Variable | OL-HDF | PD | ||||
---|---|---|---|---|---|---|
25(OH)D <15 ng/mL Deficiency | 25(OH)D ≥15 ng/mL Insufficiency | P | APD (n = 24) | CAPD (n = 13) | P | |
Age (years) | 51.4±14.3 | 57.1 ± 13.9 | 0.26 | 64.3 ± 20.0 | 65.5 ± 19.3 | 0.87 |
Male sex, n (%) | 4 (25.0) | 7 (43.8) | 0.26 | 10 (41.7) | 5 (38.5) | 0.85 |
Dialysis duration (years) | 7.6 ± 5.9 | 6.4 ± 4.8 | 0.54 | 4.3 ± 2.2 | 3.6±1.7 | 0.32 |
Diabetes, n (%) | 7 (43.8) | 5 (31.3) | 0.46 | 13 (54.2) | 5 (38.5) | 0.36 |
Treatment with RAS blockade, n (%) | 9 (56.3) | 4 (25.0) | 13 (54.2) | 5 (38.5) | 0.36 | |
History of peritonitis (%) | NA | NA | NA | 11 (45.8) | 1 (7.7) | |
25(OH)D (ng/mL) | 11.4 ± 2.4 | 23.9 ± 7.7 | 9.3 ± 5.1 | 12.7 ± 6.7 | 0.09 | |
Kt/V weekly Kt/V for patients receiving PD; 25(OH)D, 25-hydroxyvitamin D (calcifediol); APD, ambulatory PD; CAPD, continuous ambulatory PD; RAS, renin–angiotensin system; CCl, Creatinine clearance; hs-CRP, high sensitive C-reactive protein; NA, not applicable; iPTH, intact parathyroid hormone; RAS, renin–angiotensin system; URR, urea reduction ratio; nPNA, normalized protein nitrogen; | 2.4 ± 0.5 | 2.3 ± 0.3 | 0.73 | 2.2 ± 0.5 | 2.1 ± 0.4 | 0.41 |
URR (%) | 84.6 ± 6.6 | 85.8 ± 3.2 | 0.52 | NA | NA | NA |
Access blood flow (mL/min) | 832.9 ± 364.9 | 1,238.9 ± 384.9 | NA | NA | NA | |
Weekly CCl (mL/min) | NA | NA | NA | 61.3 ± 32.3 | 64.1±20.1 | 0.78 |
Body mass index (kg/m2) | 25.4 ± 7.7 | 20.3±2.9 | 21.8 ± 3.6 | 22.1 ± 3.7 | 0.81 | |
nPNA (g of N/kg/day) | 1.1 ± 0.3 | 1.2 ± 0.5 | 0.34 | 1.05±0.3 | 1.07 ± 0.3 | 0.84 |
Serum albumin (g/dL) | 4.0 ± 0.4 | 4.1 ± 0.5 | 0.45 | 3.3 ± 0.5 | 3.6 ± 0.7 | 0.21 |
Protein loss via dialysate (g/day) | NA | NA | NA | 4.7 ± 3.2 | 5.1 ± 1.6 | 0.66 |
Hemoglobin (g/dL) | 10.2±1.1 | 11.3 ± 1.3 | 11.2 ± 1.3 | 10.7 ± 2.1 | 0.38 | |
Uric acid (mg/dL) | 7.4±1.4 | 7.7±1.6 | 0.64 | 6.0±1.6 | 5.9 ± 0.7 | 0.72 |
Corrected calcium (mg/dL) | 9.5 ± 0.9 | 9.5 ± 0.7 | 0.93 | 9.6 ± 0.9 | 9.5 ± 0.8 | 0.76 |
Phosphate (mg/dL) | 4.7±1.5 | 5.0±1.1 | 0.53 | 4.4±1.5 | 4.6±1.3 | 0.68 |
iPTH (pg/mL) | 743.8 ± 505.0 | 454.9 ± 248.1 | 0.09 | 518.5±601.9 | 521.9 ± 615.2 | 0.98 |
hs-CRP (mg/L) | 6.6 ± 9.8 | 4.9 ± 4.5 | 0.55 | 6.3 ± 6.8 | 6.7 ± 7.8 | 0.88 |
Variable | KT deceased donor (n=23) | KT living, related donor (n=19) | P |
---|---|---|---|
