The Impact of Anaesthesia on Hyperalgesia, Testosterone, Cortisol, C-Reactive Protein, and Glucose Levels After Spine Surgery: Prospective Randomised Controlled Trial
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
[1] Fletcher D, Stamer UM, Pogatzki-Zahn E, Zaslansky R, Tanase NV, Perruchoud C, et al. Chronic postsurgical pain in Europe. Eur J Anaesthesiol 2015; 32(10): 725–34. https://doi.org/10.1097/EJA.0000000000000319FletcherDStamerUMPogatzki-ZahnEZaslanskyRTanaseNVPerruchoudCChronic postsurgical pain in Europe. 2015; 32(10): 725–34. https://doi.org/10.1097/EJA.0000000000000319Search in Google Scholar
[2] Joly V, Richebe P, Guignard B, Fletcher D, Maurette P, Sessler D, et al. Remifentanil-induced Postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology 2005; 103: 147–155. https://doi.org/10.1097/00000542-200507000-00022JolyVRichebePGuignardBFletcherDMaurettePSesslerDRemifentanil-induced Postoperative hyperalgesia and its prevention with small-dose ketamine. 2005; 103: 147–155. https://doi.org/10.1097/00000542-200507000-00022Search in Google Scholar
[3] Leal P, Sakata RK. Methods for the assessment of opioid-induced hyperalgesia in the perioperative period. Revisa Dor 2014; 15(4): 296–299. https://doi.org/10.5935/1806-0013.20140064LealPSakataRK.Methods for the assessment of opioid-induced hyperalgesia in the perioperative period. 2014; 15(4): 296–299. https://doi.org/10.5935/1806-0013.20140064Search in Google Scholar
[4] Schmidt R, Thews G. Human Physiology. 3rd edition. Moskwa: Mir 2005: 64–66.SchmidtRThewsG.. 3rd edition. Moskwa: Mir2005: 64–66.Search in Google Scholar
[5] Lesnak JB, Inoue S, Lima L, Rasmussen L, Sluka KA. Testosterone protects against the development of widespread muscle pain in mice. Pain 2020; 161(12): 2898–2908. https://doi.org/10.1097/j.pain.0000000000001985LesnakJBInoueSLimaLRasmussenLSlukaKA.Testosterone protects against the development of widespread muscle pain in mice. 2020; 161(12): 2898–2908. https://doi.org/10.1097/j.pain.0000000000001985Search in Google Scholar
[6] Gaumond I, Arsenault P, Marchand S. Specificity of female and male sex hormones on excitatory and inhibitory phases of formalin-induced nociceptive responses. Brain Research 2005; 1052(1): 105–111. https://doi.org/10.1016/j.brainres.2005.06.011GaumondIArsenaultPMarchandS.Specificity of female and male sex hormones on excitatory and inhibitory phases of formalin-induced nociceptive responses. 2005; 1052(1): 105–111. https://doi.org/10.1016/j.brainres.2005.06.011Search in Google Scholar
[7] White H, Robinson T. A novel use for testosterone to treat central sensitization of chronic pain in fibromyalgia patients. Int Immunopharmacol 2015; 27(2): 244–248. https://doi.org/10.1016/j.intimp.2015.05.020WhiteHRobinsonT.A novel use for testosterone to treat central sensitization of chronic pain in fibromyalgia patients. 2015; 27(2): 244–248. https://doi.org/10.1016/j.intimp.2015.05.020Search in Google Scholar
[8] Benedetti F, Amanzio M, Vighetti S, Asteggiano G. The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. J Neuro 2006; 26(46): 12014–12022. https://doi.org/10.1523/JNEUROSCI.2947-06.2006BenedettiFAmanzioMVighettiSAsteggianoG.The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. 2006; 26(46): 12014–12022. https://doi.org/10.1523/JNEUROSCI.2947-06.2006Search in Google Scholar
[9] Colloca L, Benedetti F. Nocebo hyperalgesia: how anxiety is turned into pain. Curr Opin Anaesthesiol 2007; 20(5): 435–439. https://doi.org/10.1097/ACO.0b013e3282b972fbCollocaLBenedettiF.Nocebo hyperalgesia: how anxiety is turned into pain. 2007; 20(5): 435–439. https://doi.org/10.1097/ACO.0b013e3282b972fbSearch in Google Scholar
