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Helminth therapy: Advances in the use of parasitic worms against Inflammatory Bowel Diseases and its challenges


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Adisakwattana, P., Nuamtanong, S., Kusolsuk, T., Chairoj, M., Yenchitsomanas, P.T., Chaisri, U. (2013): Non-encapsulated Trichinella spp., T. papuae, diminishes severity of DSS-induced colitis in mice. Asian Pac. J. Allergy Immunol., 31: 106 – 114. DOI: 10.12932/AP0238.31.2.201310.12932/AP0238.31.2.201323859409Open DOISearch in Google Scholar

Allen, J.E., Maizels, R.M. (2011): Diversity and dialogue in immunity to helminths. Nat. Rev. Immunol., 11: 375 – 388. DOI: 10.1038/nri299210.1038/nri299221610741Open DOISearch in Google Scholar

Barthlott, T., Kassiotis, G., Stockinger, B. (2003): T cell regulation as a side effect of homeostasis and competition. J. Exp. Med., 197: 451 – 460. doi: 10.1084/jem.2002138710.1084/jem.20021387219385912591903Open DOISearch in Google Scholar

Bernstein, R.M. (2001): Injections and surgical therapy in chronic pain. Clin. J. Pain., 17: 94 – 10410.1097/00002508-200112001-0001811783838Open DOISearch in Google Scholar

Biedermann, L., Zeitz, J., Mwinyi, J., Sutter-Minder, E., Rehman, A., Ott, S. J., Steurer-Stey, C., Frei, A., Frei, P., Scharl, M., Loessner, M. J., Vavricka, S. R., Fried, M., Schreiber, S., Schuppler, M., Rogler, G. (2013) : Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans. PLoS One, 8: e59260. DOI: 10.1371/journal.pone.005926010.1371/journal.pone.0059260359760523516617Search in Google Scholar

Bilbo, S.D., Wray, G.A., Perkins, S.E., Parker, W. (2011): Reconstitution of the human biome as the most reasonable solution for epidemics of allergic and autoimmune diseases. Med. Hypotheses., 77: 494 – 504. DOI: 10.1016/j.mehy.2011.06.01910.1016/j.mehy.2011.06.01921741180Open DOISearch in Google Scholar

Blum, A.M., Hang, L., Setiawan, T.,. Urban, J.P., Stoyanoff, K.M., Leung, J., Weinstock, J.V. (2012): Heligmosomoides polygyrus bakeri induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut T cell responses. J. Immunol., 189 (5): 2512 – 2520. DOI: 10.4049/jimmunol.110289210.4049/jimmunol.1102892342432122844110Open DOISearch in Google Scholar

Bodammer, P., Waitz, G., Loebermann, M., Holtfreter, M.C., Maletzki, C., Krueger, M.R., Nizze, H., Emmrich, J., Reisinger, E.C. (2011): Schistosoma mansoni infection but not egg antigen promotes recovery from colitis in outbred NMRI mice. Dig. Dis. Sci., 56: 70 – 78. DOI: 10.1007/s10620-010-1237-y10.1007/s10620-010-1237-y20428947Open DOISearch in Google Scholar

Brandtzaeg, P., Haraldsen, G., Rugtveit, J. (1997): Immunopathology of human inflammatory bowel disease. Springer Semin. Immunopathol., 18: 555 – 589. DOI: 10.1007/BF0082405810.1007/BF008240589144870Open DOISearch in Google Scholar

Broadhurst, M.J., Ardeshir, A., Kanwar, B., Mirpuri, J., Gundra, U.M., Leung, J.M., Wiens, K.E., Vujkovic-Cvijin, I., Kim, C.C., Yarovinsky, F., Lerche, N.W., McCune, J.M., Loke, P. (2012): Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog., 8: e1003000. DOI: 10.1371/journal.ppat.100300010.1371/journal.ppat.1003000349956623166490Search in Google Scholar

