<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Various pyridine compounds, either identified or implied as intermediates in the mammalian metabolism of nicotine or present in tobacco or tobacco smoke, have been studied by gas chromatography-mass spectrometry. Spectral and gas chromatographic data for these compounds, which provide a basis for further studies of pyridine compounds in plant and animal tissue, are given. The utility of these data in studies on nicotine and its metabolites in body fluids from humans is illustrated by a determination of nicotine in the plasma from two smokers using quantitative mass fragmentography with the aid of deuterated nicotine. </p></abstract>

Various pyridine compounds, either identified or implied as intermediates in the mammalian metabolism of nicotine or present in tobacco or tobacco smoke, have been studied by gas chromatography-mass spectrometry. Spectral and gas chromatographic data for these compounds, which provide a basis for further studies of pyridine compounds in plant and animal tissue, are given. The utility of these data in studies on nicotine and its metabolites in body fluids from humans is illustrated by a determination of nicotine in the plasma from two smokers using quantitative mass fragmentography with the aid of deuterated nicotine.

Studies on the ldentification of Tobacco Alkaloids, their Mammalian Metabolites and Related Compounds by Gas Chromatography – Mass Spectrometry

Swedish Tobacco Company, Researdt Department, Stockholm, Sweden

Department of Pharmacology, Medical College of Virginia, Ridunond, Virginia, U.S.A.

Department of Toxicology, Swedish Medical Researdt Council, Karolinska Institutet, Stockholm, Sweden

Contributions to Tobacco & Nicotine Research

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Various pyridine compounds, either identified or implied as intermediates in the mammalian metabolism of nicotine or present in tobacco or tobacco smoke, have...

Studies on the ldentification of Tobacco Alkaloids, their Mammalian Metabolites and Related Compounds by Gas Chromatography – Mass Spectrometry

Publicado en línea: 14 ago 2014

Páginas: 339 - 349

DOI: https://doi.org/10.2478/cttr-2013-0399

© Beiträge zur Tabakforschung International

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.