This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
AIOM-AIRTum. [The number of cancer in Italy 2019]. [Italian]. Brescia: Intermedia Editore; 2019. Available at: www.medinews.itAIOM-AIRTumBresciaIntermedia Editore2019Available atwww.medinews.itSearch in Google Scholar
AIOM Linee guida. [Breast neoplasms, 2019]. [Italian]. [internet]. 2019. [cited 2020 Oct 14]. Available at: https://www.aiom.it/linee-guida-aiomneoplasie-della-mammella-2019AIOM Linee guida2019[cited 2020 Oct 14]. Available athttps://www.aiom.it/linee-guida-aiomneoplasie-della-mammella-2019Search in Google Scholar
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomized trials Lancet 2011; 378: 1707-16. doi: 10.1016/S0140-6736(11)61629-2Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomized trials201137817071610.1016/S0140-6736(11)61629-2325425222019144Open DOISearch in Google Scholar
Hickey BE, James ML, Lehman M, Hider PN, Jeffery M, Francis DP, et al. Fraction size in radiation therapy for breast conservation in early breast cancer. Cochrane Database Syst Rev, 2016; 7: CD003860. doi: 10.1002/14651858.CD003860.pub4.HickeyBEJamesMLLehmanMHiderPNJefferyMFrancisDPet alFraction size in radiation therapy for breast conservation in early breast cancer20167CD00386010.1002/14651858.CD003860.pub4645786227425588Open DOISearch in Google Scholar
Valle LF, Agarwal S, Bickel KE, Herchek HA, Nalepinski DC, Kapadia NS. Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials. Breast Cancer Res Treat 2017; 162: 409-17. doi: 10.1007/ s10549-017-4118-7ValleLFAgarwalSBickelKEHerchekHANalepinskiDCKapadiaNSHypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials20171624091710.1007/s10549-017-4118-728160158Open DOISearch in Google Scholar
Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, et al. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol 2013; 14: 1269-77. doi: 10.1016/S1470-2045(13)70497-2VeronesiUOrecchiaRMaisonneuvePVialeGRotmenszNSangalliCet alIntraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial20131412697710.1016/S1470-2045(13)70497-224225155Open DOISearch in Google Scholar
Maluta S, Dall’Oglio S, Goer DA, Marciai N. Intraoperative electron radiotherapy (IOERT) as an alternative to standard whole breast irradiation: only for low-risk subgroups? Breast Care 2014; 9: 102-6. doi: 10.1159/000362392MalutaSDall’OglioSGoerDAMarciaiNIntraoperative electron radiotherapy (IOERT) as an alternative to standard whole breast irradiation: only for low-risk subgroups?20149102610.1159/000362392403831224944552Open DOISearch in Google Scholar
Sedlmayer F, Reitsamer R, Wenz F, Sperk E, Fussl C, Kaiser J, et al. Intraoperative radiotherapy (IORT) as boost in breast cancer. Radiat Oncol 2017; 12: 23. doi: 10.1186/s13014-016-0749-9SedlmayerFReitsamerRWenzFSperkEFusslCKaiserJet alIntraoperative radiotherapy (IORT) as boost in breast cancer2017122310.1186/s13014-016-0749-9524457428103903Open DOISearch in Google Scholar
Fastner G, Gaisberger C, Kaiser J, Scherer P, Ciabattoni A, Petoukhova A, et al. ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy with electrons (IOERT) in breast cancer. Radiother Oncol 2020; 149: 150-15. doi: 10.1016/j.radonc.2020.04.059FastnerGGaisbergerCKaiserJSchererPCiabattoniAPetoukhovaAet alESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy with electrons (IOERT) in breast cancer20201491501510.1016/j.radonc.2020.04.05932413529Open DOISearch in Google Scholar
Russo G, Casarino C, Arnetta G, Candiano G, Stefano A, Alongi F, et al. Dose distribution changes with shielding disc misalignments and wrong orientations in breast IOERT: a Monte Carlo-GEANT4 and experimental study. J Appl Clin Med Phys 2012; 13: 74-92 doi: 10.1120/jacmp.v13i5.3817RussoGCasarinoCArnettaGCandianoGStefanoAAlongiFet alDose distribution changes with shielding disc misalignments and wrong orientations in breast IOERT: a Monte Carlo-GEANT4 and experimental study201213749210.1120/jacmp.v13i5.3817571824222955646Open DOISearch in Google Scholar
Vidali C, Severgnini M, Urbani M, Toscano L, Perulli A, Bortul M. FMECA application to intraoperative electron beam radiotherapy procedure as a quality method to prevent and reduce patient’s risk in conservative surgery for breast cancer. Front Med 2017; 4: 138 doi: 10.3389/fmed.2017.00138VidaliCSevergniniMUrbaniMToscanoLPerulliABortulMFMECA application to intraoperative electron beam radiotherapy procedure as a quality method to prevent and reduce patient’s risk in conservative surgery for breast cancer2017413810.3389/fmed.2017.00138558138828894737Open DOISearch in Google Scholar
Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, et al. Accelerated partial breast irradiation: executive summary for the update of an ASTRO evidence-based consensus statement. Pract Radiat Oncol 2017; 7: 73-9. doi: 10.1016/j.prro.2016.09.007CorreaCHarrisEELeonardiMCSmithBDTaghianAGThompsonAMet alAccelerated partial breast irradiation: executive summary for the update of an ASTRO evidence-based consensus statement2017773910.1016/j.prro.2016.09.00727866865Open DOISearch in Google Scholar
Sedlmayer F, Fastner G, Sedlmayer F. Intra-operative electron boost and hypofractionated whole-breast irradiation during breast-conserving treatment (BCT) (HIOB). ClinicalTrials.gov Identifier: NCT01343459. [internet]. [cited 2020 Oct 13]. Available at: https://clinicaltrials.gov/ct2/show/NCT01343459SedlmayerFFastnerGSedlmayerFIntra-operative electron boost and hypofractionated whole-breast irradiation during breast-conserving treatment (BCT) (HIOB)[internet]. [cited 2020 Oct 13]. Available athttps://clinicaltrials.gov/ct2/show/NCT01343459Search in Google Scholar
Fastner G, Reitsamer R, Urbanski B, Kopp P, Murawa D, Adamczyk B, et al. Toxicity and cosmetic outcome after hypofractionated whole breast irradiation and boost-IOERT in early stage breast cancer (HIOB): first results of a prospective multicenter trial (NCT01343459). Radiother Oncol 2020; 146: 136-42. doi: 10.1016/j.radonc.2020.02.001FastnerGReitsamerRUrbanskiBKoppPMurawaDAdamczykBet alToxicity and cosmetic outcome after hypofractionated whole breast irradiation and boost-IOERT in early stage breast cancer (HIOB): first results of a prospective multicenter trial (NCT01343459)20201461364210.1016/j.radonc.2020.02.00132151790Open DOISearch in Google Scholar
Severgnini M, de Denaro M, Bortul M, Vidali C, Beorchia A. In vivo dosimetry and shielding disk alignment verification by EBT3 GAFCHROMIC film in breast IOERT treatment. J Appl Clin Med Phys 2015; 16: 112-20. doi: 10.1120/jacmp.v16i1.5065SevergniniMde DenaroMBortulMVidaliCBeorchiaAIn vivo dosimetry and shielding disk alignment verification by EBT3 GAFCHROMIC film in breast IOERT treatment2015161122010.1120/jacmp.v16i1.5065568999025679150Open DOISearch in Google Scholar
Ciocca, M, Cantone MC, Veronese I, Cattani F, Pedroli G, Molinelli S, et al. Application of failure mode and effects analysis to intraoperative radiation therapy using mobile electron linear accelerators. Int J Radiat Oncol Biol Phys 2012; 82: e305-11. doi: 10.1016/j.ijrobp.2011.05.010CioccaMCantoneMCVeroneseICattaniFPedroliGMolinelliSet alApplication of failure mode and effects analysis to intraoperative radiation therapy using mobile electron linear accelerators201282e3051110.1016/j.ijrobp.2011.05.01021708432Open DOISearch in Google Scholar
López-Tarjuelo J, Bouché-Babiloni A, Santos-Serra A, Morillo-Macías V, Calvo FA, Kubyshin Y, et al. Failure mode and effect analysis oriented to risk-reduction interventions in intraoperative electron radiation therapy: the specific impact of patient transportation, automation, and treatment planning availability. Radiother Oncol 2014; 113: 283-9 doi: 10.1016/j. radonc.2014.11.012López-TarjueloJBouché-BabiloniASantos-SerraAMorillo-MacíasVCalvoFAKubyshinYet alFailure mode and effect analysis oriented to risk-reduction interventions in intraoperative electron radiation therapy: the specific impact of patient transportation, automation, and treatment planning availability2014113283910.1016/j.radonc.2014.11.01225465728Open DOISearch in Google Scholar
Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995; 31: 1341-6. doi: 10.1016/0360-3016(95)00060-CCoxJDStetzJPajakTFToxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)1995311341610.1016/0360-3016(95)00060-C7713792Open DOISearch in Google Scholar
Rubin P, Constine LS, Fajardo LF, Phillips TF, Wasserman TH. RTOG Late Effects Working Group. Overview of late effects of normal tissues (LENT) scoring system. Int J Radiat Oncol Biol Phys 1995; 31: 1041-2. doi: 10.1016/0360-3016(95)00057-6RubinPConstineLSFajardoLFPhillipsTFWassermanTHRTOG Late Effects Working Group. Overview of late effects of normal tissues (LENT) scoring system1995311041210.1016/0360-3016(95)00057-67713774Open DOISearch in Google Scholar
