Therapeutic efficacy of Albendazole and Mefloquine alone or in combination against early and late stages of Trichinella spiralis infection in mice

ABDEL-FATTAH, N.S., AHMED, N.S. (2011): Evaluation of mefloquine-praziquantel combination therapy in pre-patent and patent Schistosoma mansoni infection in mice. Sci Parasitol, 12(3):139–149ABDEL-FATTAH N.S. AHMED N.S. 2011 Evaluation of mefloquine-praziquantel combination therapy in pre-patent and patent Schistosoma mansoni infection in mice Sci Parasitol 12 3 139 149Search in Google Scholar

ABDEL-HAFEEZ, E., KAMAL, A., ABDELGELIL, N., ABDEL-FATAH, M. (2015): Parasites transmitted to human by ingestion of different types of meat, El-Minia City, El-Minia Governorate, Egypt. J Egypt Soc Parasitol, 45(3): 671–680. DOI: 10.12816/0017935ABDEL-HAFEEZ E. KAMAL A. ABDELGELIL N. ABDEL-FATAH M. 2015 Parasites transmitted to human by ingestion of different types of meat, El-Minia City, El-Minia Governorate, Egypt J Egypt Soc Parasitol 45 3 671 680 10.12816/001793526939246Open DOISearch in Google Scholar

ABOU-SHADY, O.M., MOHAMMED, S.S., ATTIA, S.S., YUSUF, H.-A.S., HELMY, D.O. (2016): Therapeutic effect of mefloquine on Schistosoma mansoni in experimental infection in mice. J Parasit Dis, 40(2): 259–267. DOI: 10.1007/s12639-014-0489-4ABOU-SHADY O.M. MOHAMMED S.S. ATTIA S.S. YUSUF H.-A.S. HELMY D.O. 2016 Therapeutic effect of mefloquine on Schistosoma mansoni in experimental infection in mice J Parasit Dis 40 2 259 267 10.1007/s12639-014-0489-4492747127413290Open DOISearch in Google Scholar

ABOU RAYIA, D.M., SAD, A.E., ASHOUR, D.S., OREIBY, R.M. (2017): Implication of artemisinin nematocidal activity on experimental trichinellosis: In vitro and in vivo studies. Parasitol Int, 66(2): 56–63. DOI: 10.1016/j.parint.2016.11.012ABOU RAYIA D.M. SAD A.E. ASHOUR D.S. OREIBY R.M. 2017 Implication of artemisinin nematocidal activity on experimental trichinellosis: In vitro and in vivo studies Parasitol Int 66 2 56 63 10.1016/j.parint.2016.11.01227894908Open DOISearch in Google Scholar

AKIHO, H., DENG, Y., BLENERHASETT, P., KANBAYASHI, H., COLLINS, S.M. (2005): Mechanisms underlying the maintenance of muscle hyper contractility in a model of post-infective gut dysfunction. Gastroenterology, 129(1): 131–141. DOI: 10.1053/j.gastro.2005.03.049 ALY, N., SELEM, R., ZALAT, R., KHALIL, H., TALHA, B. (2017): An innovative repurposing of mefloquine; assessment of its therapeutic efficacy in treating Cryptosporidium parvum infection of both immunocompetent and immunocompromised mice. J Egypt Soc Parasitol, 47(2): 253–262. DOI: 10.12816/JESP.2017.77763AKIHO H. DENG Y. BLENERHASETT P. KANBAYASHI H. COLLINS S.M. 2005 Mechanisms underlying the maintenance of muscle hyper contractility in a model of post-infective gut dysfunction Gastroenterology 129 1 131 141 10.1053/j.gastro.2005.03.049 ALY, N., SELEM, R., ZALAT, R., KHALIL, H., TALHA, B. (2017): An innovative repurposing of mefloquine; assessment of its therapeutic efficacy in treating Cryptosporidium parvum infection of both immunocompetent and immunocompromised mice. J Egypt Soc Parasitol, 47(2): 253–262. 10.12816/JESP.2017.7776316012943Open DOISearch in Google Scholar

ANDREWS, K.T., FISHER, G., SKINER-ADAMS, T.S. (2014): Drug repurposing and human parasitic protozoan diseases. Int J Parasitol Drugs Drug Resist, 4(2): 95–111. DOI: 10.1016/j.ijpddr.2014.02.002ANDREWS K.T. FISHER G. SKINER-ADAMS T.S. 2014 Drug repurposing and human parasitic protozoan diseases Int J Parasitol Drugs Drug Resist 4 2 95 111 10.1016/j.ijpddr.2014.02.002409505325057459Open DOISearch in Google Scholar

