<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this study was to prepare fast-dissolving tablets of meloxicam after its complexation with β-cyclodextrin (β-CD) and to investigate the effect of using different superdisintegrants on the disintegration and release of meloxicam from the tablets. A complex of meloxicam with β-CD was prepared by spray drying and then compressed in the form of tablets utilizing the direct compression technique. Three superdisintegrants were employed at various levels - sodium starch glycolate, croscarmellose sodium, and crospovidone. Co-spray dried micro-crystalline cellulose and mannitol (Avicel HFE-102) were used as diluents in the tablets. Prior to compression, the pre-compression parameters showed satisfactory flow properties. Post-compression parameters showed that all tablet formulations had acceptable mechanical properties. Wetting and disintegration times were prolonged by increasing the level of sodium starch glycolate in the tablets. This was attributed to the formation of a viscous gel layer around the tablets by sodium starch glycolate whereas this effect was not observed with croscarmellose sodium and crospovidone. Dissolution studies showed fast release of meloxicam except in tablets containing a high level of sodium starch glycolate. Complexation of meloxicam with β-CD significantly improved the solubility of the drug and improved the mechanical properties of tablets produced by direct compression.</p></abstract>

The aim of this study was to prepare fast-dissolving tablets of meloxicam after its complexation with β-cyclodextrin (β-CD) and to investigate the effect of using different superdisintegrants on the disintegration and release of meloxicam from the tablets. A complex of meloxicam with β-CD was prepared by spray drying and then compressed in the form of tablets utilizing the direct compression technique. Three superdisintegrants were employed at various levels - sodium starch glycolate, croscarmellose sodium, and crospovidone. Co-spray dried micro-crystalline cellulose and mannitol (Avicel HFE-102) were used as diluents in the tablets. Prior to compression, the pre-compression parameters showed satisfactory flow properties. Post-compression parameters showed that all tablet formulations had acceptable mechanical properties. Wetting and disintegration times were prolonged by increasing the level of sodium starch glycolate in the tablets. This was attributed to the formation of a viscous gel layer around the tablets by sodium starch glycolate whereas this effect was not observed with croscarmellose sodium and crospovidone. Dissolution studies showed fast release of meloxicam except in tablets containing a high level of sodium starch glycolate. Complexation of meloxicam with β-CD significantly improved the solubility of the drug and improved the mechanical properties of tablets produced by direct compression.

Development and evaluation of fast-dissolving tablets of meloxicam-β-cyclodextrin complex prepared by direct compression

Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid-Jordan

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Alzaytoonah Private University of Jordan, Amman-Jordan

Acta Pharmaceutica

The aim of this study was to prepare fast-dissolving tablets of meloxicam after its complexation with β-cyclodextrin (β-CD) and to investigate the effect of...

Development and evaluation of fast-dissolving tablets of meloxicam-β-cyclodextrin complex prepared by direct compression

Online veröffentlicht: 15. März 2011

Seitenbereich: 83 - 91

DOI: https://doi.org/10.2478/v10007-011-0005-7

Schlüsselwörter
meloksikam, natrijev škrobni glikolat, natrijeva sol kroskarmeloze, krospovidon, β-ciklodekstrin

This content is open access.

Development and evaluation of fast-dissolving tablets of meloxicam-β-cyclodextrin complex prepared by direct compression

Online veröffentlicht: 15. März 2011

Seitenbereich: 83 - 91

DOI: https://doi.org/10.2478/v10007-011-0005-7

Schlüsselwörtermeloksikam, natrijev škrobni glikolat, natrijeva sol kroskarmeloze, krospovidon, β-ciklodekstrin

This content is open access.

Schlüsselwörter
meloksikam, natrijev škrobni glikolat, natrijeva sol kroskarmeloze, krospovidon, β-ciklodekstrin