[10] Hannibal K, Bishop M. Chronic stress, cortisol dysfunction, and pain: A psychoneuroendocrine rationale for stress management in pain rehabilitation. Phys Ther 2014; 94(12): 1816–1825. https://doi.org/10.2522/ptj.20130597HannibalKBishopM.Chronic stress, cortisol dysfunction, and pain: A psychoneuroendocrine rationale for stress management in pain rehabilitation. 2014; 94(12): 1816–1825. https://doi.org/10.2522/ptj.20130597Search in Google Scholar
[11] Van Uum S, Sauvé B, Fraser L, Morley-Forster P, Paul T, Koren G. Elevated content of cortisol in hair of patients with severe chronic pain: A novel biomarker for stress. Stress 2008; 11(6): 483–488. https://doi.org/10.1080/10253890801887388Van UumSSauvéBFraserLMorley-ForsterPPaulTKorenG.Elevated content of cortisol in hair of patients with severe chronic pain: A novel biomarker for stress. 2008; 11(6): 483–488. https://doi.org/10.1080/10253890801887388Search in Google Scholar
[12] Vachon-Presseau E, Roy M, Martel M-O, Caron E, Marin M-F, Chen J, et al. The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans. Brain 2013; 136(3): 815–827. https://doi.org/10.1093/brain/aws371Vachon-PresseauERoyMMartelM-OCaronEMarinM-FChenJThe stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans. 2013; 136(3): 815–827. https://doi.org/10.1093/brain/aws371Search in Google Scholar
[13] Choi J, Chung M, Lee Y. Modulation of pain sensation by stress-related testosterone and cortisol. Anaesthesia 2012; 67(10): 1146–1151. https://doi.org/10.1111/j.1365-2044.2012.07267.xChoiJChungMLeeY.Modulation of pain sensation by stress-related testosterone and cortisol. 2012; 67(10): 1146–1151. https://doi.org/10.1111/j.1365-2044.2012.07267.xSearch in Google Scholar
[14] Sturmer T. Pain and high sensitivity C reactive protein in patients with chronic low back pain and acute sciatic pain. Ann Rheum Dis 2005; 64(6): 921–925. http://dx.doi.org/10.1136/ard.2004.027045SturmerT.Pain and high sensitivity C reactive protein in patients with chronic low back pain and acute sciatic pain. 2005; 64(6): 921–925. http://dx.doi.org/10.1136/ard.2004.027045Search in Google Scholar
[15] Chi C-H, Shiesh S-C, Chen K-W, Wu M-H, Lin X-Z. C-reactive protein for the evaluation of acute abdominal pain. Am J Emerg Med 1996; 14(3): 254–256. https://doi.org/10.1016/S0735-6757(96)90169-2ChiC-HShieshS-CChenK-WWuM-HLinX-Z.C-reactive protein for the evaluation of acute abdominal pain. 1996; 14(3): 254–256. https://doi.org/10.1016/S0735-6757(96)90169-2Search in Google Scholar
[16] Schistad E, Stubhaug A, Furberg A-S, Engdahl BL, Nielsen CS. 2017. C-reactive protein and cold-pressor tolerance in the general population. Pain 2017; 158(7): 1280–1288. https://doi.org/10.1097/j.pain.0000000000000912SchistadEStubhaugAFurbergA-SEngdahlBLNielsenCS.C-reactive protein and cold-pressor tolerance in the general population. 2017; 158(7): 1280–1288. https://doi.org/10.1097/j.pain.0000000000000912Search in Google Scholar
[17] Dmytriiev D. PO-0914 Postoperative hyperalgesia in children after oncology surgery correlates with raised level of cortisol, interleukin 6 (il6), il8 and C-reactive protein. Arch Dis Childh 2014; 99 (Suppl2): A549.1–A549. http://dx.doi.org/10.1136/archdis-child-2014-307384.1535DmytriievD.PO-0914 Postoperative hyperalgesia in children after oncology surgery correlates with raised level of cortisol, interleukin 6 (il6), il8 and C-reactive protein. 2014; 99 (Suppl2): A549.1–A549. http://dx.doi.org/10.1136/archdis-child-2014-307384.1535Search in Google Scholar
[18] Sterling M, Head J, Cabot PJ, Farrell M. Serum C-reactive protein levels predict regional brain responses to noxious cold stimulation of the hand in chronic whiplash associated disorders. Scand J Pain 2016; 11(1): 19–26. https://doi.org/10.1016/j.sjpain.2015.11.003SterlingMHeadJCabotPJFarrellM.Serum C-reactive protein levels predict regional brain responses to noxious cold stimulation of the hand in chronic whiplash associated disorders. 2016; 11(1): 19–26. https://doi.org/10.1016/j.sjpain.2015.11.003Search in Google Scholar
