State of the art in breast intraoperative electron radiation therapy after intraoperative ultrasound introduction

1AIOM-AIRTum. [The number of cancer in Italy 2019]. [Italian]. Brescia: Intermedia Editore; 2019. Available at: www.medinews.itAIOM-AIRTum [The number of cancer in Italy 2019]. [Italian] Brescia Intermedia Editore 2019 Available at www.medinews.itSearch in Google Scholar

2AIOM Linee guida. [Breast neoplasms, 2019]. [Italian]. [internet]. 2019. [cited 2020 Oct 14]. Available at: https://www.aiom.it/linee-guida-aiomneoplasie-della-mammella-2019AIOM Linee guida [Breast neoplasms, 2019]. [Italian]. [internet] 2019 [cited 2020 Oct 14]. Available at https://www.aiom.it/linee-guida-aiomneoplasie-della-mammella-2019Search in Google Scholar

3Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomized trials Lancet 2011; 378: 1707-16. doi: 10.1016/S0140-6736(11)61629-2Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomized trials Lancet 2011 378 1707 16 10.1016/S0140-6736(11)61629-2325425222019144Open DOISearch in Google Scholar

4Hickey BE, James ML, Lehman M, Hider PN, Jeffery M, Francis DP, et al. Fraction size in radiation therapy for breast conservation in early breast cancer. Cochrane Database Syst Rev, 2016; 7: CD003860. doi: 10.1002/14651858.CD003860.pub4.Hickey BE James ML Lehman M Hider PN Jeffery M Francis DP et al Fraction size in radiation therapy for breast conservation in early breast cancer Cochrane Database Syst Rev 2016 7 CD003860 10.1002/14651858.CD003860.pub4645786227425588Open DOISearch in Google Scholar

5Valle LF, Agarwal S, Bickel KE, Herchek HA, Nalepinski DC, Kapadia NS. Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials. Breast Cancer Res Treat 2017; 162: 409-17. doi: 10.1007/ s10549-017-4118-7Valle LF Agarwal S Bickel KE Herchek HA Nalepinski DC Kapadia NS Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials Breast Cancer Res Treat 2017 162 409 17 10.1007/s10549-017-4118-728160158Open DOISearch in Google Scholar

6Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, et al. Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial. Lancet Oncol 2013; 14: 1269-77. doi: 10.1016/S1470-2045(13)70497-2Veronesi U Orecchia R Maisonneuve P Viale G Rotmensz N Sangalli C et al Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial Lancet Oncol 2013 14 1269 77 10.1016/S1470-2045(13)70497-224225155Open DOISearch in Google Scholar

7Maluta S, Dall’Oglio S, Goer DA, Marciai N. Intraoperative electron radiotherapy (IOERT) as an alternative to standard whole breast irradiation: only for low-risk subgroups? Breast Care 2014; 9: 102-6. doi: 10.1159/000362392Maluta S Dall’Oglio S Goer DA Marciai N Intraoperative electron radiotherapy (IOERT) as an alternative to standard whole breast irradiation: only for low-risk subgroups? Breast Care 2014 9 102 6 10.1159/000362392403831224944552Open DOISearch in Google Scholar

8Sedlmayer F, Reitsamer R, Wenz F, Sperk E, Fussl C, Kaiser J, et al. Intraoperative radiotherapy (IORT) as boost in breast cancer. Radiat Oncol 2017; 12: 23. doi: 10.1186/s13014-016-0749-9Sedlmayer F Reitsamer R Wenz F Sperk E Fussl C Kaiser J et al Intraoperative radiotherapy (IORT) as boost in breast cancer Radiat Oncol 2017 12 23 10.1186/s13014-016-0749-9524457428103903Open DOISearch in Google Scholar

9Fastner G, Gaisberger C, Kaiser J, Scherer P, Ciabattoni A, Petoukhova A, et al. ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy with electrons (IOERT) in breast cancer. Radiother Oncol 2020; 149: 150-15. doi: 10.1016/j.radonc.2020.04.059Fastner G Gaisberger C Kaiser J Scherer P Ciabattoni A Petoukhova A et al ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy with electrons (IOERT) in breast cancer Radiother Oncol 2020 149 150 15 10.1016/j.radonc.2020.04.05932413529Open DOISearch in Google Scholar

