[1. Refsum H, Ueland PM, Nygård O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998; 49:31-62.10.1146/annurev.med.49.1.319509248]Open DOISearch in Google Scholar
[2. Djuric D, Jakovljevic V, Rasic-Markovic A, Djuric A, Stanojlovic O. Homocysteine, folic acid and coronary artery disease: possible impact on prognosis and therapy. Indian J Chest Dis Allied Sci. 2008; 50(1):39-48.]Search in Google Scholar
[3. Kim YI. Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr Rev. 1999; 57(10):314-21.1057590810.1111/j.1753-4887.1999.tb06905.x10575908]Search in Google Scholar
[4. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr. 2000; 71(5 Suppl):1295S-303S.10.1093/ajcn/71.5.1295s10799405]Search in Google Scholar
[5. Nelen WL. Hyperhomocysteinaemia and human reproduction. Clin Chem Lab Med. 2001; 39(8):758-63.10.1515/CCLM.2001.12611592447]Search in Google Scholar
[6. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 1998; 55(11):1449-55.10.1001/archneur.55.11.14499823829]Search in Google Scholar
[7. Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr. 2000; 71(2):614S-620S.10.1093/ajcn/71.2.614s10681269]Search in Google Scholar
[8. Troen AM. The central nervous system in animal models of hyperhomocysteinemia. Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29(7):1140-51.10.1016/j.pnpbp.2005.06.02516111797]Search in Google Scholar
[9. Kloor D, Stumvoll W, Schmid H, Kömpf J, Mack A, Osswald H. Localization of S-adenosylhomocysteine hydrolase in the rat kidney. J Histochem Cytochem. 2000; 48(2):211-8.10.1177/00221554000480020610639487]Search in Google Scholar
[10. Ntaios G, Savopoulos C, Grekas D, Hatzitolios A. The controversial role of B-vitamins in cardiovascular risk: An update. Arch Cardiovasc Dis. 2009; 102(12):847-54.10.1016/j.acvd.2009.07.00219963194]Search in Google Scholar
[11. Ball RO, Courtney-Martin G, Pencharz PB. The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006; 136(6 Suppl):1682S-1693S.10.1093/jn/136.6.1682S16702340]Search in Google Scholar
[12. Škovierová H, Vidomanová E, Mahmood S, Sopková J, Drgová A, Červeňová T, Halašová E, Lehotský J. The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health. Int J Mol Sci. 2016; 17(10).10.3390/ijms17101733508576327775595]Search in Google Scholar
[13. Chamberlin ME, Ubagai T, Mudd SH, Wilson WG, Leonard JV, Chou JY. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. Journal of Clinical Investigation. 1996; 98(4), 1021–7.10.1172/JCI118862]Search in Google Scholar
[14. Mudd SH, Jenden DJ, Capdevila A, Roch M, Levy HL, Wagner C. Isolated hypermethioninemia: measurements of S-adenosylmethionine and choline. Metabolism. 2000; 49(12):1542-7.10.1053/meta.2000.1852111145114]Search in Google Scholar
[15. Hasegawa T. Prolonged stress will induce Alzheimer’s disease in elderly people by increased release of homocysteic acid. Med Hypotheses. 2007; 69(5):1135-9.10.1016/j.mehy.2007.02.03417499446]Search in Google Scholar
[16. Blandini F, Fancellu R, Martignoni E, Mangiagalli A, Pacchetti C, Samuele A, Nappi G. Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease. Clin Chem. 2001; 47(6):1102-4.10.1093/clinchem/47.6.1102]Search in Google Scholar
[17. Hankey GJ, Eikelboom JW. Homocysteine and stroke. Curr Opin Neurol. 2001; 14(1):95-102.10.1097/00019052-200102000-0001511176224]Open DOISearch in Google Scholar
[18. Moustafa AA, Hewedi DH, Eissa AM, Frydecka D, Misiak B. Homocysteine levels in schizophrenia and affective disorders—focus on cognition. Frontiers in Behavioral Neuroscience. 2014; 6 (8):34310.3389/fnbeh.2014.00343]Search in Google Scholar
