Molecular mechanisms of colistin resistance mediated by pmrCAB genes in Acinetobacter baumannii isolated from patients hospitalized in Isfahan medical centers

[1] Howard A, O’Donoghue M, Feeney A, Sleator RD. Acinetobacter baumannii: an emerging opportunistic pathogen. Virulence. 2012; 3: 243–250. HowardA O’DonoghueM FeeneyA SleatorRD Acinetobacter baumannii: an emerging opportunistic pathogen Virulence 2012 3 243 250 Search in Google Scholar

[2] Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspectives in medicinal chemistry. 2014; 6: 25–64. FairRJ TorY Antibiotics and bacterial resistance in the 21st century Perspectives in medicinal chemistry 2014 6 25 64 Search in Google Scholar

[3] Manchanda V, Sanchaita S, Singh N. Multidrug resistant acinetobacter. Journal of Global Infectious Diseases. 2010; 2: 291–304. ManchandaV SanchaitaS SinghN Multidrug resistant acinetobacter Journal of Global Infectious Diseases 2010 2 291 304 Search in Google Scholar

[4] Pietsch F, O’Neill AJ, Ivask A, Jenssen H, Inkinen J, Kahru A, Ahonen M, Schreiber F. Selection of resistance by antimicrobial coatings in the healthcare setting. J Hosp Infect. 2020; 106: 115–125. PietschF O’NeillAJ IvaskA JenssenH InkinenJ KahruA AhonenM SchreiberF Selection of resistance by antimicrobial coatings in the healthcare setting J Hosp Infect 2020 106 115 125 Search in Google Scholar

[5] Bassetti M, Peghin M, Vena A, Giacobbe DR. Treatment of Infections Due to MDR Gram-Negative Bacteria. Front Med. 2019; 6. BassettiM PeghinM VenaA GiacobbeDR Treatment of Infections Due to MDR Gram-Negative Bacteria Front Med 2019 6 Search in Google Scholar

[6] Moffatt JH, Harper M, Harrison P, Hale JD, Vinogradov E, Seemann T, Henry R, Crane B, St Michael F, Cox AD et al. Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. Antimicrob Agents Chemother. 2010; 54: 4971–4977. MoffattJH HarperM HarrisonP HaleJD VinogradovE SeemannT HenryR CraneB St MichaelF CoxAD Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production Antimicrob Agents Chemother 2010 54 4971 4977 Search in Google Scholar

[7] Novović K, Jovčić B. Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and Epidemiology. Antibiotics. 2023; 12: 516. NovovićK JovčićB Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and Epidemiology Antibiotics 2023 12 516 Search in Google Scholar

[8] Chen HD, Groisman EA. The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications. Annu Rev Microbiol. 2013; 67: 83–112. ChenHD GroismanEA The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications Annu Rev Microbiol 2013 67 83 112 Search in Google Scholar

[9] Farizano JV, Pescaretti Mde L, López FE, Hsu FF, Delgado MA. The PmrAB system-inducing conditions control both lipid A remodeling and O-antigen length distribution, influencing the Salmonella Typhimurium-host interactions. The Journal of Biological Chemistry. 2012; 287: 38778–38789. FarizanoJV PescarettiMde L LópezFE HsuFF DelgadoMA The PmrAB system-inducing conditions control both lipid A remodeling and O-antigen length distribution, influencing the Salmonella Typhimurium-host interactions The Journal of Biological Chemistry 2012 287 38778 38789 Search in Google Scholar

[10] Charretier Y, Diene SM, Baud D, Chatellier S, Santiago-Allexant E, van Belkum A, Guigon G, Schrenzel J. Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii. Antimicrob Agents Chemother. 2018; 62. CharretierY DieneSM BaudD ChatellierS Santiago-AllexantE van BelkumA GuigonG SchrenzelJ Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii Antimicrob Agents Chemother 2018 62 Search in Google Scholar

[11] Wu C-Y, Tseng C-S, Lee Y-J. Infected calcium oxalate stone leading to pyogenic spondylodiscitis and bilateral lower limb weakness: a case report. Annals of Medicine & Surgery. 2023. WuC-Y TsengC-S LeeY-J Infected calcium oxalate stone leading to pyogenic spondylodiscitis and bilateral lower limb weakness: a case report Annals of Medicine & Surgery 2023 Search in Google Scholar

[12] Villa EA, Escalante-Semerena JC. Acinetobacter baumannii Catabolizes Ethanolamine in the Absence of a Metabolosome and Converts Cobinamide into Adenosylated Cobamides. mBio. 2022; e01793–01722. VillaEA Escalante-SemerenaJC Acinetobacter baumannii Catabolizes Ethanolamine in the Absence of a Metabolosome and Converts Cobinamide into Adenosylated Cobamides mBio 2022 e01793 01722 Search in Google Scholar

