Scholar
[Sersa G, Miklavcic D, Cemazar M, Rudolf Z, Pucihar G, Snoj M. Electrochemotherapy in treatment of tumours. EJSO 2008; 34: 232-40.10.1016/j.ejso.2007.05.01617614247]Search in Google Scholar
[Sersa G, Jarm T, Kotnik T, Coer A, Podkrajsek M, Sentjurc M, et al. Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma. Brit J Cancer 2008, 98: 388-98.10.1038/sj.bjc.6604168236146418182988]Search in Google Scholar
[Sersa G, Krzic M, Sentjurc M, Ivanusa T, Beravs K, Kotnik V, et al. Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin. Brit J Cancer 2002; 87: 1047-54.10.1038/sj.bjc.6600606236431412434299]Search in Google Scholar
[Coer A, Cemazar M, Plaza N, Sersa G. Comparison between hypoxic markers pimonidazole and glucose transporter 1 (Glut-1) in murine fibrosarcoma tumours after electrochemotherapy. Radiol Oncol 2009; 43: 195-202.]Search in Google Scholar
[Citrin D, Camphausen K. Advancement of antiangiogenic and vascular disrupting agents combined with radiation. In: Mehta MP, editor. Radiation oncology advances. New York: Springer Science; 2008. p. 150-68.10.1007/978-0-387-36744-6_8]Search in Google Scholar
[Teicher BA, Holden SA, Ara G, Sotomayor EA, Huang ZD, Chen YN, et al. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int J Cancer 1994; 57: 920-5.10.1002/ijc.2910570624]Search in Google Scholar
[Teicher BA, Holden SA, Ara G, Korbut T, Menon K. Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma. Cancer Chemother Pharmacol 1996; 38: 169-77.10.1007/s002800050466]Search in Google Scholar
[Murata R, Nishimura Y, Hiraoka M. An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma. Int J Radiat Oncol Biol Phys 1997; 37: 1107-13.10.1016/S0360-3016(96)00628-1]Search in Google Scholar
[Lund EL, Bastholm L, Kristjansen PE. Therapeutic synergy of TNP-470 and ionizing radiation: effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenografts. Clin Cancer Res 2000; 6: 971-8.]Search in Google Scholar
[Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, et al. Combined effects of angiostatin and ionizing radiation in antitumor therapy. Nature 1998; 394: 287-91.10.1038/284129685160]Search in Google Scholar
[Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, et al. Antitumor interaction of short-course endostatin and ionizing radiation. Cancer J 2000; 6: 287-93.]Search in Google Scholar
[Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, et al. Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 1999; 59: 3374-8.]Search in Google Scholar
[Lee CG, Heijn M, di Tomaso E, Griffon-Etienne G, Ancukiewicz M, Koike C, et al. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 2000; 60: 5565-70.]Search in Google Scholar
[Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, et al. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J 2002; 8: 47-54.10.1097/00130404-200201000-0000911895203]Search in Google Scholar
[Geng L, Donnelly E, McMahon G, Lin PC, Sierra-Rivera E, Oshinka H, et al. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res 2001; 61: 2413-9.]Search in Google Scholar
[Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiationinduced longterm control of human tumor xenografts. Cancer Res 2001; 61: 39-44.]Search in Google Scholar
[Fenton BM, Paoni SF, Ding I. Pathophysiological effects of vascular endothelial growth factor receptor-2-blocking antibody plus fractionated radiotherapy on murine mammary tumors. Cancer Res 2004; 64: 5712-9.10.1158/0008-5472.CAN-04-043415313911]Search in Google Scholar