[19. Sunden SL, Renduchintala MS, Park EI, Miklasz SD, Garrow TA. Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys. 1997; 345(1):171-4.10.1006/abbi.1997.02469281325]Search in Google Scholar
[20. Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 1996; 54(12):382-90.10.1111/j.1753-4887.1996.tb03851.x9155210]Search in Google Scholar
[21. Sachdev PS, Parslow RA, Lux O, Salonikas C, Wen W, Naidoo D, Christensen H, Jorm AF. Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Psychol Med. 2005; 35(4):529-38.10.1017/S0033291704003721]Open DOISearch in Google Scholar
[22. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Yoon JS. Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. Br J Psychiatry. 2008; 192(4):268-74.10.1192/bjp.bp.107.03951118378986]Search in Google Scholar
[23. Hermesh H, Weizman A, Shahar A, Munitz H. Vitamin B12 and folic acid serum levels in obsessive compulsive disorder.]Search in Google Scholar
[24. Atmaca M, Tezcan E, Kuloglu M, Kirtas O, Ustundag B. Serum folate and homocysteine levels in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci. 2005; 59(5):616-20.10.1111/j.1440-1819.2005.01425.x16194269]Search in Google Scholar
[25. Levine J, Timinsky I, Vishne T, Dwolatzky T, Roitman S, Kaplan Z, Kotler M, Sela BA, Spivak B. Elevated serum homocysteine levels in male patients with PTSD. Depress Anxiety. 2008; 25(11):E154-7.10.1002/da.20400]Open DOISearch in Google Scholar
[26. Sharma V, Biswas D. Cobalamin deficiency presenting as obsessive compulsive disorder: case report. Gen Hosp Psychiatry. 2012; 34(5):578.e7-8.10.1016/j.genhosppsych.2011.11.006]Search in Google Scholar
[27. Hrncic D, Mikić J, Rasic-Markovic A, Velimirović M, Stojković T, Obrenović R, Rankov-Petrović B, Šušić V, Djuric D, Petronijević N, Stanojlovic O. Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress. Can J Physiol Pharmacol. 2016; 94(10):1074-82.10.1139/cjpp-2015-0581]Search in Google Scholar
[28. Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav. 1986; 24(3):525–910.1016/0091-3057(86)90552-6]Open DOISearch in Google Scholar
[29. Pellow S, Chopin P, File SE, Briley M. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 1985; 14(3):149–67.10.1016/0165-0270(85)90031-7]Open DOISearch in Google Scholar
[30. Ennaceur A. Tests of unconditioned anxiety - pitfalls and disappointments. Physiol Behav. 2014; 135:55-71. doi: 10.1016/j.physbeh.2014.05.032.10.1016/j.physbeh.2014.05.032]Open DOISearch in Google Scholar
[31. Selakovic D, Joksimovic J, Obradovic D, Milovanovic D, Djuric M, Rosic G. The adverse effects of exercise and supraphysiological dose of testosterone-enanthate (TE) on exploratory activity in elevated plus maze (EPM) test – indications for using total exploratory activity (TEA) as a new parameter for exploratory activity estimation in Neuroendocrinol Lett 2016; 37(5):101–6.]Search in Google Scholar
[32. Escorihuela RM, Fernández-Teruel A, Gil L, Aguilar R, Tobeña A, Driscoll P. Inbred Roman high- and low-avoidance rats: differences in anxiety, novelty-seeking, and shuttlebox behaviors. Physiol Behav. 1999; 67(1):19-26.10.1016/S0031-9384(99)00064-5]Search in Google Scholar
[33. Lepicard EM, Joubert C, Hagneau I, Perez-Diaz F, Chapouthier G. Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice. Pharmacol Biochem Behav. 2000; 67(4):739-48.10.1016/S0091-3057(00)00419-6]Search in Google Scholar