Valdivieso-Casique MF, Rodríguez R, Rodríguez-Bescós S, Lardíes D, Guerra P, Ledesma MJ, et al. RADIANCE − a planning software for intra-operative radiation therapy. Transl Cancer Res 2015; 4: 196-209. doi: 10.3978/j. issn.2218-676X.2015.04.05Valdivieso-CasiqueMFRodríguezRRodríguez-BescósSLardíesDGuerraPLedesmaMJet alRADIANCE − a planning software for intra-operative radiation therapy2015419620910.3978/j.issn.2218-676X.2015.04.05Open DOISearch in Google Scholar
Fastner G, Sedlmayer F, Merz F, Deutschmann H, Reitsamer R, Menzel C, et al. IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysis. Radiother Oncol 2013; 108: 279-86. doi: 10.1016/j.radonc.2013.05.031FastnerGSedlmayerFMerzFDeutschmannHReitsamerRMenzelCet alIORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysis20131082798610.1016/j.radonc.2013.05.03123830467Open DOISearch in Google Scholar
Kaiser J, Reitsamer R, Kopp P, Gaisberger C, Kopp M, Fischer T, et al. Intraoperative electron radiotherapy (IOERT) in the treatment of primary breast cancer. Breast Care 2018; 13: 162-7. doi: 10.1159/000489637KaiserJReitsamerRKoppPGaisbergerCKoppMFischerTet alIntraoperative electron radiotherapy (IOERT) in the treatment of primary breast cancer201813162710.1159/000489637606266830069175Open DOISearch in Google Scholar
Merrick HW 3rd, Hager E, Dobelbower RR Jr. Intraoperative radiation therapy for breast cancer. Surg Oncol Clin N Am 2003; 12: 1065-78. doi: 10.1016/s1055-3207(03)00098-xMerrickHW3rdHagerEDobelbowerRRJr.Intraoperative radiation therapy for breast cancer20031210657810.1016/s1055-3207(03)00098-x14989133Open DOISearch in Google Scholar
Lemanski C, Azria D, Thezenas S, Gutowski M, Saint-Aubert B, Rouanet P, et al. Intraoperative radiotherapy given as a boost for early breast cancer: long-term clinical and cosmetic results. Int J Radiat Oncol Biol Phys 2006; 64: 1410-5. doi: 10.1016/j.ijrobp.2005.10.025LemanskiCAzriaDThezenasSGutowskiMSaint-AubertBRouanetPet alIntraoperative radiotherapy given as a boost for early breast cancer: long-term clinical and cosmetic results2006641410510.1016/j.ijrobp.2005.10.02516442241Open DOISearch in Google Scholar
Wong WW, Pockaj BA, Vora SA, Halyard MY, Gray RJ, Schild SE. Six-year outcome of a prospective study evaluating tumor bed boost with intraoperative electron irradiation followed by whole-breast irradiation for early-stage breast cancer. Breast J 2014; 20: 125-30. doi:10.1111/tbj.12235WongWWPockajBAVoraSAHalyardMYGrayRJSchildSESix-year outcome of a prospective study evaluating tumor bed boost with intraoperative electron irradiation followed by whole-breast irradiation for early-stage breast cancer2014201253010.1111/tbj.1223524372873Open DOISearch in Google Scholar
Konig L, Lang K, Heil J, Golatta M, Major G, Krug D, et al. Acute toxicity and early oncological outcomes after intraoperative electron radiotherapy (IOERT) as boost followed by whole breast cancer patients – first clinical results from a single center. Front Oncol 2019; 9: 384. doi: 10.3389/ fonc.2019.00384KonigLLangKHeilJGolattaMMajorGKrugDet alAcute toxicity and early oncological outcomes after intraoperative electron radiotherapy (IOERT) as boost followed by whole breast cancer patients – first clinical results from a single center2019938410.3389/fonc.2019.00384653670231165041Open DOISearch in Google Scholar
Ivaldi GB, Leonardi MC, Orecchia R, Zerini D, Morra A, Galimberti V, et al. Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women. Int J Radiat Oncol Biol Phys 2008; 72: 485-93. doi: 10.1016/j.ijrobp.2007.12.038IvaldiGBLeonardiMCOrecchiaRZeriniDMorraAGalimbertiVet alPreliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women2008724859310.1016/j.ijrobp.2007.12.03818407434Open DOISearch in Google Scholar
Bhandari T, Babaran W, Forouzannia A, Williams V, Harness J, Carpenter M, et al. A prospective phase I comparison of toxicity and cosmesis outcomes of single-fraction IORT and hypofractionated radiotherapy with IORT boost in early-stage breast cancer. Brachytherapy 2017; 16: 1232-1238.e2. doi: 10.1016/j.brachy.2017.09.002BhandariTBabaranWForouzanniaAWilliamsVHarnessJCarpenterMet alA prospective phase I comparison of toxicity and cosmesis outcomes of single-fraction IORT and hypofractionated radiotherapy with IORT boost in early-stage breast cancer20171612321238e210.1016/j.brachy.2017.09.00229032999Open DOISearch in Google Scholar