[
Ang, C.W., Jarrad, A.M., Cooper, M.A. and Blaskovich, M.A. 2017. Nitroimidazoles: molecular fireworks that combat a broad spectrum of infectious diseases. Journal of Medicinal Chemistry, 60(18): 7636-7657.
]Search in Google Scholar
[
Commission-Decision-2002/657/EC. 2002. Implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Official Journal of the European Union, L221/8: 8-36.
]Search in Google Scholar
[
CRL. 2007. CRLs view on state-of-the-art analytical methods for the national residues plans for control of residues. Sanco. p. 3228. [cited 2016 Aug 27]. Available from: http://www.rivm.nl/bibliotheek/digitaaldepot/crlguidance2007.pdf.
]Search in Google Scholar
[
CRLs-20/1/2010. 2010. Community Reference Laboratories Residues: Guidelines For The Validation Of Screening Methods For Residues Of Veterinary Medicines (Initial Validation And Transfer).
]Search in Google Scholar
[
Cronly, M., Behan, P., Foley, B., Malone, E., Martin, S., Doyle, M. and Regan, L. 2010. Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS). Food Additives and Contaminants, 27(9): 1233-1246.
]Search in Google Scholar
[
Dmitrovic, J. and Durden, D.A. 2013. Analysis of fumagillin in honey by LC-MS/MS. Journal of AOAC International, 96(3): 687-695.
]Search in Google Scholar
[
Dugheri, S., Bonari, A., Pompilio, I., Colpo, M., Mucci, N., Montalti, M. and Arvangeli, G. 2017. Development of an Innovative Gas Chromatography– Mass Spectrometry Method for Assessment of Formaldehyde in the Workplace Atmosphere. Acta Chromatographica, 29(4):1-4.
]Search in Google Scholar
[
EMA. 2019. EMA/CVMP/CHMP/682198/2017. European Medicines Agency, Categorisation of antibiotics in the European Union.
]Search in Google Scholar
[
European Commission. 1996. Council directive 96/23/EC. Official Journal of the European Union, L125:10–32.
]Search in Google Scholar
[
European Commission. 2009. Commission Regulation No 470/2009 of the European Parliament and of the Council of 6 May 2009 laying down Community procedures for the establishment of residue limits of pharmacologically active substances in foodstuffs of animal origin, repealing Council Regulation (EEC) No. 2377/90 and amending Directive 2001/82/EC of the European Parliament and of the Council and Regulation (EC) No. 726/2004 of the European Parliament and of the Council. Official Journal of the European Union, L152: 11–22.
]Search in Google Scholar
[
European Commission. 2010. Commission regulation EU No 37/2010. Offi cial Journal of the European Union, L15:1–72.
]Search in Google Scholar
[
Formato, G., Rivera-Gomis, J., Bubnic, J., Martín-Hernández, R., Milito, M., Croppi, S. and Higes, M. 2022. Nosemosis prevention and control. Applied Sciences, 12(2): 783.
]Search in Google Scholar
[
Galajda, R., Valenčáková, A., Sučik, M. and Kandráčová, P. 2021. Nosema disease of European honey bees. Journal of Fungi, 7(9): 714.
]Search in Google Scholar
[
Galarini, R., Saluti, G., Giusepponi, D., Rossi, R. and Moretti, S. 2015. Multiclass determination of 27 antibiotics in honey. Food Control, 48: 12-24.
]Search in Google Scholar
[
Goulson, D., Nicholls, E., Botías, C. and Rotheray, E.L. 2015. Bee declines driven by combined stress from parasites, pesticides, and lack of flowers. Science, 347(6229): 1255957.
]Search in Google Scholar
[
Grupe, A.C. and Quandt, C.A. 2020. A growing pandemic: A review of Nosema parasites in globally distributed domesticated and native bees. PLoS pathogens, 16(6): e1008580.
]Search in Google Scholar
[
Guo, X.-C., Xia, Z.-Y., Wang, H.-H., Kang, W.-Y., Lin, L.-M., Cao, W.-Q., Zhang, H.-W. and Zhou, W.-H. 2017. Molecularly imprinted solid phase extraction method for simultaneous determination of seven nitroimidazoles from honey by HPLC-MS/MS. Talanta, 166: 101-108.
]Search in Google Scholar
[
Guo, Y., Wang, J., Hao, L., Wu, Q., Wang, C. and Wang, Z. 2021. Triazine-triphenylphosphine based porous organic polymer as sorbent for solid phase extraction of nitroimidazoles from honey and water. Journal of Chromatography A, 1649: 462238.
]Search in Google Scholar
[
Guruceaga, X., Perez-Cuesta, U., Abad-Diaz de Cerio, A., Gonzalez, O., Alonso, R.M., Hernando, F. L., Ramirez-Garcia, A. and Rementeria, A. 2019. Fumagillin, a mycotoxin of Aspergillus fumigatus: biosynthesis, biological activities, detection, and applications. Toxins, 12(1): 7.