ATTIA, R., MAHMOUD, A., FARAG, H., MAKBOUL, R., MOHAMED, M., IBRAHEIM, Z. (2015): Effect of myrrh and thyme on Trichinella spiralis enteral and parenteral phases with inducible nitric oxide expression in mice. Mem Inst Oswaldo Cruz, 110(8): 1035–1041. DOI: 10.1590/0074-02760150295ATTIA R. MAHMOUD A. FARAG H. MAKBOUL R. MOHAMED M. IBRAHEIM Z. 2015 Effect of myrrh and thyme on Trichinella spiralis enteral and parenteral phases with inducible nitric oxide expression in mice Mem Inst Oswaldo Cruz 110 8 1035 1041 10.1590/0074-02760150295470802426676322Open DOISearch in Google Scholar

BAI, X., HU, X., LIU, X., TANG, B., LIU, M. (2017): Current research of trichinellosis in China. Front Microbiol, 8: 1–7. DOI: 10.3389/fmicb.2017.01472BAI X. HU X. LIU X. TANG B. LIU M. 2017 Current research of trichinellosis in China Front Microbiol 8 1 7 10.3389/fmicb.2017.01472553937628824597Open DOISearch in Google Scholar

BALASUBRAMANIAN, A., TERAMOTO, T., KULKARNI, A.A., BHATTACHARJEE, A.K., PADMANABHAN, R. (2017): Antiviral activities of selected antimalarial against dengue virus type 2 and Zika virus. Antiviral Res, 137, 141–150. DOI: 10.1016/j.antiviral.2016.11.015BALASUBRAMANIAN A. TERAMOTO T. KULKARNI A.A. BHATTACHARJEE A.K. PADMANABHAN R. 2017 Antiviral activities of selected antimalarial against dengue virus type 2 and Zika virus Antiviral Res 137 141–150 10.1016/j.antiviral.2016.11.01527889529Open DOISearch in Google Scholar

BARNES, E.H., DOBSON, R.J., BARGER, I.A. (1995): Worm control and anthelmintic resistance: adventures with a model. In Parasitology Today (Vol. 11, Issue 2, pp. 56–63). Elsevier Current Trends. DOI: 10.1016/0169-4758(95)80117-0BARNES E.H. DOBSON R.J. BARGER I.A. 1995 Worm control and anthelmintic resistance: adventures with a model In Parasitology Today Vol. 11 Issue 2 pp 56 63 Elsevier Current Trends 10.1016/0169-4758(95)80117-015275374Open DOISearch in Google Scholar

CAPO, V.A., DESPOMMIER, D.D., POLVERE, R.I. (1998): Trichinella spiralis: vascular endothelial growth factor is up-regulated within the nurse cell during the early phase of its formation. J Parasitol, 84(2): 209. PMID: 9576489CAPO V.A. DESPOMMIER D.D. POLVERE R.I. 1998 Trichinella spiralis: vascular endothelial growth factor is up-regulated within the nurse cell during the early phase of its formation J Parasitol 84 2 209 PMID: 957648910.2307/3284472Search in Google Scholar

CEBALLOS, L., KROLEWIECKI, A., JUÁREZ, M., MORENO, L., SCHAER, F., ALVAREZ, L.I., CIMINO, R., WALSON, J., LANUSE, C.E. (2018): Assessment of serum pharmacokinetics and urinary excretion of albendazole and its metabolites in human volunteers. PLoS Negl Trop Dis, 12(1): e0005945. DOI:10.1371/journal.pntd.0005945CEBALLOS L. KROLEWIECKI A. JUÁREZ M. MORENO L. SCHAER F. ALVAREZ L.I. CIMINO R. WALSON J. LANUSE C.E. 2018 Assessment of serum pharmacokinetics and urinary excretion of albendazole and its metabolites in human volunteers PLoS Negl Trop Dis 12 1 e0005945 10.1371/journal.pntd.0005945577300029346367Open DOISearch in Google Scholar

CODINA, A.V., GARCÍA, A., LEONARDI, D., VASCONI, M.D., DIMASO, R.J., LAMAS, M.C., HINRICHSEN, L.I. (2015): Efficacy of albendazole:β-cyclodextrin citrate in the parenteral stage of Trichinella spiralis infection. Int J Biol Macromol, 77, 203–206. DOI: 10.1016/j.ijbiomac.2015.02.049CODINA A.V. GARCÍA A. LEONARDI D. VASCONI M.D. DIMASO R.J. LAMAS M.C. HINRICHSEN L.I. 2015 Efficacy of albendazole:β-cyclodextrin citrate in the parenteral stage of Trichinella spiralis infection Int J Biol Macromol 77 203–206 10.1016/j.ijbiomac.2015.02.04925790725Open DOISearch in Google Scholar

DAYAN, A.D. (2003): Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics. Acta Trop, 86(2–3): 141–159. DOI: 10.1016/S0001-706X(03)00031-7DAYAN A.D. 2003 Albendazole, mebendazole and praziquantel Review of non-clinical toxicity and pharmacokinetics. Acta Trop 86 2–3 141 159 10.1016/S0001-706X(03)00031-712745134Open DOISearch in Google Scholar