Cader, M.Z., Kaser, A. (2013): Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut, 62: 1653 – 1664. DOI: 10.1136/gutjnl-2012-30395510.1136/gutjnl-2012-303955Open DOISearch in Google Scholar

Chandrashekara, S. (2012): The treatment strategies of autoimmune disease may need a different approach from conventional protocol: A review. Indian J. Pharmacol., 44: 665 – 671. DOI: 10.4103/0253-7613.10323510.4103/0253-7613.103235Open DOISearch in Google Scholar

Chassaing, B., Aitken, J.D., Malleshappa, M., Vijay-Kumar, M. (2015): Dextran sulfate sodium (DSS)-induced colitis in mice. Curr. Protoc. Immunol., 104: 15 – 25. DOI: 10.1002/0471142735.im1525s10410.1002/0471142735.im1525s104Open DOISearch in Google Scholar

Chen, C.C., Louie, S., McCormick, B., Walker, W.A., Shi, H.N. (2005): Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice. Infect. Immun., 73: 5468 – 5481. DOI: 10.1128/IAI.73.9.5468-5481.200510.1128/IAI.73.9.5468-5481.2005Open DOISearch in Google Scholar

Chen, C.C., Louie, S., McCormick, B.A., Walker, W.A., Shi, H.N. (2006): Helminth primed dendritic cells alter the host response to enteric bacterial infection. J. Immunol.,176: 472 – 48310.4049/jimmunol.176.1.472Search in Google Scholar

Cleynen, I., Boucher, G., Jostins, L. et al. (2016): Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes: a genetic association study. Lancet, 9, 156 – 167. DOI: 10.1016/S0140-6736(15)00465-110.1016/S0140-6736(15)00465-1Open DOISearch in Google Scholar

Correale, J. (2014): Helminth/Parasite treatment of multiple sclerosis. Curr. Treat Options Neurol.,16: 296. DOI: 10.1007/s11940-014-0296-310.1007/s11940-014-0296-324744099Open DOISearch in Google Scholar

Croese, J., Giacomin, P., Navarro, S., Clouston, A., McCann, L., Dougall, A., Ferreira, I., Susianto, A., O’Rourke, P., Howlett, M., McCarthy, J., Engwerda, C., Jones, D., Loukas, A. (2015): Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease. J. Allergy Clin. Immunol.,135: 508 – 516. DOI: 10.1016/j.jaci.2014.07.02210.1016/j.jaci.2014.07.02225248819Open DOISearch in Google Scholar

Croese, J., O’neil, J., Masson, J., Cooke, S., Melrose, W., Pritchard, D., Speare, R. (2006): A proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donors. Gut, 55: 136 – 137. doi: 10.1136/gut.2005.07912910.1136/gut.2005.079129185638616344586Open DOISearch in Google Scholar

Daveson, A.J., Jones, D.M., Gaze, S., McSorley, H., Clouston, A., Pascoe, A., Cooke, S., Speare, R., Macdonald, G.A., Anderson, R., McCarthy, J.S., Loukas, A., Croese, J. (2011): Effect of hookworm infection on wheat challenge in celiac disease – a randomised double-blinded placebo controlled trial. PLoS One, 8: e17366. DOI: 10.1371/journal.pone.001736610.1371/journal.pone.0017366305088821408161Search in Google Scholar

Donskow, K., Drela, N., Doligalska, M. (2011): Heligmosomoides bakeri antigen rescues CD4-positive T cells from glucocorticoid-induced apoptosis by Bcl-2 protein expression. Parasite Immunol., 33: 158 – 169. DOI: 10.1111/j.1365-3024.2010.01262.x10.1111/j.1365-3024.2010.01262.x21306399Open DOISearch in Google Scholar

Donskowysoniewska, K., Bien, J., Brodaczewska, K., Krawczak, K., Doligalska, M. (2013b): Colitis promotes adaptation of an intestinal nematode: a Heligmosomoides polygyrus mouse model system. PLoS One, 22: e78034. DOI: 10.1371/journal.pone.007803410.1371/journal.pone.0078034380561224167594Search in Google Scholar

