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Brucella – Virulence Factors, Pathogenesis and Treatment

PATRYCJA GŁOWACKA

PATRYCJA GŁOWACKA

Biological Threats Identification and Countermeasure Center of the General Karol Kaczkowski Military Institute of Hygiene and EpidemiologyPuławy, Poland
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GŁOWACKA, PATRYCJA
, 
DOROTA ŻAKOWSKA

DOROTA ŻAKOWSKA

Biological Threats Identification and Countermeasure Center of the General Karol Kaczkowski Military Institute of Hygiene and EpidemiologyPuławy, Poland
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ŻAKOWSKA, DOROTA
, 
KATARZYNA NAYLOR

KATARZYNA NAYLOR

Lublin Medical University, Department of Didactics and Medical SimulationLublin, Poland
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NAYLOR, KATARZYNA
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MARCIN NIEMCEWICZ

MARCIN NIEMCEWICZ

Biological Threats Identification and Countermeasure Center of the General Karol Kaczkowski Military Institute of Hygiene and EpidemiologyPuławy, Poland
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NIEMCEWICZ, MARCIN
 y 
AGATA BIELAWSKA-DRÓZD

AGATA BIELAWSKA-DRÓZD

Biological Threats Identification and Countermeasure Center of the General Karol Kaczkowski Military Institute of Hygiene and EpidemiologyPuławy, Poland
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BIELAWSKA-DRÓZD, AGATA
  
30 jun 2018
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Categoría del artículo: mini-review
Publicado en línea: 30 jun 2018
Páginas: 151 - 161
Recibido: 17 oct 2017
Aceptado: 28 feb 2018
DOI: https://doi.org/10.21307/pjm-2018-029
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© 2018 PATRYCJA GŁOWACKA et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1.

Mammalian cell invasion and intracellular trafficking.Smooth Brucella invasion into a cell by lipid rafts and acquisition of Rab5 and EEA1 markers – early BCV. β-1,2-glucans present in mature BCV and modification of lipid rafts. Then, the transient BCV interacts with lysosomes, T4SS is activated and it regulates intracellular trafficking from autophagosome to endoplasmatic reticulum (BCV acquires LAMP1 and Sec61β markers – late BCV – occurs only in epithelial cells). BCV acquires the endoplasmic reticulum markers (calnexin, calreticulin and Sec61-β) and the Brucella replicates. Rough Brucella organisms do not penetrate cell by lipid rafts, and therefore is exterminated.
Mammalian cell invasion and intracellular trafficking.Smooth Brucella invasion into a cell by lipid rafts and acquisition of Rab5 and EEA1 markers – early BCV. β-1,2-glucans present in mature BCV and modification of lipid rafts. Then, the transient BCV interacts with lysosomes, T4SS is activated and it regulates intracellular trafficking from autophagosome to endoplasmatic reticulum (BCV acquires LAMP1 and Sec61β markers – late BCV – occurs only in epithelial cells). BCV acquires the endoplasmic reticulum markers (calnexin, calreticulin and Sec61-β) and the Brucella replicates. Rough Brucella organisms do not penetrate cell by lipid rafts, and therefore is exterminated.
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4 veces al año
Temas de la revista:
Ciencias de la vida, Microbiología y virología
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