DUN, I.J., WRIGHT, K.A. (1985): Cell injury caused by Trichinella spiralis in the mucosal epithelium of B10A mice. J Parasitol, 71(6): 757–766. DOI: 10.2307/3281709DUN I.J. WRIGHT K.A. 1985 Cell injury caused by Trichinella spiralis in the mucosal epithelium of B10A mice J Parasitol 71 6 757 766 10.2307/3281709Open DOISearch in Google Scholar

DYAB, A. (2019): Prevalence and histopathology of Trichinella Spiralis larvae of slaughtered pigs in Cairo Governorate, Egypt. J Egypt Soc Parasitol, 49(2): 439–442. DOI: 10.21608/JESP.2019.68187 ELGENDY, D.I., OTHMAN, A.A., HASBY SAD, M.A., SOLIMAN, N.A., MWAFY, S.E. (2020): Resveratrol reduces oxidative damage and inflammation in mice infected with Trichinella spiralis J Helminthol, 94, e140. DOI: 10.1017/S0022149X20000206DYAB A. 2019 Prevalence and histopathology of Trichinella Spiralis larvae of slaughtered pigs in Cairo Governorate, Egypt J Egypt Soc Parasitol 49 2 439 442 10.21608/JESP.2019.68187 ELGENDY, D.I., OTHMAN, A.A., HASBY SAD, M.A., SOLIMAN, N.A., MWAFY, S.E. (2020): Resveratrol reduces oxidative damage and inflammation in mice infected with Trichinella spiralis J Helminthol, 94, e140. 10.1017/S0022149X20000206Open DOISearch in Google Scholar

ELMEHY, D.A., ISMAIL, H.I., SOLIMAN, N.A., AMER, B.S., ELKALINY, H.H., EL-EBIARY, A.A., GAMEA, G.A. (2021): Oxidative stress mediated apoptotic potential of mefloquine on experimental trichinellosis. Acta Trop, 213, 105760. DOI: 10.1016/j.actatropica.2020.105760ELMEHY D.A. ISMAIL H.I. SOLIMAN N.A. AMER B.S. ELKALINY H.H. EL-EBIARY A.A. GAMEA G.A. 2021 Oxidative stress mediated apoptotic potential of mefloquine on experimental trichinellosis Acta Trop 213 105760 10.1016/j.actatropica.2020.10576033221280Open DOISearch in Google Scholar

FAKAHANY, A.F., YOUNIS, M.S., EL HAMSHARY, A.M., FOUAD, M., HASAN, M., ALI, H. (2014): Effect of mefloquine on worm burden and tegumental changes in experimental Schistosoma mansoni infection. J Microsc Ultrastruct, 2(1): 7–11. DOI: 10.1016/j.jmau.2014.03.001 GUTMAN, J., GREEN, M., DURAND, S., ROJAS, O.V., GANGULY, B., QUEZADA, W.M., UTZ, G.C., SLUTSKER, L., RUEBUSH, T.K., BACON, D.J. (2009): Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria. Malar J, 8(1): 58. DOI: 10.1186/14752875-8-58FAKAHANY A.F. YOUNIS M.S. EL HAMSHARY A.M. FOUAD M. HASAN M. ALI H. 2014 Effect of mefloquine on worm burden and tegumental changes in experimental Schistosoma mansoni infection J Microsc Ultrastruct 2 1 7 11 10.1016/j.jmau.2014.03.001 GUTMAN, J., GREEN, M., DURAND, S., ROJAS, O.V., GANGULY, B., QUEZADA, W.M., UTZ, G.C., SLUTSKER, L., RUEBUSH, T.K., BACON, D.J. (2009): Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria. Malar J, 8(1): 58. 10.1186/14752875-8-58Open DOISearch in Google Scholar

JIANG, P., WANG, Z.-Q., CUI, J., ZHANG, X. (2012): Comparison of artificial digestion and Baermann’s methods for detection of Trichinella spiralis pre-encapsulated larvae in muscles with low-level infections. Foodborne Pathog Dis, 9(1): 27–31. DOI: 10.1089/fpd.2011.0985JIANG P. WANG Z.-Q. CUI J. ZHANG X. 2012 Comparison of artificial digestion and Baermann’s methods for detection of Trichinella spiralis pre-encapsulated larvae in muscles with low-level infections Foodborne Pathog Dis 9 1 27 31 10.1089/fpd.2011.098521988397Open DOISearch in Google Scholar

