[1. C. J. Kim, Drug release from compressed hydrophilic POLYOX-WSR tablets, J. Pharm. Sci.84 (1995) 303–306; https://doi.org/10.1002/jps.260084030810.1002/jps.2600840308]Search in Google Scholar
[2. L. Maggi, R. Bruni and U. Conte, High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms, Int. J. Pharm.195 (2000) 229–238; https://doi.org/10.1016/S0378-5173(99)00402-010.1016/S0378-5173(99)00402-0]Search in Google Scholar
[3. A. Apicella, B. Cappello, M. A. Del Nobile, M. I. La Rotonda, G. Mensitieri and L. Nicolais, Poly (ethylene oxide) (PEO) and different molecular weight PEO blends monolithic devices for drug release, Biomaterials14 (1993) 83–90; https://doi.org/10.1016/0142-9612(93)90215-N10.1016/0142-9612(93)90215-N]Search in Google Scholar
[4. P. Draksler, D. Lamešić and B. Janković, Physical properties of polymers used in pharmacy – Do we really know them?, Farm. Vestn.67 (2016) 265–272.]Search in Google Scholar
[5. B. Hammouda, D. L. Ho and S. Kline, Insight into clustering in poly(ethylene oxide) solutions, Macromolecules37 (2004) 6932–6937; https://doi.org/10.1021/ma049623d10.1021/ma049623d]Search in Google Scholar
[6. D. L. Ho, B. Hammouda and S. R. Kline, Clustering of poly(ethylene oxide) in water revisited, J. Polymer Sci. Part B: Polymer Physics41 (2002) 135–138; https://doi.org/10.1002/polb.1034010.1002/polb.10340]Search in Google Scholar
[7. D. Rivero, L. M. Gouveia, A. J. Müller and A. E. Sáez, Shear-thickening behavior of high molecular weight poly(ethylene oxide) solutions, Rheol. Acta.51 (2011) 13–20; https://doi.org/10.1007/s00397-011-0569-710.1007/s00397-011-0569-7]Search in Google Scholar
[8. A. S. Hoffman, The origins and evolution of “controlled” drug delivery systems, J. Control. Release132 (2008) 153–163; https://doi.org/10.1016/j.jconrel.2008.08.01210.1016/j.jconrel.2008.08.012]Search in Google Scholar
[9. Q. T. Nguyen, E. Favre, Z. H. Ping and J. Néel, Clustering of solvents in membranes and its influence on membrane transport properties, J. Memb. Sci.113 (1996) 137–150; https://doi.org/10.1016/0376-7388(95)00219-710.1016/0376-7388(95)00219-7]Search in Google Scholar
[10. J. H. Park and Y. H. Bae, Hydrogels based on poly(ethylene oxide) and poly(tetramethylene oxide) or poly(dimethyl siloxane). II. Physical properties and bacterial adhesion, J. Appl. Polym. Sci. 89 (2003) 1505–1514; https://doi.org/10.1002/app.1221710.1002/app.12217]Search in Google Scholar
[11. S. K. Mallapragada and N. A. Peppas, Crystal dissolution-controlled release systems: I. Physical characteristics and modeling analysis, J. Control. Release45 (1997) 87–94; https://doi.org/10.1016/S0168-3659(96)01549-010.1016/S0168-3659(96)01549-0]Search in Google Scholar
[12. S. K. Mallapragada, N. A. Peppas and P. Colombo, Crystal dissolution-controlled release systems. II. Metronidazole release from semicrystalline poly(vinyl alcohol) systems, J. Biomed. Mater. Res.36 (1997) 125–130; https://doi.org/10.1002/(SICI)1097-4636(199707)36:1%3C125::AID-JBM15 %3E3.0.CO;2-H]Search in Google Scholar
[13. B. Hammouda, Solvation characteristics of a model water-soluble polymer, J. Polym. Sci. Part B Polym. Phys.44 (2006) 3195–3199; https://doi.org/10.1002/polb.2096710.1002/polb.20967]Search in Google Scholar