Donskowysoniewska, K., Brodaczewska, K., Doligalska, M. (2013a): Heligmosomoides polygyrus antigens inhibit the intrinsic pathway of apoptosis by overexpression of survivin and Bcl-2 protein in CD4 T cells. Prion, 7: 319 – 327. DOI:10.4161/pri.2500810.4161/pri.25008390431823787700Open DOISearch in Google Scholar

Donskow-Lysoniewska, K., Majewski, P., Brodaczewska, K., Jozwicka, K., Doligalska, M. (2012): Heligmosmoides polygyrus fourth stages induce protection against DSS induced colitis and change opioid expression in the intestine. Parasite Immunol., 34: 536 – 546. DOI: 10.1111/pim.1200310.1111/pim.1200322889318Open DOISearch in Google Scholar

Du, L., Tang, H., Ma, Z., Xu, J., Gao, W., Chen, J., Gan, W., Zhang, Z., Yu, X., Zhou, X., Hu, X. (2011): The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice. Dig. Dis. Sci., 56: 2810 – 2817. DOI: 10.1007/s10620-011-1689-810.1007/s10620-011-1689-821476030Open DOISearch in Google Scholar

Elliott, D.E., Li, J., Blum, A., Metwali, A., Qadir, K., Urban, J.F. Jr, Weinstock, J.V. (2003): Exposure to schistosome eggs protects mice from TNBS-induced colitis. Am. J. Physiol. Gastrointest. Liver Physiol., 284: G385 – G391. DOI: 10.1152/ajpgi.00049.200210.1152/ajpgi.00049.200212431903Open DOISearch in Google Scholar

Elliott, D.E., Metwali, A., Leung, J., Setiawan, T., Blum, A.M., Ince, M.N., Bazzone, L.E., Stadecker, M.J., Urban, J.F. Jr, Weinstock, J.V. (2008): Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production. J. Immunol., 181: 2414 – 2419Search in Google Scholar

Elliott, D.E., Setiawan, T., Metwali, A., Blum, A., Urban, J.F. Jr., Weinstock, J.V. (2004): Heligmosomoides polygyrus inhibits established colitis in IL-10-deficient mice. Eur. J. Immunol., 34: 2690 – 2698. DOI: 10.1002/eji.20032483310.1002/eji.20032483315368285Search in Google Scholar

Elliott, D.E., Urban, J.F. Jr., Argo, C.K., Weinstock, J.V. (2000): Does the failure to acquire helminthic parasites predispose to Crohn’s disease? FASEB J., 14: 1848 – 1855. doi: 10.1096/fj.99-0885hyp10.1096/fj.99-0885hyp10973934Open DOISearch in Google Scholar

Erb, K.J. (2009): Can helminths or helminth-derived products be used in humans to prevent or treat allergic diseases? Trends Immunol., 30: 75 – 82. DOI: 10.1016/j.it.2008.11.00510.1016/j.it.2008.11.00519138565Open DOISearch in Google Scholar

Finlay, C.M., Walsh, K.P., Mills, K.H. (2014): Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases. Immunol. Rev., 259: 206 – 230. DOI: 10.1111/imr.1216410.1111/imr.1216424712468Open DOISearch in Google Scholar

Fleming, J.O., Isaak, A., Lee, J.E., Luzzio, C.C., Carrithers, M.D., Cook, T.D., Field, A.S., Boland, J., Fabry, Z. (2011): Probiotic helminth administration in relapsing-remitting multiple sclerosis: a phase 1 study. Mult. Scler., 17: 743 – 754. DOI: 10.1177/135245851139805410.1177/1352458511398054Open DOISearch in Google Scholar

Goodridge, H.S., Stepek, G., Harnett, W., Harnett, M.M. (2005): Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology, 115: 296 – 304. DOI: 10.1111/j.1365-2567.2005.02167.x10.1111/j.1365-2567.2005.02167.xOpen DOISearch in Google Scholar

Gouy De Bellocq, J., Ferte, H., Depaquit, J., Justine, J.L., Tillier, A., Durette-Desset, M.C. (2001): Phylogeny of the Trichostrongylina (Nematoda) inferred from 28S rDNA sequences. Mol. Phylogenet. Evol., 19: 430 – 442. DOI: 10.1006/mpev.2001.092510.1006/mpev.2001.0925Open DOISearch in Google Scholar

Hadis, U., Wahl, B., Schulz, O., Hardtke-Wolenski, M., Schippers, A., Wagner, N., Müller, W., Sparwasser, T., Förster, R., Pabst, O. (2011): Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity, 34: 237 – 246. DOI: 10.1016/j.immuni.2011.01.01610.1016/j.immuni.2011.01.016Open DOISearch in Google Scholar

Hang, L., Setiawan, T., Blum, A.M., Urban, J., Stoyanoff, K., Arihiro, S., Reinecker, H.C., Weinstock, J.V. (2010): Heligmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity. J. Immunol, 185: 3184 – 3189. DOI: 10.4049/jimmunol.100094110.4049/jimmunol.1000941Open DOISearch in Google Scholar

Helmby, H. (2015): Human helminth therapy to treat inflammatory disorders - where do we stand? BMC Immunol., 16: 12. DOI: 10.1186/s12865-015-0074-310.1186/s12865-015-0074-3Open DOISearch in Google Scholar

Herrera, L.A., Ostrosky-Wegman, P. (2001): Do helminths play a role in carcinogenesis? Trends Parasitol., 17: 172 – 175. DOI: 10.1016/S1471-4922(00)01942-510.1016/S1471-4922(00)01942-5Open DOISearch in Google Scholar

Hokke, C.H., Deelder, A.M., Hoffmann, K.F., Wuhrer, M. (2007): Glycomics-driven discoveries in schistosome research. Exp. Parasitol., 117: 275 – 283. DOI: 10.1016/j.exppara.2007.06.00310.1016/j.exppara.2007.06.00317659278Open DOISearch in Google Scholar

Huby, F., Hoste, H., Mallet, S., Fournel, S., Nano, J.L. (1995): Effects of the excretory/secretory products of six nematode species, parasites of the digestive tract, on the proliferation of HT29-D4 and HGT-1 cell lines. Epithelial Cell Biol., 4: 156 – 162Search in Google Scholar

Hunter, M.M., Wang, A., Hirota, C.L., Mckay, D.M. (2005): Neutralizing anti-IL-10 antibody blocks the protective effect of tapeworm infection in a murine model of chemically induced colitis. J. Immunol., 174: 7368 – 7375. DOI: 10.4049/jimmunol.174.11.736810.4049/jimmunol.174.11.736815905584Search in Google Scholar

Hunter, M.M., Wang, A., Mckay, D.M. (2007): Helminth infection enhances disease in a murine TH2 model of colitis. Gastroenterology, 132: 1320 – 1330. DOI: 10.1053/j.gastro.2007.01.03810.1053/j.gastro.2007.01.03817408663Open DOISearch in Google Scholar

Ince, M.N., Elliott, D.E., Setiawan, T., Metwali, A., Blum, A., Chen, H.L., Urban, J.F., Flavell, R.A., Weinstock, J.V. (2009): Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation. J. Immunol., 39: 1870 – 1878. DOI: 10.1002/eji.20083895610.1002/eji.200838956288299319544487Open DOISearch in Google Scholar

Kappus, K.D., Lundgren, R.G. Jr., Juranek, D.D., Roberts, J.M., Spencer, H.C. (1994): Intestinal parasitism in the United States: update on a continuing problem. Am. J. Trop. Med. Hyg., 50, 705 – 713. DOI: 10.4269/ajtmh.1994.50.70510.4269/ajtmh.1994.50.7058024063Open DOISearch in Google Scholar

