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Freeze-dried collagen nanocomposite sponges loaded with nicaraven-incorporated gelatin nanofibers for excisional diabetic wound healing: In vitro and in vivo studies

Huanli Hu

Huanli Hu

Medical College, Xuchang UniversityXuchang, China
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Hu, Huanli
 y 
Xueyang Zheng

Xueyang Zheng

Nursing Department, Xuchang Central HospitalXuchang, China
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Zheng, Xueyang
  
30 jun 2025
Freeze-dried collagen nanocomposite sponges loaded with nicaraven-incorporated gelatin nanofibers for excisional diabetic wound healing: In vitro and in vivo studies's Cover Image
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Categoría del artículo: Research Article
Publicado en línea: 30 jun 2025
Páginas: 40 - 51
Recibido: 18 abr 2024
Aceptado: 10 feb 2025
DOI: https://doi.org/10.2478/msp-2025-0006
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© 2025 Huanli Hu and Xueyang Zheng, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

SEM images of nicaraven-loaded and nicaraven-free gelatin nanofibers.
SEM images of nicaraven-loaded and nicaraven-free gelatin nanofibers.

Figure 2

SEM images of NICGELCOL and GELCOL sponges.
SEM images of NICGELCOL and GELCOL sponges.

Figure 3

MTT assay with L929 cells cultured on NICGELCOL and GELCOL scaffolds during 5 days of culture on the scaffolds.
MTT assay with L929 cells cultured on NICGELCOL and GELCOL scaffolds during 5 days of culture on the scaffolds.

Figure 4

Swelling properties of NICGELCOL and GELCOL sponges incubated in PBS for 24 h.
Swelling properties of NICGELCOL and GELCOL sponges incubated in PBS for 24 h.

Figure 5

MTT assay with L929 cells cultured with 1% H2O2 and NICGELCOL and GELCOL sponges. * shows p-value <0.05.
MTT assay with L929 cells cultured with 1% H2O2 and NICGELCOL and GELCOL sponges. * shows p-value <0.05.

Figure 6

Radical scavenging activity of NICGELCOL and GELCOL sponges compared with ascorbic acid as the control group.
Radical scavenging activity of NICGELCOL and GELCOL sponges compared with ascorbic acid as the control group.

Figure 7

In vitro wound closure with L929 cells cultured with NICGELCOL and GELCOL sponges on days 1 and 2. * shows p-value <0.05.
In vitro wound closure with L929 cells cultured with NICGELCOL and GELCOL sponges on days 1 and 2. * shows p-value <0.05.

Figure 8

In vivo wound closure assay with NICGELCOL and GELCOL sponges in diabetic rats on days 7 and 14 after wounding. * shows p-value <0.05.
In vivo wound closure assay with NICGELCOL and GELCOL sponges in diabetic rats on days 7 and 14 after wounding. * shows p-value <0.05.

Figure 9

Histopathological studies in diabetic wounds treated with NICGELCOL and GELCOL sponges and histomorphometric analysis. * shows p-value <0.05.
Histopathological studies in diabetic wounds treated with NICGELCOL and GELCOL sponges and histomorphometric analysis. * shows p-value <0.05.

Figure 10

ELISA results demonstrating the tissue concentrations of IL6 and TNF-α in wound tissues treated with NICGELCOL and GELCOL sponges. * shows p-value <0.05.
ELISA results demonstrating the tissue concentrations of IL6 and TNF-α in wound tissues treated with NICGELCOL and GELCOL sponges. * shows p-value <0.05.
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Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Ciencia de los materiales, Ciencia de los materiales, otros, Nanomateriales, Materiales funcionales e inteligentes, Características y propiedades de los materiales
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