New steroidal derivatives synthesized using 3β-hydroxyandrosten-17-one as starting material

In this study, we synthesized some new substituted steroidal derivatives using 3β-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD₅₀) of synthesized compounds are reported.