KALAISELVAN, R., MOHANTA, G.P., MADHUSUDAN, S., MANA, P.K., MANAVALAN, R. (2007): Enhancement of bioavailability and anthelmintic efficacy of albendazole by solid dispersion and cyclodextrin complexation techniques. Pharmazie, 62(8): 604–607. PMID: 17867556 KAMILI, C., KAKATAPAR THY, R.S., VATTIKUTTI, U.M., CHIDRAWAR, V., AMMINENI, S. (2017): Anti-proliferative and anti-angiogenic activities of ion-channel modulators: In-ovo, in-vitro and in-vivo study. Asian Pac J Trop Biomed, 7(6): 555–562. DOI: 10.1016/j.apjtb.2017.05.005KALAISELVAN R. MOHANTA G.P. MADHUSUDAN S. MANA P.K. MANAVALAN R. 2007 Enhancement of bioavailability and anthelmintic efficacy of albendazole by solid dispersion and cyclodextrin complexation techniques Pharmazie 62 8 604 607 PMID: 17867556 KAMILI, C., KAKATAPAR THY, R.S., VATTIKUTTI, U.M., CHIDRAWAR, V., AMMINENI, S. (2017): Anti-proliferative and anti-angiogenic activities of ion-channel modulators: In-ovo, in-vitro and in-vivo study. Asian Pac J Trop Biomed, 7(6): 555–562 10.1016/j.apjtb.2017.05.005Open DOISearch in Google Scholar

KANG, Y.-J., JO, J.-O., CHO, M.-K., YU, H.-S., OCK, M. S., CHA, H.J. (2011): Trichinella spiralis infection induces angiogenic factor thymosin β4 expression. Vet Parasitol, 181(2–4): 222–228. DOI: 10.1016/j.vetpar.2011.03.058KANG Y.-J. JO J.-O. CHO M.-K. YU H.-S. OCK M. S. CHA H.J. 2011 Trichinella spiralis infection induces angiogenic factor thymosin β4 expression Vet Parasitol 181 2–4 222 228 10.1016/j.vetpar.2011.03.05821531510Open DOISearch in Google Scholar

KEISER, J., CHOLLET, J., XIAO, S.H., MEI, J.Y., JIAO, P.Y., UTZINGER, J., TANER, M. (2009): Mefloquine-An amino alcohol with promising antischistosomal properties in mice. PLoS Negl Trop Dis, 3(1). DOI: 10.1371/journal.pntd.0000350KEISER J. CHOLLET J. XIAO S.H. MEI J.Y. JIAO P.Y. UTZINGER J. TANER M. 2009 Mefloquine-An amino alcohol with promising antischistosomal properties in mice PLoS Negl Trop Dis 3 1 10.1371/journal.pntd.0000350260081319125172Open DOISearch in Google Scholar

KEISER, J., N’GUESAN, N. A., ADOUBRYN, K. D., SILUÉ, K.D., VOUNATSOU, P., HATZ, C., UTZINGER, J., N’GORAN, E.K. (2010): Efficacy and safety of mefloquine, artesunate, mefloquine‐artesunate, and praziquantel against Schistosoma haematobium : randomized, exploratory open‐label trial. Clin Infect Dis, 50(9): 1205–1213. DOI: 10.1086/651682KEISER J. N’GUESAN N. A. ADOUBRYN K. D. SILUÉ K.D. VOUNATSOU P. HATZ C. UTZINGER J. N’GORAN E.K. 2010 Efficacy and safety of mefloquine, artesunate, mefloquine‐artesunate, and praziquantel against Schistosoma haematobium : randomized, exploratory open‐label trial Clin Infect Dis 50 9 1205 1213 10.1086/65168220350194Open DOISearch in Google Scholar

KEISER, J., UTZINGER, J. (2012): Antimalarials in the treatment of schistosomiasis. Curr Pharm Des, 18(24): 3531–3538. PMID: 22607145KEISER J. UTZINGER J. 2012 Antimalarials in the treatment of schistosomiasis Curr Pharm Des 18 24 3531 3538 PMID: 2260714510.2174/138161212801327293Search in Google Scholar

KÜSTER, T., STADELMAN, B., HERMAN, C., SCHOLL, S., KEISER, J., HEMPHILL, A. (2011): In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis. Antimicrob Agents Chemother, 55(2): 713–721. DOI: 10.1128/AAC.01392-10KÜSTER T. STADELMAN B. HERMAN C. SCHOLL S. KEISER J. HEMPHILL A. 2011 In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis Antimicrob Agents Chemother 55 2 713 721 10.1128/AAC.01392-10302878121135182Open DOISearch in Google Scholar

