[1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303–10.10.1097/00003246-200107000-0000211445675]Search in Google Scholar
[2. Mariansdatter SE, Eiset AH, Søgaard KK, Christiansen CF. Differences in reported sepsis incidence according to study design: a literature review. BMC Med Res Methodol. 2016;16:137. doi: 10.1186/s12874-016-0237-9.10.1186/s12874-016-0237-9506283327733132]Search in Google Scholar
[3. Dombrovskiy VY, Martin AA, Sunderram J, Paz HL. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med. 2007;35:1244–50.10.1097/01.CCM.0000261890.41311.E917414736]Search in Google Scholar
[4. Zhang L, Zhu G, Han L, Fu P. Early goal-directed therapy in the management of severe sepsis or septic shock in adults: a meta-analysis of randomized controlled trials. BMC Med Res Methodol. 2015;13:71. doi: 10.1186/s12916-015-0312-9.10.1186/s12916-015-0312-9439361025885654]Search in Google Scholar
[5. Martin GS. Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther. 2012;10:701–6.10.1586/eri.12.50348842322734959]Search in Google Scholar
[6. Donadello K, Scolletta S, Covajes C, et al. suPAR as a prognostic biomarker in sepsis. BMC Med. 2012;10:2. doi: 10.1186/1741-7015-10-2.10.1186/1741-7015-10-2327554522221662]Search in Google Scholar
[7. Sankar V, Webster NR. Clinical application of sepsis biomarkers. J Anesth. 2013;27:269-83.10.1007/s00540-012-1502-723108494]Search in Google Scholar
[8. Szederjesi J, Almasy E, Lazar A, et al. An evaluation of serum procalcitonin and C-reactive protein levels as diagnostic and prognostic biomarkers of severe sepsis. J Crit Care Med. 2015;1:147-53.10.1515/jccm-2015-0022595329529967823]Search in Google Scholar
[9. Liu X, Ren H, Peng D. Sepsis biomarkers: an omics perspective. Front Med. 2014;8:58-67.10.1007/s11684-014-0318-2708892124481820]Search in Google Scholar
[10. Stanilova SA. Functional relevance of IL-10 promoter polymorphisms for sepsis development. Crit Care. 2010;14:119. doi: 10.1186/cc8839.10.1186/cc8839287551020236506]Search in Google Scholar
[11. Deasy A, Read RC. Genetic variation in pro-inflammatory cytokines and meningococcal sepsis. Curr Opin Infect Dis. 2010;23:255–8.10.1097/QCO.0b013e32833939de]Search in Google Scholar
[12. Wong HR. Genetics and genomics in pediatric septic shock. Crit Care Med. 2012;40:1618–26.10.1097/CCM.0b013e318246b546332964222511139]Search in Google Scholar
[13. Namath A, Patterson AJ. Genetic polymorphisms in sepsis. Crit Care Clin. 2009;25:835–56.10.1016/j.ccc.2009.06.00419892256]Search in Google Scholar
[14. Jabandziev P, Smerek M, Michalek J, et al. Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis. Critical Care. 2014;18:R1. doi: 10.1186/cc13174.10.1186/cc13174405644124383711]Search in Google Scholar
[15. Chauhan M, McGuire W. Interleukin-6 (-174C) polymorphism and the risk of sepsis in very low birth weight infants: meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2008;93: F427-29. doi: 10.1136/adc.2007.134205.10.1136/adc.2007.13420518375611]Search in Google Scholar
[16. Teuffel O, Ethier MC, Beyene J, Sung L. Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis. Crit Care Med. 2010;38:276-82.10.1097/CCM.0b013e3181b42af019789454]Search in Google Scholar
[17. Tiancha H, Huiqin W, Jiyong J, et al. Association between lymphotoxin-alpha intron +252 polymorphism and sepsis: a meta-analysis. Scand J Infect Dis. 2011;43:436-47.10.3109/00365548.2011.56252821366408]Search in Google Scholar
[18. Angus DC, Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303–10.10.1097/00003246-200107000-0000211445675]Search in Google Scholar
[19. Surbatovic M, Veljovic M, Jevdjic J, Popovic N, Djordjevic D, Radakovic S. Immunoinflammatory Response in Critically Ill Patients: Severe Sepsis and/or Trauma. Mediators Inflamm. 2013;2013:362793. doi: 10.1155/2013/362793.10.1155/2013/362793385915924371374]Search in Google Scholar