[19] Rademaker BMP, Kalkman CJ, Odoom JA, De Wit L, Ringers J. Intraperitoneal local anaesthetics after laparoscopic cholecystectomy: Effects on postoperative pain, metabolic responses and lung function. Brit J Anaesth 1994; 72(3): 263–266. https://doi.org/10.1002/14651858.CD007337.pub4RademakerBMPKalkmanCJOdoomJADe WitLRingersJ.Intraperitoneal local anaesthetics after laparoscopic cholecystectomy: Effects on postoperative pain, metabolic responses and lung function. 1994; 72(3): 263–266. https://doi.org/10.1002/14651858.CD007337.pub4Search in Google Scholar
[20] Møller IW, Dinesen K, Søndergård S, Knigge U, Kehlet H. Effect of patient-controlled analgesia on plasma catecholamine, cortisol and glucose concentrations after cholecystectomy. Brit J Anaesth 1998; 61(2): 160–164. https://doi.org/10.1093/bja/61.2.160MøllerIWDinesenKSøndergårdSKniggeUKehletH.Effect of patient-controlled analgesia on plasma catecholamine, cortisol and glucose concentrations after cholecystectomy. 1998; 61(2): 160–164. https://doi.org/10.1093/bja/61.2.160Search in Google Scholar
[21] Mäntyselkä P, Miettola J, Niskanen L, Kumpusalo E. Chronic pain, impaired glucose tolerance and diabetes: A community-based study. Pain 2008; 137(1): 34–40. https://doi.org/10.1016/j.pain.2007.08.007MäntyselkäPMiettolaJNiskanenLKumpusaloE.Chronic pain, impaired glucose tolerance and diabetes: A communitybased study. 2008; 137(1): 34–40. https://doi.org/10.1016/j.pain.2007.08.007Search in Google Scholar
[22] Hina N, Fletcher D, Poindessous-Jazat F, Martinez V. Hyperalgesia induced by low-dose opioid treatment before orthopaedic surgery. Eur J Anaesthesiol 2015; 32(4): 255–261. https://doi.org/10.1097/EJA.0000000000000197HinaNFletcherDPoindessous-JazatFMartinezV.Hyperalgesia induced by low-dose opioid treatment before orthopaedic surgery. 2015; 32(4): 255–261. https://doi.org/10.1097/EJA.0000000000000197Search in Google Scholar
[23] Edwards DA, O’Neal JL. Oral contraceptives decrease saliva testosterone but do not affect the rise in testosterone associated with athletic competition. Horm Behav 2009; 56(2): 195–198. https://doi.org/10.1016/j.yhbeh.2009.01.008EdwardsDAO’NealJL.Oral contraceptives decrease saliva testosterone but do not affect the rise in testosterone associated with athletic competition. 2009; 56(2): 195–198. https://doi.org/10.1016/j.yhbeh.2009.01.008Search in Google Scholar
[24] Graham CA, Bancroft J, Doll HA, Greco T, Tanner A. Does oral contraceptive-induced reduction in free testosterone adversely affect the sexuality or mood of women? Psychoneuroendocrinology 2007; 32(3): 246–255. https://doi.org/10.1016/j.psyneuen.2006.12.011GrahamCABancroftJDollHAGrecoTTannerA.Does oral contraceptive-induced reduction in free testosterone adversely affect the sexuality or mood of women?2007; 32(3): 246–255. https://doi.org/10.1016/j.psyneuen.2006.12.011Search in Google Scholar
[25] Kocoska-Maras L, Hirschberg AL, Byström B, Schoultz BV, Rådestad AF. Testosterone addition to estrogen therapy: Effects on inflammatory markers for cardiovascular disease. Gynecol Endocrinol 2009; 25(12): 823–827. https://doi.org/10.3109/09513590903056134Kocoska-MarasLHirschbergALByströmBSchoultzBVRådestadAF.Testosterone addition to estrogen therapy: Effects on inflammatory markers for cardiovascular disease. 2009; 25(12): 823–827. https://doi.org/10.3109/09513590903056134Search in Google Scholar