LIU, Y., CHEN, S., XUE, R., ZHAO, J., DI, M. (2016): Mefloquine effectively targets gastric cancer cells through phosphatase-dependent inhibition of PI3K/Akt/mTOR signaling pathway. Biochem Biophys Res Commun, 470(2): 350–355. DOI: 10.1016/j.bbrc.2016.01.046 LOOAREESUWAN, S., WHITE, N., WARELL, D., FORGO, I., DUBACH, U., RANALDER, U., SCHWARTZ, D. (1987): Studies of mefloquine bioavailability and kinetics using a stable isotope technique: a comparison of Thai patients with falciparum malaria and healthy Caucasian volunteers. Br J Clin Pharmacol, 24(1): 37–42. DOI: 10.1111/j.1365-2125.1987.tb03133.xLIU Y. CHEN S. XUE R. ZHAO J. DI M. 2016 Mefloquine effectively targets gastric cancer cells through phosphatase-dependent inhibition of PI3K/Akt/mTOR signaling pathway Biochem Biophys Res Commun 470 2 350 355 10.1016/j.bbrc.2016.01.046 LOOAREESUWAN, S., WHITE, N., WARELL, D., FORGO, I., DUBACH, U., RANALDER, U., SCHWARTZ, D. (1987): Studies of mefloquine bioavailability and kinetics using a stable isotope technique: a comparison of Thai patients with falciparum malaria and healthy Caucasian volunteers. Br J Clin Pharmacol, 24(1): 37–42. 0.1111/j.1365-2125.1987.tb03133.x26780727Open DOISearch in Google Scholar

MANECK, T., HAGGENMULLER, Y., KEISER, J. (2010): Morphological effects and tegumental alterations induced by mefloquine on Schistosomula and adult flukes of Schistosoma mansoni. Parasitology, 137(1): 85–98. DOI: 10.1017/S0031182009990965MANECK T. HAGGENMULLER Y. KEISER J. 2010 Morphological effects and tegumental alterations induced by mefloquine on Schistosomula and adult flukes of Schistosoma mansoni Parasitology 137 1 85 98 10.1017/S003118200999096519814844Open DOISearch in Google Scholar

MATADAMAS-MARTÍNEZ, F., NOGUEDA-TORES, B., HERNÁNDEZ-CAMPOS, A., HERNÁNDEZ-LUIS, F., CASTILLO, R., MENDOZA, G., AMBROSIO, J.R., ANDRÉS-ANTONIO, G., YÉPEZ-MULIA, L. (2013): Analysis of the effect of a 2-(trifluoromethyl)-1H-benzimidazole derivative on Trichinella spiralis muscle larvae. Vet Parasitol, 194(2–4): 193–197. DOI: 10.1016/j.vetpar.2013.01.054MATADAMAS-MARTÍNEZ F. NOGUEDA-TORES B. HERNÁNDEZ-CAMPOS A. HERNÁNDEZ-LUIS F. CASTILLO R. MENDOZA G. AMBROSIO J.R. ANDRÉS-ANTONIO G. YÉPEZ-MULIA L. 2013 Analysis of the effect of a 2-(trifluoromethyl)-1H-benzimidazole derivative on Trichinella spiralis muscle larvae Vet Parasitol 194 2–4 193 197 10.1016/j.vetpar.2013.01.05423462252Open DOISearch in Google Scholar

MORSY, T.A., IBRAHIM, B.B., HARIDY, F.M., RIFAAT, M.M. (2000) Trichinella encysted larvae in slaughtered pigs in Cairo (1995–1999). J Egypt Soc Parasitol, 30(3): 753–760. PMID: 11198373MORSY T.A. IBRAHIM B.B. HARIDY F.M. RIFAAT M.M. 2000 Trichinella encysted larvae in slaughtered pigs in Cairo (1995–1999) J Egypt Soc Parasitol 30 3 753 760 PMID: 11198373Search in Google Scholar

NADA, S.M., MOHAMMAD, S.M., Moad1, H.S., EL-SHAFEY, M., AL-GHANDOUR, A.M. IBRAHIM, N. (2018): Therapeutic effect of Nigella sativa and ivermectin versus albendazole on experimental trichinellosis in mice. J Egypt Soc Parasitol, 48(1): 85–92. DOI: 10.12816/jesp.2018.77029NADA S.M. MOHAMMAD S.M. Moad1 H.S. EL-SHAFEY M. AL-GHANDOUR A.M. IBRAHIM N. 2018 Therapeutic effect of Nigella sativa and ivermectin versus albendazole on experimental trichinellosis in mice J Egypt Soc Parasitol 48 1 85 92 10.12816/jesp.2018.77029Open DOISearch in Google Scholar

NASEF, N.E., MOHARM, I.M., ATIA, A.F., BARAKAT, R.M., ABOU HUSEIN, N.M., MOHAMED, A.S. (2018): Therapeutic efficacy of chitosan nano-particles and albendazole in intestinal murine trichinellosis. J Egypt Soc Parasitol, 48(3): 493–502. DOI: 10.12816/jesp.2018.76543NASEF N.E. MOHARM I.M. ATIA A.F. BARAKAT R.M. ABOU HUSEIN N.M. MOHAMED A.S. 2018 Therapeutic efficacy of chitosan nano-particles and albendazole in intestinal murine trichinellosis J Egypt Soc Parasitol 48 3 493 502 10.12816/jesp.2018.76543Open DOISearch in Google Scholar

