1. bookVolumen 30 (2022): Edición 3 (July 2022)
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Revista
eISSN
2284-5623
Primera edición
08 Aug 2013
Calendario de la edición
4 veces al año
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access type Acceso abierto

Associations of serum vitamin D and Fok I polymorphism of receptor gene with unexplained recurrent spontaneous abortion

Publicado en línea: 18 Jul 2022
Volumen & Edición: Volumen 30 (2022) - Edición 3 (July 2022)
Páginas: 293 - 304
Recibido: 12 Oct 2021
Aceptado: 20 May 2022
Detalles de la revista
License
Formato
Revista
eISSN
2284-5623
Primera edición
08 Aug 2013
Calendario de la edición
4 veces al año
Idiomas
Inglés
Abstract

Background: To investigate the associations of serum vitamin D and Fok I polymorphism of its receptor (VDR) with unexplained recurrent spontaneous abortion (URSA).

Methods: Ninety URSA patients and another 104 healthy pregnant women were selected as URSA and control groups, respectively. 25-Hydroxyvitamin D [25-(OH)D] level was detected by chemiluminescence. VDR gene Fok I polymorphism was analyzed by PCR, and the distribution of genotype frequency was calculated by Hardy-Weinberg equilibrium test. Association between Fok I polymorphism and susceptibility to URSA was investigated by logistic regression analysis.

Results: Gestational age, uterine height, waist circumference, 25-(OH)D level and proportions of Fok I FF and Ff genotypes were significantly lower in the URSA group (P<0.05). Compared with ff genotype, risk of URSA reduced for Ff and FF genotypes. Compared with allele f, risk of URSA was lower for allele F. 25-(OH)D level of ff genotype was significantly lower in the URSA group, which was lower than that of FF genotype (P<0.05). Compared with women with 25-(OH)D level >30 ng/mL and F allele (FF+Ff), the risk of URSA increased 2.45-, 2.43- and 5.34-fold for those with 25-(OH)D level >30 ng/mL and ff genotype, with 25-(OH)D level ≤30 ng/mL, and with ff genotype and 25-(OH)D level ≤30 ng/mL, respectively.

Conclusions: The 25-(OH)D level of the URSA group was significantly lower than that of normal pregnant women. Probably, VDR gene Fok I polymorphism is associated with URSA occurrence, and allele F decreases the risk. The risk of URSA dramatically increases in women with ff genotype and 25-(OH)D deficiency.

Keywords

1. Zhao X, Jiang Y, Ping Y, Guo H, He M, Feng X. Associations between tumor necrosis factor-α and inter-leukin-6 polymorphisms and unexplained recurrent spontaneous abortion risk: A meta-analysis. Medicine (Baltimore). 2019;98(46):e17919. DOI: 10.1097/MD.0000000000017919686779931725642 Abierto DOISearch in Google Scholar

2. Yang Y, Cheng L, Deng X, Yu H, Chao L. Expression of GRIM-19 in unexplained recurrent spontaneous abortion and possible pathogenesis. Mol Hum Reprod. 2018;24(7):366-74. DOI: 10.1093/molehr/gay02029741731 Abierto DOISearch in Google Scholar

3. Ni L, Sun XQ, Zhao DX, Zhu ZW. Low molecular weight heparin monotherapy for recurrent abortion with antiphospholipid system: A protocol of a systematic review. Medicine (Baltimore). 2019;98(8):e14619. DOI: 10.1097/MD.0000000000014619640810730813192 Abierto DOISearch in Google Scholar

4. Arslan E, Branch DW. Antiphospholipid syndrome: Diagnosis and management in the obstetric patient. Best Pract Res Clin Obstet Gynaecol. 2020;64:31-40. DOI: 10.1016/j.bpobgyn.2019.10.00131704207 Abierto DOISearch in Google Scholar

5. Lu C, Liu Y, Jiang HL. Aspirin or heparin or both in the treatment of recurrent spontaneous abortion in women with antiphospholipid antibody syndrome: a meta-analysis of randomized controlled trials. J Matern Fetal Neonatal Med. 2019;32(8):1299-311. DOI: 10.1080/14767058.2017.140497929179589 Abierto DOISearch in Google Scholar

