<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>A new series of cyclooxygenase-2 inhibitors with 2-amino--5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for cyclooxygenase inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay, anti-inflammatory activity by the carrageenean induced rat paw oedema test and analgesic activity by the tail flick method. Some compounds exhibited significant biological activity.</p></abstract>

A new series of cyclooxygenase-2 inhibitors with 2-amino--5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for cyclooxygenase inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay, anti-inflammatory activity by the carrageenean induced rat paw oedema test and analgesic activity by the tail flick method. Some compounds exhibited significant biological activity.

2-Amino-5-sulfanyl-1,3,4-thiadiazoles: A new series of selective cyclooxygenase-2 inhibitors

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Takshshsila Campus Khandwa Road, Indore, Madhya Pradesh-452017, India

Acta Pharmaceutica

A new series of cyclooxygenase-2 inhibitors with 2-amino--5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized...

2-Amino-5-sulfanyl-1,3,4-thiadiazoles: A new series of selective cyclooxygenase-2 inhibitors

Online veröffentlicht: 22. Dez. 2008

Seitenbereich: 317 - 326

DOI: https://doi.org/10.2478/v10007-008-0011-6

Schlüsselwörter
2-amino-5-sulfanil-1,3,4-tiadiazoli, ciklooksigenaza-1, ciklooksigenaza-2, protuupalno djelovanje, analgetsko djelovanje

This content is open access.

2-Amino-5-sulfanyl-1,3,4-thiadiazoles: A new series of selective cyclooxygenase-2 inhibitors

Online veröffentlicht: 22. Dez. 2008

Seitenbereich: 317 - 326

DOI: https://doi.org/10.2478/v10007-008-0011-6

Schlüsselwörter2-amino-5-sulfanil-1,3,4-tiadiazoli, ciklooksigenaza-1, ciklooksigenaza-2, protuupalno djelovanje, analgetsko djelovanje

This content is open access.

Schlüsselwörter
2-amino-5-sulfanil-1,3,4-tiadiazoli, ciklooksigenaza-1, ciklooksigenaza-2, protuupalno djelovanje, analgetsko djelovanje