[13] Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Therapeutic advances in drug safety. 2014; 5: 229–241. LlorC BjerrumL Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem Therapeutic advances in drug safety 2014 5 229 241 Search in Google Scholar

[14] Ezadi F, Jamali A, Heidari A, Javid N, Ardebili A. Heteroresistance to colistin in oxacillinase-producing carbapenem-resistant Acinetobacter baumannii clinical isolates from Gorgan, Northern Iran. Journal of Global Antimicrobial Resistance. 2020; 21: 380–385. EzadiF JamaliA HeidariA JavidN ArdebiliA Heteroresistance to colistin in oxacillinase-producing carbapenem-resistant Acinetobacter baumannii clinical isolates from Gorgan, Northern Iran Journal of Global Antimicrobial Resistance 2020 21 380 385 Search in Google Scholar

[15] El-Sayed Ahmed MAE, Zhong LL, Shen C, Yang Y, Doi Y, Tian GB: Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019). Emerging microbes & infections. 2020; 9: 868–885. El-Sayed AhmedMAE ZhongLL ShenC YangY DoiY TianGB Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019) Emerging microbes & infections 2020 9 868 885 Search in Google Scholar

[16] Bialvaei AZ, Samadi Kafil H: Colistin, mechanisms and prevalence of resistance. Curr Med Res Opin. 2015; 31: 707–721. BialvaeiAZ Samadi KafilH Colistin, mechanisms and prevalence of resistance Curr Med Res Opin 2015 31 707 721 Search in Google Scholar

[17] Babaei S, Pourabdollah M, Aslanimehr M, Nikkhahi F, Mahmoodian S, Hasani Y, Sheikholeslami FM: Frequency of Multi-Drug Resistance and Molecular Characteristics of Resistance to Colistin in Acinetobacter baumannii Collected from Patients in Intensive Care Units with Ventilator-Associated Pneumonia. TANAFFOS (Respiration). 2021; 20: 345–352. BabaeiS PourabdollahM AslanimehrM NikkhahiF MahmoodianS HasaniY SheikholeslamiFM Frequency of Multi-Drug Resistance and Molecular Characteristics of Resistance to Colistin in Acinetobacter baumannii Collected from Patients in Intensive Care Units with Ventilator-Associated Pneumonia TANAFFOS (Respiration) 2021 20 345 352 Search in Google Scholar

[18] Safar F, Fariba L, Alireza D, Maryam S, Roya R, Leila R, Ahad B, Behrooz N, Samaneh S: The molecular characterization of colistin-resistant isolates of Acinetobacter baumannii from patients at intensive care units. Iran J Microbiol. 2022; 14. SafarF FaribaL AlirezaD MaryamS RoyaR LeilaR AhadB BehroozN SamanehS The molecular characterization of colistin-resistant isolates of Acinetobacter baumannii from patients at intensive care units Iran J Microbiol 2022 14 Search in Google Scholar

[19] Hojabri Z, Pajand O, Bonura C, Aleo A, Giammanco A, Mammina C: Molecular epidemiology of Acinetobacter baumannii in Iran: endemic and epidemic spread of multiresistant isolates. The Journal of Antimicrobial Chemotherapy. 2014; 69: 2383–2387. HojabriZ PajandO BonuraC AleoA GiammancoA MamminaC Molecular epidemiology of Acinetobacter baumannii in Iran: endemic and epidemic spread of multiresistant isolates The Journal of Antimicrobial Chemotherapy 2014 69 2383 2387 Search in Google Scholar

[20] Farshadzadeh Z, Hashemi FB, Rahimi S, Pourakbari B, Esmaeili D, Haghighi MA, Majidpour A, Shojaa S, Rahmani M, Gharesi S et al: Wide distribution of carbapenem resistant Acinetobacter baumannii in burns patients in Iran. Frontiers in Microbiology. 2015; 6: 1146. FarshadzadehZ HashemiFB RahimiS PourakbariB EsmaeiliD HaghighiMA MajidpourA ShojaaS RahmaniM GharesiS Wide distribution of carbapenem resistant Acinetobacter baumannii in burns patients in Iran Frontiers in Microbiology 2015 6 1146 Search in Google Scholar

[21] Halaji M, Rezaei A, Zalipoor M, Faghri J: Investigation of Class I, II, and III Integrons Among Acinetobacter baumannii Isolates from Hospitalized Patients in Isfahan, Iran. Oman medical journal. 2018; 33: 37–42.. HalajiM RezaeiA ZalipoorM FaghriJ Investigation of Class I, II, and III Integrons Among Acinetobacter baumannii Isolates from Hospitalized Patients in Isfahan, Iran Oman medical journal 2018 33 37 42 Search in Google Scholar

