Acceso abierto

Topical Helichrysum italicum Essential Oil-Based Ointment Hastens Excisional Wound Healing by Alleviating Inflammation and Oxidative Stress in Diabetic Rats

Marijana Andjic

Marijana Andjic

  • University of Kragujevac, Faculty of Medical Sciences, Department of PharmacyKragujevac, Serbia
  • Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic DisordersKragujevac, Serbia
Buscar este autor en
Sciendo|Google Scholar
Andjic, Marijana
, 
Aleksandar Kocovic

Aleksandar Kocovic

  • University of Kragujevac, Faculty of Medical Sciences, Department of PharmacyKragujevac, Serbia
  • Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic DisordersKragujevac, Serbia
Buscar este autor en
Sciendo|Google Scholar
Kocovic, Aleksandar
, 
Ksenija Vucicevic

Ksenija Vucicevic

University of Kragujevac, Faculty of Medical Sciences, Department of PharmacyKragujevac, Serbia
Buscar este autor en
Sciendo|Google Scholar
Vucicevic, Ksenija
, 
Vladimir Jakovljevic

Vladimir Jakovljevic

  • Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic DisordersKragujevac, Serbia
  • Department of Human Pathology, 1st Moscow State Medical, University IM SechenovMoscow, Russia
  • University of Kragujevac, Faculty of Medical Sciences, Department of PhysiologyKragujevac, Serbia
Buscar este autor en
Sciendo|Google Scholar
Jakovljevic, Vladimir
, 
Igor Simanic

Igor Simanic

  • Specialized Hospital for Rehabilitation and Orthopedic ProstheticsBeograd, Serbia
  • University of Kragujevac, Faculty of Medical Sciences, Department of Physical Medicine and RehabilitationKragujevac, Serbia
Buscar este autor en
Sciendo|Google Scholar
Simanic, Igor
, 
Milica Vukasinovic Vesic

Milica Vukasinovic Vesic

Faculty of Sport, University “Union-Nikola Tesla”Belgrade, Serbia
Buscar este autor en
Sciendo|Google Scholar
Vukasinovic Vesic, Milica
 y 
Jovana Bradic

Jovana Bradic

  • University of Kragujevac, Faculty of Medical Sciences, Department of PharmacyKragujevac, Serbia
  • Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic DisordersKragujevac, Serbia
Buscar este autor en
Sciendo|Google Scholar
Bradic, Jovana
  
12 dic 2024
Topical Helichrysum italicum Essential Oil-Based Ointment Hastens Excisional Wound Healing by Alleviating Inflammation and Oxidative Stress in Diabetic Rats's Cover Image
Acerca de este artículo
Artículo anterior
Artículo siguiente
Cite
Descargar portada
Categoría del artículo: Original Scientific Article
Publicado en línea: 12 dic 2024
Recibido: 09 sept 2024
Aceptado: 23 sept 2024
DOI: https://doi.org/10.2478/eabr-2024-0012
Palabras clave
© 2024 Marijana Andjic et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

Photograph of H. italicum essential oil – based ointment
Photograph of H. italicum essential oil – based ointment

Figure 2.

Effects of applied ointments on the wound contraction.Values are expressed as mean ± standard deviation (n = 8). a p < 0.05 compared to CTRL group; b p < 0.05 compared to SSD group; c p < 0.05 compared to OINT group; d p < 0.05 compared to HIOINT group. CTRL – control; SSD – silver sulfadiazine; OINT – ointment base; HIOINT – H. italicum ointment;
Effects of applied ointments on the wound contraction.Values are expressed as mean ± standard deviation (n = 8). a p < 0.05 compared to CTRL group; b p < 0.05 compared to SSD group; c p < 0.05 compared to OINT group; d p < 0.05 compared to HIOINT group. CTRL – control; SSD – silver sulfadiazine; OINT – ointment base; HIOINT – H. italicum ointment;

Figure 3.

Effects of applied ointments on the markers inflammation: A) TNF-α; B) IL-6; C) IL-10. Values are expressed as mean ± standard deviation (n = 8).a p < 0.05 compared to CTRL group; b p < 0.05 compared to SSD group; c p < 0.05 compared to OINT group; d p < 0.05 compared to HIOINT group. CTRL – control; SSD – silver sulfadiazine; OINT – ointment base; HIOINT – H. italicum ointment;
Effects of applied ointments on the markers inflammation: A) TNF-α; B) IL-6; C) IL-10. Values are expressed as mean ± standard deviation (n = 8).a p < 0.05 compared to CTRL group; b p < 0.05 compared to SSD group; c p < 0.05 compared to OINT group; d p < 0.05 compared to HIOINT group. CTRL – control; SSD – silver sulfadiazine; OINT – ointment base; HIOINT – H. italicum ointment;

Figure 4.

Effects of applied ointments on the oxidative stress markers in wound tissue: A) TBARS; B) SOD; C) CAT; D) GSH. Values are expressed as mean ± standard deviation (n = 8).a p < 0.05 compared to CTRL group; b p < 0.05 compared to SSD group; c p < 0.05 compared to OINT group; d p < 0.05 compared to HIOINT group. CTRL – control; SSD – silver sulfadiazine; OINT – ointment base; HIOINT – H. italicum ointment;
Effects of applied ointments on the oxidative stress markers in wound tissue: A) TBARS; B) SOD; C) CAT; D) GSH. Values are expressed as mean ± standard deviation (n = 8).a p < 0.05 compared to CTRL group; b p < 0.05 compared to SSD group; c p < 0.05 compared to OINT group; d p < 0.05 compared to HIOINT group. CTRL – control; SSD – silver sulfadiazine; OINT – ointment base; HIOINT – H. italicum ointment;

Organoleptic characteristics and spreadability of ointment with H_ italicum essential oil after 3 and 180 days of preparation

Parameters 3 days 180 days
Colour Yellow Yellow
Odour Characteristic odor of the essential oil Characteristic odor of the essential oil
Consistency Semi-solid Semi-solid
Homogenity Homogeneous ointment Homogeneous ointment
Spreadability Easily Easily

Ointment base and H_ italicum essential oil –based ointment formulations_

Ingredient Ointment Base (%) Ointment HIEO (%)
HIEO / 0.50
Cholesterol 5.00 5.00
Lanolin 15.00 15.00
Parafinum liquidum 15.00 15.00
Vaselinum album 65.00 ad 65.00
Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Medicina, Medicina Clínica, Medicina Clínica, otros
RSS Feed de revista