Open Access

The Effects of Methionine-Enriched and Vitamins (Folate, Pyridoxine and Cobalamine)-Deficient Diet on Exploratory Activity in Rats - A Brief Report


Cite

1. Refsum H, Ueland PM, Nygård O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998; 49:31-62.10.1146/annurev.med.49.1.319509248Open DOISearch in Google Scholar

2. Djuric D, Jakovljevic V, Rasic-Markovic A, Djuric A, Stanojlovic O. Homocysteine, folic acid and coronary artery disease: possible impact on prognosis and therapy. Indian J Chest Dis Allied Sci. 2008; 50(1):39-48.Search in Google Scholar

3. Kim YI. Folate and cancer prevention: a new medical application of folate beyond hyperhomocysteinemia and neural tube defects. Nutr Rev. 1999; 57(10):314-21.1057590810.1111/j.1753-4887.1999.tb06905.x10575908Search in Google Scholar

4. Scholl TO, Johnson WG. Folic acid: influence on the outcome of pregnancy. Am J Clin Nutr. 2000; 71(5 Suppl):1295S-303S.10.1093/ajcn/71.5.1295s10799405Search in Google Scholar

5. Nelen WL. Hyperhomocysteinaemia and human reproduction. Clin Chem Lab Med. 2001; 39(8):758-63.10.1515/CCLM.2001.12611592447Search in Google Scholar

6. Clarke R, Smith AD, Jobst KA, Refsum H, Sutton L, Ueland PM. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 1998; 55(11):1449-55.10.1001/archneur.55.11.14499823829Search in Google Scholar

7. Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr. 2000; 71(2):614S-620S.10.1093/ajcn/71.2.614s10681269Search in Google Scholar

8. Troen AM. The central nervous system in animal models of hyperhomocysteinemia. Prog Neuropsychopharmacol Biol Psychiatry. 2005; 29(7):1140-51.10.1016/j.pnpbp.2005.06.02516111797Search in Google Scholar

9. Kloor D, Stumvoll W, Schmid H, Kömpf J, Mack A, Osswald H. Localization of S-adenosylhomocysteine hydrolase in the rat kidney. J Histochem Cytochem. 2000; 48(2):211-8.10.1177/00221554000480020610639487Search in Google Scholar

10. Ntaios G, Savopoulos C, Grekas D, Hatzitolios A. The controversial role of B-vitamins in cardiovascular risk: An update. Arch Cardiovasc Dis. 2009; 102(12):847-54.10.1016/j.acvd.2009.07.00219963194Search in Google Scholar

11. Ball RO, Courtney-Martin G, Pencharz PB. The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006; 136(6 Suppl):1682S-1693S.10.1093/jn/136.6.1682S16702340Search in Google Scholar

12. Škovierová H, Vidomanová E, Mahmood S, Sopková J, Drgová A, Červeňová T, Halašová E, Lehotský J. The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health. Int J Mol Sci. 2016; 17(10).10.3390/ijms17101733508576327775595Search in Google Scholar

13. Chamberlin ME, Ubagai T, Mudd SH, Wilson WG, Leonard JV, Chou JY. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. Journal of Clinical Investigation. 1996; 98(4), 1021–7.10.1172/JCI118862Search in Google Scholar

14. Mudd SH, Jenden DJ, Capdevila A, Roch M, Levy HL, Wagner C. Isolated hypermethioninemia: measurements of S-adenosylmethionine and choline. Metabolism. 2000; 49(12):1542-7.10.1053/meta.2000.1852111145114Search in Google Scholar

15. Hasegawa T. Prolonged stress will induce Alzheimer’s disease in elderly people by increased release of homocysteic acid. Med Hypotheses. 2007; 69(5):1135-9.10.1016/j.mehy.2007.02.03417499446Search in Google Scholar

16. Blandini F, Fancellu R, Martignoni E, Mangiagalli A, Pacchetti C, Samuele A, Nappi G. Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease. Clin Chem. 2001; 47(6):1102-4.10.1093/clinchem/47.6.1102Search in Google Scholar

17. Hankey GJ, Eikelboom JW. Homocysteine and stroke. Curr Opin Neurol. 2001; 14(1):95-102.10.1097/00019052-200102000-0001511176224Open DOISearch in Google Scholar