10Russo G, Casarino C, Arnetta G, Candiano G, Stefano A, Alongi F, et al. Dose distribution changes with shielding disc misalignments and wrong orientations in breast IOERT: a Monte Carlo-GEANT₄ and experimental study. J Appl Clin Med Phys 2012; 13: 74-92 doi: 10.1120/jacmp.v13i5.3817Russo G Casarino C Arnetta G Candiano G Stefano A Alongi F et al Dose distribution changes with shielding disc misalignments and wrong orientations in breast IOERT: a Monte Carlo-GEANT₄ and experimental study J Appl Clin Med Phys 2012 13 74 92 10.1120/jacmp.v13i5.3817571824222955646Open DOISearch in Google Scholar

11Vidali C, Severgnini M, Urbani M, Toscano L, Perulli A, Bortul M. FMECA application to intraoperative electron beam radiotherapy procedure as a quality method to prevent and reduce patient’s risk in conservative surgery for breast cancer. Front Med 2017; 4: 138 doi: 10.3389/fmed.2017.00138Vidali C Severgnini M Urbani M Toscano L Perulli A Bortul M FMECA application to intraoperative electron beam radiotherapy procedure as a quality method to prevent and reduce patient’s risk in conservative surgery for breast cancer Front Med 2017 4 138 10.3389/fmed.2017.00138558138828894737Open DOISearch in Google Scholar

12Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, et al. Accelerated partial breast irradiation: executive summary for the update of an ASTRO evidence-based consensus statement. Pract Radiat Oncol 2017; 7: 73-9. doi: 10.1016/j.prro.2016.09.007Correa C Harris EE Leonardi MC Smith BD Taghian AG Thompson AM et al Accelerated partial breast irradiation: executive summary for the update of an ASTRO evidence-based consensus statement Pract Radiat Oncol 2017 7 73 9 10.1016/j.prro.2016.09.00727866865Open DOISearch in Google Scholar

13Sedlmayer F, Fastner G, Sedlmayer F. Intra-operative electron boost and hypofractionated whole-breast irradiation during breast-conserving treatment (BCT) (HIOB). ClinicalTrials.gov Identifier: NCT01343459. [internet]. [cited 2020 Oct 13]. Available at: https://clinicaltrials.gov/ct2/show/NCT01343459Sedlmayer F Fastner G Sedlmayer F Intra-operative electron boost and hypofractionated whole-breast irradiation during breast-conserving treatment (BCT) (HIOB) ClinicalTrials.gov Identifier: NCT01343459 [internet]. [cited 2020 Oct 13]. Available at https://clinicaltrials.gov/ct2/show/NCT01343459Search in Google Scholar

14Fastner G, Reitsamer R, Urbanski B, Kopp P, Murawa D, Adamczyk B, et al. Toxicity and cosmetic outcome after hypofractionated whole breast irradiation and boost-IOERT in early stage breast cancer (HIOB): first results of a prospective multicenter trial (NCT01343459). Radiother Oncol 2020; 146: 136-42. doi: 10.1016/j.radonc.2020.02.001Fastner G Reitsamer R Urbanski B Kopp P Murawa D Adamczyk B et al Toxicity and cosmetic outcome after hypofractionated whole breast irradiation and boost-IOERT in early stage breast cancer (HIOB): first results of a prospective multicenter trial (NCT01343459) Radiother Oncol 2020 146 136 42 10.1016/j.radonc.2020.02.00132151790Open DOISearch in Google Scholar

15Severgnini M, de Denaro M, Bortul M, Vidali C, Beorchia A. In vivo dosimetry and shielding disk alignment verification by EBT3 GAFCHROMIC film in breast IOERT treatment. J Appl Clin Med Phys 2015; 16: 112-20. doi: 10.1120/jacmp.v16i1.5065Severgnini M de DenaroM BortulM VidaliC BeorchiaA In vivo dosimetry and shielding disk alignment verification by EBT3 GAFCHROMIC film in breast IOERT treatment J Appl Clin Med Phys 2015 16 112 20 10.1120/jacmp.v16i1.5065568999025679150Open DOISearch in Google Scholar