[22] Rezaei A, Fazeli H, Moghadampour M, Halaji M, Faghri J: Determination of antibiotic resistance pattern and prevalence of OXA-type carbapenemases among Acinetobacter baumannii clinical isolates from inpatients in Isfahan, central Iran. Le infezioni in medicina. 2018; 26: 61–66. RezaeiA FazeliH MoghadampourM HalajiM FaghriJ Determination of antibiotic resistance pattern and prevalence of OXA-type carbapenemases among Acinetobacter baumannii clinical isolates from inpatients in Isfahan, central Iran Le infezioni in medicina 2018 26 61 66 Search in Google Scholar

[23] Rezaei A, Fazeli H, Halaji M, Moghadampour M, Faghri J: Prevalence of metallo-beta-lactamase producing Acinetobacter baumannii isolated from intensive care unit in tertiary care hospitals. Ann Ig. 2018; 30: 330–336. RezaeiA FazeliH HalajiM MoghadampourM FaghriJ Prevalence of metallo-beta-lactamase producing Acinetobacter baumannii isolated from intensive care unit in tertiary care hospitals Ann Ig 2018 30 330 336 Search in Google Scholar

[24] Farajzadeh Sheikh A, Shahin M, Shokoohizadeh L, Halaji M, Shahcheraghi F, Ghanbari F: Molecular epidemiology of colistin-resistant Pseudomonas aeruginosa producing NDM-1 from hospitalized patients in Iran. Iranian journal of basic medical sciences. 2019; 22: 38–42. Farajzadeh SheikhA ShahinM ShokoohizadehL HalajiM ShahcheraghiF GhanbariF Molecular epidemiology of colistin-resistant Pseudomonas aeruginosa producing NDM-1 from hospitalized patients in Iran Iranian journal of basic medical sciences 2019 22 38 42 Search in Google Scholar

[25] Behera IC, Swain SK, Chandra M: Incidence of colistin-resistant Acinetobacter baumannii in an Indian tertiary care teaching hospital. Int J Adv Res (Indore). 2017; 3: 283–286. BeheraIC SwainSK ChandraM Incidence of colistin-resistant Acinetobacter baumannii in an Indian tertiary care teaching hospital Int J Adv Res (Indore) 2017 3 283 286 Search in Google Scholar

[26] Oikonomou O, Sarrou S, Papagiannitsis C, Georgiadou S, Mantzarlis K, Zakynthinos E, Dalekos G, Petinaki E: Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: mechanisms of resistance, molecular identification and epidemiological data. BMC Infect Dis. 2015; 15: 1–6. OikonomouO SarrouS PapagiannitsisC GeorgiadouS MantzarlisK ZakynthinosE DalekosG PetinakiE Rapid dissemination of colistin and carbapenem resistant Acinetobacter baumannii in Central Greece: mechanisms of resistance, molecular identification and epidemiological data BMC Infect Dis 2015 15 1 6 Search in Google Scholar

[27] Lima WG, Alves MC, Cruz WS, Paiva MC: Chromosomally encoded and plasmid-mediated polymyxins resistance in Acinetobacter baumannii: a huge public health threat. Eur J Clin Microbiol Infect. 2018; 37: 1009–1019. LimaWG AlvesMC CruzWS PaivaMC Chromosomally encoded and plasmid-mediated polymyxins resistance in Acinetobacter baumannii: a huge public health threat Eur J Clin Microbiol Infect 2018 37 1009 1019 Search in Google Scholar

[28] Ilsan NA, Lee YJ, Kuo SC, Lee IH, Huang TW: Antimicrobial Resistance Mechanisms and Virulence of Colistin- and Carbapenem-Resistant Acinetobacter baumannii Isolated from a Teaching Hospital in Taiwan. Microorganisms. 2021; 9. IlsanNA LeeYJ KuoSC LeeIH HuangTW Antimicrobial Resistance Mechanisms and Virulence of Colistin- and Carbapenem-Resistant Acinetobacter baumannii Isolated from a Teaching Hospital in Taiwan Microorganisms 2021 9 Search in Google Scholar

[29] Lesho E, Yoon EJ, McGann P, Snesrud E, Kwak Y, Milillo M, Onmus-Leone F, Preston L, St Clair K, Nikolich M et al: Emergence of colistin-resistance in extremely drug-resistant Acinetobacter baumannii containing a novel pmrCAB operon during colistin therapy of wound infections. The Journal of infectious diseases. 2013; 208: 1142–1151. LeshoE YoonEJ McGannP SnesrudE KwakY MililloM Onmus-LeoneF PrestonL St ClairK NikolichM Emergence of colistin-resistance in extremely drug-resistant Acinetobacter baumannii containing a novel pmrCAB operon during colistin therapy of wound infections The Journal of infectious diseases 2013 208 1142 1151 Search in Google Scholar

