Degradation of hydroxychloroquine in aqueous solutions under electron beam treatment

1 Tarazona, J. v., Martínez, M., Martínez, M. A., & Anadon, A. (2021). Environmental impact assess-ment of COVID-19 therapeutic solutions. A prospective analysis. Sci. Total Environ., 778. https://doi.org/10.1016/j.scitotenv.2021.146257. Tarazona J. v. Martínez M. Martínez M. A. Anadon A. ( 2021 ). Environmental impact assess-ment of COVID-19 therapeutic solutions. A prospective analysis . Sci. Total Environ ., 778 . https://doi.org/10.1016/j.scitotenv.2021.146257 . Search in Google Scholar

2 Kumar, V., Garg, S., & Sharma, P. (2018). Chemical kinetics and stability studies of Amlodipine Besyl-ate. Asian Journal of Pharmaceutical Research and Development, 6(2), 87–92. Kumar V. Garg S. Sharma P. ( 2018 ). Chemical kinetics and stability studies of Amlodipine Besyl-ate . Asian Journal of Pharmaceutical Research and Development , 6 ( 2 ), 87 – 92 . Search in Google Scholar

3 Kumar, S., Pratap, B., Dubey, D., Kumar, A., Shukla, S., & Dutta, V. (2022). Constructed wetlands for the removal of pharmaceuticals and personal care prod-ucts (PPCPs) from wastewater: origin, impacts, treat-ment methods, and SWOT analysis. Environ. Monit. Assess., 194(12), 1–16. https://doi.org/10.1007/ S10661-022-10540-8. Kumar S. Pratap B. Dubey D. Kumar A. Shukla S. Dutta V. ( 2022 ). Constructed wetlands for the removal of pharmaceuticals and personal care prod-ucts (PPCPs) from wastewater: origin, impacts, treat-ment methods, and SWOT analysis . Environ. Monit. Assess ., 194 ( 12 ), 1 – 16 . https://doi.org/10.1007/ S10661-022-10540-8 . Search in Google Scholar

4 Efrain Merma Chacca, D., Maldonado, I., & Vilca, F. Z. (2022). Environmental and ecotoxicological effects of drugs used for the treatment of COVID 19. Front. Environ. Sci., 10, 1287. https://doi.org/10.3389/FENVS.2022.940975. Efrain Merma Chacca D. Maldonado I. Vilca F. Z. ( 2022 ). Environmental and ecotoxicological effects of drugs used for the treatment of COVID 19 . Front. Environ. Sci ., 10 , 1287 . https://doi.org/10.3389/ FENVS.2022.940975 . Search in Google Scholar

5 Monsef, R., & Salavati-Niasari, M. (2022). Electro-chemical sensor based on a chitosan-molybdenum vanadate nanocomposite for detection of hydroxychlo-roquine in biological samples. J. Colloid Interface Sci., 613, 1–14. https://doi.org/10.1016/J.JCIS.2022.01.039. Monsef R. Salavati-Niasari M. ( 2022 ). Electro-chemical sensor based on a chitosan-molybdenum vanadate nanocomposite for detection of hydroxychlo-roquine in biological samples . J. Colloid Interface Sci ., 613 , 1 – 14 . https://doi.org/10.1016/J.JCIS.2022.01.039 . Search in Google Scholar

6 Pushpanjali, P. A., Manjunatha, J. G., Hareesha, N., Girish, T., Al-Kahtani, A. A., Tighezza, A. M., & Ataollahi, N. (2022). Electrocatalytic determination of hydroxychloroquine using sodium dodecyl sulphate modified carbon nanotube paste electrode. Top. Catal., 1, 1–9. https://doi.org/10.1007/S11244-022-01568-8. Pushpanjali P. A. Manjunatha J. G. Hareesha N. Girish T. Al-Kahtani A. A. Tighezza A. M. Ataollahi N. ( 2022 ). Electrocatalytic determination of hydroxychloroquine using sodium dodecyl sulphate modified carbon nanotube paste electrode . Top. Catal ., 1 , 1 – 9 . https://doi.org/10.1007/S11244-022-01568-8 . Search in Google Scholar

7 Dabic, D., Babic, S., & Skoric, I. (2019). The role of photodegradation in the environmental fate of hydroxychloroquine. Chemosphere, 230. https://doi. org/10.1016/j.chemosphere.2019.05.032. Dabic D. Babic S. Skoric I. ( 2019 ). The role of photodegradation in the environmental fate of hydroxychloroquine . Chemosphere , 230 . https://doi.org/10.1016/j.chemosphere.2019.05.032 . Search in Google Scholar

8 Babić, S., Dabić, D., & Ćurković, L. (2017). Fate of hydroxychloroquine in the aquatic environment. In CEST2017-15th International Conference on En-vironmental Science and Technology, 31 August-2 September 2017, Rhodes, Greece, pp. 1–5. Babić S. Dabić D. Ćurković L. ( 2017 ). Fate of hydroxychloroquine in the aquatic environment . In CEST2017-15th International Conference on En-vironmental Science and Technology, 31 August-2 September 2017 , Rhodes, Greece , pp. 1 – 5 . Search in Google Scholar

9 Sayed, A. E. D. H., Hamed, M., & Soliman, H. A. M. (2021). Spirulina platensis alleviated the hemo-toxicity, oxidative damage and histopathological alterations of hydroxychloroquine in Catfish (Clarias gariepinus). Front. Physiol., 12, 881. https://doi. org/10.3389/FPHYS.2021.683669/BIBTEX. Sayed A. E. D. H. Hamed M. Soliman H. A. M. ( 2021 ). Spirulina platensis alleviated the hemo-toxicity, oxidative damage and histopathological alterations of hydroxychloroquine in Catfish (Clarias gariepinus) . Front. Physiol ., 12 , 881 . https://doi.org/10.3389/FPHYS.2021.683669/BIBTEX . Search in Google Scholar

10 da Luz, T. M., Araújo, A. P. da C., