[
Abot A., Cani P.D., Knauf C. (2018). Impact of intestinal peptides on the enteric nervous system: novel approaches to control glucose metabolism and food intake. Front. Endocrinol., 9: 328.10.3389/fendo.2018.00328
]Search in Google Scholar
[
Baptista I.L., Silva W.J., Artiol G.G., Guilherme J.P.L.F., Leal M.L., Aoki M.S., Miyabara E.H., Moriscot A.S. (2013). Correction: leucine and HMB differentially modulate proteasome system in skeletal muscle under different sarcopenic conditions. PLoS One, 8: 10.1371.10.1371/annotation/9060434b-c1df-4d52-8cda-88b9fbfaea51
]Search in Google Scholar
[
Barrett K.E., Barman S.M., Brooks H.L., Ganong W.F. (2019). Ganong’s review of medical physiology. McGraw-Hill Education, London.
]Search in Google Scholar
[
Bertram C., Hanson M. (2002). Prenatal programming of postnatal endocrine responses by glucocorticoids. Reproduction, 124: 459–467.10.1530/rep.0.1240459
]Search in Google Scholar
[
Bik W. (2007). Vasoactive intestinal peptide-immunomodulatory factor and its role in respiratory diseases (in Polish). Post. Nauk Med., 10: 408–413.
]Search in Google Scholar
[
Blicharski T., Tomaszewska E., Dobrowolski P., Hułas-Stasiak M., Muszyński S. (2017). A metabolite of leucine (β-hydroxy-β-methylbutyrate) given to sows during pregnancy alters bone development of their newborn offspring by hormonal modulation. PLOS One, 12: e0179693.10.1371/journal.pone.0179693
]Search in Google Scholar
[
Cheng W.-Y., Chen L.-K., Peng L.-N., Wang M. (2020). Oral nutritional supplementation with HMB not only improved muscle mass, but also intramuscular fat deposition in older adults: A 12-week randomized controlled trial. Clin. Nut. ESPEN, 40: 466.10.1016/j.clnesp.2020.09.182
]Search in Google Scholar
[
Cieślak D., Nieradko-Iwanicka B. (2018). β-Hydroxy β-methylbutyrate (HMB) supplementation during pregnancy and perinatal period in animals studies and possible application in humans. J. Educ. Health Sport, 8: 11–18.
]Search in Google Scholar
[
Delgado M., Pozo D., Ganea D. (2004). The significance of vasoactive intestinal peptide in immunomodulation. Pharmacol. Rev., 56: 249–290.10.1124/pr.56.2.7
]Search in Google Scholar
[
Dibner J.J., Buttin P. (2002). Use of organic acids as a model to study the impact of gut microflora on nutrition and metabolism. J. Appl. Poultry Res., 11: 453–463.10.1093/japr/11.4.453
]Search in Google Scholar
[
Dobrowolski P., Muszyński S., Donaldson J., Jakubczak A., Żmuda A., Taszkun I., Rycerz K., Mielnik-Błaszczak M., Kuc D., Tomaszewska E. (2021). The effects of prenatal supplementation with β-hydroxy-β-methylbutyrate and/or alpha-ketoglutaric acid on the development and maturation of mink intestines are dependent on the number of pregnancies and the sex of the offspring. Animals, 11: 1468.10.3390/ani11051468
]Search in Google Scholar
[
Duan Y., Li F., Song B., Zheng C., Zhong Y., Xu K., Kong X., Yin Y., Wang W., Shu G. (2019). β-hydroxy-β-methyl butyrate, but not α-ketoisocaproate and excess leucine, stimulates skeletal muscle protein metabolism in growing pigs fed low-protein diets. J. Funct. Foods, 52: 34–42.10.1016/j.jff.2018.10.029
]Search in Google Scholar
[
Duan Y., Song B., Zheng C., Zhong Y., Guo Q., Zheng J., Yin Y., Li J., Li F. (2021). Dietary beta-hydroxy beta-methyl butyrate supplementation alleviates liver injury in lipopolysaccharide-challenged piglets. Oxid. Med. Cell. Longev., 2021: 1–9.10.1155/2021/5546843