16Ciocca, M, Cantone MC, Veronese I, Cattani F, Pedroli G, Molinelli S, et al. Application of failure mode and effects analysis to intraoperative radiation therapy using mobile electron linear accelerators. Int J Radiat Oncol Biol Phys 2012; 82: e305-11. doi: 10.1016/j.ijrobp.2011.05.010Ciocca M CantoneMC VeroneseI CattaniF PedroliG MolinelliS et al Application of failure mode and effects analysis to intraoperative radiation therapy using mobile electron linear accelerators Int J Radiat Oncol Biol Phys 2012 82 e305 11 10.1016/j.ijrobp.2011.05.01021708432Open DOISearch in Google Scholar

17López-Tarjuelo J, Bouché-Babiloni A, Santos-Serra A, Morillo-Macías V, Calvo FA, Kubyshin Y, et al. Failure mode and effect analysis oriented to risk-reduction interventions in intraoperative electron radiation therapy: the specific impact of patient transportation, automation, and treatment planning availability. Radiother Oncol 2014; 113: 283-9 doi: 10.1016/j. radonc.2014.11.012López-Tarjuelo J Bouché-Babiloni A Santos-Serra A Morillo-Macías V Calvo FA Kubyshin Y et al Failure mode and effect analysis oriented to risk-reduction interventions in intraoperative electron radiation therapy: the specific impact of patient transportation, automation, and treatment planning availability Radiother Oncol 2014 113 283 9 10.1016/j.radonc.2014.11.01225465728Open DOISearch in Google Scholar

18Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995; 31: 1341-6. doi: 10.1016/0360-3016(95)00060-CCox JD Stetz J Pajak TF Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 1995 31 1341 6 10.1016/0360-3016(95)00060-C7713792Open DOISearch in Google Scholar

19Rubin P, Constine LS, Fajardo LF, Phillips TF, Wasserman TH. RTOG Late Effects Working Group. Overview of late effects of normal tissues (LENT) scoring system. Int J Radiat Oncol Biol Phys 1995; 31: 1041-2. doi: 10.1016/0360-3016(95)00057-6Rubin P Constine LS Fajardo LF Phillips TF Wasserman TH RTOG Late Effects Working Group. Overview of late effects of normal tissues (LENT) scoring system Int J Radiat Oncol Biol Phys 1995 31 1041 2 10.1016/0360-3016(95)00057-67713774Open DOISearch in Google Scholar

20Valdivieso-Casique MF, Rodríguez R, Rodríguez-Bescós S, Lardíes D, Guerra P, Ledesma MJ, et al. RADIANCE − a planning software for intra-operative radiation therapy. Transl Cancer Res 2015; 4: 196-209. doi: 10.3978/j. issn.2218-676X.2015.04.05Valdivieso-Casique MF Rodríguez R Rodríguez-Bescós S Lardíes D Guerra P Ledesma MJ et al RADIANCE − a planning software for intra-operative radiation therapy Transl Cancer Res 2015 4 196 209 10.3978/j.issn.2218-676X.2015.04.05Open DOISearch in Google Scholar

21Fastner G, Sedlmayer F, Merz F, Deutschmann H, Reitsamer R, Menzel C, et al. IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysis. Radiother Oncol 2013; 108: 279-86. doi: 10.1016/j.radonc.2013.05.031Fastner G Sedlmayer F Merz F Deutschmann H Reitsamer R Menzel C et al IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysis Radiother Oncol 2013 108 279 86 10.1016/j.radonc.2013.05.03123830467Open DOISearch in Google Scholar

22Kaiser J, Reitsamer R, Kopp P, Gaisberger C, Kopp M, Fischer T, et al. Intraoperative electron radiotherapy (IOERT) in the treatment of primary breast cancer. Breast Care 2018; 13: 162-7. doi: 10.1159/000489637Kaiser J Reitsamer R Kopp P Gaisberger C Kopp M Fischer T et al Intraoperative electron radiotherapy (IOERT) in the treatment of primary breast cancer Breast Care 2018 13 162 7 10.1159/000489637606266830069175Open DOISearch in Google Scholar

