<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Heart failure (HF) is a common condition, especially in older patients. Considering the increase of life expectancy the total number of HF patients is expected to grow in the future, which makes HF an important focus of research. New high-throughput techniques, such as the “omics” (genomics, transcriptomics, metabolomics) have brought new insight into disease pathophysiology, facilitating the discovery of an impressive number of candidate biomarkers. In this review we consider different perspectives on the evaluation and clinical potential of biomarkers in heart failure as their usefulness in clinical settings is constantly being evaluated in order to bring them closer to the point-of-care. In addition, we examine recent advances in the methods of detection and quantification of biomarkers</p></abstract>

Heart failure (HF) is a common condition, especially in older patients. Considering the increase of life expectancy the total number of HF patients is expected to grow in the future, which makes HF an important focus of research. New high-throughput techniques, such as the “omics” (genomics, transcriptomics, metabolomics) have brought new insight into disease pathophysiology, facilitating the discovery of an impressive number of candidate biomarkers. In this review we consider different perspectives on the evaluation and clinical potential of biomarkers in heart failure as their usefulness in clinical settings is constantly being evaluated in order to bring them closer to the point-of-care. In addition, we examine recent advances in the methods of detection and quantification of biomarkers

Advances in the detection and quantification of candidate and established biomarkers in heart failure

“Iuliu Haţieganu” University of Medicine and Pharmacy, Department of Pharmacology, Physiology and Pathophysiology, Cluj-Napoca

“Iuliu Haţieganu” University of Medicine and Pharmacy, Department of Botanic and Molecular Biology, Cluj-Napoca

“Iuliu Haţieganu” University of Medicine and Pharmacy, Department of Toxicology, Cluj-Napoca

Revista Romana de Medicina de Laborator

Heart failure (HF) is a common condition, especially in older patients. Considering the increase of life expectancy the total number of HF patients is expected...

Advances in the detection and quantification of candidate and established biomarkers in heart failure

Publicado en línea: 19 sept 2013

Páginas: 255 - 265

DOI: https://doi.org/10.2478/rrlm-2013-0029

This content is open access.