[20. Kothari N, Bogra J, Abbas H, et al. Tumor Necrosis Factor gene polymorphism results in high TNF level in sepsis and septic shock. Cytokine. 2013;61:676–81.10.1016/j.cyto.2012.11.01623317877]Search in Google Scholar
[21. Jeremic V, Tamara Alempijevic T, Srdan Mijatovic S, et al. Clinical relevance of IL-6 gene polymorphism in severely injured patients. Bosn J Basic Med Sci. 2014;14:110-7.10.17305/bjbms.2014.2274433395224856384]Search in Google Scholar
[22. Allam G, Alsulaimani AA, Alzaharani AK, Nasr A. Neonatal infections in Saudi Arabia: Association with cytokine gene Polymorphisms. Centr Eur J Immunol. 2015;40:68-77.10.5114/ceji.2015.50836447254226155186]Search in Google Scholar
[23. Baghel K, Srivastava RN, Chandra A, et al. TNF-α, IL-6, and IL-8 Cytokines and Their Association with TNF-α-308 G/A Polymorphism and Postoperative Sepsis. J Gastrointest Surg. 2014;18:1486–94.10.1007/s11605-014-2574-524944154]Search in Google Scholar
[24. Feng B, Mao ZR, Pang K, Zhang SI, Li L. Association of tumor necrosis factor α −308G/A and interleukin-6 −174G/C gene polymorphism with pneumonia-induced sepsis. J Crit Care. 2015;30:920-2.10.1016/j.jcrc.2015.04.12326025100]Search in Google Scholar
[25. Gao JW, Zhang AQ, Pan W, Yue CI, Zeng L, Gu W, Jiang J. Association between IL-6-174G/C Polymorphism and the Risk of Sepsis and Mortality: A Systematic Review and Meta Analysis. PloS One. 2015;10:e0118843. doi: 10.1371/journal.pone.0118843.10.1371/journal.pone.0118843434848025734339]Search in Google Scholar
[26. Faix JD. Biomarkers of sepsis. Crit Rev Clin Lab Sci. 2013;50:23-36.10.3109/10408363.2013.764490361396223480440]Search in Google Scholar
[27. Uusitalo-Seppala R, Koskinen P, Leino A, et al. Early detection of severe sepsis in the emergency room: diagnostic value of plasma C-reactive protein, procalcitonin, and interleukin-6. Scand J Infect Dis. 2011;43:883–90.10.3109/00365548.2011.60032521892899]Search in Google Scholar
[28. Miguel-Bayarri V, Casanoves-Laparra EB, Pallas-Beneyto L, Sancho-Chinesta S, Martin-Osorio LF, et al. Prognostic value of the biomarkers procalcitonin, interleukin-6 and C-reactive protein in severe sepsis. Med Intensiva. 2012;36:556–62.10.1016/j.medin.2012.01.01422495097]Search in Google Scholar
[29. Tschaikowsky K, Hedwig-Geissing M, Braun GG, Radespiel-Troeger M. Predictive value of procalcitonin, interleukin-6, and C reactive protein for survival in postoperative patients with severe sepsis. J Crit Care. 2011;26:54–64.10.1016/j.jcrc.2010.04.01120646905]Search in Google Scholar
[30. Palmiere C, Augsburger M. Markers for sepsis diagnosis in the forensic setting: state of the art. Croat Med J. 2014;55:103–14.10.3325/cmj.2014.55.103400971124778096]Search in Google Scholar
[31. Fishman D, Faulds G, Jeffery R et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998;1:1369-76.10.1172/JCI26295089849769329]Search in Google Scholar
[32. Kilpinen S, Hulkkonen J, Wang XY, Hurme M. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. Eur Cytokine Netw. 2001;12:62-8.]Search in Google Scholar
[33. Georgescu AM, Banescu C, Badea I, et al. IL-6 gene polymorphisms and sepsis in ICU adult Romanian patients: a prospective study. Rev Romana Med Lab. 2017; 25. doi: 10.1515/rrlm-2016-0044.10.1515/rrlm-2016-0044]Search in Google Scholar
[34. Baier RJ, Loggins J, Yanamandra K. IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants. BMC Med. 2006;4:10. doi:10.1186/1741-7015-4-10.10.1186/1741-7015-4-10151339016611358]Search in Google Scholar