Keubler, L.M., Buettner, M., Häger, C., Bleich, A. (2015): A multihit model: colitis lessons from the Interleukin-10-deficient mouse. Inflamm. Bowel Dis., 2: 1967 – 1975. DOI: 10.1097/MIB.000000000000046810.1097/MIB.0000000000000468451168426164667Search in Google Scholar

Khan, A.R., Fallon, P.G. (2013): Helminth therapies: translating the unknown unknowns to known knowns. Int. J. Parasitol., 43: 293 – 299. DOI: 10.1016/j.ijpara.2012.12.00210.1016/j.ijpara.2012.12.00223291459Open DOISearch in Google Scholar

Khan, W.I., Blennerhasset, P.A., Varghese, A.K., Chowdhury, S.K., Omsted, P., Deng, Y., Collins, S.M. (2002): Intestinal nematode infection ameliorates experimental colitis in mice. Infect. Immun., 70: 5931 – 5937. doi: 10.1128/IAI.70.11.5931-5937.200210.1128/IAI.70.11.5931-5937.200213029412379667Open DOISearch in Google Scholar

Lakatos, P.L. (2006): Recent trends in the epidemiology of inflammatory bowel diseases: up or down? World J. Gastroenterol., 14: 6102-6108. doi: 10.3748/wjg.v12.i38.610210.3748/wjg.v12.i38.6102408810117036379Open DOISearch in Google Scholar

Leitner, G.C., Vogelsang, H. (2016): Pharmacological-and non-pharmacological therapeutic approaches in inflammatory bowel disease in adults. World J. Gastrointest. Pharmacol. Ther., 6: 5 – 20. DOI: 10.4292/wjgpt.v7.i1.510.4292/wjgpt.v7.i1.5473495426855808Open DOISearch in Google Scholar

Leong, R.W., Mitrev, N., Ko, Y. (2016): Hygiene hypothesis: Is the evidence the same all over the world? Dig. Dis., 34: 35 – 42. DOI: 10.1159/00044292210.1159/00044292226982573Open DOISearch in Google Scholar

Leung, J., Hang, L., Blum, A., Setiawan, T., Stoyanoff, K., Weinstock, J. (2012): Heligmosomoides polygyrus abrogates antigen-specific gut injury in a murine model of inflammatory bowel disease. Inflamm. Bowel Dis., 18: 1447 – 1455. DOI: 10.1002/ibd.2285810.1002/ibd.22858412341722223533Open DOISearch in Google Scholar

Li, X., Sundquist, J., Hemminki, K., Sundquist, K. (2011): Risk of inflammatory bowel disease in firstand second-generation immigrants in Sweden: a nationwide follow-up study. Inflamm. Bowel Dis., 17: 1784 – 1791. DOI: 10.1002/ibd.2153510.1002/ibd.2153521744434Open DOISearch in Google Scholar

MacDonald, T.T., Monteleone, G. (2005): Immunity, inflammation, and allergy in the gut. Science, 25: 1920 – 1925. DOI: 10.1126/science.110644210.1126/.1106442Open DOISearch in Google Scholar

Maizels, R.M., Balic, A., Gomez-Escobar, N., Nair, M., Taylor, M.D., Allen, J.E. (2004): Helminth parasites – masters of regulation. Immunol. Rev., 201, 89 – 116. DOI: 10.1111/j.0105-2896.2004.00191.x10.1111/j.0105-2896.2004.00191.xOpen DOISearch in Google Scholar

Maizels, R.M., Hewitson, J.P., Smith, K.A. (2012): Susceptibility and immunity to helminth parasites. Curr. Opin. Immunol., 24: 459 – 466. DOI: 10.1016/j.coi.2012.06.00310.1016/j.coi.2012.06.003Open DOISearch in Google Scholar

Mann, E.R., Li, X. (2014): Intestinal antigen-presenting cells in mucosal immune homeostasis: crosstalk between dendritic cells, macrophages and B-cells. World J. Gastroenterol., 7: 9653 – 9664. DOI: 10.3748/wjg.v20.i29.965310.3748/wjg.v20.i29.9653Open DOISearch in Google Scholar