25(OH)D (ng/mL) | 13.7 ± 6.0 | 17.5 ± 5.7 | |
Age (years) | 48.5±10.5 | 48.1 ± 13.3 | 0.91 |
Male sex, n (%) | 12 (52.2) | 8 (42.1) | 0.52 |
Post transplantation time (years) | 7.6 ± 5.7 | 6.5 ± 5.4 | 0.51 |
Treatment with RAS blockade, n (%) | 7 (30.4) | 4 (21.1) | 0.49 |
Diabetes, n (%) | 5 (21.7) | 2 (10.5) | 0.33 |
Prednisolone use, n (%) | 12 (52.2) | 14 (73.7) | 0.15 |
Tacrolimus-based, n (%) | 8 (34.8) | 9 (47.4) | 0.41 |
Blood urea nitrogen (mg/dL) | 27.4±15.3 | 21.1±19.6 | 0.25 |
Creatinine (mg/dL) | 1.9±2.2 | 1.5±1.5 | 0.45 |
24-Hour urine protein (g/day) | 1.7±2.8 | 0.4±0.3 | |
Body mass index (kg/m2) | 23.1±4.2 | 23.2±4.4 | 0.97 |
Albumin (g/dL) | 3.9±0.5 | 4.3±0.4 | |
nPNA (g of N/kg/day) | 1.1±0.3 | 0.9±0.2 | |
Hemoglobin (g/dL) | 11.8±1.7 | 12.1±1.6 | 0.55 |
Fasting blood sugar (mg/dL) | 93.9±18.5 | 109.9±57.3 | 0.21 |
Uric acid (mg/dL) | 6.9±2.5 | 6.8±2.1 | 0.79 |
Corrected calcium (mg/dL) | 9.7±0.8 | 9.6±0.6 | 0.58 |
Phosphate (mg/dL) | 3.3±1.0 | 3.4±0.7 | 0.77 |
iPTH (pg/mL) | 267.0±297.3 | 144.8±145.3 | 0.13 |
Variable | OL-HDF (n = 32) | PD (n = 37) | KT (n = 42) | P |
---|---|---|---|---|
Age (y) | 54.3±14.2 | 64.7±19.5 | 48.3±11.7 | |
Male sex, n (%) | 11 (34.4) | 15 (40.5) | 20 (47.6) | 0.51 |
Body weight (kg) | 52.0 (18) | 53.3 (11) | 60.3 (21) | 0.32 |
Body mass index (kg/m2) | 20.5 (8) | 21.0 (5) | 22.3 (6) | 0.47 |
RRT duration (years) | 5.6 (6.7) | 3.5 (2.9) | 4.7 (8.6) | |
Presence of diabetes, n (%) | 12 (37.5) | 18 (48.6) | 7 (16.7) | |
RAS blockade (%) | 40.6 | 48.6 | 26.2 | 0.11 |
Erythropoietin (units/kg) | 209.8±206.3 | 150.7±133.3 | 73.2±44.8 | 0.14 |
Diabetic nephropathy | 9 (28.1%) | 17 (45.9%) | 5 (11.9%) | |
Glomerulonephritis | 6 (18.7%) | 6 (16.2%) | 18 (42.9%) | |
Obstruction | 2 (6.3%) | 2 (5.4%) | 2 (4.8%) | 0.96 |
Polycystic kidney disease | 1 (3.1%) | 1 (2.7%) | 3 (7.1%) | 0.58 |
Hypertension | 10 (31.3%) | 5 (13.5%) | 1 (2.1%) | |
Unknown | 4 (12.5%) | 6 (16.2%) | 13 (31.0%) | 0.11 |
25(OH)D (ng/mL) | 17.7±8.5 | 10.5±5.9 | 15.4±6.1 | |
Hemoglobin (g/dL) | 10.9 (1.2) | 11.0 (1.6) | 11.9 (2.4) | |
Blood urea nitrogen (mg/dL) | 72.6±24.0 | 52.7±22.7 | 24.5±17.5 | |
Creatinine (mg/dL) | 10.3 (3.2) | 8.0 (6.3) | 1.2 (0.9) | |
Uric acid (mg/dL) | 7.6 ± 1.5 | 5.9±1.3 | 6.9 ± 2.3 | |
Bicarbonate (mEq/L) | 24.1 ± 2.3 | 26.2 ± 3.0 | 23.7 ± 3.4 | |