6. Hovdenak N, Haram K. Influence of mineral and vitamin supplements on pregnancy outcome. Eur J Obstet Gynecol Reprod Biol. 2012;164(2):127-32. DOI: 10.1016/j.ejogrb.2012.06.02022771225 Abierto DOISearch in Google Scholar

7. Han JC, Wang JG, Chen GH, Zhang JL, Zhang N, Qu HX, et al. 1α-Hydroxycholecalciferol improves the growth performance and up-regulates the mRNA expression of vitamin D receptor in the small intestine and kidney of broiler chickens. Poult Sci. 2018;97(4):1263-70. DOI: 10.3382/ps/pex42329452375 Abierto DOISearch in Google Scholar

8. He Q, Huang Y, Zhang L, Yan Y, Liu J, Song X, et al. Association between vitamin D receptor polymorphisms and hepatitis B virus infection susceptibility: A meta-analysis study. Gene. 2018;645:105-12. DOI: 10.1016/j.gene.2017.12.02729248582 Abierto DOISearch in Google Scholar

9. Sun X, Cao ZB, Tanisawa K, Taniguchi H, Kubo T, Higuchi M. Effects of chronic endurance exercise training on serum 25(OH)D concentrations in elderly Japanese men. Endocrine. 2018;59(2):330-7. DOI: 10.1007/s12020-017-1478-z29170904 Abierto DOISearch in Google Scholar

10. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev. 2016;96(1):365-408. DOI: 10.1152/physrev.00014.2015483949326681795 Abierto DOISearch in Google Scholar

11. Salimi S, Farajian-Mashhadi F, Tabatabaei E, Shahrakipour M, Yaghmaei M, Mokhtari M. Estrogen receptor alpha XbaI GG genotype was associated with severe preeclampsia. Clin Exp Hypertens. 2017;39(3):220-4. DOI: 10.1080/10641963.2016.1235182 Abierto DOISearch in Google Scholar

12. Zhou L, Yao F, Luan H, Wang Y, Dong X, Zhou W, et al. Three novel functional polymorphisms in the promoter of FGFR2 gene and breast cancer risk: a HuGE review and meta-analysis. Breast Cancer Res Treat. 2012;136(3):885-97. DOI: 10.1007/s10549-012-2300-5 Abierto DOISearch in Google Scholar

13. Ghattas MH, Mehanna ET, Mesbah NM, Abo-Elmatty DM. Association of estrogen receptor alpha gene polymorphisms with metabolic syndrome in Egyptian women. Metabolism. 2013;62(10):1437-42. DOI: 10.1016/j. metabol.2013.05.014 Abierto DOISearch in Google Scholar

14. Ali R, Fawzy I, Mohsen I, Settin A. Evaluation of vitamin D receptor gene polymorphisms (Fok-I and Bsm-I) in T1DM Saudi children. J Clin Lab Anal. 2018;32(5):e22397. DOI: 10.1002/jcla.22397 Abierto DOISearch in Google Scholar

15. Stovall TG. Obstetrics and gynecology. J Am Coll Surg. 1999;188(2):136-9. DOI: 10.1016/S1072-7515(98)00307-X Abierto DOISearch in Google Scholar

16. Obstetrics Subgroup, Chinese Society of Obstetrics and Gynecology, Chinese Medical Association. [Chinese expert consensus on the diagnosis and tretment of recurrent spontaneous abortion]. Zhonghua Fu Chan Ke Za Zhi. 2016;51(1):3-9. Search in Google Scholar

17. Palacios C, De-Regil LM, Lombardo LK, Pe-a-Rosas JP. Vitamin D supplementation during pregnancy: Updated meta-analysis on maternal outcomes. J Steroid Biochem Mol Biol. 2016;164:148-55. DOI: 10.1016/j. jsbmb.2016.02.008 Abierto DOISearch in Google Scholar

18. Roth DE, Gernand AD, Morris SK, Pezzack B, Islam MM, Dimitris MC, et al. Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. Trials. 2015;16:300. DOI: 10.1186/s13063-015-0825-8449994626169781 Abierto DOISearch in Google Scholar

19. Rizzo G, Garzon S, Fichera M, Panella MM, Catena U, Schiattarella A, et al. Vitamin D and Gestational Diabetes Mellitus: Is There a Link? Antioxidants (Basel). 2019;8(11):511. DOI: 10.3390/antiox8110511691223431731439 Abierto DOISearch in Google Scholar

