<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_raon-2020-0002_s_006_w2aab3b8c51b1b7b1aab1c16b1Aa"><h3>Background</h3><p>The aim of the study was to evaluate the safety and feasibility of intra-arterial mitomycin C (MMC) infusion after selective internal radiation therapy (SIRT) using Yttrium-90 (<sup>90</sup>Y) resin microspheres in liver metastatic breast cancer (LMBC) patients.</p></sec><sec id="j_raon-2020-0002_s_007_w2aab3b8c51b1b7b1aab1c16b2Aa"><h3>Patients and methods</h3><p>The prospective pilot study included LMBC patients from 2012–2018. Patients first received infusion of <sup>90</sup>Y resin microspheres, after 6–8 weeks response to treatment was assessed by MRI, <sup>18</sup>F-FDG PET/CT and laboratory tests. After exclusion of progressive disease, MMC infusion was administrated 8 weeks later in different dose cohorts; A: 6 mg in 1 cycle, B: 12 mg in 2 cycles, C: 24 mg in 2 cycles and D: maximum of 72 mg in 6 cycles. In cohort D the response was evaluated after every 2 cycles and continued after exclusion of progressive disease. Adverse events (AE) were reported according to CTCAE version 5.0.</p></sec><sec id="j_raon-2020-0002_s_008_w2aab3b8c51b1b7b1aab1c16b3Aa"><h3>Results</h3><p>Sixteen patients received <sup>90</sup>Y treatment. Four patients were excluded for MMC infusion, because of extra hepatic disease progression (n = 3) and clinical and biochemical instability (n = 1). That resulted in the following number of patient per cohort; A: 2, B: 1, C: 3 and D: 6. In 4 of the 12 patients (all cohort D) the maximum dose of MMC was adjusted due biochemical toxicities (n = 2) and progressive disease (n = 2). One grade 3 AE occurred after <sup>90</sup>Y treatment consisting of a gastrointestinal ulcer whereby prolonged hospitalization was needed.</p></sec><sec id="j_raon-2020-0002_s_009_w2aab3b8c51b1b7b1aab1c16b4Aa"><h3>Conclusions</h3><p>Sequential treatment of intra-arterial infusion of MMC after <sup>90</sup>Y SIRT was feasible in 75% of the patients when MMC was administrated in different escalating dose cohorts. However, caution is needed to prevent reflux after <sup>90</sup>Y SIRT in LMBC patients.</p></sec></abstract>

BackgroundThe aim of the study was to evaluate the safety and feasibility of intra-arterial mitomycin C (MMC) infusion after selective internal radiation therapy (SIRT) using Yttrium-90 (90Y) resin microspheres in liver metastatic breast cancer (LMBC) patients.Patients and methodsThe prospective pilot study included LMBC patients from 2012–2018. Patients first received infusion of 90Y resin microspheres, after 6–8 weeks response to treatment was assessed by MRI, 18F-FDG PET/CT and laboratory tests. After exclusion of progressive disease, MMC infusion was administrated 8 weeks later in different dose cohorts; A: 6 mg in 1 cycle, B: 12 mg in 2 cycles, C: 24 mg in 2 cycles and D: maximum of 72 mg in 6 cycles. In cohort D the response was evaluated after every 2 cycles and continued after exclusion of progressive disease. Adverse events (AE) were reported according to CTCAE version 5.0.ResultsSixteen patients received 90Y treatment. Four patients were excluded for MMC infusion, because of extra hepatic disease progression (n = 3) and clinical and biochemical instability (n = 1). That resulted in the following number of patient per cohort; A: 2, B: 1, C: 3 and D: 6. In 4 of the 12 patients (all cohort D) the maximum dose of MMC was adjusted due biochemical toxicities (n = 2) and progressive disease (n = 2). One grade 3 AE occurred after 90Y treatment consisting of a gastrointestinal ulcer whereby prolonged hospitalization was needed.ConclusionsSequential treatment of intra-arterial infusion of MMC after 90Y SIRT was feasible in 75% of the patients when MMC was administrated in different escalating dose cohorts. However, caution is needed to prevent reflux after 90Y SIRT in LMBC patients.

Sequential intra-arterial infusion of <sup>90</sup>Y-resin microspheres and mitomycin C in chemo refractory liver metastatic breast cancer patients: a single centre pilot study

Radiology and Oncology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Sequential intra-arterial infusion of Y-resin microspheres and mitomycin C in chemo refractory liver metastatic breast cancer patients: a single centre pilot study

BackgroundThe aim of the study was to evaluate the safety and feasibility of intra-arterial mitomycin C (MMC) infusion after selective internal radiation...

Sequential intra-arterial infusion of ⁹⁰Y-resin microspheres and mitomycin C in chemo refractory liver metastatic breast cancer patients: a single centre pilot study

Article Category: Research Article

Publicado en línea: 21 ene 2020

Páginas: 33 - 39

Recibido: 19 ago 2019

Aceptado: 04 dic 2019

DOI: https://doi.org/10.2478/raon-2020-0002

© 2020 Brigitte Maximiliana Aarts, Elisabeth Geneviève Klompenhouwer, Raphaëla Carmen Dresen, Christophe Michel Albert Louis Omer Deroose, Regina Gien Hoa Beets-Tan, Kevin Punie, Patrick Neven, Hans Wildiers, Geert Maleux, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Sequential intra-arterial infusion of 90Y-resin microspheres and mitomycin C in chemo refractory liver metastatic breast cancer patients: a single centre pilot study

Article Category: Research Article

Publicado en línea: 21 ene 2020

Páginas: 33 - 39

Recibido: 19 ago 2019

Aceptado: 04 dic 2019

DOI: https://doi.org/10.2478/raon-2020-0002

© 2020 Brigitte Maximiliana Aarts, Elisabeth Geneviève Klompenhouwer, Raphaëla Carmen Dresen, Christophe Michel Albert Louis Omer Deroose, Regina Gien Hoa Beets-Tan, Kevin Punie, Patrick Neven, Hans Wildiers, Geert Maleux, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Sequential intra-arterial infusion of ⁹⁰Y-resin microspheres and mitomycin C in chemo refractory liver metastatic breast cancer patients: a single centre pilot study