[35. Ahrens P, Kattner E, Kohler B, et al. Mutations of genes involved in the innate immune system as predictors of sepsis in very low birth weight infants. Pediatr Res. 2004;55:652-6.10.1203/01.PDR.0000112100.61253.8514739370]Search in Google Scholar
[36. Martin-Loeches I, Sole-Violan J, Rodriguez de Castro F, Isabel Garcia-Laorden M, Borderias L, et al. Variants at the promoter of the interleukin-6 gene are associated with severity and outcome of pneumococcal community-acquired pneumonia. Intensive Care Med. 2012;38:256–62.10.1007/s00134-011-2406-y22113815]Search in Google Scholar
[37. Sole-Violan J, Rodriguez de Castro F, Isabel Garcia-Laorden M, Blanquer J, Aspa J, et al. Genetic variability in the severity and outcome of community-acquired pneumonia. Respir Med. 2010;104:440–7.10.1016/j.rmed.2009.10.00919900796]Search in Google Scholar
[38. Davis SM, Clark EAS, Nelson LT, Silver RM. The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis. Am J Obstet Gynecol. 2010;202:308.e301–308.e308.10.1016/j.ajog.2010.01.00620207250]Search in Google Scholar
[39. Carregaro F, Carta A, Cordeiro JA, Lobo SM, Tajara EH, et al. Polymorphisms IL10–819 and TLR-2 are potentially associated with sepsis in brazilian patients. Mem Inst Oswaldo Cruz. 2010;105:649–56.10.1590/S0074-02762010000500008]Search in Google Scholar
[40. Shalhub S, Junker CE, Imahara SD, Mindrinos MN, Dissanaike S, et al. Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study. J Trauma. 2009;66:115–22.10.1097/TA.0b013e3181938d50274063219131814]Search in Google Scholar
[41. Cesur S, Sengui A, Kurtoglu Y, et al. Prognostic value of cytokines (TNF-α, IL-10, Leptin) and C-reactive protein serum levels in adult patients with nosocomial sepsis. J Microb Infect Dis. 2011;1:101-9.10.5799/ahinjs.02.2011.03.0024]Search in Google Scholar
[42. Zeng L, Gu W, Chen K, et al. Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies. Crit Care. 2009,13:R188. doi:10.1186/cc8182.10.1186/cc8182281191719939284]Search in Google Scholar
[43. Surbatovic M, Grujic K, Cikota B, et al. Polymorphisms of genes encoding tumor necrosis factor-alpha, interleukin-10, cluster of differentiation-14 and interleukin-1ra in critically ill patients. J Crit Care. 2010;25,542.e1–542.e8.]Search in Google Scholar
[44. Stanilova SA, Miteva LD, Karakolev ZT, Stefanov CS. Interleukin-10-1082 promoter polymorphism in association with cytokine production and sepsis susceptibility. Intensive Care Med. 2006;32:260–6.10.1007/s00134-005-0022-416435103]Search in Google Scholar
[45. Ouyang L, Lv YD, Hou C, Wu GB, He ZH. Quantitative analysis of the association between interleukin-10 1082A/G polymorphism and susceptibility to sepsis. Mol Biol Rep. 2013;40:4327–32.10.1007/s11033-013-2520-823716201]Search in Google Scholar
[46. Pan W, Zhang AQ, Yue CL, et al. Association between interleukin-10 polymorphisms and sepsis: a meta-analysis. Epidemiol Infect. 2015;143:366–75.10.1017/S095026881400070325497741]Search in Google Scholar
[47. Cardoso CP, de Oliveira AJ, Botoni FA, et al. Interleukin-10 rs2227307 and CXCR2 rs1126579 polymorphisms modulate the predisposition to septic shock. Mem Inst Oswaldo Cruz. 2015;110:453-60.10.1590/0074-02760150003450140726038959]Search in Google Scholar
[48. Accardo Palumbo A, Forte GI, Pileri D, et al. Analysis of IL-6, IL-10 and IL-17 genetic polymorphisms as risk factors for sepsis development in burned patients. Burns. 2012;38:208-13.10.1016/j.burns.2011.07.02222079540]Search in Google Scholar
[49. Kofoed K, Andersen O, Kronborg G, et al. Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study. Crit Care. 2007;11:R38.10.1186/cc5723220645617362525]Search in Google Scholar
[50. Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med. 2002;162:1028–32.10.1001/archinte.162.9.102811996613]Search in Google Scholar