[Hess C, Vuong V, Hegyi I, Riesterer O, Wood J, Fabbro D, et al. Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumor growth. Brit J Cancer 2001; 85: 2010-6.10.1054/bjoc.2001.2166236401011747347]Search in Google Scholar
[Williams KJ, Telfer BA, Brave S, Kendrew J, Whittaker L, Stratford IJ, et al. ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule-dependent enhancement of antitumor activity. Clin Cancer Res 2004; 10: 8587-93.10.1158/1078-0432.CCR-04-114715623642]Search in Google Scholar
[Brazelle WD, Shi W, Siemann DW. VEGF associated tyrosine kinase inhibition increases the tumor response to single and fractionated dose radiotherapy. Int J Radiat Oncol Biol Phys 2006; 65: 836-41.10.1016/j.ijrobp.2006.02.02316751064]Search in Google Scholar
[Cao C, Albert JM, Geng L, Ivy PS, Sandler A, Johnson DH, et al. Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer. Cancer Res 2006; 66: 11409-15.10.1158/0008-5472.CAN-06-2414]Search in Google Scholar
[Williams KJ, Telfer BA, Shannon AM, Babur M, Stratford IJ, Wedge SR. Combining radiotherapy with AZD2171, a potent inhibitor of vascular endothelial growth factor signaling: pathophysiologic effects and therapeutic benefit. Mol Cancer Ther 2007; 6: 599-606.10.1158/1535-7163.MCT-06-0508]Search in Google Scholar
[Schueneman AJ, Himmelfarb E, Geng L, Tan J, Donnelly E, Mendel D, et al. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res 2003; 63: 4009-16.]Search in Google Scholar
[Lu B, Geng L, Musiek A, Tan J, Cao C, Donnelly E, et al. Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium. Int J Radiat Oncol Biol Phys 2004; 58: 844-50.10.1016/j.ijrobp.2003.10.049]Search in Google Scholar
[Wachberger P, Burd R, Dicke AP. Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction. Clin Cancer Res 2003; 9: 1957-71.]Search in Google Scholar
[Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.10.1126/science.1104819]Search in Google Scholar
[Shannon, A. M., Williams, K. J. Antiangiogenics and radiotherapy. J Pharm Pharmacol 2008; 60: 1029-36.10.1211/jpp.60.8.0009]Search in Google Scholar
[Horsman MR, Siemann DW. Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies. Cancer Res 2006; 66:11520-39.10.1158/0008-5472.CAN-06-2848]Search in Google Scholar
[Chaplin DJ, Hill SA. The development of combretastatin A4 phosphate as a vascular targeting agent. Int J Radiat Oncol Biol Phys 2002; 54: 1491-6.10.1016/S0360-3016(02)03924-X]Search in Google Scholar
[Sersa G, Willingham V, Milas L. Anti-tumor effects of tumor necrosis factor alone or combined with radiotherapy. Int J Cancer 1988; 42: 129-34.10.1002/ijc.2910420124]Search in Google Scholar
[Nishiguchi I, Willingham V, Milas L. Tumor necrosis factor as an adjunct to fractionated radiotherapy in the treatment of murine tumors. Int J Radiat Oncol Biol Phys 1990; 18: 555-8.10.1016/0360-3016(90)90060-W]Search in Google Scholar
[Horsman MR, Murata R, Overgaard J. Improving local tumor control by combining vascular targeting drugs, mild hyperthermia, and radiation. Acta Oncol 2001; 40: 497-503.10.1080/02841860175028823511504310]Search in Google Scholar
[Wilson WW, Li AE, Cowan D, Siim BG. Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid. Int J Radiat Oncol Biol Phys 1998; 42: 905-8.10.1016/S0360-3016(98)00358-7]Search in Google Scholar
[Murata R, Siemann DW, Overgaard J, Horsman MR. Improved tumor response by combining radiation and the vascular damaging drug 5,6-dimethylxanthenone- 4-acetic acid. Radiat Res 2001; 156: 503-9.10.1667/0033-7587(2001)156[0503:ITRBCR]2.0.CO;2]Search in Google Scholar