Corrected calcium (mg/dL) | 9.5 (1.2) | 9.5 (0.9) | 9.6 (1.0) | 0.68 |
Phosphate (mg/dL) | 4.9 (1.4) | 4.2 (1.4) | 3.3 (0.8) | |
Total cholesterol (mg/dL) | 157.9 ± 30.9 | 175.3 ± 45.5 | 195.4±43.5 | |
Triglyceride (mg/dL) | 98 (71.5) | 127.0 (149) | 117.5 (66.3) | 0.21 |
Low density lipoprotein (mg/dL) | 88.0 (30.3) | 84 (31.5) | 112.5 (55) | |
High density lipoprotein (mg/dL) | 48.7±14.5 | 42.9±18.8 | 63.8 ± 21.7 | |
Intact parathyroid hormone (pg/mL) | 534.4 (496.8) | 288.8 (339.0) | 106.2 (231.4) | |
Albumin (g/dL) | 4.1 (0.8) | 3.6 (0.8) | 4.2 (0.5) | |
Kt/V | 2.4 ± 0.4 | 2.2±0.5 | NA | 0.07 |
nPNA (g of N/kg/day) | 1.1 (0.4) | 1.0 (0.3) | 1.0 (0.4) | 0.10 |
Determinants | Unadjusted OR | 95% CI | P | Adjusted OR | 95% CI | P |
---|---|---|---|---|---|---|
Treatment with RAS blockade | 5.15 | 2.01, 13.16 | 7.45 | 2.17, 25.62 | ||
Triglyceride (mg/dL) OR per 10 mg/dL increase in serum triglyceride | 1.08 | 1.02, 1.14 | 1.08 | 1.01, 1.16 | ||
Uric acid (g/dL) | 0.75 | 0.59, 0.94 | 0.72 | 0.52, 0.99 | ||
iPTH (pg/mL) OR per 10 pg/mL increase in serum iPTH | 1.01 | 1.00, 1.02 | 1.02 | 1.00, 1.04 | ||
Phosphate (mg/dL) | 0.95 | 0.71, 1.26 | 0.72 | 0.57 | 0.36, 0.90 | |
Calcium (mg/dL) | 0.89 | 0.55, 1.43 | 0.62 | 0.61 | 0.30, 1.23 | 0.17 |
Albumin (g/dL) OR per 0.1 g/dL increase in serum albumin | 0.94 | 0.88, 1.01 | 0.08 | 0.93 | 0.85, 1.02 | 0.11 |
Female gender | 1.76 | 0.81, 3.84 | 0.16 | 2.42 | 0.86, 6.82 | 0.10 |
Authors (year) | Countries | Study design | Population (n) | Duration of RRT (months) | Age (years) | [25(OH)D] (ng/mL) | Prevalence of low [25(OH)D] (ng/mL) % |
---|---|---|---|---|---|---|---|
Saabetal. [ | USA | retrospective | HD (131) | 66.5 [4–303] | 59.0 [25–90] | 16.9±8.5 | Deficient (<15) 51 |
(2007) | Insufficient (<30) 92 | ||||||
Del Valle etal. [ | Argentina | cross-sectional | HD (84) | 41.0±29.6 | 58.9±16.6 | 24.4 (5–79) | Deficient (<15) 22.6 |
(2007) | Insufficient (15–30) 53.5 | ||||||
Jean et al. [ | France | cross-sectional | HD (253) | 62±74 | 66.7±14 | 14.8±10.4 | Deficient (<10) 42 |
(2008) | Insufficient (10–30) 47 | ||||||
Blairetal. [ | USA | retrospective, | HD (344) | 37.1±34.5 | 61.9±16.3 | 21.0±13.5 | Deficiency (<40) 92.4 |
(2008) | multi-centered | ||||||
Porter etal. [ | USA | retrospective | HD (96) | 68.4±55.2 | 52.5±14.6 | 14.7±6.0 | Deficient (<15) 56 |