[14. D. Cohn and A. Hotovely-Salomon, Biodegradable multiblock PEO/PLA thermoplastic elastomers: molecular design and properties, Polymer46 (2005) 2068–2075; https://doi.org/10.1016/j.polymer.2005.01.01210.1016/j.polymer.2005.01.012]Search in Google Scholar
[15. H. W. Starkweather Jr., Clustering of water in polymers, J. Polym. Sci. Part B Polym. Lett.1 (1963) 133–138; https://doi.org/10.1002/pol.1963.11001030510.1002/pol.1963.110010305]Search in Google Scholar
[16. I. Caraballo, Factors affecting drug release from hydroxypropyl methylcellulose matrix systems in the light of classical and percolation theories, Expert Opin. Drug Deliv.7 (2010) 1291–1301; https://doi.org/10.1517/17425247.2010.52819910.1517/17425247.2010.52819920977292]Search in Google Scholar
[17. J. D. Bonny and H. Leuenberger, Matrix type controlled release systems: I. Effect of percolation on drug dissolution kinetics, Pharm. Acta Helv.66 (1991) 160–164.]Search in Google Scholar
[18. A. Aharony and D. Stauffer, Introduction to Percolation Theory, Revised ed, Taylor & Francis, London, 2003.]Search in Google Scholar
[19. T. Gonçalves-Araújo, A. R. Rajabi-Siahboomi and I. Caraballo, Application of percolation theory in the study of an extended release verapamil hydrochloride formulation, Int. J. Pharm.361 (2008) 112–117; https://doi.org/10.1016/j.ijpharm.2008.05.02210.1016/j.ijpharm.2008.05.02218621491]Search in Google Scholar
[20. I. Fuertes, A. Miranda, M. Millán and I. Caraballo, Estimation of the percolation thresholds in acyclovir hydrophilic matrix tablets, Eur. J. Pharm. Biopharm.64 (2006) 336–342; https://doi.org/10.1016/j.ejpb.2006.05.00910.1016/j.ejpb.2006.05.00916876392]Search in Google Scholar
[21. S. Baumgartner, G. Lahajnar, A. Sepe and J. Kristl, Quantitative evaluation of polymer concentration profile during swelling of hydrophilic matrix tablets using 1H {NMR} and {MRI} methods, Eur. J. Pharm. Biopharm.59 (2005) 299–306; http://doi.org/10.1016/j.ejpb.2004.08.01010.1016/j.ejpb.2004.08.01015661502]Search in Google Scholar
[22. Y. Y. Chen, L. P. Hughes, L. F. Gladden and M. D. Mantle, Quantitative ultra-fast MRI of HPMC swelling and dissolution, J. Pharm. Sci.99 (2010) 3462–3472; https://doi.org/10.1002/jps.2211010.1002/jps.2211020229597]Search in Google Scholar
[23. P. P. Dorożyński, P. Kulinowski, A. Młynarczyk and G. J. Stanisz, MRI as a tool for evaluation of oral controlled release dosage forms, Drug Discov. Today17 (2012) 110–123; https://doi.org/10.1016/j.drudis.2011.10.02610.1016/j.drudis.2011.10.02622094243]Search in Google Scholar
[24. U. Mikac, J. Kristl and S. Baumgartner, Using quantitative magnetic resonance methods to understand better the gel-layer formation on polymer-matrix tablets, Expert Opin. Drug Deliv.8 (2011) 677–692; https://doi.org/10.1517/17425247.2011.56655410.1517/17425247.2011.56655421501097]Search in Google Scholar
[25. A. Hu, C. Chen, M. D. Mantle, B. Wolf, L. F. Gladden, A. Rajabi-Siahboomi, S. Missaghi, L. Mason and C. D. Melia, The properties of HPMC:PEO extended release hydrophilic matrices and their response to ionic environments, Pharm. Res. 34 (2017) 941–956; https://doi.org/10.1007/s11095-016-2031-010.1007/s11095-016-2031-0]Search in Google Scholar
