[
1. Urwin M, Symmons D, Allison T, Brammah T, Busby H, Roxby M et al. Estimating the burden of musculoskeletal disorders in the community: the comparative prevalence of symptoms at different anatomical sites, and the relation to social deprivation. Ann Rheum Dis. 1998; 57:649e55.10.1136/ard.57.11.64917524949924205
]Search in Google Scholar
[
2. Lawrence RC et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis. Rheum. 2008; 58:26-35. doi: 10.1002/art.23176.326666418163497
]Open DOISearch in Google Scholar
[
3. Sobh MM, Abdalbary M, Elnagar S et al. Secondary Osteoporosis and Metabolic Bone Diseases. J Clin Med. 2022; 11(9):2382. doi: 10.3390/jcm11092382.910222135566509
]Open DOISearch in Google Scholar
[
4. Findlay DM, Atkins GJ. Osteoblast-chondrocyte interactions in osteoarthritis. Curr Osteoporos Rep. 2014 Mar; 12(1):127-34. doi: 10.1007/s11914-014-0192-5.393376724458429
]Open DOISearch in Google Scholar
[
5. Yuan XL, Meng HY, Wang YC, Peng J, Guo QY, Wang AY, Lu SB. Bone-cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies. Osteoarthritis Cartilage. 2014 Aug; 22(8):1077-89. doi: 10.1016/j.joca.2014.05.023.24928319
]Open DOISearch in Google Scholar
[
6. Fernandes JC, Martel-Pelletier J, Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology. 2002; 39(1-2):237-46.
]Search in Google Scholar
[
7. Eymard F, Chevalier X. Inflammation of the infrapatellar fat pad. Joint Bone Spine. 2016 Jul; 83(4):389-93. doi: 10.1016/j.jbspin.2016.02.016.27068617
]Open DOISearch in Google Scholar
[
8. Steinberg J, Southam L, Fontalis A et al. Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis. Ann Rheum Dis. 2021; 80:1070-1074.10.1136/annrheumdis-2020-219760829259533903094
]Search in Google Scholar
[
9. Lv Z, Yang YX, Li J, Fei Y, Guo H, Sun Z, Lu J, Xu X, Jiang Q, Ikegawa S, Shi D. Molecular Classification of Knee Osteoarthritis. Front Cell Dev Biol. 2021 Aug 27; 9:725568. doi: 10.3389/fcell.2021.725568.842996034513847
]Open DOISearch in Google Scholar
[
10. Taouis M, Benomar Y. Is resistin the master link between inflammation and inflammation-related chronic diseases? Mol Cell Endocrinol. 2021 Aug 1; 533:111341. doi: 10.1016/j.mce.2021.111341.34082045
]Open DOISearch in Google Scholar
[
11. Junker S, Frommer KW, Krumbholz G, Tsiklauri L, Gerstberger R, Rehart S, Steinmeyer J, Rickert M, Wenisch S, Schett G, Müller-Ladner U, Neumann E. Expression of adipokines in osteoarthritis osteophytes and their effect on osteoblasts. Matrix Biol. 2017 Oct; 62:75-91. doi: 10.1016/j.matbio.2016.11.005.27884778
]Open DOISearch in Google Scholar
[
12. Zhang Y, McAlindon TE, Hannan MT, Chaisson CE, Klein R, Wilson PW, Felson DT. Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: the Framingham Study. Arthritis Rheum. 1998 Oct; 41(10):1867-73. doi: 10.1002/1529-0131(199810)41:10<1867::AID-ART20>3.0.CO;2-W.
]Open DOISearch in Google Scholar
[
13. Johnson VL, Hunter DJ. The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol. 2014 Feb; 28(1):5-15. doi: 10.1016/j.berh.2014.01.004.
]Open DOISearch in Google Scholar
[
14. Madry H, Kon E, Condello V, Peretti GM, Steinwachs M, Seil R, Berruto M, Engebretsen L, Filardo G, Angele P. Early osteoarthritis of the knee. Knee Surg Sports Traumatol Arthrosc. 2016 Jun; 24(6):1753-62. doi: 10.1007/s00167-016-4068-3.
]Open DOISearch in Google Scholar
[
15. Si H-B, Yang T-M, Li L, Tian M, Zhou L, Li D-P et al. miR-140 attenuates the progression of early-stage osteoarthritis by retarding chondrocyte senescence. Mol. Ther. Nucleic acids. 2019; 19,15-30. doi: 10.1016/j.omtn.2019.10.032.