[34. Rodgers RJ, Dalvi A. Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev. 1997; 21(6):801-10.10.1016/S0149-7634(96)00058-9]Search in Google Scholar
[35. Belzung C, Griebel G. Measuring normal and pathological anxiety-like behavior in mice: a review. Behav Brain Res. 2001; 125(1-2):141-9.10.1016/S0166-4328(01)00291-1]Search in Google Scholar
[36. Cole JC, Rodgers RJ. Ethological comparison of the effects of diazepam and acute/chronic imipramine on the behaviour of mice in the elevated plus-maze. Pharmacol Biochem Behav. 1995; 52(3):473-8.10.1016/0091-3057(95)00163-Q]Search in Google Scholar
[37. Onaolapo AY, Onaolapo OJ, Blessing IC, Hameed SA, Raimot R. Low-dose L-methionine-associated changes in behavioural indices in young rats. International Journal of Neuroscience and Behavioral Science. 2016; 4:11-9.10.13189/ijnbs.2016.040102]Search in Google Scholar
[38. Young SN, Shalchi M. The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain. J Psychiatry Neurosci. 2005; 30(1):44–8.]Search in Google Scholar
[39. Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci. 2000; 20(18):6920-6.10.1523/JNEUROSCI.20-18-06920.2000]Search in Google Scholar
[40. Folbergrová J. Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. Exp Neurol. 1997; 145(2 Pt 1):442-50.10.1006/exnr.1997.64649217080]Search in Google Scholar
[41. Rammal H, Bouayed J, Younos C, Soulimani R. Evidence that oxidative stress is linked to anxiety-related behaviour in mice. Brain Behav Immun. 2008; 22(8):1156-9. doi: 10.1016/j.bbi.2008.06.005.10.1016/j.bbi.2008.06.00518620042]Open DOISearch in Google Scholar
[42. Hovatta I, Juhila J, Donner J. Oxidative stress in anxiety and comorbid disorders. Neurosci Res. 2010; 68(4):261-75. doi: 10.1016/j.neures.2010.08.007.10.1016/j.neures.2010.08.00720804792]Open DOISearch in Google Scholar
[43. Lalonde R, Barraud H, Ravey J, Guéant JL, Bronowicki JP, Strazielle C. Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice. Brain Res. 2008; 1188:122-31.10.1016/j.brainres.2007.10.06818061153]Open DOISearch in Google Scholar
[44. Miller JW, Nadeau MR, Smith D, Selhub J. Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats. Am J Clin Nutr. 1994; 59(5):1033-9.10.1093/ajcn/59.5.10338172087]Search in Google Scholar
[45. Taysi S, Keles MS, Gumustekin K, Akyuz M, Boyuk A, Cikman O, Bakan N. Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats. Eur Rev Med Pharmacol Sci. 2015; 19(1):154-60.]Search in Google Scholar
[46. Wei W, Liu YH, Zhang CE, Wang Q, Wei Z, Mousseau DD, Wang JZ, Tian Q, Liu GP. Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. J Alzheimers Dis. 2011; 27(3):639-50.10.3233/JAD-2011-11077021860088]Search in Google Scholar
[47. Chengfeng S, Wei L, Xinxing W, Lei W, Rui Z, Lingjia Q. Hyperhomocysteinemia is a result, rather than a cause, of depression under chronic stress. PLoS One. 2014; 9(10):e106625.10.1371/journal.pone.0106625418682025286230]Search in Google Scholar
[48. Cruz AP, Frei F, Graeff FG. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol Biochem Behav. 1994; 49(1):171-6.10.1016/0091-3057(94)90472-3]Open DOISearch in Google Scholar
[49. Rodgers RJ, Johnson NJ. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol Biochem Behav. 1995; 52(2):297-303.10.1016/0091-3057(95)00138-M]Open DOISearch in Google Scholar
[50. Rodgers RJ, Cao BJ, Dalvi A, Holmes A. Animal models of anxiety: an ethological perspective. Braz J Med Biol Res. 1997; 30(3):289-304.10.1590/S0100-879X1997000300002]Open DOISearch in Google Scholar