(2013) | Insufficient (16–30) 44 | ||||||
Alwakeeletal. [ | Saudi | cross-sectional | PD (27) | 27.5±18.5 | 46.0±21.0 | 16.1±8.2 | Deficient (<15) 59.2 |
(2014) | Arabia | Insufficient (15–25) 29.6 | |||||
Ewers etal. [ | Denmark | cross-sectional | KT (173) | 88.8 (39.6–152.4) | 53.4±11.7 | F21.6 (15–31) | Deficient (<15) 29.0 |
(2008) | M 18.2 (12–27) | Insufficient (16–30) 51.0 | |||||
Marcenetal. [ | Spain | retrospective | KT (509) | 113.0±76.0 | 45.4±14.5 | 20.0±10.6 | Deficient (<16) 38.3 |
(2009) | Insufficient (16–30) 46.9 | ||||||
Kulshresthaetal. [ | USA | cross-sectional | KT (74) | 51.2 (47.9–53.5) | 46.0±16.0 | MS 20.5 ±7.2 | Deficient (<16) 29.7 |
(2013) | Without MS 24.8±11.1 | Insufficient (16–30) 51.4 | |||||
Beiqueetal. [ | Canada | retrospective | KT (331) | 80.4 (34.8–129.6) | 51.0 (41.5–60.2) | 31.3 (23.4–39.9) | Deficient (<30) 45.3 |
(2013) | |||||||
Clayton etal. [ | Australia | cross-sectional | HD (120) | 29.5 (11.6–53.1) | 64.1 (53.1–74.7) | 20.0 (12.7–26.0) | HD deficient (<20) 49 |
(2009) | PD (31) | 20.6 (10.5–43.8) | 68.6 (58.1–72.1) | 13.6 (8.4–15.0) | HD insufficient (20–30) 33 | ||
PD deficient 77 | |||||||
PD insufficient 19 | |||||||
Iguaceletal. [ | Spain | cross-sectional | OL-HDF (33) | 27.5 (12.0–70.5) | 60.0±16.0 | 19 (13–27) | Deficient (5–15) 51.0 |
(2010) | HD (61) PD (21) | 11 (6–16) 9 (6–12) | Insufficient (16–30) 42.0 | ||||
Hannaetal. [ | Australia | cross-sectional | HD (26) | 22 (2–166) | 63.6±15.1 | 21.5 (4.1–50.4) | HD deficient (<10) 3.8 |
(2014) | PD (30) | 17 (1–70) | 56.9±16.2 | 13.2 (5.0–33.2) | HD insufficient (10–20) 30.8 | ||
PD deficient 33.3 | |||||||
Eyaletal. [ | Israel | cross-sectional | HD (50) | 90.4±74.6 | 56.2±15.4 | 30.3±19.1 | HD deficient (<15) 10 |
(2013) | 23.5 ± 9.9 | HD insufficient (16–30) 52 | |||||
KT (103) | KT deficient 22.3 | ||||||
KT insufficient 52.4 | |||||||
The present | Thailand | cross-sectional, | OL-HDF (32) | 72.6±57.4 | 55.5+16.8 | 17.7±8.5 | OL-HDF deficient (<15) 50 |
study 44 | retrospective, | OL-HDF insufficient (15-30) | |||||
single-center | PD (37) | 10.5±5.9 | |||||
PD deficient 82 | |||||||
PD insufficient 18 | |||||||
KT (42) | 15.4 ± 6.1 | ||||||
PD deficient 82 PD insufficient 18 | |||||||
KT insufficient 45 |