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Utility of urinary markers in the assessment of renal dysfunction in familial glomerulonephritis in Dobermann dogs


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Concentration of urinary markers in sick Dobermann dogs divided into subgroups (expressed as mean and range)

Variable Subgroup A (n – 5) Subgroup B (n – 5)
uRBP/uCr (mg/g) 15.8 (2.6–ALD)* 0.38 (0.27–0.43)
uTHP/uCr (mg/g) 0.093 (0–0.093) 1.52 (0.39–3.7)*
uIgG/uCr (mg/g) 742.77 (34.02–2410.81)* 50.5 (0–85.17)

Results for blood biochemical parameters in sick Dobermann dogs and healthy dogs (expressed as mean and range)

Variable (reference range) Dobermann dogs (n = 10) Mean (range) Healthy dogs (n = 12) Mean (range)
Alanine transferase (u/L) (3–50) 43 (35–49) 47 (21–101)
Aspartate aminotransferase (u/L) (1–37) 18 (24–38) 28 (18–46)
Total bilirubin (mg/dL) (≤ 0.60) 0.36 (0.27–0.47) 0.2 (0.1–0.5)
Urea (mg/dL) (20.0–45.0) 35.9 (24.6–36.6) 37.7 (27.5–59.7)
Creatinine (μmol/L) (88–150) 114.9 (79.6–141.4) 106.1 (53–150.3)
Alkaline phosphatase (u/L) (20–155) 137 (98–150) 122 (110–143)
Glucose (mg/dL) (70–120) 98 (80–118) 117.2 (66–136)
Albumin (g/dL) (3.30–5.60) 3.54 (3.34–3.80) 3.7 (3.3–4.5)
Total protein (g/dL) (5.50–7.00) 6.26 (5.23–6.90) 6.7 (2.2–8.6)
Amylase (u/L) (388–1800) 595 (422–743) 602 (498–703)
Gamma glutamylotransferase (u/L) (5–25) 18 (12–24) 14 (8–23)

Results for routine urinary parameters of renal function in sick Dobermann dogs and healthy dogs (expressed as mean and range)

Variable Dobermann dogs (n = 10) Healthy dogs (n = 12)
uCr (mg/dL) 74.1 (20.0–149.6) 135.64 (53.91–212.82)
Specific gravity 1.03 (1.02–1.03) 1.03
UPC 1.3 (0.5–2.3) <0.5

Concentrations of urinary markers in sick Dobermann dogs and healthy dogs (expressed as mean and range)

Variable Doberman Pinscher dogs (n = 10) Healthy dogs (n = 12)
uRBP/uCr (mg/g) 2.82 (0.27–10.3)* 0.23 (0.08–0.41)
uTHP/uCr (mg/g) 0.7 (0–3.7) 0.2 (0–0.45)
uIgG/uCr (mg/g) 460.4 (34.02–2410.81)* 0
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Inglés
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4 veces al año
Temas de la revista:
Life Sciences, Molecular Biology, Microbiology and Virology, other, Medicine, Veterinary Medicine