[Li L, Rojiani A, Siemann DW. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy. Int J Radiat Oncol Biol Phys 1998; 42: 899-903.10.1016/S0360-3016(98)00320-4]Search in Google Scholar
[Chaplin DJ, Pettit GR, Hill SA. Anti-vascular approaches to solid tumor therapy: evaluation of combretastatin A4 phosphate. Anticancer Res 1999; 19: 189-96.]Search in Google Scholar
[Murata R, Siemann DW, Overgaard J, Horsman MR. Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumors. Radiother Oncol 2001; 60: 155-61.10.1016/S0167-8140(01)00384-X]Search in Google Scholar
[Li L, Rojiani AM, Siemann DW. Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma. Acta Oncol 2002; 41: 91-7.10.1080/028418602317314127]Search in Google Scholar
[Ahmed B, Landuyt W, Griffioen AW, van Oosterom A, van den Bogaert W, Lambin P. In vivo antitumor effect of combretastatin A-4 phosphate added to fractionated radiation. Anticancer Res 2006; 26: 307-10.]Search in Google Scholar
[Horsman MR, Murata R. Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response. Int J Radiat Oncol Biol Phys 2003; 57: 1047-55.10.1016/S0360-3016(03)00769-7]Search in Google Scholar
[Raben D, Bianco C, Damiano V, Bianco R, Melisi D, Mignogna C, et al. Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human nonsmall cell lung cancer xenograft model. Mol Cancer Ther 2004; 3: 977-83.10.1158/1535-7163.977.3.8]Search in Google Scholar
[Wachsberger PR, Burd R, Marero N, Daskalakis C, Ryan A, McCue P, et al. Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma. Clin Cancer Res 2005; 11: 835-42.10.1158/1078-0432.835.11.2]Search in Google Scholar
[Siemann DW, Rojiani AM. The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors. Int J Radiat Oncol Biol Phys 2005; 62: 846-53.10.1016/j.ijrobp.2005.02.048]Search in Google Scholar
[Shi W, Siemann DW. Preclinical studies of the novel vascular disrupting agent MN-029. Anticancer Res 2005; 25: 3899-904.]Search in Google Scholar
[Siemann DW, Horsman MR. Targeting the tumor vasculature: a strategy to improve radiation therapy. Expert Rev Anticancer Ther 2004; 4: 321-7.10.1586/14737140.4.2.321]Search in Google Scholar
[Sersa G, Kranjc S, Cemazar M. Improvement of combined modality therapy with cisplatin and radiation using electroporation of tumors. Int J Radiat Oncol Biol Phys 2000; 46: 1037-41.10.1016/S0360-3016(99)00464-2]Search in Google Scholar
[Kranjc S, Cemazar M, Grosel A, Scancar J, Sersa G. Electroporation of LPB sarcoma cells in vitro and tumors in vivo increases radiosensitizing effect of cisplatin. Anticancer Res 2003; 23: 275-82.]Search in Google Scholar
[Kranjc S, Grosel A, Cemazar M, Sentjurc M, Sersa G. Improvement of combined modality therapy with bleomycin and radiation using electroporation of LPB sarcoma cells and tumors in mice. BMC Cancer 2005; 5: 115.10.1186/1471-2407-5-115]Search in Google Scholar
[Kranjc S, Tevz G, Kamensek U, Vidic S, Cemazar M, Sersa G. Radiosensitizing effect of electrochemotherapy in a fractionated radiation regime in radiosensitive murine sarcoma and radioresistant adenocarcinoma tumor model. Radiat Res 2009; 172: 677-85.10.1667/RR1873.119929414]Search in Google Scholar
[Sersa G, Cemazar M, Rudolf Z, Fras AP. Adenocarcinoma skin metastases treated by electrochemotherapy with cisplatin combined with radiation. Radiol Oncol 1999; 33: 291-6.]Search in Google Scholar