[51. Wang H, Wei Y, Zeng Y, et al. The association of polymorphisms of TLR4 and CD14 genes with susceptibility to sepsis in a Chinese population. BMC Med Genet. 2014;15:123.10.1186/s12881-014-0123-4441169625394369]Search in Google Scholar
[52. Schlüter B, Raufhake C, Erren M, et al. Effect of the interleukin-6 promoter polymorphism (-174 G/C) on the incidence and outcome of sepsis. Crit Care Med. 2002;30:32-7.10.1097/00003246-200201000-0000511902285]Search in Google Scholar
[53. Oku R, Oda S, Nakada TA, et al. Differential pattern of cell-surface and soluble TREM 1 between sepsis and SIRS. Cytokine. 2013;61:112–7.10.1016/j.cyto.2012.09.00323046618]Search in Google Scholar
[54. Su L, Han B, Liu C, et al. Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study. BMC Infect Dis. 2012;12:157. doi: 10.1186/1471-2334-12-157.10.1186/1471-2334-12-157342647522809118]Search in Google Scholar
[55. Su L, Liu C, Li C, et al. Dynamic Changes in Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) and its Gene Polymorphisms are Associated with Sepsis Prognosis. Inflammation. 2012;35:1833-43.10.1007/s10753-012-9504-z22798017]Search in Google Scholar
[56. Peng LS, Li J, Zhou GS, Deng LH, Yao HG. Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and septic shock in a Chinese Han population. World J Emerg Med. 2015;6:123-30.10.5847/wjem.j.1920-8642.2015.02.007445847226056543]Search in Google Scholar
[57. Chen QX, Zhou HD, Wu SJ, et al. Lack of association between TREM-1 gene polymorphisms and severe sepsis in a Chinese Han population. Hum Immunol. 2008;69:220–26.10.1016/j.humimm.2008.01.01318396215]Search in Google Scholar
[58. Lemari J, Barraud D, Gibot S. Host response biomarkers in sepsis: overview on sTREM-1 detection. Methods Mol Biol. 2015;1237:225-39.10.1007/978-1-4939-1776-1_1725319790]Search in Google Scholar
[59. Dimopoulou I, Pelekanou A, Mavrou I, et al. Early serum levels of soluble triggering receptor expressed on myeloid cells–1 in septic patients: Correlation with monocyte gene expression. J Crit Care. 2012;27:294–300.10.1016/j.jcrc.2011.06.01321855288]Search in Google Scholar
[60. Masson S, Caironi P, Spanuth E, et al. Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care. 2014, 18:R6. doi: 10.1186/cc13183.10.1186/cc13183405604624393424]Search in Google Scholar
[61. Endo S, Suzuki Y, Takahashi G, et al. Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study. J Infect Chemother. 2012;18:891-7.10.1007/s10156-012-0435-222692596]Search in Google Scholar
[62. Yaegashi Y, Shirakawa K, Sato N, et al. Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother. 2005;11:234-8.10.1007/s10156-005-0400-416258819]Search in Google Scholar
[63. Okamura Y, Yokoi H. Development of a point-of-care assay system for measurement of presepsin (sCD14-ST). Clin Chim Acta. 2011;412:2157–61.10.1016/j.cca.2011.07.02421839732]Search in Google Scholar
[64. Zhang AQ, Yue CI, Gu W, Du J, Wang HY, Jiang J. Association between CD14 Promoter -159C/T Polymorphism and the Risk of Sepsis and Mortality: A Systematic Review and Meta-Analysis. PLoS One. 2013;8:e71237. doi: 10.1371/journal.pone.0071237.10.1371/journal.pone.0071237374717123990939]Search in Google Scholar
[65. Lorente L, Martin MM, Borreguero-Leon JM, et al. The 4G/4G Genotype of PAI-1 Polymorphism Is Associated with Higher Plasma PAI-1 Concentrations and Mortality in Patients with Severe Sepsis. PLoS One. 2015;10:e0129565. doi: 10.1371/journal.pone.0129565.10.1371/journal.pone.0129565446625226066833]Search in Google Scholar
[66. Madách K, Aladzsity I, Szilágyi A, et al. 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study. Crit Care. 2010;14:R79. doi: 10.1186/cc8992.10.1186/cc8992288720220429897]Search in Google Scholar