McGuckin, M.A., Eri, R., Simms, L.A., Florin, T.H., Radford-Smith, G. (2009): Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm. Bowel Dis., 15: 100 – 113. DOI: 10.1002/ibd.2053910.1002/ibd.20539Open DOISearch in Google Scholar

McSorley, H.J., Hewitson, J.P., Maizels, R.M. (2013): Immunomodulation by helminth parasites: defining mechanisms and mediators. Int. J. Parasitol., 43: 301 – 310. DOI: 10.1016/j.ijpara.2012.11.01110.1016/j.ijpara.2012.11.011Open DOISearch in Google Scholar

Melon, A., Wang, A., Phan, V., Mckay, D.M. (2010): Infection with Hymenolepis diminuta is more effective than daily corticosteroids in blocking chemically induced colitis in mice. J. Biomed. Biotechnol., 384523. DOI: 10.1155/2010/38452310.1155/2010/384523Open DOISearch in Google Scholar

Metwali, A., Setiawan, T., Blum, A.M., Urban, J., Elliott, D.E., Hang, L., Weinstock, J.V. (2006): Induction of CD8+ regulatory T cells in the intestine by Heligmosomoides polygyrus infection. Am. J. Physiol. Gastrointest. Liver Physiol., 291: G253 – G259. DOI: 10.1152/ajpgi.00409.200510.1152/ajpgi.00409.2005Search in Google Scholar

Molodecky, N.A., Soon, I.S., Rabi, D.M., Ghali, W.A., Ferris, M., Chernoff, G., Benchimol, E.I., Panaccione, R., Ghosh, S., Barkema, H.W., Kaplan, G.G. (2012): Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology, 142: 46 – 54. DOI: 10.1053/j.gastro.2011.10.00110.1053/j.gastro.2011.10.001Open DOISearch in Google Scholar

Monroy, F.G., Enriquez, F.J. (1992): Heligmosomoides polygyrus: a model for chronic gastrointestinal helminthiasis. Parasitol. Today, 8: 49 – 54. DOI: 10.1016/0169-4758(92)90084-F10.1016/0169-4758(92)90084-Open DOISearch in Google Scholar

Morampudi, V., Bhinder, G., Wu, X., Dai, C., Sham, H.P., Vallance, B.A., Jacobson, K. (2014): DNBS/TNBS colitis models: providing insights into inflammatory bowel disease and effects of dietary fat. J. Vis. Exp., 84: 51297. DOI:10.3791/5129710.3791/51297414059824637969Search in Google Scholar

Moreels, T.G., Nieuwendijk, R.J., De Man, J.G., De Winter, B.Y., Herman, A.G., Van Marck, E.A., Pelckmans, P.A. (2004): Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats. Gut, 53: 99 – 10710.1136/gut.53.1.99177391014684583Search in Google Scholar

Mulvenna, J., Hamilton, B., Nagaraj, S.H., Smyth, D., Loukas, A., Gorman, J.J. (2009): Proteomics analysis of the excretory/secretory component of the blood-feeding stage of the hookworm, Ancylostoma caninum. Mol. Cell. Proteomics, 8: 109 – 121. DOI: 10.1074/mcp.M800206-MCP20010.1074/mcp.M800206-MCP20018753127Search in Google Scholar

Niewiadomski, O., Studd, C., Wilson, J., Williams, J., Hair, C., Knight, R., Prewett, E., Dabkowski, P., Alexander, S., Allen, B., Dowling, D., Connell, W., Desmond, P., Bell, S. (2016): Influence of food and lifestyle on the risk of developing inflammatory bowel disease. Intern. Med. J., 46: 669 – 676. DOI: 10.1111/imj.1309410.1111/imj.1309427059169Open DOISearch in Google Scholar

Packham, G., Stevenson, F.K. (2005): Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia. Immunology, 114: 441 – 449. DOI: 10.1111/j.1365-2567.2005.02117.x10.1111/j.1365-2567.2005.02117.x178211815804279Open DOISearch in Google Scholar