18. Moustafa AA, Hewedi DH, Eissa AM, Frydecka D, Misiak B. Homocysteine levels in schizophrenia and affective disorders—focus on cognition. Frontiers in Behavioral Neuroscience. 2014; 6 (8):34310.3389/fnbeh.2014.00343Search in Google Scholar

19. Sunden SL, Renduchintala MS, Park EI, Miklasz SD, Garrow TA. Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys. 1997; 345(1):171-4.10.1006/abbi.1997.02469281325Search in Google Scholar

20. Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev. 1996; 54(12):382-90.10.1111/j.1753-4887.1996.tb03851.x9155210Search in Google Scholar

21. Sachdev PS, Parslow RA, Lux O, Salonikas C, Wen W, Naidoo D, Christensen H, Jorm AF. Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Psychol Med. 2005; 35(4):529-38.10.1017/S0033291704003721Open DOISearch in Google Scholar

22. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Yoon JS. Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. Br J Psychiatry. 2008; 192(4):268-74.10.1192/bjp.bp.107.03951118378986Search in Google Scholar

23. Hermesh H, Weizman A, Shahar A, Munitz H. Vitamin B12 and folic acid serum levels in obsessive compulsive disorder.Search in Google Scholar

24. Atmaca M, Tezcan E, Kuloglu M, Kirtas O, Ustundag B. Serum folate and homocysteine levels in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci. 2005; 59(5):616-20.10.1111/j.1440-1819.2005.01425.x16194269Search in Google Scholar

25. Levine J, Timinsky I, Vishne T, Dwolatzky T, Roitman S, Kaplan Z, Kotler M, Sela BA, Spivak B. Elevated serum homocysteine levels in male patients with PTSD. Depress Anxiety. 2008; 25(11):E154-7.10.1002/da.20400Open DOISearch in Google Scholar

26. Sharma V, Biswas D. Cobalamin deficiency presenting as obsessive compulsive disorder: case report. Gen Hosp Psychiatry. 2012; 34(5):578.e7-8.10.1016/j.genhosppsych.2011.11.006Search in Google Scholar

27. Hrncic D, Mikić J, Rasic-Markovic A, Velimirović M, Stojković T, Obrenović R, Rankov-Petrović B, Šušić V, Djuric D, Petronijević N, Stanojlovic O. Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress. Can J Physiol Pharmacol. 2016; 94(10):1074-82.10.1139/cjpp-2015-0581Search in Google Scholar

28. Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav. 1986; 24(3):525–910.1016/0091-3057(86)90552-6Open DOISearch in Google Scholar

29. Pellow S, Chopin P, File SE, Briley M. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods. 1985; 14(3):149–67.10.1016/0165-0270(85)90031-7Open DOISearch in Google Scholar

30. Ennaceur A. Tests of unconditioned anxiety - pitfalls and disappointments. Physiol Behav. 2014; 135:55-71. doi: 10.1016/j.physbeh.2014.05.032.10.1016/j.physbeh.2014.05.032Open DOISearch in Google Scholar

31. Selakovic D, Joksimovic J, Obradovic D, Milovanovic D, Djuric M, Rosic G. The adverse effects of exercise and supraphysiological dose of testosterone-enanthate (TE) on exploratory activity in elevated plus maze (EPM) test – indications for using total exploratory activity (TEA) as a new parameter for exploratory activity estimation in Neuroendocrinol Lett 2016; 37(5):101–6.Search in Google Scholar

32. Escorihuela RM, Fernández-Teruel A, Gil L, Aguilar R, Tobeña A, Driscoll P. Inbred Roman high- and low-avoidance rats: differences in anxiety, novelty-seeking, and shuttlebox behaviors. Physiol Behav. 1999; 67(1):19-26.10.1016/S0031-9384(99)00064-5Search in Google Scholar

33. Lepicard EM, Joubert C, Hagneau I, Perez-Diaz F, Chapouthier G. Differences in anxiety-related behavior and response to diazepam in BALB/cByJ and C57BL/6J strains of mice. Pharmacol Biochem Behav. 2000; 67(4):739-48.10.1016/S0091-3057(00)00419-6Search in Google Scholar

34. Rodgers RJ, Dalvi A. Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev. 1997; 21(6):801-10.10.1016/S0149-7634(96)00058-9Search in Google Scholar