[Tamaskar I, Pili R. Update on novel agents in renal cell carcinoma. Expert Rev Anticancer Ther 2009; 9: 1817-27.10.1586/era.09.15719954293]Search in Google Scholar
[Zhu AX, Duda DG, Sahani DV, Jain RK. Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies. Cancer J 2009; 15: 263-8.10.1097/PPO.0b013e3181af5e35479251919672141]Search in Google Scholar
[Ocvirk J. Advances in the treatment of metastatic colorectal carcinoma. Radiol Oncol 2009; 43: 1-8.10.2478/v10019-009-0004-1]Search in Google Scholar
[Pallis AG, Serfass L, Dziadziusko R, van Meerbeeck JP, Fennell D, Lacombe D, et al. Targeted therapies in the treatment of advanced/metastatic NSCLC. Eur J Cancer 2009; 45: 2473-87.10.1016/j.ejca.2009.06.00519596191]Search in Google Scholar
[Yang SX. Bevacizumab and breast cancer: current therapeutic progress and future perspectives. Expert Rev Anticancer Ther 2009; 9: 1715-25.10.1586/era.09.153281903919954282]Search in Google Scholar
[Seiwert TY, Haraf DJ, Cohen EE, Stenson K, Witt ME, Dekker A, et al. Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer. J Clin Oncol 2008; 26: 1732-41.10.1200/JCO.2007.13.170618375903]Search in Google Scholar
[Lai A, Filka E, McGibbon B, Nghiemphu PL, Graham C, Yong WH, et al. Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. Int J Radiat Oncol Biol Phys 2008; 71: 1372-80.10.1016/j.ijrobp.2007.11.06818355978]Search in Google Scholar
[Willett CG, Duda DG, di Tomaso E, Boucher Y, Ancukiewicz M, Sahani DV, et al. Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol 2009; 27: 3020-6.10.1200/JCO.2008.21.1771270223419470921]Search in Google Scholar
[Koukourakis MI, Giatromanolaki A, Sheldon H, Buffa FM, Kouklakis G, Ragoussis I, et al. Tumor and Angiogenesis Research Group. Phase I/II trial of bevacizumab and radiotherapy for locally advanced inoperable colorectal cancer: vasculature-independent radiosensitizing effect of bevacizumab. Clin Cancer Res 2009; 15: 7069-76.10.1158/1078-0432.CCR-09-068819887481]Search in Google Scholar
[Crane CH, Winter K, Regine WF, Safran H, Rich TA, Curran W, et al. Phase II study of bevacizumab with concurrent capecitabine and radiation followed by maintenance gemcitabine and bevacizumab for locally advanced pancreatic cancer: Radiation Therapy Oncology Group RTOG 0411. J Clin Oncol 2009; 27: 4096-102.10.1200/JCO.2009.21.8529273442119636002]Search in Google Scholar
[Spigel DR, Hainsworth JD, Yardley DA, Raefsky E, Patton J, Peacock N, et al. Tracheoesophageal fistula formation in patients with lung cancer treated with chemoradiation and bevacizumab. J Clin Oncol 2010; 28: 43-8.10.1200/JCO.2009.24.735319901100]Search in Google Scholar
[Kao J, Packer S, Vu HL, Schwartz ME, Sung MW, Stock RG, et al. Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases: acute toxicity and preliminary response. Cancer 2009; 115: 3571-80.10.1002/cncr.24412437026619536893]Search in Google Scholar
[Ng QS, Goh V, Carnell D, Meer K, Padhani AR, Saunders MI, et al. Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2007; 67: 1375-80.10.1016/j.ijrobp.2006.11.02817275203]Search in Google Scholar
[Gridelli C, Rossi A, Maione P, Rossi E, Castaldo V, Sacco PC, et al. Vascular disrupting agents: a novel mechanism of action in the battle against nonsmall cell lung cancer. Oncologist 2009; 14: 612-20.10.1634/theoncologist.2008-028719474164]Search in Google Scholar
[Heath VL, Bicknell R. Anticancer strategies involving the vasculature. Nat Rev Clin Oncol 2009; 6: 395-404.10.1038/nrclinonc.2009.5219424102]Search in Google Scholar