[26] Herrera AY, Hodis HN, Mack WJ, Mather M. Estradiol therapy after menopause mitigates effects of stress on cortisol and working memory. J Clin Endocrinol Metabol 2017; 102(12): 4457–4466. https://doi.org/10.1210/jc.2017-00825HerreraAYHodisHNMackWJMatherM.Estradiol therapy after menopause mitigates effects of stress on cortisol and working memory. 2017; 102(12): 4457–4466. https://doi.org/10.1210/jc.2017-00825Search in Google Scholar
[27] Niedermeyer HP, Zahneisen G, Luppa P, Busch R, Arnold W. Cortisol levels in the human perilymph after intravenous administration of prednisolone. Audiol Neurotol 2003; 8(6): 316–321. https://doi.org/10.1159/000073516NiedermeyerHPZahneisenGLuppaPBuschRArnoldW.Cortisol levels in the human perilymph after intravenous administration of prednisolone. 2003; 8(6): 316–321. https://doi.org/10.1159/000073516Search in Google Scholar
[28] Leal PC, Salomão R, Brunialti MKC, Sakata RK. Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: A double-blind, randomized study. J Clin Anesth 2015; 27(4): 331–337. https://doi.org/10.1016/j.jclinane.2015.02.002LealPC, SalomãoRBrunialtiMKCSakataRK.Evaluation of the effect of ketamine on remifentanil-induced hyperalgesia: A double-blind, randomized study. 2015; 27(4): 331–337. https://doi.org/10.1016/j.jclinane.2015.02.002Search in Google Scholar
[29] Hay JL, White JM, Bochner F, Somogyi AA, Semple TJ, Rounsefell B. Hyperalgesia in Opioid-Managed Chronic Pain and Opioid-Dependent Patients. J Pain 2009; 10(3): 316–322. https://doi.org/10.1016/j.jpain.2008.10.003HayJLWhiteJMBochnerFSomogyiAASempleTJRounsefellB.Hyperalgesia in Opioid-Managed Chronic Pain and Opioid-Dependent Patients. 2009; 10(3): 316–322. https://doi.org/10.1016/j.jpain.2008.10.003Search in Google Scholar
[30] Steyaert A, Lavand’homme P. Postoperative opioids. Eur J Anaesthesiol 2013; 30(2): 50–52. https://doi.org/10.1097/EJA.0b013e32835b9db2SteyaertALavand’hommeP.Postoperative opioids. 2013; 30(2): 50–52. https://doi.org/10.1097/EJA.0b013e32835b9db2Search in Google Scholar
[31] Carroll I, Barelka P, Wang CKM, Wang BM, Gillespie MJ, McCue R, et al. A Pilot Cohort Study of the Determinants of Longitudinal Opioid Use After Surgery. Anesth Analges 2012; 115(3): 694–702. https://doi.org/10.1213/ANE.0b013e31825c049fCarrollIBarelkaPWangCKMWangBMGillespieMJMcCueRA Pilot Cohort Study of the Determinants of Longitudinal Opioid Use After Surgery. 2012; 115(3): 694–702. https://doi.org/10.1213/ANE.0b013e31825c049fSearch in Google Scholar
[32] Andersen LØ, Gaarn-Larsen L, Kristensen BB, Husted H, Otte KS, Kehlet H. Subacute pain and function after fast-track hip and knee arthroplasty. Anaesthesia 2009; 64(5): 508–513. https://doi.org/10.1111/j.1365-2044.2008.05831.xAndersenLØGaarn-LarsenLKristensenBBHustedHOtteKSKehletH.Subacute pain and function after fast-track hip and knee arthroplasty. 2009; 64(5): 508–513. https://doi.org/10.1111/j.1365-2044.2008.05831.xSearch in Google Scholar
[33] Tennant F. The physiologic effects of pain on the endocrine system. Pain Ther 2013; 2(2): 75–86. https://doi.org/10.1007/s40122-013-0015-xTennantF.The physiologic effects of pain on the endocrine system. 2013; 2(2): 75–86. https://doi.org/10.1007/s40122-013-0015-xSearch in Google Scholar
[34] Katz N, Mazer NA. The impact of opioids on the endocrine system. Clin J Pain 2009; 25(2): 170–175. https://doi.org/10.1097/AJP.0b013e3181850df6KatzNMazerNA.The impact of opioids on the endocrine system. 2009; 25(2): 170–175. https://doi.org/10.1097/AJP.0b013e3181850df6Search in Google Scholar
[35] Seyfried O, Hester J. Opioids and endocrine dysfunction. Brit J Pain 2012; 6(1): 17–24. https://doi.org/10.1177/2049463712438299SeyfriedOHesterJ.Opioids and endocrine dys function. 2012; 6(1): 17–24. https://doi.org/10.1177/2049463712438299Search in Google Scholar
[36] Tennant F, Lichota L. Testosterone replacement in chronic pain patients. Practical Pain Management 2010; 10: 12–15.TennantFLichotaL.Testosterone replacement in chronic pain patients. 2010; 10: 12–15.Search in Google Scholar