35. Belzung C, Griebel G. Measuring normal and pathological anxiety-like behavior in mice: a review. Behav Brain Res. 2001; 125(1-2):141-9.10.1016/S0166-4328(01)00291-1Search in Google Scholar

36. Cole JC, Rodgers RJ. Ethological comparison of the effects of diazepam and acute/chronic imipramine on the behaviour of mice in the elevated plus-maze. Pharmacol Biochem Behav. 1995; 52(3):473-8.10.1016/0091-3057(95)00163-QSearch in Google Scholar

37. Onaolapo AY, Onaolapo OJ, Blessing IC, Hameed SA, Raimot R. Low-dose L-methionine-associated changes in behavioural indices in young rats. International Journal of Neuroscience and Behavioral Science. 2016; 4:11-9.10.13189/ijnbs.2016.040102Search in Google Scholar

38. Young SN, Shalchi M. The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain. J Psychiatry Neurosci. 2005; 30(1):44–8.Search in Google Scholar

39. Kruman II, Culmsee C, Chan SL, Kruman Y, Guo Z, Penix L, Mattson MP. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci. 2000; 20(18):6920-6.10.1523/JNEUROSCI.20-18-06920.2000Search in Google Scholar

40. Folbergrová J. Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. Exp Neurol. 1997; 145(2 Pt 1):442-50.10.1006/exnr.1997.64649217080Search in Google Scholar

41. Rammal H, Bouayed J, Younos C, Soulimani R. Evidence that oxidative stress is linked to anxiety-related behaviour in mice. Brain Behav Immun. 2008; 22(8):1156-9. doi: 10.1016/j.bbi.2008.06.005.10.1016/j.bbi.2008.06.00518620042Open DOISearch in Google Scholar

42. Hovatta I, Juhila J, Donner J. Oxidative stress in anxiety and comorbid disorders. Neurosci Res. 2010; 68(4):261-75. doi: 10.1016/j.neures.2010.08.007.10.1016/j.neures.2010.08.00720804792Open DOISearch in Google Scholar

43. Lalonde R, Barraud H, Ravey J, Guéant JL, Bronowicki JP, Strazielle C. Effects of a B-vitamin-deficient diet on exploratory activity, motor coordination, and spatial learning in young adult Balb/c mice. Brain Res. 2008; 1188:122-31.10.1016/j.brainres.2007.10.06818061153Open DOISearch in Google Scholar

44. Miller JW, Nadeau MR, Smith D, Selhub J. Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats. Am J Clin Nutr. 1994; 59(5):1033-9.10.1093/ajcn/59.5.10338172087Search in Google Scholar

45. Taysi S, Keles MS, Gumustekin K, Akyuz M, Boyuk A, Cikman O, Bakan N. Plasma homocysteine and liver tissue S-adenosylmethionine, S-adenosylhomocysteine status in vitamin B6-deficient rats. Eur Rev Med Pharmacol Sci. 2015; 19(1):154-60.Search in Google Scholar

46. Wei W, Liu YH, Zhang CE, Wang Q, Wei Z, Mousseau DD, Wang JZ, Tian Q, Liu GP. Folate/vitamin-B12 prevents chronic hyperhomocysteinemia-induced tau hyperphosphorylation and memory deficits in aged rats. J Alzheimers Dis. 2011; 27(3):639-50.10.3233/JAD-2011-11077021860088Search in Google Scholar

47. Chengfeng S, Wei L, Xinxing W, Lei W, Rui Z, Lingjia Q. Hyperhomocysteinemia is a result, rather than a cause, of depression under chronic stress. PLoS One. 2014; 9(10):e106625.10.1371/journal.pone.0106625418682025286230Search in Google Scholar

48. Cruz AP, Frei F, Graeff FG. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol Biochem Behav. 1994; 49(1):171-6.10.1016/0091-3057(94)90472-3Open DOISearch in Google Scholar

49. Rodgers RJ, Johnson NJ. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol Biochem Behav. 1995; 52(2):297-303.10.1016/0091-3057(95)00138-MOpen DOISearch in Google Scholar

50. Rodgers RJ, Cao BJ, Dalvi A, Holmes A. Animal models of anxiety: an ethological perspective. Braz J Med Biol Res. 1997; 30(3):289-304.10.1590/S0100-879X1997000300002Open DOISearch in Google Scholar

eISSN:
2335-075X
ISSN:
1820-8665
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, other