]Search in Google Scholar
[
El Karim I.A., Linden G.J., Orr D.F., Lundy F.T. (2008). Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. J. Neuroimmunol., 2000: 11–16.10.1016/j.jneuroim.2008.05.014
]Search in Google Scholar
[
Fahrenkrug J. (1993). Transmitter role of vasoactive intestinal peptide. Pharmacol. Toxicol., 72: 354–363.10.1111/j.1600-0773.1993.tb01344.x
]Search in Google Scholar
[
Florian V., Caroline F., Francis C., Camille S., Fabielle A. (2013). Leptin modulates enteric neurotransmission in the rat proximal colon: An in vitro study. Regul. Pept., 185: 73–78.10.1016/j.regpep.2013.06.010
]Search in Google Scholar
[
Flummer C., Theil P.K. (2012). Effect of β-hydroxy β-methyl butyrate supplementation of sows in late gestation and lactation on sow production of colostrum and milk and piglet performance. J. Anim. Sci., 90 (suppl 4): 372–374.10.2527/jas.53971
]Search in Google Scholar
[
Francis D.H. (1999). Colibacillosis in pigs and its diagnosis. Swine Health Prod., 7: 241–244.
]Search in Google Scholar
[
Friedman J. (2014). 20 years of leptin: leptin at 20: an overview. J. Endocrinol., 223: T1–T8.10.1530/JOE-14-0405
]Search in Google Scholar
[
Fung T.C., Olson C.A., Hsiao E.Y. (2017). Interactions between the microbiota, immune and nervous systems in health and disease. Nat. Neurosci., 20: 145–155.10.1038/nn.4476
]Search in Google Scholar
[
Gonzalez-Rey E., Delgado M. (2005). Role of vasoactive intestinal peptide in inflammation and autoimmunity. Curr. Opin. Investig. Drugs, 6: 1116–1123.
]Search in Google Scholar
[
Grela E.R., Skomiał J. (2015). Nutritional recommendations and nutritional value of feed for pigs, 2nd ed. Institute of Physiology and Animal Nutrition of Polish Academy of Science, Jabłonna, Poland, pp. 1–95.
]Search in Google Scholar
[
Groschwitz K.R., Hogan S.P. (2009). Intestinal barrier function: Molecular regulation and disease pathogenesis. J. Allergy Clin. Immunol., 124: 3–20.10.1016/j.jaci.2009.05.038
]Search in Google Scholar
[
Hales C.N., Barker D.J., Clark P.M., Cox L.J., Fall C., Osmond C., Winter P.D. (1991). Fetal and infant growth and impaired glucose tolerance at age 64. Br. Med. J., 303: 1019–1022.10.1136/bmj.303.6809.1019
]Search in Google Scholar
[
Hao Y., Jackson J.R., Wang Y., Edens N., Pereira S.L., Alway S.E. (2011). β-Hydroxy-β-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats. Am. J. Physiol. Regul. Integr. Comp. Physiol., 301: R701–R715.10.1152/ajpregu.00840.2010
]Search in Google Scholar
[
Hollander D., Kaunitz J.D. (2019). The “Leaky Gut”: Tight junctions but loose associations? Digest. Dis. Sci., 65: 1277–1287.10.1007/s10620-019-05777-2
]Search in Google Scholar
[
Holst J.J., Fahrenkrug J., Knuhtsen S., Jensen S.L., Poulsen S.S., Vagn Nielsen O. (1984). Vasoactive intestinal polypeptide (VIP) in the pig pancreas: role of VIPergic nerves in control of fluid and bicarbonate secretion. Regul. Pept., 8: 245–259.10.1016/0167-0115(84)90066-1
]Search in Google Scholar
[
Konturek S. (1985). Physiology of the gastrointestinal tract, 2nd ed. PZWL, Warsaw, Poland, 515 pp.
]Search in Google Scholar
[
Lis I., Bogdański P., Karolkiewicz J. (2014). The effect of β-hydroxy-β-methylbutyrate (HMB) on muscle protein metabolism. Farm. Współ., 7: 32–40.