[37] Glintborg D, Vaegter HB, Christensen LL, Bendix E, Graven-Nielsen T, Andersen PG, et al. Testosterone replacement therapy of opioid-induced male hypogonadism improved body composition but not pain perception: a double-blind, randomized, and placebo-controlled trial. Eur J Endocrinol 2020; 182(6): 539–548. https://doi.org/10.1530/EJE-19-0979GlintborgDVaegterHBChristensenLLBendixEGraven-NielsenTAndersenPGTestosterone replacement therapy of opioid-induced male hypogonadism improved body composition but not pain perception: a double-blind, randomized, and placebo-controlled trial. 2020; 182(6): 539–548. https://doi.org/10.1530/EJE-19-0979Search in Google Scholar
[38] Choi JC. Testosterone and cortisol modulate pain sensation: 14AP7-9. Eur J Anaesthesiol 2012; 29: 209–210.ChoiJC.Testosterone and cortisol modulate pain sensation: 14AP7-9. 2012; 29: 209–210.Search in Google Scholar
[39] Ismail S, Ahmed A, Hoda MQ, Asghar S, Habib A, Aziz A. Bilateral mid-axillary transversus abdominis plane block does not attenuate stress response to total abdominal hysterectomy. Eur J Anaesthesiol 2021; 38(7): 768–776. https://doi.org/10.1097/eja.0000000000001413IsmailSAhmedAHodaMQAsgharSHabibAAzizA.Bilateral mid-axillary transversus abdominis plane block does not attenuate stress response to total abdominal hysterectomy. 2021; 38(7): 768–776. https://doi.org/10.1097/eja.0000000000001413Search in Google Scholar
[40] Oleshchenko I, Cok OY, Iureva T, Zabolotskii D, Kripak A. Effect of pterygopalatine blockade on perioperative stress and inflammatory outcomes following paediatric cataract surgery. Reg Anesth Pain Med 2020; 45(3): 204–208. http://dx.doi.org/10.1136/rapm-2019-100823OleshchenkoICokOYIurevaTZabolotskiiDKripakA.Effect of pterygopalatine blockade on perioperative stress and inflammatory outcomes following paediatric cataract surgery. 2020; 45(3): 204–208. http://dx.doi.org/10.1136/rapm-2019-100823Search in Google Scholar
[41] Çnar SÖ, Kum Ü, Cevizci N, Kayaoglu S, Oba S. Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair. Eur J Anaesthesiol 2009; 26(5): 430–434. http://dx.doi.org/10.1097/EJA.0b013e32832974fcÇnarSÖKumÜCevizciNKayaogluSObaS.Effects of levobupivacaine infiltration on postoperative analgesia and stress response in children following inguinal hernia repair. 2009; 26(5): 430–434. http://dx.doi.org/10.1097/EJA.0b013e32832974fcSearch in Google Scholar
[42] Stocche R. Effects of intrathecal sufentanil on plasma oxytocin and cortisol concentrations in women during the first stage of labor. Reg Anesth Pain Med 2001; 26(6): 545–550. http://dx.doi.org/10.1053/rapm.2001.27851StoccheR.Effects of intrathecal sufentanil on plasma oxytocin and cortisol concentrations in women during the first stage of labor. 2001; 26(6): 545–550. http://dx.doi.org/10.1053/rapm.2001.27851Search in Google Scholar
[43] Naito Y, Tamai S, Shingu K, Shindo K, Matsui T, Segawa H, et al. Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology 1992; 77(3): 426–431. https://doi.org/10.1097/00000542-199209000-00004NaitoYTamaiSShinguKShindoKMatsuiTSegawaHResponses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. 1992; 77(3): 426–431. https://doi.org/10.1097/00000542-199209000-00004Search in Google Scholar
[44] Tennant F, Hermann L. Normalization of serum cortisol concentration with opioid treatment of severe chronic pain. Pain Med 2002; 3(2): 132–134. https://doi.org/10.1046/j.1526-4637.2002.02019.xTennantFHermannL.Normalization of serum cortisol con centration with opioid treatment of severe chronic pain. 2002; 3(2): 132–134. https://doi.org/10.1046/j.1526-4637.2002.02019.xSearch in Google Scholar