]Open DOISearch in Google Scholar
[
16. Miyaki S, Asahara H. Macro view of microRNA function in osteoarthritis. Nat Rev Rheumatol. 2012 Sep; 8(9):543-52. doi: 10.1038/nrrheum.2012.128.
]Open DOISearch in Google Scholar
[
17. Murata K, Yoshitomi H, Tanida S, Ishikawa M, Nishitani K, Ito H, Nakamura T. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther. 2010; 12(3):R86. doi: 10.1186/ar3013.
]Open DOISearch in Google Scholar
[
18. Chen B, Deng Y, Tan Y, Qin J, Chen LB. Association between severity of knee osteoarthritis and serum and synovial fluid interleukin 17 concentrations. J Int Med Res. 2014 Feb; 42(1):138-44. doi: 10.1177/0300060513501751.
]Open DOISearch in Google Scholar
[
19. Scanzello CR, Umoh E, Pessler F, Diaz-Torne C, Miles T, Dicarlo E, Potter HG, Mandl L, Marx R, Rodeo S, Goldring SR, Crow MK. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. Osteoarthritis Cartilage. 2009 Aug; 17(8):1040-8. doi: 10.1016/j.joca.2009.02.011.
]Open DOISearch in Google Scholar
[
20. Roemer FW, Kwoh CK, Fujii T, Hannon MJ, Boudreau RM, Hunter DJ, Eckstein F, John MR, Guermazi A. From Early Radiographic Knee Osteoarthritis to Joint Arthroplasty: Determinants of Structural Progression and Symptoms. Arthritis Care Res (Hoboken). 2018 Dec; 70(12):1778-1786. doi: 10.1002/acr.23545.
]Open DOISearch in Google Scholar
[
21. Chmielewski TL, Trumble TN, Joseph AM, Shuster J, Indelicato PA, Moser MW, Cicuttini FM, Leeuwenburgh C. Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction. Osteoarthritis Cartilage. 2012 Nov; 20(11):1294-301. doi: 10.1016/j.joca.2012.07.014.
]Open DOISearch in Google Scholar
[
22. Eastell R, Christiansen C, Grauer A, Kutilek S, Libanati C, McClung MR, Reid IR, Resch H, Siris E, Uebelhart D, Wang A, Weryha G, Cummings SR. Effects of denosumab on bone turnover markers in postmenopausal osteoporosis. J Bone Miner Res. 2011 Mar; 26(3):530-7. doi: 10.1002/jbmr.251.20839290
]Open DOISearch in Google Scholar
[
23. Attur M, Krasnokutsky S, Statnikov A, Samuels J, Li Z, Friese O, Hellio Le Graverand-Gastineau MP, Rybak L, Kraus VB, Jordan JM, Aliferis CF, Abramson SB. Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers. Arthritis Rheumatol. 2015 Nov; 67(11):2905-15. doi: 10.1002/art.39279.462632126195278
]Open DOISearch in Google Scholar
[
24. Collins KH, Paul HA, Reimer RA, Seerattan RA, Hart DA, Herzog W. Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model. Osteoarthritis Cartilage. 2015 Nov; 23(11):1989-98. doi: 10.1016/j.joca.2015.03.014.26521745
]Open DOISearch in Google Scholar
[
25. Kohno T, Wang H, Amaya F, Brenner GJ, Cheng JK, Ji RR, Woolf CJ. Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. J Neurosci. 2008 Apr 23; 28(17):4533-40. doi: 10.1523/JNEUROSCI.5349-07.2008.265386318434532
]Open DOISearch in Google Scholar
[
26. Yoneda T, Hata K, Nakanishi M, Nagae M, Nagayama T, Wakabayashi H, Nishisho T, Sakurai T, Hiraga T. Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain. Bone. 2011 Jan; 48(1):100-5. doi: 10.1016/j.bone.2010.07.009.20637323
]Open DOISearch in Google Scholar
[
27. Shi J, Zhao W, Ying H, Du J, Chen J, Chen S, Shen B. The relationship of platelet to lymphocyte ratio and neutrophil to monocyte ratio to radiographic grades of knee osteoarthritis. Z Rheumatol. 2018 Aug; 77(6):533-537. doi: 10.1007/s00393-017-0348-7.28681116
]Open DOISearch in Google Scholar
