Further evidence of high level of persistence of pediatric bipolar-I disorder from childhood onto young adulthood: a five-year follow up

Wozniak, Janet; Wolenski, Rebecca; Fitzgerald, Maura; Faraone, Stephen V.; Joshi, Gagan; Uchida, Mai; Biederman, Joseph

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Further evidence of high level of persistence of pediatric bipolar-I disorder from childhood onto young adulthood: a five-year follow up

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10 jul 2018

Scandinavian Journal of Child and Adolescent Psychiatry and Psychology

Volumen 6 (2018): Edición 1 (Junio 2018)

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Categoría del artículo: research-article

Publicado en línea: 10 jul 2018

Páginas: 40 - 51

DOI: https://doi.org/10.21307/sjcapp-2018-005

Palabras clave
adolescent, bipolar disorder, children, follow-up, major depression, subthreshold

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Persistence of DSM-IV BP-I in youth at the 5-year follow-up.

One-year prevalences of comorbid psychiatric disorders.a Compared to syndromatic and symptomatic remission. b Compared to symptomatic persistence. *P<0.05, **P<0.005, ***P<0.001

Current (last month) global functioning and one-year prevalence of school functioning.a Compared to syndromatic and symptomatic remission.b Compared to symptomatic persistence. *P<0.05, **P<0.005. ***P<0.001

Family history (FHx) of psychiatric disorders.

Demographic characteristics of subjects with syndromatic and symptomatic remission, syndromatic persistence, and syndromatic persistence

	Syndromatic and Symptomatic Remission (N=13)	Symptomatic Persistence (N=21)	Syndromatic Persistence (N=34)
	N (%)	N (%)	N (%)	Test Statistic	p-Value
Sex (male)	10 (77)	14 (67)	27 (79)	$χ_{2}^{2} = 1.16$	0.56
Caucasian	13 (100)	20 (95)	33 (97)	Exact	1.00
	Mean±SD	Mean±SD	Mean±SD
Age at baseline^[range]	11.5±3.6^[4-16]	9.2±3.5^[4-17]	9.3±3.4^[4-17]	F_{(2, 65)}=2.14	0.13
Age at follow-up^[range]	16.9±4.2^[9-22]	14.5±3.8^[9-23]	14.4±3.6^[7-23]	F_{2, 65}=2.24	0.11
SES	1.5±1.0	2.0±1.0	1.8±1.0	$χ_{2}^{2} = 2.68$	0.26

Characteristics of bipolar disorder

	Syndromatic and Symptomatic Remission (N=13)	Symptomatic Persistence (N=21)	Syndromatic Persistence (N=34)
	Median (Q1, Q3)^†	Median (Q1, Q3)	Median (Q1, Q3)	Test Statistic	p-Value
Baseline Duration	3 (1, 7)	3 (2, 6)	5 (2, 7)	$χ_{2}^{2} = 1.16$	0.56
Lifetime duration	7 (4, 9)	8 (5, 10)	10 (7, 14)^*,‡,§	$χ_{2}^{2} = 9.15$	0.01
	Mean±SD	Mean±SD	Mean±SD
Baseline # of symptoms	5.5±1.3	5.8±1.1	6.3±0.9^*,‡	F_{2, 65}=3.41	0.04
Lifetime # of symptoms	6.1±0.9	6.0±1.0	6.7±0.7^,‡,§,*	F_{2, 65}=5.25	0.008
	N (%)	N (%)	N (%)
Baseline ultra-rapid or ultradian cycling	5 (38)	5 (24)	13 (39)	$χ_{2}^{2} = 1.47$	0.48
Lifetime ultra-rapid or ultradian cycling	7 (54)	8 (38)	22 (65)	$χ_{2}^{2} = 3.61$	0.17
Severe impairment at baseline	7 (54)	14 (67)	25 (74)	$χ_{2}^{2} = 1.64$	0.44

Idioma:: Inglés

Calendario de la edición:: 1 veces al año
Temas de la revista:: Medicina, Ciencias médicas básicas, Ciencias médicas básicas, otros

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Further evidence of high level of persistence of pediatric bipolar-I disorder from childhood onto young adulthood: a five-year follow up

Categoría del artículo: research-article

Publicado en línea: 10 jul 2018

Páginas: 40 - 51

DOI: https://doi.org/10.21307/sjcapp-2018-005

Palabras clave
adolescent, bipolar disorder, children, follow-up, major depression, subthreshold

© 2018 Janet Wozniak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Demographic characteristics of subjects with syndromatic and symptomatic remission, syndromatic persistence, and syndromatic persistence

Characteristics of bipolar disorder

Further evidence of high level of persistence of pediatric bipolar-I disorder from childhood onto young adulthood: a five-year follow up

Janet Wozniak

Rebecca Wolenski

Maura Fitzgerald

Stephen V. Faraone

Gagan Joshi

Mai Uchida

Joseph Biederman

Categoría del artículo: research-article

Publicado en línea: 10 jul 2018

Páginas: 40 - 51

DOI: https://doi.org/10.21307/sjcapp-2018-005

Palabras claveadolescent, bipolar disorder, children, follow-up, major depression, subthreshold

© 2018 Janet Wozniak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1.

Figure 2.

Figure 3.

Figure 4.

Demographic characteristics of subjects with syndromatic and symptomatic remission, syndromatic persistence, and syndromatic persistence

Characteristics of bipolar disorder

Palabras clave
adolescent, bipolar disorder, children, follow-up, major depression, subthreshold