20. Ghashut RA, Talwar D, Kinsella J, Duncan A, McMillan DC. The effect of the systemic inflammatory response on plasma vitamin 25 (OH) D concentrations adjusted for albumin. PLoS One. 2014;9(3):e92614. DOI: 10.1371/journal.pone.0092614396543624667823 Abierto DOISearch in Google Scholar

21. Sun D, Luo F, Xing JC, Zhang F, Xu JZ, Zhang ZH. 1,25(OH)2 D3 inhibited Th17 cells differentiation via regulating the NF-κB activity and expression of IL-17. Cell Prolif. 2018;51(5):e12461. DOI: 10.1111/cpr.12461652887629687949 Abierto DOISearch in Google Scholar

22. Yücel C, Budak S, Kısa E, Celik O, Kozacıoglu Z. The sufficiency of 6 core sextant prostate biopsy in patients with prostate specific antigen (PSA) values over 20 ng/mL. Arch Ital Urol Androl. 2018;90(2):104-6. DOI: 10.4081/aiua.2018.2.10429974721 Abierto DOISearch in Google Scholar

23. De Nunzio C, Lombardo R, Nacchia A, Tema G, Tubaro A. Repeat prostate-specific antigen (PSA) test before prostate biopsy: a 20% decrease in PSA values is associated with a reduced risk of cancer and particularly of high-grade cancer. BJU Int. 2018;122(1):83-8. DOI: 10.1111/bju.1419729533522 Abierto DOISearch in Google Scholar

24. Li N, Wu HM, Hang F, Zhang YS, Li MJ. Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface. Braz J Med Biol Res. 2017;50(11):e6527. DOI: 10.1590/1414-431x20176527559728728902929 Abierto DOISearch in Google Scholar

25. Nguyen TP, Yong HE, Chollangi T, Borg AJ, Brennecke SP, Murthi P. Placental vitamin D receptor expression is decreased in human idiopathic fetal growth restriction. J Mol Med (Berl). 2015;93(7):795-805. DOI: 10.1007/s00109-015-1267-125716068 Abierto DOISearch in Google Scholar

26. Zong L, Chu P, Huang P, Guo Y, Lv Y. Effect of vitamin D on the learning and memory ability of FGR rat and NMDA receptor expression in hippocampus. Exp Ther Med. 2017;14(1):581-6. DOI: 10.3892/etm.2017.4523548844128672970 Abierto DOISearch in Google Scholar

27. Grzesiak M. Vitamin D 3 Action Within the Ovary-an Updated Review. Physiol Res. 2020;69(3):371-8. DOI: 10.33549/physiolres.934266864830832469224 Abierto DOISearch in Google Scholar

28. Liu Z, Wang X, Jiang K, Ji X, Zhang YA, Chen Z. TNFα-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells. Aging Dis. 2019;10(6):1207-20. DOI: 10.14336/AD.2018.1028684459131788333 Abierto DOISearch in Google Scholar

29. Li C, Zhou Y, Rychahou P, Weiss HL, Lee EY, Perry CL, et al. SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation. Cell Mol Gastroenterol Hepatol. 2020;10(1):43-57. DOI: 10.1016/j.jcmgh.2020.01.004721047831954883 Abierto DOISearch in Google Scholar

30. Barchitta M, Maugeri A, La Rosa MC, Magnano San Lio R, Favara G, Panella M, et al. Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the “Mamma & Bambino” Cohort and A Meta-Analysis. Nutrients. 2018;10(9):1172. DOI: 10.3390/nu10091172616437930150529 Abierto DOISearch in Google Scholar

31. Aslani S, Hossein-Nezhad A, Mirzaei K, Maghbooli Z, Afshar AN, Karimi F. VDR FokI polymorphism and its potential role in the pathogenesis of gestational diabetes mellitus and its complications. Gynecol Endocrinol. 2011;27(12):1055-60. DOI: 10.3109/09513590.2011.56978621663527 Abierto DOISearch in Google Scholar

32. Brodowski L, Burlakov J, Myerski AC, von Kaisenberg CS, Grundmann M, Hubel CA, et al. Vitamin D prevents endothelial progenitor cell dysfunction induced by sera from women with preeclampsia or conditioned media from hypoxic placenta. PLoS One. 2014;9(6):e98527. DOI: 10.1371/journal.pone.0098527404172924887145 Abierto DOISearch in Google Scholar

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