<abstract xmlns="http://www.w3.org/1999/xhtml">

Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release. With this in view, we aimed at achieving furosemide’s longer gastric retention and waste minimization by preparing matrix and compression coated tablets incorporating different grades of Eudragit® and poly(ethylene oxide) (PEO), polyvinylpyrrolidone (PVP) and lactose monohydrate. Dissolution profiles of the new formulations were compared with that of the main stream drug Lasix®, 40 mg tablets. The results indicate that the use of Eudragit® in conjunction with either PVP or lactose monohydrate led to a slower release rate in the intestinal fluids compared to Lasix®. Moreover, furosemide release in the intestinal pH from matrix tablets and compression coated tablets was not noticeably different. Formulations incorporating PEO led to sustained release, in intestinal fluids, which depended on the molecular weight of PEO.
</abstract>

Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release. With this in view, we aimed at achieving furosemide’s longer gastric retention and waste minimization by preparing matrix and compression coated tablets incorporating different grades of Eudragit® and poly(ethylene oxide) (PEO), polyvinylpyrrolidone (PVP) and lactose monohydrate. Dissolution profiles of the new formulations were compared with that of the main stream drug Lasix®, 40 mg tablets. The results indicate that the use of Eudragit® in conjunction with either PVP or lactose monohydrate led to a slower release rate in the intestinal fluids compared to Lasix®. Moreover, furosemide release in the intestinal pH from matrix tablets and compression coated tablets was not noticeably different. Formulations incorporating PEO led to sustained release, in intestinal fluids, which depended on the molecular weight of PEO.

Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and dry-coated tablets

Section of Pharmaceutical Technology, Department of Pharmacy

National and Kapodistrian University of Athens

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Modified release of furosemide from Eudragits and poly(ethylene oxide)-based matrices and dry-coated tablets

Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious,...

Modified release of furosemide from Eudragits^® and poly(ethylene oxide)-based matrices and dry-coated tablets

Publicado en línea: 01 nov 2019

Páginas: 49 - 61

Aceptado: 04 abr 2019

DOI: https://doi.org/10.2478/acph-2020-0010

Palabras clave
matrix tablets, compression coated tablets, furosemide, Eudragit, poly(ethylene oxide), polyvinylpyrrolidone

© 2020 Marilena Vlachou et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and dry-coated tablets

Publicado en línea: 01 nov 2019

Páginas: 49 - 61

Aceptado: 04 abr 2019

DOI: https://doi.org/10.2478/acph-2020-0010

Palabras clavematrix tablets, compression coated tablets, furosemide, Eudragit, poly(ethylene oxide), polyvinylpyrrolidone

© 2020 Marilena Vlachou et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Modified release of furosemide from Eudragits^® and poly(ethylene oxide)-based matrices and dry-coated tablets

Palabras clave
matrix tablets, compression coated tablets, furosemide, Eudragit, poly(ethylene oxide), polyvinylpyrrolidone