[45] Cassuto J, Sinclair R, Bonderovic M. Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand 2006; 50(3): 265–282. https://doi.org/10.1111/j.1399-6576.2006.00936.xCassutoJSinclairRBonderovicM.Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. 2006; 50(3): 265–282. https://doi.org/10.1111/j.1399-6576.2006.00936.xSearch in Google Scholar
[46] Bagry H, Delacuadrafontaine J, Asenjo J, Bracco D, Carli F. Effect of a continuous peripheral nerve block on the inflammatory response in knee arthroplasty. Reg Anesth Pain Med 2008; 33(1): 17–23. https://doi.org/10.1016/j.rapm.2007.06.398BagryHDelacuadrafontaineJAsenjoJBraccoDCarliF.Effect of a continuous peripheral nerve block on the inflammatory response in knee arthroplasty. 2008; 33(1): 17–23. https://doi.org/10.1016/j.rapm.2007.06.398Search in Google Scholar
[47] Kristek G, Radoš I, Kristek D, Kapural L, Nešković N, Škiljić S, et al. Influence of postoperative analgesia on systemic inflammatory response and postoperative cognitive dysfunction after femoral fractures surgery: a randomized controlled trial. Reg Anesth Pain Med 2019; 44(1): 59–68. http://dx.doi.org/10.1136/rapm-2018-000023KristekGRadošIKristekDKapuralLNeškovićNŠkiljićSInfluence of postoperative analgesia on systemic inflammatory response and postoperative cognitive dysfunction after femoral fractures surgery: a randomized controlled trial. 2019; 44(1): 59–68. http://dx.doi.org/10.1136/rapm-2018-000023Search in Google Scholar
[48] Hashimoto K, Tsuji A, Takenaka S, Ohmura A, Ueki R, Noma H, et al. C-reactive protein level on postoperative day one is associated with chronic postsurgical pain after mastectomy. Anesthesiol Pain Med 2018; 8(4): e79331. http://dx.doi.org/10.5812/aapm.79331HashimotoKTsujiATakenakaSOhmuraAUekiRNomaHC-reactive protein level on postoperative day one is associated with chronic postsurgical pain after mastectomy. 2018; 8(4): e79331. http://dx.doi.org/10.5812/aapm.79331Search in Google Scholar
[49] Oh AR, Park J, Lee S-H, Kim J, Lee JH, Min JJ, et al. Elevated high-sensitivity C-reactive protein concentrations may be associated with increased postdischarge mortality in patients with myocardial injury after noncardiac surgery. Eur J Anaesthesiol 2021; 38(1): 33–40. http://dx.doi.org/10.1097/EJA.0000000000001409OhARParkJLeeS-HKimJLeeJHMinJJElevated high-sensitivity C-reactive protein concentrations may be associated with increased postdischarge mortality in patients with myocardial injury after noncardiac surgery. 2021; 38(1): 33–40. http://dx.doi.org/10.1097/EJA.0000000000001409Search in Google Scholar
[50] Ogata H, Matsuki Y, Okamoto T, Ueki R, Kariya N, Tatara T, et al. Intra-operative nociceptive responses and postoperative major complications after gastrointestinal surgery under general anaesthesia. Eur J Anaesthesiol 2021; 38(12): 1215–1222. http://dx.doi.org/10.1097/EJA.0000000000001505OgataHMatsukiYOkamotoTUekiRKariyaNTataraTIntra-operative nociceptive responses and postoperative major complications after gastrointestinal surgery under general anaesthesia. 2021; 38(12): 1215–1222. http://dx.doi.org/10.1097/EJA.0000000000001505Search in Google Scholar
[51] Miles ME, Rice MJ. Recent advances in perioperative glucose monitoring. Curr Opin Anaesthesiol 2017; 30(6): 718–722. http://dx.doi.org/10.1097/ACO.0000000000000521MilesMERiceMJ.Recent advances in perioperative glucose monitoring. 2017; 30(6): 718–722. http://dx.doi.org/10.1097/ACO.0000000000000521Search in Google Scholar
[52] Tennant F, Hermann L. Normalization of serum cortisol concentration with opioid treatment of severe chronic pain. Pain Med 2002; 3(2): 132–134. http://dx.doi.org/10.1046/j.1526-4637.2002.02019.xTennantFHermannL.Normalization of serum cortisol concentration with opioid treatment of severe chronic pain. 2002; 3(2): 132–134. http://dx.doi.org/10.1046/j.1526-4637.2002.02019.xSearch in Google Scholar