Volumen 5 (2022): Edición 1 (June 2022)

Myositis ossificans (MO) is a rare group of diseases in which heterotopic ossification occurs in muscles, tendons, nerves, or even subcutaneous fat. MO can occur in patients of all ages, but usually appears in young adults who practice sports or have a history of mechanical trauma, burns, infections or drug abuse.

The article highlights the case of a 29-year-old athletic female who noticed, by random palpation, a small lump in her left biceps, near the radial insertion. The lump was not painful and noticeable with the naked eye.

Rest and NSAIDs were recommended and all went well for about 3 months.

However, after almost a week from that moment, the pain was excruciating, inflammation extend on the arm and forearm, she could not extend her arm anymore and its circumference was 30 cm from 24 initially.

A biopsy was performed and the result was calcified fibrous tissue with suggestive aspect of myositis ossificans. Surgery was planned with reconstruction of the biceps tendon in mind.

After surgery, the elbow was splinted at 90 degrees for two weeks, then dynamic splinting was performed with increasingly wider range of motion until full recovery was achieved.

MO is a rare disease that involves many differential diagnoses, some of which are deadly and each with its own particularities, different imaging aspects and different treatments.

Pelvic lymphadenectomy with radical hysterectomy is the basic treatment in locally advanced cervical cancer, but, for carefully selected cases, this intervention can be extended and high Para-Aortic lymphadenectomy can be performed to the site of emergence of the renal arteries. The mortality of the procedure has decreased significantly since the 1900s when it was introduced by Wertheim, while the 5-year DFS reached rates of over 90%.

The purpose of this article was to analyze bone metastases as being the most common site of recurrence of breast cancer. Bone metastases secondary to breast cancer have a negative impact on patient survival, mobility and quality of life. In addition, the clinical complications of bone cancer metastases of breast cancer are associated with a significant financial burden for the individual and society.

This article summarized the implications of breast cancer musculoskeletal metastases based on clinical application in an emergency hospital, including patient workup, procedural strategy and techniques.

Introduction: Breast cancer continues to be the most frequent malignancy in women worldwide. Considerable advances in oncology over the years have led to decreased mortality in early stage (EBC) and locally advanced (ABC) breast cancer, but this has raised concerns about possible long-term effects of anticancer treatment nonetheless.

Purpose: The present paper aims to describe the efficacy and safety of osteoclast inhibitors, both as antiresorptive agents, reducing osteoporosis and fracture risk, and as adjuvant anticancer agents, potentially improving disease-related outcomes in patients with early stage and locally advanced breast cancer.

Materials and methods: In this article, literature sources were selected and evaluated using the PRISMA 2020 guideline.

Conclusions: Bisphosphonates are recommended for early stage and advanced breast cancer patients, either premenopausal or postmenopausal, with osteoporosis. Denosumab may also be used for postmenopausal women. Bisphosphonates also showed a statistically significant benefit for overall survival in postmenopausal women only. However, denosumab is not presently used for indications other than prevention or treatment of osteoporosis.

Introduction: In most patients, metastatic breast cancer (MBC) is incurable. Consequently, the goal in this setting is life prolongation and quality of life improvement, although possible long-term effects of anticancer treatment need to be considered. Bone is the most common site of metastasis in breast cancer and its complex management includes minimizing the risk of skeletal-related events (SRE), maximizing pain control, stabilizing or even restoring function, preventing spinal cord compression, hypercalcemia of malignancy and fractures and reducing the need for radiotherapy and orthopedic surgery.

Aim: The present paper aims to compare the efficacy and safety of zoledronic acid (and other bisphosphonates) with denosumab in the management of bone metastases in breast cancer patients.

Materials and methods: In this article, required information was collected through literature review and keyword query using the PRISMA 2020 guideline.

Conclusions: In the metastatic setting, it appears that denosumab is indeed superior to zoledronic acid in delaying and preventing skeletal related events, except for spinal cord compression and risk of surgery, and equally efficient in treatment of already present bone pain and hypercalcemia of malignancy, with similar adverse effects, overall survival and disease progression.

Gonarthrosis is one of the main causes of pain and limitation of physical activity in elderly patients. The diagnosis is established based on the clinical and radiological examination, and the treatment consists of non-surgical measures. The final stage of gonarthrosis is treated surgically and consists of total knee arthroplasty.

The molecular study in gonarthrosis aims to identify patients with early stages of arthrosis, with reversible potential, who can benefit from etiological treatment and non-pharmacological measures to slow down the evolution of the disease or even reversibility. Total knee arthroplasty is a surgical intervention with the role of reducing the symptoms and restoring the functionality of the affected joint.

Total knee arthroplasty remains the surgical intervention of choice in the case of patients in the final stage of the evolution of the disease with very good functional outcome.