[26. T. M. Hyde and L. F. Gladden, Simultaneous measurement of water and polymer concentration profiles during swelling of poly(ethylene oxide) using magnetic resonance imaging, Polymer39 (1998) 811–819; http://doi.org/10.1016/S0032-3861(97)00328-510.1016/S0032-3861(97)00328-5]Search in Google Scholar
[27. T. Tajiri, S. Morita, R. Sakamoto, M. Suzuki, S. Yamanashi, Y. Ozaki and S. Kitamura, Release mechanisms of acetaminophen from polyethylene oxide/polyethylene glycol matrix tablets utilizing magnetic resonance imaging, Int. J. Pharm.395 (2010) 147–153; https://doi.org/10.1016/j.ijpharm.2010.05.02110.1016/j.ijpharm.2010.05.021]Search in Google Scholar
[28. S. Abrahmsén-Alami, A. Körner, I. Nilsson and A. Larsson, New release cell for {NMR} microim-aging of tablets: swelling and erosion of poly(ethylene oxide), J. Pharm. Biomed. Anal. 342 (2007) 105–114; http://doi.org/10.1016/j.ijpharm.2007.05.00510.1016/j.ijpharm.2007.05.005]Search in Google Scholar
[29. Q. Zhang, L. Gladden, P. Avalle and M. Mantle, In vitro quantitative 1H and 19F nuclear magnetic resonance spectroscopy and imaging studies of fluvastatinTM in Lescol® XL tablets in a USP-IV dissolution cell, J. Control. Release156 (2011) 345–354; https://doi.org/10.1016/j.jconrel.2011.08.03910.1016/j.jconrel.2011.08.039]Search in Google Scholar
[30. C. Dahlberg, S. V. Dvinskikh, M. Schuleit and I. Furó, Polymer swelling, drug mobilization and drug recrystallization in hydrating solid dispersion tablets studied by multinuclear NMR micro-imaging and spectroscopy, Mol. Pharm. 8 (2011) 1247–1256; https://doi.org/10.1021/mp200051e10.1021/mp200051e]Search in Google Scholar
[31. C. A. Fyfe and A. I. Blazek, Investigation of hydrogel formation from hydroxypropylmethyl-cellulose (HPMC) by NMR spectroscopy and NMR imaging techniques, Macromolecules30 (1997) 6230–6237; https://doi.org/10.1021/ma970076o10.1021/ma970076o]Search in Google Scholar
[32. C. A. Fyfe, H. Grondey, A. I. Blazek-Welsh, S. K. Chopra and B. J. Fahie, {NMR} imaging investigations of drug delivery devices using a flow-through {USP} dissolution apparatus, J. Control. Release68 (2000) 73–83; http://doi.org/10.1016/S0168-3659(00)00237-610.1016/S0168-3659(00)00237-6]Search in Google Scholar
[33. L. Maggi, L. Segale, M. L. Torre, E. Ochoa Machiste and U. Conte, Dissolution behaviour of hydro-philic matrix tablets containing two different polyethylene oxides (PEOs) for the controlled release of a water-soluble drug. Dimensionality study, Biomaterials23 (2002) 1113–1119; https://doi.org/10.1016/S0142-9612(01)00223-X10.1016/S0142-9612(01)00223-X]Search in Google Scholar
[34. H. D. Bale and P. W. Schmidt, Small-angle X-ray-scattering investigation of submicroscopic porosity with fractal properties, Phys. Rev. Lett.53 (1984) 596–599; https://doi.org/10.1103/PhysRev-Lett.53.596]Search in Google Scholar
[35. S. Baumgartner, G. Lahajnar, A. Sepe and J. Kristl, Investigation of the state and dynamics of water in hydrogels of cellulose ethers by1H NMR spectroscopy, AAPS PharmSciTech3 (2002) 86; https://doi.org/10.1208/pt03043610.1208/pt030436275134512916930]Search in Google Scholar
[36. B. Narasimhan and N. A. Peppas, Molecular analysis of drug delivery systems controlled by dissolution of the polymer carrier, J. Pharm. Sci.86 (1997) 297–304; https://doi.org/10.1021/js960372z10.1021/js960372z]Search in Google Scholar