]Search in Google Scholar
[
Hanson, F.R. and Eble, T.E. 1949. An antiphage agent isolated from Aspergillus sp. Journal of Bacteriology, 58(4): 527-529.
]Search in Google Scholar
[
Hristov, P., Shumkova, R., Palova, N. and Neov, B. 2020. Factors associated with honey bee colony losses: A mini-review. Veterinary Sciences, 7(4): 166.
]Search in Google Scholar
[
Huang, X., Lin, J. and Yuan, D. 2011. Simple and sensitive determination of nitroimidazole residues in honey using stir bar sorptive extraction with mixed mode monolith followed by liquid chromatography. Journal of Separation Science, 34(16-17): 2138-2144.
]Search in Google Scholar
[
ISO-11843-2, Capability of detection—Part 2: Methodology in the linear calibration case, (2000).
]Search in Google Scholar
[
Kanda, M., Sasamoto, T., Takeba, K., Hayashi, H., Kusano, T., Matsushima, Y., Nakajima, T., Kanai, S. and Takano, I. 2011. Rapid determination of fumagillin residues in honey by liquid chromatography/tandem mass spectrometry using the QuEChERS method. Journal of AOAC International, 94(3): 878-885.
]Search in Google Scholar
[
Kanda, M., Sasamoto, T., Takeba, K., Hayashi, H., Kusano, T., Matsushima, Y., Nakajima, T., Kanai, S. and Takano, I. 2012. Rapid determination of nitroimidazole residues in honey by liquid chromatography/tandem mass spectrometry. Journal of AOAC International, 95(3): 923-931.
]Search in Google Scholar
[
Karabagias, I.K., Badeka, A.V., Kontakos, S., Karabournioti, S. and Kontominas, M.G. 2014. Botanical discrimination of Greek unifloral honeys with physico-chemical and chemometric analyses. Food Chemistry, 165: 181-190.
]Search in Google Scholar
[
Kasiotis, K.M., Baira, E., Iosifidou, S., Bergele, K., Manea-Karga, E., Theologidis, I., Barmpouni, T., Tsipi, D. and Machera, K. 2022. Characterization of Ikaria heather honey by Untargeted Ultrahigh-Performance Liquid Chromatography-High Resolution Mass Spectrometry Metabolomics and melissopalynological analysis. Frontiers in Chemistry, 10:924881.
]Search in Google Scholar
[
Kasiotis, K.M., Manea-Karga, E., Tzanetou, E.N., Barmpouni, T., Liapatas, G. and Machera, K. 2023. Introducing direct probe electrospray ionization tandem mass spectrometry in apiculture: Comparison with other mass spectrometric methods for the determination of antibiotics in bees and honey. International Journal of Mass Spec-trometry, 489: 117064.
]Search in Google Scholar
[
Kunat-Budzyńska, M., Budzyński, M., Schulz, M., Strachecka, A., Gancarz, M., Rusinek, R. and Ptaszyńska, A.A. 2022. Natural substances, probiotics, and synthetic agents in the treatment and prevention of honeybee nosemosis. Pathogens, 11(11): 1269.
]Search in Google Scholar
[
Lei, H., Guo, J., Lv, Z., Zhu, X., Xue, X., Wu, L. and Cao, W. 2018. Simultaneous determination of nitroimidazoles and quinolones in honey by modified QuEChERS and LC-MS/MS analysis. International Journal of Analytical Chemistry, 2018(1): 4271385.
]Search in Google Scholar
[
Li, X., Ke, Y., Wang, Y., Wang, C., Ye, D., Hu, X., Zhou, L., Xia, X. 2018. Confirmatory analysis of nitroimidazoles and hydroxy metabolites in honey by Dispersive-Solid Phase Extraction and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry. Molecules, 23:3350.
]Search in Google Scholar
[
Liu, Z., Wang, J., Guo, Y., Liu, J., Wang, J., Wang, C., Wu, Q. and Wang, Z. 2022. Amino-functionalized hypercrosslinked polymer as sorbent for effective extraction of nitroimidazoles from water, drink and honey samples. Journal of Chromatography A, 1676: 463206.
]Search in Google Scholar
[
Mazur, E.D. and Gajda, A.M. 2022. Nosemosis in honeybees: a review guide on biology and diagnostic methods. Applied Sciences, 12(12): 5890.
]Search in Google Scholar
[
Melekhin, A., Tolmacheva, V., Goncharov, N., Apyari, V., Parfenov, M. Y., Bulkatov, D., Dmitrienko, S. and Zolotov, Y.A. 2024. Rapid multi-residue LC-MS/MS determination of nitrofuran metabolites, nitroimidazoles, amphenicols, and quinolones in honey with ultrasonic-assisted derivatization–magnetic solid-phase extraction. Journal of Pharmaceutical and Biomedical Analysis, 237: 115764.
]Search in Google Scholar
[
Mitrowska, K. and Antczak, M. 2017. Transfer of nitroimidazoles from contaminated beeswax to honey. Food Additives & Contaminants: Part A, 34(4): 573-581.
