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The Impact of Anaesthesia on Hyperalgesia, Testosterone, Cortisol, C-Reactive Protein, and Glucose Levels After Spine Surgery: Prospective Randomised Controlled Trial

Maksym Barsa
Maksym Barsa
 y 
Olha Filyk
Olha Filyk
   | 25 abr 2023
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Article Category: Original paper
Publicado en línea: 25 abr 2023
Páginas: -
DOI: https://doi.org/10.2478/rjaic-2023-0005
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© 2023 Maksym Barsa et al., published by sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1.

CONSORT follow-up diagram.
CONSORT follow-up diagram.

Figure 2.

A graphical representation of the statistical ranges of administered fentanyl and morphine hydrochloride in the study groups: (a) fentanyl during surgery in SG and CG; (b) morphine hydrochloride total amount after surgery in SG and CG.
A graphical representation of the statistical ranges of administered fentanyl and morphine hydrochloride in the study groups: (a) fentanyl during surgery in SG and CG; (b) morphine hydrochloride total amount after surgery in SG and CG.

Figure 3.

A graphical representation of the statistical ranges of mechanical pain thresholds: (a) in study group; (b) in control group.
A graphical representation of the statistical ranges of mechanical pain thresholds: (a) in study group; (b) in control group.

Figure 4.

A graphical representation of the statistic ranges of testosterone levels in SG: (a) Men 20–49 years old; (b) Men ≥50 years old; (c) Women 20–49 years old; (d) Women ≥50 years old.
A graphical representation of the statistic ranges of testosterone levels in SG: (a) Men 20–49 years old; (b) Men ≥50 years old; (c) Women 20–49 years old; (d) Women ≥50 years old.

Figure 5.

A graphical representation of the statistic ranges of testosterone levels in CG: (a) Men 20–49 years old; (b) Men ≥50 years old; (c) Women 20–49 years old; (d) Women ≥50 years old.
A graphical representation of the statistic ranges of testosterone levels in CG: (a) Men 20–49 years old; (b) Men ≥50 years old; (c) Women 20–49 years old; (d) Women ≥50 years old.

Figure 6.

A graphical representation of the statistical ranges of cortisol levels in the studied groups: (a) in SG; (b) in CG.
A graphical representation of the statistical ranges of cortisol levels in the studied groups: (a) in SG; (b) in CG.

Figure 7.

A graphical representation of the statistical ranges of CRP levels in the studied groups: (a) in SG; (b) in CG.
A graphical representation of the statistical ranges of CRP levels in the studied groups: (a) in SG; (b) in CG.

The baseline characteristics of patients.

SG (n=27) CG (n=26)
Men (n=26)
Age 20–49 years old (n) 7 7
Age ≥50 years old (n) 7 6
Women (n=24)
Age 20–49 years old (n) 6 8
Age ≥50 years old (n) 7 5
ASA
I (n) 11 9
II (n) 16 17
BMI (kg/m2) 26.6 (CI 95% 23.4–29.7) 26.6 (CI 95% 23.4–29.7)

The average mechanical pain thresholds in SG and CG before surgery and after surgery.

Before Surgery After Surgery
SG 14.49 (95% CI 10.72–25.21) g/mm2 16.70 (95% CI 13.02–20.57) g/mm2
CG 21.45 (95% CI 18.80–24.10) g/mm2 4.75 (95% CI 4.13–5.38) g/mm2

Reference values of serum testosterone, cortisol C-reactive protein, and glucose levels.

TESTOSTERONE
Men 20–49 years 8.64–29.0 nmol/l
Men ≥50 years 6.68–25.7 nmol/l
Women 20–49 years 0.290–1.67 nmol/l
Women ≥50 years 0.101–1.42 nmol/l
CORTISOL
AM 7:00–10:00 171–536 nmol/l
PM 16:00–20:00 64–327 nmol/l
C-REACTIVE PROTEIN
<5 mg/ml
GLUCOSE
4.11–6.05 mmol/l

The average testosterone levels in CG before surgery and after surgery.

General anaesthesia without BESPB (CG)
Before Surgery After Surgery
Men 20–49 years old 26.94 (95% CI 25.37–28.52) 6.79 (95% CI 5.28–8.29)
Men 20–49 years old 17.67 (95%CI 14.23–21.1) 2.63 (95% CI 0.88–4.39)
Women 20–49 years old 1.09 (95% CI 0.85–1.32) 0.11 (95% CI 0.08–0.14)
Women ≥50 years old 1.15 (95% CI 0.82–1.48) 0.1 (95% CI 0.1–0.1)

The average testosterone levels in SG before surgery and after surgery.

General anaesthesia with BESPB (SG)
Before Surgery After Surgery
Men 20–49 years old 20.73 (95% CI 19.07–22.38) 21.11 (95% CI 20.00 –22.23)
Men 20–49 years old 19.38 (95% CI 13.11–25.65) 16.35 (95% CI 8.21–24.49)
Women 20–49 years old 0.65 (95% CI 0.20–1.16) 0.62 (95% CI 0.11–1.13)
Women ≥50 years old 0.55 (95% CI 0.04–1.07) 0.71 (95% CI 0.07–1.35)

The average glucose levels in SG and CG before and after surgery.

Before Surgery After Surgery
SG 5.09 (95% CI 4.88–5.3) 6.06 (95% CI 5.83–6.3)
CG 5.2 (95% CI 4.9–5.5) 9.23 (95% CI 8.63–9.83)

The average C-reactive protein levels in Groups 1 and 2 before and after surgery.

Before Surgery After Surgery
SG 1.95 (95% CI 1.48 to 2.42) 2.34 (95% CI 1.88 to 2.81)
CG 1.48 (95% CI 0.89 to 2.06) 8.54 (95% CI 8 to 9.1)

The average cortisol levels in Groups 1 and 2 before and after surgery.

Before Surgery After Surgery
SG 291.6 (95%CI 265.74–317.46) 322 (95% CI 290.35–353.65)
CG 296.4 (95% CI 270.8–567.2) 767.24 (95% CI 720.02–814.46)
eISSN:
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Inglés
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2 veces al año
Temas de la revista:
Medicine, Clinical Medicine, other, Surgery, Anaesthesiology, Emergency Medicine and Intensive-Care Medicine
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