[37. N. A. Peppas and J. J. Sahlin, A simple equation for the description of solute release. III. Coupling of diffusion and relaxation, Int. J. Pharm.57 (1989) 169–172; https://doi.org/10.1016/0378-5173(89)90306-210.1016/0378-5173(89)90306-2]Search in Google Scholar
[38. T. Higuchi, Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci.52 (1963) 1145–1149; https://doi.org/10.1002/jps.260052121010.1002/jps.2600521210]Search in Google Scholar
[39. R. W. Korsmeyer, R. Gurny, E. Doelker, P. Buri and N. A. Peppas, Mechanisms of solute release from porous hydrophilic polymers, Int. J. Pharm.15 (1983) 25–35; https://doi.org/10.1016/0378-5173(83)90064-910.1016/0378-5173(83)90064-9]Search in Google Scholar
[40. A. Körner, A. Larsson, A. Andersson and L. Piculell, Swelling and polymer erosion for poly(ethylene oxide) tablets of different molecular weights polydispersities, J. Pharm. Sci.99 (2010) 1225–1238; https://doi.org/10.1002/jps.2189210.1002/jps.2189219718760]Search in Google Scholar
[41. M. Efentakis and M. Vlachou, Evaluation of high molecular weight poly(oxyethylene) (Polyox) polymer: studies of flow properties and release rates of furosemide and captopril from controlled-release hard gelatin capsules, Pharm. Dev. Technol.5 (2000) 339–46; https://doi.org/10.1081/PDT-10010054910.1081/PDT-100100549]Search in Google Scholar
[42. H. Li, R. J. Hardy and X. Gu, Effect of drug solubility on polymer hydration and drug dissolution from polyethylene oxide (PEO) matrix tablets, AAPS PharmSciTech9 (2008) 437–443; https://doi.org/10.1208/s12249-008-9060-x10.1208/s12249-008-9060-x297692418431663]Search in Google Scholar
[43. L. Wang, K. Chen, H. Wen, D. Ouyang, X. Li, Y. Gao, W. Pan and X. Yang, Design and evaluation of hydrophilic matrix system containing polyethylene oxides for the zero-order controlled delivery of water-insoluble drugs, AAPS PharmSciTech18 (2017) 82–92; https://doi.org/10.1208/s12249-016-0498-y10.1208/s12249-016-0498-y26883263]Search in Google Scholar
[44. C.-J. Kim, Effects of drug solubility, drug loading, and polymer molecular weight on drug release from Polyox tablets, Drug Dev. Ind. Pharm. 24 (1998) 645–651; https://doi.org/10.3109/0363904980908236610.3109/036390498090823669876509]Search in Google Scholar
[45. D. H. Choi, J. Y. Lim, S. Shin, W. J. Choi, S. H. Jeong and S. Lee, A novel experimental design method to optimize hydrophilic matrix formulations with drug release profiles and mechanical properties, J. Pharm. Sci.103 (2014) 3083–3094; https://doi.org/10.1002/jps.2408010.1002/jps.2408025055971]Search in Google Scholar
[46. J. S. Park, J. Y. Shim, K. V. T. Nguyen, J. S. Park, S. Shin, Y. W. Choi, J. Lee, J.-H. Yoon and S. H. Jeong, A pharma-robust design method to investigate the effect of PEG and PEO on matrix tablets, Int. J. Pharm.393 (2010) 79–87; https://doi.org/10.1016/j.ijpharm.2010.04.00910.1016/j.ijpharm.2010.04.009]Search in Google Scholar
[47. P. Draksler, B. Janković, Z. Abramović, Z. Lavrič and A. Meden, Assessment of critical material attributes of polyethylene oxide for formulation of prolonged-release tablets, Drug Dev. Ind. Pharm.45 (2019) 1949–1958; https://doi.org/10.1080/03639045.2019.168999110.1080/03639045.2019.1689991]Search in Google Scholar