[30] Yang YS, Jeng WY, Lee YT, Hsu CJ, Chou YC, Kuo SC, Chen CC, Hsu WJ, The Action Study G, Chen HY et al: Ser253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis. Emerging microbes & infections. 2021; 10: 1873–1880. YangYS JengWY LeeYT HsuCJ ChouYC KuoSC ChenCC HsuWJ The Action StudyG ChenHY Ser253Leu substitution in PmrB contributes to colistin resistance in clinical Acinetobacter nosocomialis Emerging microbes & infections 2021 10 1873 1880 Search in Google Scholar

[31] Gordillo Altamirano FL, Kostoulias X, Subedi D, Korneev D, Peleg AY, Barr JJ: Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study. EBioMedicine. 2022; 80: 104045. Gordillo AltamiranoFL KostouliasX SubediD KorneevD PelegAY BarrJJ Phage-antibiotic combination is a superior treatment against Acinetobacter baumannii in a preclinical study EBioMedicine 2022 80 104045 Search in Google Scholar

[32] Seleim SM, Mostafa MS, Ouda NH, Shash RY: The role of pmrCAB genes in colistin-resistant Acinetobacter baumannii. Scientific reports. 2022; 12: 20951. SeleimSM MostafaMS OudaNH ShashRY The role of pmrCAB genes in colistin-resistant Acinetobacter baumannii Scientific reports 2022 12 20951 Search in Google Scholar

[33] Gerson S, Betts JW, Lucaßen K, Nodari CS, Wille J, Josten M, Göttig S, Nowak J, Stefanik D, Roca I et al: Investigation of Novel pmrB and eptA Mutations in Isogenic Acinetobacter baumannii Isolates Associated with Colistin Resistance and Increased Virulence In Vivo. Antimicrob Agents Chemother. 2019; 63. GersonS BettsJW LucaßenK NodariCS WilleJ JostenM GöttigS NowakJ StefanikD RocaI Investigation of Novel pmrB and eptA Mutations in Isogenic Acinetobacter baumannii Isolates Associated with Colistin Resistance and Increased Virulence In Vivo Antimicrob Agents Chemother 2019 63 Search in Google Scholar

[34] Sharma J, Sharma D, Singh A, Sunita K: Colistin Resistance and Management of Drug Resistant Infections. Can J Infect Dis Med Microbiol. 2022; 2022: 4315030. SharmaJ SharmaD SinghA SunitaK Colistin Resistance and Management of Drug Resistant Infections Can J Infect Dis Med Microbiol 2022 2022 4315030 Search in Google Scholar

[35] Aghapour Z, Gholizadeh P, Ganbarov K, Bialvaei AZ, Mahmood SS, Tanomand A, Yousefi M, Asgharzadeh M, Yousefi B, Kafil HS: Molecular mechanisms related to colistin resistance in Enterobacteriaceae. Infect Drug Resist. 2019; 12: 965. AghapourZ GholizadehP GanbarovK BialvaeiAZ MahmoodSS TanomandA YousefiM AsgharzadehM YousefiB KafilHS Molecular mechanisms related to colistin resistance in Enterobacteriaceae Infect Drug Resist 2019 12 965 Search in Google Scholar

[36] Gerson S, Lucaßen K, Wille J, Nodari CS, Stefanik D, Nowak J, Wille T, Betts JW, Roca I, Vila J et al: Diversity of amino acid substitutions in PmrCAB associated with colistin resistance in clinical isolates of Acinetobacter baumannii. Int J Antimicrob Agents. 2020; 55: 105862. GersonS LucaßenK WilleJ NodariCS StefanikD NowakJ WilleT BettsJW RocaI VilaJ Diversity of amino acid substitutions in PmrCAB associated with colistin resistance in clinical isolates of Acinetobacter baumannii Int J Antimicrob Agents 2020 55 105862 Search in Google Scholar

[37] Pourhajibagher M, Hashemi FB, Pourakbari B, Aziemzadeh M, Bahador A: Antimicrobial Resistance of Acinetobacter baumannii to Imipenem in Iran: A Systematic Review and Meta-Analysis. The open microbiology journal. 2016; 10: 32–42. PourhajibagherM HashemiFB PourakbariB AziemzadehM BahadorA Antimicrobial Resistance of Acinetobacter baumannii to Imipenem in Iran: A Systematic Review and Meta-Analysis The open microbiology journal 2016 10 32 42 Search in Google Scholar