]Search in Google Scholar
[
Liu Y. (2015). Fatty acids, inflammation and intestinal health in pigs. J. Anim. Sci. Biotechnol., 6: 41.10.1186/s40104-015-0040-1
]Search in Google Scholar
[
Luppi A. (2017). Swine enteric colibacillosis: diagnosis, therapy and antimicrobial resistance. Porc. Health Manag., 3: 16.10.1186/s40813-017-0063-4
]Search in Google Scholar
[
Matthews S.G. (2001). Antenatal glucocorticoids and the developing brain: mechanisms of action. Semin. Neonatol., 6: 309–317.10.1053/siny.2001.0066
]Search in Google Scholar
[
Milart P., Paluszkiewicz P., Dobrowolski P., Tomaszewska E., Smolinska K., Debinska I., Gawel K., Walczak K., Bednarski J., Turska M., Raban M., Kocki T., Turski W.A. (2019). Kynurenic acid as the neglected ingredient of commercial baby formulas. Sci. Rep., 9: 6108.10.1038/s41598-019-42646-4
]Search in Google Scholar
[
Mou Q., Yang H.-S., Yin Y.-L., Huang P.-F. (2019). Amino acids influencing intestinal development and health of the piglets. Animals, 9: 302.10.3390/ani9060302
]Search in Google Scholar
[
Muszyński S., Dobrowolski P., Kasperek K., Knaga S., Kwiecień M., Donaldson J., Kutyła M., Kapica M., Tomaszewska E. (2020). Effects of yeast (Saccharomyces cerevisiae) probiotics supplementation on bone quality characteristics in young Japanese Quail (Coturnix japonica): the role of sex on the action of the gut-bone axis. Animals, 10: 440.10.3390/ani10030440
]Search in Google Scholar
[
Nissen S.L., Abumrad N.N. (1997). Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB). J. Nutr. Biochem., 8: 300–311.10.1016/S0955-2863(97)00048-X
]Search in Google Scholar
[
Nissen S., Faidley T.D., Zimmerman D.R., Izard R., Fisher C.T. (1994). Colostral milk fat percentage and pig performance are enhanced by feeding the leucine metabolite β-hydroxy-β-methyl butyrate to sows. J. Anim. Sci., 72: 2331–2337.10.2527/1994.7292331x
]Search in Google Scholar
[
Nissen S., Sharp R.L., Panton L., Vukovich M., Trappe S., Fuller J.C. (2000). β-hydroxy-β-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors. J. Nutr., 130: 1937–1945.10.1093/jn/130.8.1937
]Search in Google Scholar
[
Novotný J., Reichel P., Kovačocyová K., Cigánková V., Almášiová V., Šipoš D. (2016). Haemorrhagic bowel syndrome in fattening pigs. Acta Vet., 66: 138–146.10.1515/acve-2016-0012
]Search in Google Scholar
[
Ostaszewski P., Kozłowska E., Siwicki A., Krzyżanowski J., Fuller Jr.J.C., Nissen S. (1998). The immunomodulating activity of dietary ß-hydroxy-ß-methylbutyrate (HMB) in weanling pigs. J. Anim. Sci., 76 (Suppl.1): 136.
]Search in Google Scholar
[
Park H.K., Ahima R.S. (2014). Leptin signaling. F1000Prime Rep., 6: 73.10.12703/P6-73
]Search in Google Scholar
[
Partanen K., Piva A., Bach Knudsen K.E., Lindberg J.E. (2001).
]Search in Google Scholar
[
Organic acids – their efficacy and modes of action in pigs. In: Gut environment of pigs. Nottingham University Press, UK, pp. 201–217.
