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The Acute Effects of Different Spironolactone Doses on Oxidative Stress in Streptozotocin-Induced Diabetic Rats

Stefan Simovic

Stefan Simovic

  • University of Kragujevac, Faculty of Medical Sciences, Department of Internal MedicineSerbia
  • Clinic for Cardiology, Clinical Center KragujevacSerbia
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Simovic, Stefan
, 
Aleksandra Vranic

Aleksandra Vranic

University of Kragujevac, Faculty of Medical Sciences, Department of PharmacySerbia
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Vranic, Aleksandra
, 
Petar Ristic

Petar Ristic

Clinic of Endocrinology, Military Medical AcademyBelgrade, Serbia
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Ristic, Petar
, 
Jovana Jeremic

Jovana Jeremic

University of Kragujevac, Faculty of Medical Sciences, Department of PharmacySerbia
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Jeremic, Jovana
, 
Ivan Srejovic

Ivan Srejovic

University of Kragujevac, Faculty of Medical Sciences, Department of PhysiologySerbia
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Srejovic, Ivan
, 
Jasna Petrovic

Jasna Petrovic

General Hospital “Valjevo”Valjevo, Serbia
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Petrovic, Jasna
, 
Vladimir Jakovljevic

Vladimir Jakovljevic

  • University of Kragujevac, Faculty of Medical Sciences, Department of PhysiologySerbia
  • Department of Human PathologyMoscow, Russia
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Jakovljevic, Vladimir
, 
Stefani Bolevich

Stefani Bolevich

Department of PathophysiologyMoscow, Russia
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Bolevich, Stefani
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Sergey Bolevich

Sergey Bolevich

Department of Human PathologyMoscow, Russia
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Bolevich, Sergey
 y 
Vladimir Zivkovic

Vladimir Zivkovic

University of Kragujevac, Faculty of Medical Sciences, Department of PhysiologySerbia
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Zivkovic, Vladimir
  
26 may 2021
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Categoría del artículo: Original Scientific Article
Publicado en línea: 26 may 2021
Páginas: 103 - 112
Recibido: 16 mar 2021
Aceptado: 22 mar 2021
DOI: https://doi.org/10.2478/sjecr-2021-0025
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© 2024 Stefan Simovic et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

Parameters of oxidative stress in healthy rats perfused with 0.1 μM of spironolactone compared with diabetic rats perfused with 0.1 μM of spironolactone. (a) Hydrogen peroxide (H2O2) (b) Nitrites (NO2-) (c) Superoxide anion radical (O2-) (d) Index of lipid peroxidation (measured as TBARS). Data is presented as mean ± SD. CPP, coronary perfusion pressure.
Parameters of oxidative stress in healthy rats perfused with 0.1 μM of spironolactone compared with diabetic rats perfused with 0.1 μM of spironolactone. (a) Hydrogen peroxide (H2O2) (b) Nitrites (NO2-) (c) Superoxide anion radical (O2-) (d) Index of lipid peroxidation (measured as TBARS). Data is presented as mean ± SD. CPP, coronary perfusion pressure.

Figure 2.

Parameters of oxidative stress in healthy rats perfused with 3 μM of spironolactone compared with diabetic rats perfused with 3 μM of spironolactone. (a) Hydrogen peroxide (H2O2) (b) Nitrites (NO2-) (c) Superoxide anion radical (O2-) (d) Index of lipid peroxidation (measured as TBARS). Data is presented as mean ± SD. CPP, coronary perfusion pressure.
Parameters of oxidative stress in healthy rats perfused with 3 μM of spironolactone compared with diabetic rats perfused with 3 μM of spironolactone. (a) Hydrogen peroxide (H2O2) (b) Nitrites (NO2-) (c) Superoxide anion radical (O2-) (d) Index of lipid peroxidation (measured as TBARS). Data is presented as mean ± SD. CPP, coronary perfusion pressure.

Figure 3.

Parameters of oxidative stress in healthy rats perfused with 0.1 μM of spironolactone compared with healthy rats perfused with 3 μM of spironolactone. (a) Hydrogen peroxide (H2O2) (b) Nitrites (NO2−) (c) Superoxide anion radical (O2−) (d) Index of lipid peroxidation (measured as TBARS). Data is presented as mean ± SD. CPP, coronary perfusion pressure.
Parameters of oxidative stress in healthy rats perfused with 0.1 μM of spironolactone compared with healthy rats perfused with 3 μM of spironolactone. (a) Hydrogen peroxide (H2O2) (b) Nitrites (NO2−) (c) Superoxide anion radical (O2−) (d) Index of lipid peroxidation (measured as TBARS). Data is presented as mean ± SD. CPP, coronary perfusion pressure.

Figure 4.

Parameters of oxidative stress in diabetic rats perfused with 0.1 μM of spironolactone compared with diabetic rats perfused with 3 μM of spironolactone. (a) Hydrogen peroxide (H2O2) (b) Nitrites (NO2−) (c) Superoxide anion radical (O2−)(d) Index of lipid peroxidation (measured as TBARS). Data is presented as mean ± SD. CPP, coronary perfusion pressure.
Parameters of oxidative stress in diabetic rats perfused with 0.1 μM of spironolactone compared with diabetic rats perfused with 3 μM of spironolactone. (a) Hydrogen peroxide (H2O2) (b) Nitrites (NO2−) (c) Superoxide anion radical (O2−)(d) Index of lipid peroxidation (measured as TBARS). Data is presented as mean ± SD. CPP, coronary perfusion pressure.

Percentage of reduction or increase in the each of the parameters of oxidative stress in healthy and diabetic rats treated with different spironolactone doses_

40 cmH2O 60 cmH2O 80 cmH2O 100 cmH2O 120 cmH2O
H2O2 0.1 μM spironolactone healthy vs. control +20.49 +1.34 +1.30 −7.57 0.00
3 μM spironolactone healthy vs. control +11.12 −3.88 +0.79 −12.62 +9.40
0.1 μM spironolactone diabetic vs. diabetic −0.12 −11.62 −0.28 +8.73 −8.08
3 μM spironolactone diabetic vs. diabetic −12.22 −33.73 −37.84 −20.12 −43.83
NO2− 0.1 μM spironolactone healthy vs. control +13.69 −10.83 −20.12 −19.92 −31.26
3 μM spironolactone healthy vs. control −2.03 −13.64 −0.36 −4.74 +0.90
0.1 μM spironolactone diabetic vs. diabetic +4.12 −6.74 −4.91 +1.26 −0.98
3 μM spironolactone diabetic vs. diabetic −3.46 −11.98 −14.09 −9.54 −11.25
O2− 0.1 μM spironolactone healthy vs. control +5.55 −53.58 −14.75 +41.34 −16.96
3 μM spironolactone healthy vs. control +16.83 −6.04 −16.97 −20.30 −11.92
0.1 μM spironolactone diabetic vs. diabetic −21.85 −3.80 +32.66 +19.34 +67.14
3 μM spironolactone diabetic vs. diabetic +6.31 −32.84 −25.24 −15.17 −46.94
TBARS 0.1 μM spironolactone healthy vs. control +7.85 +1.32 −6.91 −10.89 −9.93
3 μM spironolactone healthy vs. control +7.64 +5.60 +27.74 +28.50 +31.63
0.1 μM spironolactone diabetic vs. diabetic +5.25 −6.02 −7.06 +0.60 −3.87
3 μM spironolactone diabetic vs. diabetic −13.61 −48.17 −49.53 −46.99 −47.15
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