Prasanphanich, N.S., Mickum, M.L., Heimburg-Molinaro, J., Cummings, R.D. (2013): Glycoconjugates in host-helminth interactions. Front. Immunol., 4: 240. DOI: 10.3389/fimmu.2013.0024010.3389/fimmu.2013.00240375526624009607Open DOISearch in Google Scholar

Probert, C.S., Jayanthi, V., Pinder, D., Wicks, A.C., Mayberry, J.F. (1992): Epidemiological study of ulcerative proctocolitis in Indian migrants and the indigenous population of Leicestershire. Gut, 33: 687 – 69310.1136/gut.33.5.68713793031307684Open DOISearch in Google Scholar

Reardon, C., Sanchez, A., Hogaboam, C.M., Mckay, D.M. (2001): Tapeworm infection reduces epithelial ion transport abnormalities in murine dextran sulfate sodium induced colitis. Infect. Immun., 69: 4417 – 4423. doi: 10.1128/IAI.69.7.4417-4423.200110.1128/IAI.69.7.4417-4423.20019851411401981Open DOISearch in Google Scholar

Rescigno, M., Di Sabatino, A. (2009): Dendritic cells in intestinal homeostasis and disease. J. Clin. Invest.,119: 2441 – 2450. DOI: 10.1172/JCI3913410.1172/JCI39134273593119729841Open DOISearch in Google Scholar

Ruyssers, N.E., De Winter, B.Y., De Man, J.G., Loukas, A., Herman, A.G., Pelckmans, P.A., Moreels, T.G. (2008): Worms and the treatment of inflammatory bowel disease: are molecules the answer? Clin. Dev. Immunol., 567314. DOI: 10.1155/2008/56731410.1155/2008/567314239622018509490Search in Google Scholar

Samuelsson, S. (1976): Ulceros Colit och Proktit [Colitis Ulcerosa and Inflammantion]. University of Uppsala, Uppsala, Sweden (In Swedish)Search in Google Scholar

Sandborn, W.J., Elliott, D.E., Weinstock, J., Summers, R.W., Landry-Wheeler, A., Silver, N., Harnett, M.D., Hanauer, S.B. (2013): Randomised clinical trial: the safety and tolerability of Trichuris suis ova in patients with Crohn’s disease. Aliment. Pharmacol. Ther., 38: 255 – 263. DOI: 10.1111/apt.1236610.1111/apt.1236623730956Open DOISearch in Google Scholar

Satsangi, J., Silverberg, M.S., Vermeire, S., Colombel, J.F. (2006): The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut, 55: 749 – 753. DOI: 10.1136/gut.2005.08290910.1136/gut.2005.082909185620816698746Open DOISearch in Google Scholar

Schnoeller, C., Rausch, S., Pillai, S., Avagyan, A., Wittig, B. M., Loddenkemper, C., Hamann, A., Hamelmann, E., Lucius, R., Hartmann, S. (2008): A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages. J. Immunol., 15: 4265 – 4272. DOI: 10.4049/jimmunol.180.6.426510.4049/jimmunol.180.6.426518322239Search in Google Scholar

Setiawan, T., Metwali, A., Blum, A.M. Nedim Ince, M., Urban Jr., J.F., Elliott, D.E., Weinstock, J.V. (2007): Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine. Infect. Immun., 75: 4655 – 4663. DOI: 10.1128/IAI.00358-0710.1128/IAI.00358-07195115417606601Open DOISearch in Google Scholar

Shorter, R.G., Huizenga, K.A., Spencer, R.J. (1972): A working hypothesis for the etiology and pathogenesis of nonspecific inflammatory bowel disease. Am. J. Dig. Dis., 17: 1024 – 103210.1007/BF022391435082428Open DOISearch in Google Scholar