]Search in Google Scholar
[
Pascale A., Marchesi N., Marelli C., Coppola A., Luzi L., Govoni S., Giustina A., Gazzaruso C. (2018). Microbiota and metabolic diseases. Endocrine, 61: 357–371.10.1007/s12020-018-1605-5
]Search in Google Scholar
[
Pearson P.Y., O’Connor D.M., Schwartz M.Z. (2001). Novel effect of leptin on small intestine adaptation. J. Surf. Res., 97: 192–195.10.1006/jsre.2001.6153
]Search in Google Scholar
[
Puzio I., Muszyński S., Dobrowolski P., Kapica M., Pawłowska-Olszewska M., Donaldson J., Tomaszewska E. (2021). Alterations in small intestine and liver morphology, immunolocalization of leptin, ghrelin and nesfatin-1 as well as immunoexpression of tight junction proteins in intestinal mucosa after gastrectomy in rat model. J. Clin. Med., 10: 272.10.3390/jcm10020272
]Search in Google Scholar
[
Rudyk H., Tomaszewska E., Arciszewski M.B., Muszyński S., Tomczyk-Warunek A., Dobrowolski P., Donaldson J., Brezvyn O., Kotsyumbas I. (2020). Histomorphometrical changes in intestine structure and innervation following experimental fumonisins intoxication in male Wistar rats. Pol. J. Vet. Sci., 23: 77–88.
]Search in Google Scholar
[
Said S.I. (1991). Vasoactive intestinal polypeptide biologic role in health and disease. Trends Endocrinol. Metab., 2: 107–112.10.1016/S1043-2760(05)80006-2
]Search in Google Scholar
[
Schneider C.A., Rasband W.S., Eliceiri K.W. (2012). NIH Image to ImageJ: 25 years of image analysis. Nat. Methods, 9: 671–675.10.1038/nmeth.2089
]Search in Google Scholar
[
So K., Ng P. (2005). Treatment and prevention of neonatal osteopenia. Curr. Paediatr., 15: 106–113.10.1016/j.cupe.2004.12.011
]Search in Google Scholar
[
Suvarna S.K., Layton C., Bancroft J.D. (2013). Bancroft’s theory and practice of histological techniques, 7th ed. Churchill Livingstone, New York, USA.
]Search in Google Scholar
[
Świetlicka I., Muszyński S., Tomaszewska E., Dobrowolski P., Kwaśniewska A., Świetlicki M., Skic A., Gołacki K. (2016). Prenatally administered HMB modifies the enamel surface roughness in spiny mice offspring: An atomic force microscopy study. Arch. Oral Biol., 70: 24–31.10.1016/j.archoralbio.2016.06.001
]Search in Google Scholar
[
Tatara M.R., Śliwa E., Krupski W. (2007). Prenatal programming of skeletal development in the offspring: Effects of maternal treatment with β-hydroxy-β-methylbutyrate (HMB) on femur properties in pigs at slaughter age. Bone, 40: 1615–1622.10.1016/j.bone.2007.02.018
]Search in Google Scholar
[
Tomaszewska E., Dobrowolski P., Puzio I. (2012). Postnatal administration of 2-oxoglutaric acid improves the intestinal barrier affected by the prenatal action of dexamethasone in pigs. Nutrition, 28: 190–196.10.1016/j.nut.2011.05.010
]Search in Google Scholar
[
Tomaszewska E., Dobrowolski P., Puzio I., Prost Ł., Kurlak P., Sawczuk P., Badzian B., Stasiak M., Kostro K. (2014). Acrylamideinduced prenatal programming intestine structure in guinea pig. J. Physiol. Pharmacol., 65: 107–115.