OTHMAN, A.A., SHOHEIB, Z.S. (2016): Detrimental effects of geldanamycin on adults and larvae of Trichinella spiralis Helminthologia, 53(2): 126–132. DOI: 10.1515/helmin-2016-0003OTHMAN A.A. SHOHEIB Z.S. 2016 Detrimental effects of geldanamycin on adults and larvae of Trichinella spiralis Helminthologia 53 2 126 132 10.1515/helmin-2016-0003Open DOISearch in Google Scholar

OTHMAN, AHMAD A., ABOU RAYIA, D.M., ASHOUR, D.S., SAIED, E.M., ZINELDEEN, D.H., EL-EBIARY, A.A. (2016): Atorvastatin and metformin administration modulates experimental Trichinella spiralis infection. Parasitol Int, 65(2): 105–112. DOI: 10.1016/j.parint.2015.11.001OTHMAN AHMAD A. ABOU RAYIA D.M. ASHOUR D.S. SAIED E.M. ZINELDEEN D.H. EL-EBIARY A.A. 2016 Atorvastatin and metformin administration modulates experimental Trichinella spiralis infection Parasitol Int 65 2 105 112 10.1016/j.parint.2015.11.00126546571Open DOISearch in Google Scholar

PANIC, G., DUTHALER, U., SPEICH, B., KEISER, J. (2014): Repurposing drugs for the treatment and control of helminth infections. Int J Parasitol Drugs Drug Resist, 4(3): 185–200. DOI: 10.1016/j.ijpddr.2014.07.002PANIC G. DUTHALER U. SPEICH B. KEISER J. 2014 Repurposing drugs for the treatment and control of helminth infections Int J Parasitol Drugs Drug Resist 4 3 185 200 10.1016/j.ijpddr.2014.07.002426680325516827Open DOISearch in Google Scholar

POZIO, E., SACHINI, D., SACHI, L., TAMBURINI, A., ALBERICI, F. (2001): Failure of mebendazole in the treatment of humans with Trichinella spiralis infection at the stage of encapsulating larvae. Clin Infect Dis, 812, 1–5. DOI: 10.1086/318707POZIO E. SACHINI D. SACHI L. TAMBURINI A. ALBERICI F. 2001 Failure of mebendazole in the treatment of humans with Trichinella spiralis infection at the stage of encapsulating larvae Clin Infect Dis 812 1–5 10.1086/31870711181129Open DOISearch in Google Scholar

RODRIGUES-JUNIOR, V.S., VILLELA, A.D., GONÇALVES, R.S.B., ABBADI, B.L., TRINDADE, R.V., LÓPEZ-GAVÍN, A., TUDÓ, G., GONZÁLEZ-MARTÍN, J., BASO, L.A., DE SOUZA, M.V.N., CAMPOS, M.M., SANTOS, D.S. (2016): Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection. J Antimicrob Agents, 48(2): 203–207. DOI: 10.1016/j.ijantimicag.2016.04.029RODRIGUES-JUNIOR V.S. VILLELA A.D. GONÇALVES R.S.B. ABBADI B.L. TRINDADE R.V. LÓPEZ-GAVÍN A. TUDÓ G. GONZÁLEZ-MARTÍN J. BASO L.A. DE SOUZA M.V.N. CAMPOS M.M. SANTOS D.S. 2016 Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection J Antimicrob Agents 48 2 203 207 10.1016/j.ijantimicag.2016.04.02927364701Open DOISearch in Google Scholar

ROMERO, M., ARTIGIANI, R., COSTA, H., OSHIMA, C.T.F., MISZPUTEN, S., FRANCO, M. (2008): Evaluation of the immunoexpression of COX1, COX-2 and p53 in Crohn’s disease. Arq Gastroenterol, 45(4): 295–300. DOI: 10.1590/s0004-28032008000400007ROMERO M. ARTIGIANI R. COSTA H. OSHIMA C.T.F. MISZPUTEN S. FRANCO M. 2008 Evaluation of the immunoexpression of COX1, COX-2 and p53 in Crohn’s disease Arq Gastroenterol 45 4 295 300 10.1590/s0004-2803200800040000719148357Open DOISearch in Google Scholar

RUFENER, R., RITLER, D., ZIELINSKI, J., DICK, L., DA SILVA, E.T., DA SILVA ARAUJO, A., JOEKEL, D.E., CZOCK, D., GOEPFERT, C., MORAES, A.M., DE SOUZA, M.V.N., MÜLLER, J., MEVISSEN, M., HEMPHILL, A., LUNDSTRÖM-STADELMANN, B. (2018): Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis Int J Parasitol Drugs Drug Resist, 8(2): 331–340. DOI: 10.1016/j.ijpddr.2018.06.004RUFENER R. RITLER D. ZIELINSKI J. DICK L. DA SILVA E.T. DA SILVA ARAUJO A. JOEKEL D.E. CZOCK D. GOEPFERT C. MORAES A.M. DE SOUZA M.V.N. MÜLLER J. MEVISSEN M. HEMPHILL A. LUNDSTRÖM-STADELMANN B. 2018 Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis Int J Parasitol Drugs Drug Resist 8 2 331 340 10.1016/j.ijpddr.2018.06.004602007829933218Open DOISearch in Google Scholar