Smith, P., Mangan, N.E., Fallon, P.G. (2009): Generation of parasite antigens for use in Toll-like receptor research. Methods Mol., 517: 401 – 413. DOI: 10.1007/978-1-59745-541-1_2410.1007/978-1-59745-541-1_2419378020Open DOISearch in Google Scholar

Smith, P., Mangan, N.E., Walsh, C.M., Fallon, R.E., Mckenzie, A.N.J., Van Rooijen, N., Fallon, P.G. (2007): Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J. Immunol., 178: 4557 – 4566. DOI: 10.4049/jimmunol.178.7.455710.4049/jimmunol.178.7.455717372014Open DOISearch in Google Scholar

Strachan, D.P. (1989): Hay fever, hygiene and household size. BMJ, 299: 1259 – 126010.1136/bmj.299.6710.125918381092513902Search in Google Scholar

Summers, R.W., Elliott, D.E., Qadir, K., Urban, J.F., Thompson, R., Weinstock, J.V. (2003): Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. Am. J. Gastroenterol., 98, 2034 – 2041. DOI: 10.1111/j.1572-0241.2003.07660.x10.1111/j.1572-0241.2003.07660.x14499784Open DOISearch in Google Scholar

Summers, R.W., Elliott, D.E., Urban, J.F. Jr., Thompson, R., Weinstock, J.V. (2005a): Trichuris suis therapy in Crohn’s disease. Gut, 54: 87 – 90. DOI: 10.1136/gut.2004.04174910.1136/gut.2004.041749177438215591509Open DOISearch in Google Scholar

Summers, R.W., Elliott, D.E., Urban, J.F. Jr., Thompson, R.A., Weinstock, J.V. (2005b): Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology, 128: 825 – 832. DOI: 10.1053/j.gastro.2005.01.00510.1053/j.gastro.2005.01.005Open DOISearch in Google Scholar

Sutton, T.L., Zhao, A., Madden, K.B., Elfrey, J.E., Tuft, B.A., Sullivan, C.A., Urban, Jr., J.F., Shea-Donohue, T. (2008): Antiinflammatory mechanisms of enteric Heligmosomoides polygyrus infection against trinitrobenzene sulfonic acid-induced colitis in a murine model. Infect. Immun., 76: 4772 – 4782. DOI: 10.1128/IAI.00744-0710.1128/IAI.00744-07Open DOISearch in Google Scholar

Taylor, M.D., Van Der Werf, N., Maizels, R.M. (2012): T cells in helminth infection: the regulators and the regulated. Trends Immunol., 33: 181 – 189. DOI: 10.1016/j.it.2012.01.00110.1016/j.it.2012.01.001Open DOISearch in Google Scholar

Wilson, M.S., Maizels, R.M. (2004): Regulation of allergy and autoimmunity in helminth infection. Clin. Rev. Allergy Immunol., 26: 35 – 50. DOI: 10.1385/CRIAI:26:1:3510.1385/CRIAI:26:1:35Open DOISearch in Google Scholar

Wirtz, S., Neurath, M.F. (2007): Mouse models of inflammatory bowel disease. Adv. Drug Deliv. Rev., 59: 1073 – 1083. DOI: 10.1016/j.addr.2007.07.00310.1016/j.addr.2007.07.00317825455Open DOISearch in Google Scholar

Xia, C.M., Zhao, Y., Jiang, L., Jiang, J., Zhang, S.C. (2011): Schistosoma japonicum ova maintains epithelial barrier function during experimental colitis. World J Gastroenterol., 17: 4810 – 4816.10.3748/wjg.v17.i43.4810322963122147983Open DOISearch in Google Scholar

Zhao, Y., Zhang, S., Jiang, L., Jiang, J., Liu, H. (2009): Preventive effects of Schistosoma japonicum ova on trinitrobenzenesulfonic acid-induced colitis and bacterial translocation in mice. J. Gastroenterol. Hepatol., 24: 1775 – 1780. DOI: 10.1111/j.1440-1746.2009.05986.x10.1111/j.1440-1746.2009.05986.x20136961Open DOISearch in Google Scholar

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