]Search in Google Scholar
[
Tomaszewska E., Dobrowolski P., Świetlicka I., Muszyński S., Kostro K., Jakubczak A., Taszkun I., Żmuda A., Rycerz K., Blicharski T., Jaworska-Adamu J. (2017). Effects of maternal treatment with β-hydroxy-β-metylbutyrate and 2-oxoglutaric acid on femur development in offspring of minks of the standard dark brown type. J. Anim. Physiol. Anim. Nutr., 102: e299–e308.10.1111/jpn.12742
]Search in Google Scholar
[
Tomaszewska E., Muszyński S., Dobrowolski P., Kwiecień M., Klebaniuk R., Szymańczyk S., Tomczyk A., Kowalik S., Milczarek A., Świetlicka I. (2018). The influence of dietary replacement of soybean meal with high-tannin faba beans on gut-bone axis and metabolic response in broiler chickens. Ann. Anim. Sci., 18: 801–824.10.2478/aoas-2018-0019
]Search in Google Scholar
[
Tomaszewska E., Muszyński S., Dobrowolski P., Wiącek D., Tomczyk-Warunek A., Świetlicka I., Pierzynowski S.G. (2019). Maternal HMB treatment affects bone and hyaline cartilage development in their weaned piglets via the leptin/osteoprotegerin system. J. Anim. Physiol. Anim. Nutr., 103: 626–643.10.1111/jpn.13060
]Search in Google Scholar
[
Tomaszewska E., Dobrowolski P., Puzio I., Donaldson J., Muszyński S. (2020). Acrylamide-induced prenatal programming of bone structure in mammal model. Ann. Anim. Sci., 20: 1257–1287.10.2478/aoas-2020-0044
]Search in Google Scholar
[
Tomaszewska E., Burmańczuk N., Dobrowolski P., Świątkiewicz M., Donaldson J., Burmańczuk A., Mielnik-Błaszczak M., Kuc D., Milewski S., Muszyński S. (2021). The protective role of alpha-ketoglutaric acid on the growth and bone development of experimentally induced perinatal growth-retarded piglets. Animals, 11: 137.10.3390/ani11010137
]Search in Google Scholar
[
Tomczyk-Warunek A., Blicharski T., Jarecki J., Dobrowolski P., Muszyński S., Tomaszewska E., Rovati L.C. (2021). The effect of maternal HMB supplementation on bone mechanical and geometrical properties, as well as histomorphometry and immunolocalization of VEGF, TIMP2, MMP13, BMP2 in the bone and cartilage tissue of the humerus of their newborn piglets. PLOS One, 16: e0240642.10.1371/journal.pone.0240642
]Search in Google Scholar
[
Vu J.P., Larauche M., Flores M., Luong L., Norris J., Oh S., Liang L.-J., Waschek J., Pisegna J.R., Germano P.M. (2015). Regulation of appetite, body composition, and metabolic hormones by vasoactive intestinal polypeptide (VIP). J. Mol. Neurosci., 56: 377–387.10.1007/s12031-015-0556-z
]Search in Google Scholar
[
Wan H., Zhu J., Wu C., Zhou P., Shen Y., Lin Y., Xu S., Che L., Feng B., Li J., Fang Z., Wu D. (2017). Transfer of β-hydroxy-β-methylbutyrate from sows to their offspring and its impact on muscle fiber type transformation and performance in pigs. J. Anim. Sci. Biotechnol., 8: 2.10.1186/s40104-016-0132-6
]Search in Google Scholar
[
Winzell M.S., Ahrén B. (2007). Role of VIP and PACAP in islet function. Peptides, 28: 1805–1813.10.1016/j.peptides.2007.04.024
]Search in Google Scholar
[
Xiong X., Tan B., Song M., Ji P., Kim K., Yin Y., Liu Y. (2019). Nutritional intervention for the intestinal development and health of weaned pigs. Front. Vet. Sci., 6: 46.10.3389/fvets.2019.00046
]Search in Google Scholar
[
Yavas C., Yavas G., Acar H., Toy H., Yuce D., Akyurek S., Ata O. (2012). Amelioration of radiation-induced acute inflammation and mucosal atrophy by beta-hydroxy-beta-methylbutyrate, l-glutamıne, and l-argınıne: results of an experimental study. Support. Care Cancer, 21: 883–888.10.1007/s00520-012-1601-x
]Search in Google Scholar
[
Zheng C., Song B., Duan Y., Zhong Y., Yan Z., Zhang S., Li F. (2020). Dietary β-hydroxy-β-methylbutyrate improves intestinal function in weaned piglets after lipopolysaccharide challenge. Nutrition, 78: 110839.10.1016/j.nut.2020.110839
]Search in Google Scholar