]Search in Google Scholar
[
Mitrowska, K., Posyniak, A. and Zmudzki, J. 2014. Selective determination of fourteen nitroimidazoles in honey by high-performance liquid chromatography–tandem mass spectrometry. Analytical Letters, 47(10): 1634-1649.
]Search in Google Scholar
[
Nakamura, S. 1955. Structure of azomycin, a new antibiotic. Pharmaceutical Bulletin, 3(5): 379-383.
]Search in Google Scholar
[
Nozal, M.J., Bernal, J. L., Martín, M.T., Bernal, J., Alva-ro, A., Martín, R. and Higes, M. 2008. Trace analysis of fumagillin in honey by liquid chromatography-diode array–electrospray ionization mass spectrometry. Journal of Chromatography A, 1190(1-2): 224-2 31.
]Search in Google Scholar
[
Pasho, I., Vaso, K., Dardha, L., Marku, E. and Hoxha, V. 2024. Detection and analysis of nitroimidazole residues in Albanian honey: Implications for food safety and regulatory oversight. In Proceedings of the 4th International Conference on Innovative Academic Studies (ICIAS), Konya, Turkey 12-13 March 2024, p. 1391-1401.
]Search in Google Scholar
[
Patouna, A., Vardakas, P., Skaperda, Z., Spandidos, D.A. and Kouretas, D. 2023. Evaluation of the antioxidant potency of Greek honey from the Taygetos and Pindos mountains using a combination of cellular and molecular methods. Molecular Medicine Reports, 27, 54. https://doi.org/10.3892/mmr.2023.12941.
]Search in Google Scholar
[
Peirson, M. and Pernal, S.F. 2024. A Systematic review of fumagillin field trials for the treatment of Nosema disease in honeybee colonies. Insects, 15(1): 29.
]Search in Google Scholar
[
Rabea, D., Ryad, L., Shehata, M.R. and Khalaf-Alla, P.A. 2024. Nitroimidazole residues in Egyptian honey using UPLC-Orbitrap-HRMS. Food Additives and Contaminants: Part B, 1-13.
]Search in Google Scholar
[
Sakamoto, M., Takeba, K., Sasamoto, T., Kusano, T., Hayashi, H., Kanai, S., Kanda, M. and Nagayama, T. 2011. Determination of dimetridazole, metronidazole and ronidazole in salmon and honey by liquid chromatography coupled with tandem mass spectrometry. Journal of the Food Hygienic Society of Japan, 52(1): 51-58.
]Search in Google Scholar
[
SANTE/11312/2021. 2021. Guidance document on analytical quality control and method validation procedures for pesticides residues analysis in food and feed.
]Search in Google Scholar
[
Shendy, A.H., Al-Ghobashy, M.A., Alla, S.A.G. and Lotfy, H.M. 2016. Development and validation of a modified QuEChERS protocol coupled to LC–MS/MS for simultaneous determination of multi-class antibiotic residues in honey. Food Chemistry, 190: 982-989.
]Search in Google Scholar
[
Stanimirovic, Z., Stevanovic, J., Bajic, V. and Radovic, I. 2007. Evaluation of genotoxic effects of fumagillin by cytogenetic tests in vivo. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 628(1): 1-10.
]Search in Google Scholar
[
Tölgyesi, Á., Sharma, V.K., Fekete, S., Fekete, J., Simon, A. and Farkas, S. 2012. Development of a rapid method for the determination and confirmation of nitroimidazoles in six matrices by fast liquid chromatography–tandem mass spec-trometry. Journal of Pharmaceutical and Biomedical Analysis, 64: 40-48.
]Search in Google Scholar
[
Van den Heever, J.P., Thompson, T.S., Curtis, J.M., Ibrahim, A. and Pernal, S.F. 2014. Fumagillin: an overview of recent scientific advances and their significance for apiculture. Journal of Agricultural and Food chemistry, 62(13): 2728-2737.
]Search in Google Scholar
[
Van den Heever, J.P., Thompson, T.S., Curtis, J.M. and Pernal, S.F. 2015a. Determination of dicyclohexylamine and fumagillin in honey by LC-MS/MS. Food Analytical Methods, 8: 767-777.
]Search in Google Scholar
[
Van den Heever, J.P., Thompson, T.S., Curtis, J.M. and Pernal, S.F. 2015b. Stability of dicyclohexylamine and fumagillin in honey. Food Chemistry, 179: 152-158.
]Search in Google Scholar
[
Van Loco, J., Jànosi, A., Impens, S., Fraselle, S., Cornet, V. and Degroodt, J.M. 2007. Calculation of the decision limit (CCα) and the detection capability (CCβ) for banned substances: The imperfect marriage between the quantitative and the qualitative criteria. Analytica Chimica Acta, 586: 8-12.
]Search in Google Scholar
[
Zhou, J., Shen, J., Xue, X., Zhao, J., Li, Y., Zhang, J. and Zhang, S. 2007. Simultaneous determination of nitroimidazole residues in honey samples by high-performance liquid chromatography with ultraviolet detection. Journal of AOAC International, 90(3): 872-878.
]Search in Google Scholar