SAAD, A.E., ASHOUR, D.S., ABOU RAYIA, D.M., BEDEER, A.E. (2016): Carbonic anhydrase enzyme as a potential therapeutic target for experimental trichinellosis. Parasitol Res, 115(6): 2331–2339. DOI: 10.1007/s00436-016-4982-9SAAD A.E. ASHOUR D.S. ABOU RAYIA D.M. BEDEER A.E. 2016 Carbonic anhydrase enzyme as a potential therapeutic target for experimental trichinellosis Parasitol Res 115 6 2331 2339 10.1007/s00436-016-4982-926979731Open DOISearch in Google Scholar

SANGSTER, N. (2001): Managing parasiticide resistance. Vet Parasitol, 98(1–3): 89–109. DOI: 10.1016/s0304-4017(01)00425-3SANGSTER N. 2001 Managing parasiticide resistance Vet Parasitol 98 1–3 89 109 10.1016/s0304-4017(01)00425-311516581Open DOISearch in Google Scholar

SERNA, H., PORRAS, M., VERGARA, P. (2006): Mast cell stabilizer ketotifen [4-(1-Methyl-4-piperidylidene)-4 H -benzo[4,5]cyclohepta[1,2b]thiophen-10(9 H )-one Fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the Rat. J Pharmacol Exp Ther, 319(3): 1104–1111. DOI: 10.1124/jpet.106.104620SERNA H. PORRAS M. VERGARA P. 2006 Mast cell stabilizer ketotifen [4-(1-Methyl-4-piperidylidene)-4 H -benzo[4,5]cyclohepta[1,2b]thiophen-10(9 H )-one Fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the Rat J Pharmacol Exp Ther 319 3 1104 1111 10.1124/jpet.106.10462016988056Open DOISearch in Google Scholar

SHALABY, M.A., MOGHAZY, F.M., SHALABY, H.A., NASR, S.M. (2010): Effect of methanolic extract of Balanites aegyptiaca fruits on enteral and parenteral stages of Trichinella spiralis in rats. Parasitol Res, 107(1): 17–25. DOI: 10.1007/s00436-010-1827-9SHALABY M.A. MOGHAZY F.M. SHALABY H.A. NASR S.M. 2010 Effect of methanolic extract of Balanites aegyptiaca fruits on enteral and parenteral stages of Trichinella spiralis in rats Parasitol Res 107 1 17 25 10.1007/s00436-010-1827-920349194Open DOISearch in Google Scholar

SHARMA, N., THOMAS, S., GOLDEN, E.B., HOFMAN, F.M., CHEN, T.C., PETASIS, N.A., SCHÖNTHAL, A.H., LOUIE, S.G. (2012): Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett, 326(2): 143–154. DOI: 10.1016/j.canlet.2012.07.029SHARMA N. THOMAS S. GOLDEN E.B. HOFMAN F.M. CHEN T.C. PETASIS N.A. SCHÖNTHAL A.H. LOUIE S.G. 2012 Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent Cancer Lett 326 2 143 154 10.1016/j.canlet.2012.07.02922863539Open DOISearch in Google Scholar

SHOHEIB, Z.S., SHAMLOULA, M.M., ABDIN, A.A., SEGAI, O. (2006): Role Of α - chymotrypsin and colchicine as adjuvant therapy in experimental muscular trichinellosis : parasitological, biochemical & immunohistochemical study. Egypt J Med Microbiol, 15(4): 773–790 SINGH, N., YEH, P.J. (2017): Suppressive drug combinations and their potential to combat antibiotic resistance. J Antibiot, 70(11): 1033–1042. DOI: 10.1038/ja.2017.102SHOHEIB Z.S. SHAMLOULA M.M. ABDIN A.A. SEGAI O. 2006 Role Of α - chymotrypsin and colchicine as adjuvant therapy in experimental muscular trichinellosis : parasitological, biochemical & immunohistochemical study Egypt J Med Microbiol 15 4 773 790 SINGH, N., YEH, P.J. (2017): Suppressive drug combinations and their potential to combat antibiotic resistance. J Antibiot, 70(11): 1033–1042. 10.1038/ja.2017.10210.1038/ja.2017.102565993128874848Search in Google Scholar