[67. Perés Wingeyer SD, Cunto ER, Nogueras CM, San Juan JA, Gomez N, de Larrañaga GF. Biomarkers in sepsis at time zero: intensive care unit scores, plasma measurements and polymorphisms in Argentina. J Infect Dev Ctries. 2012;6:555–62.10.3855/jidc.210822842942]Search in Google Scholar
[68. Andersen O, Eugen-Olsen J, Kafoed K, et al. Soluble urokinase plasminogen activator receptor is a marker of dysmetabolism in HIV-infected patients receiving highly active antiretroviral therapy. J Med Virol.2008;80:209-16.10.1002/jmv.2111418098145]Search in Google Scholar
[69. Eugen-Olsen J, Andersen O, Linneberg A, et al. Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population. J Intern Med. 2010;268:296-308.10.1111/j.1365-2796.2010.02252.x20561148]Search in Google Scholar
[70. Backes Y, van der Sluijs Koenraad F, Mackie DP, et al. Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systematic review. Intensive Care Med. 2012;38:1418-28.10.1007/s00134-012-2613-1342356822706919]Search in Google Scholar
[71. Park YJ, Liu G, Tsuruta Y, et al. Participation of the urokinase receptor in neutrophil efferocytosis. Blood. 2009;114:860-70.10.1182/blood-2008-12-193524271602319398720]Search in Google Scholar
[72. Wiersinga WJ, Kager LM, Hovius JW, et al. Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. J Immunol. 2010;184:3079-86.10.4049/jimmunol.090100820142364]Search in Google Scholar
[73. Koch A, Voigt S, Kruschinski C, et al. Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Crit Care. 2011;15:R63. doi: 10.1186/cc10037.10.1186/cc10037322199621324198]Search in Google Scholar
[74. Georgescu AM, Szederjesi J, Dobreanu M, et al. Soluble urokinase-type plasminogen activator receptor (suPAR) – a possible biomarker for bacteremia in sepsis. Rev Romana Med Lab. 2015;23:59-73.]Search in Google Scholar
[75. Donadello K, Scolletta S, Covajes C, Vincent JL. suPAR as a prognostic biomarker in sepsis. BMC Med. 2012;10:2. doi: 10.1186/1741-7015-10-2.10.1186/1741-7015-10-2327554522221662]Search in Google Scholar
[76. De Kruif MD, Lemaire LC, Giebelen IA, et al. The influence of corticosteroids on the release of novel biomarkers in human endotoxemia. Intensive Care Med. 2008;34:518-22.10.1007/s00134-007-0955-x224469918080111]Search in Google Scholar
[77. Huttunen R, Syrjanen J, Vuento R, et al. Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study. J Intern Med. 2011;270:32-40.10.1111/j.1365-2796.2011.02363.x21332843]Search in Google Scholar
[78. Koch A, Tacke F. Why high suPAR is not super-diagnostic, prognostic and potential pathogenic properties of a novel biomarker in the ICU. Crit Care. 2011;15:1020. doi: 10.1186/cc10577.10.1186/cc10577338868822182777]Search in Google Scholar
[79. Molkanen T, Ruotsalainen E, Thorball CW, et al. Elevated soluble urokinase plasminogen activator receptor (suPAR) predicts mortality in Staphilococcus aureus bacteraemia. Eur J Clin Microbiol Infect Dis. 2011;30:1417-24.10.1007/s10096-011-1236-821479972]Search in Google Scholar
[80. Kafoed K, Eugen-Olsen J, Petersen J, et al. Predicting mortality in patients with systemic inflammatory response syndrome: an evaluation of two prognostic models, two soluble receptors, and a macrophage migration inhibitory factor. Eur J Clin Microbiol Infect Dis. 2008;27:375-83.10.1007/s10096-007-0447-518197443]Search in Google Scholar
[81. Walley KR, Russell JA. Protein C –1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis. Crit Care Med. 2007;35:12-7.10.1097/01.CCM.0000249823.44726.4E17080006]Search in Google Scholar
[82. Skibstead S, Bhasin MK, Aird WC, Shapiro NI. Bench-to-bedside review: Future novel diagnostics for sepsis – a systems biology approach. Critical Care. 2013;17:231. doi: 10.1186/cc12693.10.1186/cc12693405746724093155]Search in Google Scholar