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Development of hydroxyapatite-ciprofloxacin bone-implants using »Quality by design«


D. R. Dirschl and L. C. Almekinders, Osteomyelitis. Common causes and treatment recommendations, Drugs 45 (1993) 29-43.10.2165/00003495-199345010-00004Search in Google Scholar

J. T. Mader, G. C. Landon and J. H. Calhoun, Antimicrobial treatment of osteomyelitis, Clin. Orthop. 295 (1993) 87-95.Search in Google Scholar

A. K. Nayak, Hydroxyapatite synthesis methodologies: An overview, Int. J. ChemTechRes. 2 (2010) 903-907.Search in Google Scholar

D.-S. Park, I.-S. Kim, H. Kim, A. H. Chou, B.-D. Hahn, L.-H. Li and S.-J. Hwang, Improved biocompatibility of hydroxyapatite thin film prepared by aerosol deposition, J. Biomater. Res. B: Appl. Biomater. 94 (2010) 353-358; DOI: 10.1002/jbm.b.31658.10.1002/jbm.b.31658Search in Google Scholar

Q. Z. Chen, C. T. Wong, W. W. Lu, K. M. C. Cheung, J. C. Y. Leong and K. D. K. Luk, Strengthening mechanisms of bone-bonding to crystalline hydroxyapatite in-vivo, Biomaterials 25 (2004) 4243-4254; DOI: 10.1016/j.biomaterials.2003. in Google Scholar

D. J. A. Netz, P. Seoulveda, V. C. Pandolfelli, A. C. C. Spadaro, J. B. Alencastre, M. V. L. B. Bentley and J. M. Marchetti, Potential use of gelacasting hydroxyapatite porous ceramic as an implantable drug delivery system, Int. J. Pharm. 213 (2001) 117-125; DOI: 10.1016/S0378-5173(00)00659-1.10.1016/S0378-5173(00)00659-1Search in Google Scholar

B. D. Shenoy, N. Udupa and A. Nagarajkumari, Implantable drug delivery systems for centochromon, Indian J. Pharm. Sci. 59 (1997) 246-250.Search in Google Scholar

W. Zafirau, D. Parker, W. Billotte and P. K. Bajpai, Development of a ceramic device for the continuous local delivery of steroids, Biomed. Sci. Instrum. 32 (1996) 63-70.Search in Google Scholar

A. K. Nayak and K. K. Sen, Hydroxyapatite-ciprofloxacin minipellets for bone-implant delivery: Preparation, characterization, in-vitro drug adsorption and dissolution studies, Int. J. Drug Dev. Res. 1 (2009) 47-59.Search in Google Scholar

H. H. Pham, P. Luo, F. Génin and A. K. Dash, Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying technique, AAPS PharmSci Tech 3 (2002) Article 1; DOI: 10.1208/pt030101.10.1208/pt030101Search in Google Scholar

A. K. Nayak, A. Bhattacharya and K. K. Sen, Hydroxyapatite-antibiotic implantable minipellets for bacterial bone infections using precipitation technique: Preparation, characterization and in-vitro antibiotic release studies, J. Pharm. Res. 3 (2010) 53-59.Search in Google Scholar

M. J. Maltesen, S. Bjerregaard, L. Hovgaard, S. Havelund and M. van de Weert, Quality by design-spray drying of insulin intended for inhalation, Eur. J. Pharm. Biopharm. 70 (2008) 828-838; DOI: 10.1016/j.ejpb.2008. in Google Scholar

T. Higuchi, Mechanisms of sustained action medications: Theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J. Pharm. Sci. 52 (1963) 1145-1149; DOI: 10.1002/jps.2600521210.10.1002/jps.2600521210Search in Google Scholar

R. W. Korsmeyer, R. Gurny, E. Doelker, P. Buri and N. A. Peppas, Mechanisms of solute release from porous hydrophobic polymers, Int. J. Pharm. 15 (1983) 25-35; DOI: 10.1016/0378-5173(83)90064-9.10.1016/0378-5173(83)90064-9Search in Google Scholar

R. A. Lionberger, S. L. Lee, L. Lee, A. Raw and L. X. Yu, Quality by design: Concepts for ANDAs, AAPS J. 10 (2008) 268-276; DOI: 10.1208/s12248-008-9026-7.10.1208/s12248-008-9026-7275137618465252Search in Google Scholar

S. Verma, Y. Lan, R. Gokhale and D. J. Burgess, Quality by design approach to understand the process of nanosuspension preparation, Int. J. Pharm. 377 (2009) 185-198; DOI: 10.1016/j.ijpharm.2009. in Google Scholar

P. L. Granja, A. I. N. Silva, J. P. Borges, C. C. Barrias and I. F. Amaral, Preparation and characterization of injectable chitosan-hydroxyapatite microspheres, Key Eng. Mater. 254-256 (2004) 573-576.Search in Google Scholar

G. Wu, G. Wang, X. Fu and L. Zhu, Synthesis, crystal structure, stacking effect and antibacterial studies of a novel quaternary copper (II) complex with quinolone, Molecules 8 (2003) 287-296; DOI: 10.3390/80200287.10.3390/80200287Search in Google Scholar

M. H. Santos, M. de Oliveira, P. de Freitas Souza, H. S. Mansur and W. L. Vasconcelos, Synthesis control and characterization of hydroxyapatite prepared by wet precipitation process, Mater. Res. 7 (2004) 625-630; DOI: 10.1590/S1516-14392004000400017.10.1590/S1516-14392004000400017Search in Google Scholar

R. Blagoeva and A. Nedev, Monolithic controlled delivery systems: Part II. Basic mathematical models, Bioautomation 5 (2006) 106-117.Search in Google Scholar

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