23Merrick HW 3rd, Hager E, Dobelbower RR Jr. Intraoperative radiation therapy for breast cancer. Surg Oncol Clin N Am 2003; 12: 1065-78. doi: 10.1016/s1055-3207(03)00098-xMerrick HW3rd HagerE DobelbowerRRJr. Intraoperative radiation therapy for breast cancer Surg Oncol Clin N Am 2003 12 1065 78 10.1016/s1055-3207(03)00098-x14989133Open DOISearch in Google Scholar

24Lemanski C, Azria D, Thezenas S, Gutowski M, Saint-Aubert B, Rouanet P, et al. Intraoperative radiotherapy given as a boost for early breast cancer: long-term clinical and cosmetic results. Int J Radiat Oncol Biol Phys 2006; 64: 1410-5. doi: 10.1016/j.ijrobp.2005.10.025Lemanski C Azria D Thezenas S Gutowski M Saint-Aubert B Rouanet P et al Intraoperative radiotherapy given as a boost for early breast cancer: long-term clinical and cosmetic results Int J Radiat Oncol Biol Phys 2006 64 1410 5 10.1016/j.ijrobp.2005.10.02516442241Open DOISearch in Google Scholar

25Wong WW, Pockaj BA, Vora SA, Halyard MY, Gray RJ, Schild SE. Six-year outcome of a prospective study evaluating tumor bed boost with intraoperative electron irradiation followed by whole-breast irradiation for early-stage breast cancer. Breast J 2014; 20: 125-30. doi:10.1111/tbj.12235Wong WW Pockaj BA Vora SA Halyard MY Gray RJ Schild SE Six-year outcome of a prospective study evaluating tumor bed boost with intraoperative electron irradiation followed by whole-breast irradiation for early-stage breast cancer Breast J 2014 20 125 30 10.1111/tbj.1223524372873Open DOISearch in Google Scholar

26Konig L, Lang K, Heil J, Golatta M, Major G, Krug D, et al. Acute toxicity and early oncological outcomes after intraoperative electron radiotherapy (IOERT) as boost followed by whole breast cancer patients – first clinical results from a single center. Front Oncol 2019; 9: 384. doi: 10.3389/ fonc.2019.00384Konig L Lang K Heil J Golatta M Major G Krug D et al Acute toxicity and early oncological outcomes after intraoperative electron radiotherapy (IOERT) as boost followed by whole breast cancer patients – first clinical results from a single center Front Oncol 2019 9 384 10.3389/fonc.2019.00384653670231165041Open DOISearch in Google Scholar

27Ivaldi GB, Leonardi MC, Orecchia R, Zerini D, Morra A, Galimberti V, et al. Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women. Int J Radiat Oncol Biol Phys 2008; 72: 485-93. doi: 10.1016/j.ijrobp.2007.12.038Ivaldi GB Leonardi MC Orecchia R Zerini D Morra A Galimberti V et al Preliminary results of electron intraoperative therapy boost and hypofractionated external beam radiotherapy after breast-conserving surgery in premenopausal women Int J Radiat Oncol Biol Phys 2008 72 485 93 10.1016/j.ijrobp.2007.12.03818407434Open DOISearch in Google Scholar

28Bhandari T, Babaran W, Forouzannia A, Williams V, Harness J, Carpenter M, et al. A prospective phase I comparison of toxicity and cosmesis outcomes of single-fraction IORT and hypofractionated radiotherapy with IORT boost in early-stage breast cancer. Brachytherapy 2017; 16: 1232-1238.e2. doi: 10.1016/j.brachy.2017.09.002Bhandari T Babaran W Forouzannia A Williams V Harness J Carpenter M et al A prospective phase I comparison of toxicity and cosmesis outcomes of single-fraction IORT and hypofractionated radiotherapy with IORT boost in early-stage breast cancer Brachytherapy 2017 16 1232 1238e2 10.1016/j.brachy.2017.09.00229032999Open DOISearch in Google Scholar