[48. A. P. Cruz, C. D. Bertol, H. K. Stulzer, F. S. Murakami, F. T. Costella, H. V. A. Rocha and M. A. S. Silva, Swelling, erosion, and release behavior of PEO/primaquine matrix tablets, Pharm. Chem. J. 42 (2008) 413–418; https://doi.org/10.1007/s11094-008-0137-310.1007/s11094-008-0137-3]Search in Google Scholar
[49. H. Kojima, K. Yoshihara, T. Sawada, H. Kondo and K. Sako, Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets, Eur. J. Pharm. Biopharm. 70 (2008) 556–562; https://doi.org/10.1016/j.ejpb.2008.05.03210.1016/j.ejpb.2008.05.032]Search in Google Scholar
[50. Colorcon, Physico-mechanical characterization of POLYOX for tablet manufacture, 2009.]Search in Google Scholar
[51. T. D. Reynolds, S. A. Mitchell and K. M. Balwinski, Investigation of the effect of tablet surface area/volume on drug release from hydroxypropylmethylcellulose controlled-release matrix tablets, Drug Dev. Ind. Pharm. 28 (2002) 457–466; https://doi.org/10.1081/DDC-12000300710.1081/DDC-120003007]Search in Google Scholar
[52. S.-U. Choi, J. Lee and Y. W. Choi, Development of a directly compressible poly(ethylene oxide) matrix for the sustained-release of dihydrocodeine bitartrate, Drug Dev. Ind. Pharm.29 (2003) 1045–1052; https://doi.org/10.1081/DDC-12002586310.1081/DDC-120025863]Search in Google Scholar
[53. Colorcon, Formulation of Polyox ER matrices for a highly soluble active, 2009.]Search in Google Scholar
[54. Q. Zhang, Investigating polymer conformation in poly (ethylene oxide) (PEO) based systems for pharmaceutical applications a Raman spectroscopic study of the hydration process, Department of Applied Physics, Condensed Matter Physics, Chalmers University of Technology, 2011.]Search in Google Scholar
[55. A. Rangriz Shokri, T. Babadagli and A. Jafari, A critical analysis of the relationship between statistical- and fractal-fracture-network characteristics and effective fracture-network permeability, SPE Reserv. Eval. Eng.19 (2016) 494–510; https://doi.org/10.2118/181743-PA10.2118/181743-PA]Search in Google Scholar
[56. E.-Q. Chen, S.-W. Lee, A. Zhang, B.-S. Moon, P. S. Honigfort, I. Mann, H.-M. Lin, F. W. Harris, S. Z. D. Cheng, B. S. Hsiao and F. Yeh, Isothermal thickening and thinning processes in low molecular weight poly(ethylene oxide) fractions crystallized from the melt: 6. Configurational defects in molecules, Polymer40 (1999) 4543–4551; https://doi.org/10.1016/S0032-3861(99)00069-510.1016/S0032-3861(99)00069-5]Search in Google Scholar
[57. The Dow Chemical Company, What is the glass transition temperature of POLYOXTM water-soluble resins?, Dow Answ. Cent.; https://dowservice.custhelp.com/app/answers/detail/a_id/17872 (accessed October 24, 2019).]Search in Google Scholar
[58. S. Sant, V. Nadeau and P. Hildgen, Effect of porosity on the release kinetics of propafenone-loaded PEG-g-PLA nanoparticles, J. Control. Release107 (2005) 203–214; https://doi.org/10.1016/j.jconrel.2005.02.01710.1016/j.jconrel.2005.02.01716099525]Search in Google Scholar
[59. J. Ma, J. Sun, L. Fan, S. Bai, H. Panezai and Y. Jiao, Fractal evolution of dual pH- and temperature-responsive P(NIPAM-co-AA)@BMMs with bimodal mesoporous silica core and coated-copolymer shell during drug delivery procedure via SAXS characterization, Arab. J. Chem. 13 (2020) 4147–4161; https://doi.org/10.1016/j.arabjc.2019.06.01210.1016/j.arabjc.2019.06.012]Search in Google Scholar