Candida species | Fluconazole susceptibility n (%) | MIC50 | MIC90 | MIC range (μg/ml) | |
---|---|---|---|---|---|
S | R | ||||
|
12 (66.7%) | 6 (33.3%) | 16 | 1024 | 1–1024 |
Non-albicans |
4 (40%) | 6 (60%) | 128 | 1024 | 8–1024 |
|
4 (57.1%)
|
3 (42.9%) | 32 | 1024 | 8–1024 |
|
0 (0%)
|
2 (100%) | 128
|
ND
|
ND |
|
0 (0%)
|
1 (100%) | ND | ND | ND |
Isolate code | Candida species | MIC of fluconazole alone (μg/ml) | MIC of fluconazole (μg/ml) in the presence of amikacin | Modulation factor (MF)
|
---|---|---|---|---|
C1 |
|
128 | 4 | 32 |
C6 |
|
1024 | 4 | 256 |
C7 |
|
128 | 4 | 32 |
C8 |
|
1024 | 32 | 32 |
C9 |
|
1024 | 32 | 32 |
C14 |
|
256 | 4 | 64 |
C17 |
|
1024 | 4 | 256 |
C20 |
|
1024 | 4 | 256 |
C21 |
|
1024 | 4 | 256 |
C23 |
|
1024 | 4 | 256 |
C26 |
|
256 | 256 | 1 |
C28 |
|
128 | 4 | 32 |
Isolate code | Candida species | Virulence determinants | MIC of Fluconazole (μg/ml)
|
||
---|---|---|---|---|---|
Biofilm formation | Proteases production Pz value
|
Phospholipase production Pz value
|
|||
C1 |
|
Strong | 0.26 | 0.33 | 128 |
C2 |
|
Strong | 0.4 | 0.48 | 16 |
C3 |
|
Strong | 0.16 | 0.29 | 8 |
C4 |
|
Strong | 0.19 | 0.29 | 32 |
C5 |
|
Strong | 0.2 | 1 | 8 |
C6 |
|
Strong | 0.2 | 0.3 | 1024 |
C7 |
|
Strong | 0.22 | 0.23 | 128 |
C8 |
|
Weak | 0.18 | 0.21 | 1024 |
C9 |
|
Weak | 0.67 | 0.22 | 1024 |
C10 |
|
Moderate | 0.5 | 0.2 | 32 |
C11 |
|
Strong | 0.26 | 0.26 | 16 |
C12 |
|
Moderate | 0.43 | 0.23 | 32 |
C13 |
|
Strong | 0.4 | 0.2 | 8 |
C14 |
|
Strong | 0.26 | 0.3 | 256 |
C15 |
|
Strong | 0.24 | 0.24 | 16 |
C16 |
|
Strong | 0.24 | 0.24 | 8 |
C17 |
|
Strong | 0.15 | 0.27 | 1024 |
C18 |
|
Moderate | 0.25 | 0.21 | 8 |
C19 |
|
Weak | 0.15 | 0.67 | 2 |
C20 |
|
Strong | 0.14 | 0.31 | 1024 |
C21 |
|
Strong | 0.17 | 0.4 | 1024 |
C22 |
|
Weak | 0.15 | 0.39 | 1 |
C23 |
|
Strong | 0.18 | 0.32 | 1024 |
C24 |
|
Strong | 0.17 | 0.41 | 8 |
C25 |
|
Weak | 0.17 | 0.23 | 8 |
C26 |
|
Moderate | 0.2 | 0.16 | 256 |
C27 |
|
Strong | 0.16 | 0.32 | 16 |
C28 |
|
Strong | 0.16 | 0.4 | 128 |
Demographic variables | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Sex | Age group (years) | |||||||||||
Male | Female | 30–40 | 41–50 | 51–60 | 61– > 70 | |||||||
n | % | n | % | n | % | n | % | n | % | n | % | |
|
11 | 61.1 | 7 | 38.9 | 0 | 0 | 6 | 33.3 | 1 | 5.6 | 11 | 61.1 |
Non-albicans |
5 | 50 | 5 | 50 | 1 | 10 | 3 | 30 | 1 | 10 | 5 | 50 |
Total (n = 28) | 16 | 57.1 | 12 | 42.9 | 1 | 3.6 | 9 | 32.1 | 2 | 7.1 | 16 | 57.1 |
Gene | Orientation | Sequence (5′–3′) | Reference |
---|---|---|---|
|
F | TTGGTGATGAAGCCCAATCC |
|
R | CATATCGTCCCAGTTGGAAACA | ||
|
F | TTACCTGAAACTTTTGGCAAAACA |
|
R | ACTTGTGATTCTGTCGTTACCG | ||
|
F | TTTAGCCAGAACTTTCACTCATGATT |
|
R | TATTTATTTCTTCATGTTCATATGGATTGA | ||
|
F | GGTATTGGCTGGTCCTAATGTGA |
|
R | GCTTGAATCAAATAAGTGAATGGATTAC |