SIRIYASATIEN, P., YINGYOURD, P., NUCHPRAYOON, S. (2003): Efficacy of albendazole against early and late stage of Trichinella spiralis infection in mice. J Med Assoc Thai, 86(2): 8257 – S262. PMID: 12929998SIRIYASATIEN P. YINGYOURD P. NUCHPRAYOON S. 2003 Efficacy of albendazole against early and late stage of Trichinella spiralis infection in mice J Med Assoc Thai 86 2 8257 S262 PMID: 12929998Search in Google Scholar

VERCRUYSSE, J., SCHETTERS, T.P.M., KNOX, D.P., WILLADSEN, P., CLAEREBOUT, E. (2007): Control of parasitic disease using vaccines: an answer to drug resistance? Rev. sci. tech. Off. int. Epiz., 26(1): 105–115. DOI: 10.20506/rst.26.1.1728VERCRUYSSE J. SCHETTERS T.P.M. KNOX D.P. WILLADSEN P. CLAEREBOUT E. 2007 Control of parasitic disease using vaccines: an answer to drug resistance? Rev sci. tech. Off. int. Epiz 26 1 105 115 10.20506/rst.26.1.1728Open DOISearch in Google Scholar

WALLER, P.J. (1997): Anthelmintic resistance. Vet Parasitol, 72(3–4): 391–412. DOI: 10.1016/S0304-4017(97)00107-6WALLER P.J. 1997 Anthelmintic resistance Vet Parasitol 72 3–4 391 412 10.1016/S0304-4017(97)00107-69460208Open DOISearch in Google Scholar

WASSOM, D.L., DOUGHERTY, D.A., DICK, T.A. (1988): Trichinella spiralis infections of inbred mice: immunologically specific responses induced by different Trichinella isolates. J Parasitol, 74(2): 283–287. DOI: 10.2307/3282457WASSOM D.L. DOUGHERTY D.A. DICK T.A. 1988 Trichinella spiralis infections of inbred mice: immunologically specific responses induced by different Trichinella isolates J Parasitol 74 2 283 287 10.2307/3282457Open DOISearch in Google Scholar

WONG, W., BAI, X.-C., SLEEBS, B.E., TRIGLIA, T., BROWN, A., THOMPSON, J.K., JACKSON, K.E., HANSSEN, E., MARAPANA , D.S., FERNANDEZ, I.S., RALPH, S.A., COWMAN, A.F., SCHERES, S.H. W., BAUM, J. (2017): Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat Microbiol, 2(6): 17031. DOI: 10.1038/nmicrobiol.2017.31WONG W. BAI X.-C. SLEEBS B.E. TRIGLIA T. BROWN A. THOMPSON J.K. JACKSON K.E. HANSSEN E. MARAPANA D.S. FERNANDEZ I.S. RALPH S.A. COWMAN A.F. SCHERES S.H. W. BAUM J. 2017 Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis Nat Microbiol 2 6 17031 10.1038/nmicrobiol.2017.31543951328288098Open DOISearch in Google Scholar

WRANICZ, M.J., GUSTOWSKA, L., GABRYEL, P., KUCHARSKA, E., CABAJ, W. (1998): Trichinella spiralis: induction of the basophilic transformation of muscle cells by synchronous newborn larvae. Parasitol Res, 84(5): 403–407. DOI: 10.1007/s004360050418WRANICZ M.J. GUSTOWSKA L. GABRYEL P. KUCHARSKA E. CABAJ W. 1998 Trichinella spiralis: induction of the basophilic transformation of muscle cells by synchronous newborn larvae Parasitol Res 84 5 403 407 10.1007/s0043600504189610639Open DOISearch in Google Scholar

XIAO, S.H. (2013): Mefloquine, a new type of compound against Schistosomes and other helminths in experimental studies. Parasitol Res, 112(11): 3723–3740. DOI: 10.1007/s00436-013-3559-0 YADAV, A.K., TEMJENMONGLA. (2012): Efficacy of Lasia spinosa leaf extract in treating mice infected with Trichinella spiralis Parasitol Res, 110(1): 493–498. DOI: 10.1007/s00436-011-2551-9XIAO S.H. 2013 Mefloquine, a new type of compound against Schistosomes and other helminths in experimental studies Parasitol Res 112 11 3723 3740 10.1007/s00436-013-3559-0 YADAV, A.K., TEMJENMONGLA. (2012): Efficacy of Lasia spinosa leaf extract in treating mice infected with Trichinella spiralis Parasitol Res, 110(1): 493–498. 10.1007/s00436-011-2551-923979493Open DOISearch in Google Scholar

YOUSSEF, A.I., UGA, S. (2014): Review of parasitic zoonoses in Egypt. Trop Med Health, 42(1): 3–14. DOI: 10.2149/tmh.2013-23YOUSSEF A.I. UGA S. 2014 Review of parasitic zoonoses in Egypt Trop Med Health 42 1 3 14 10.2149/tmh.2013-23396584324808742Open DOISearch in Google Scholar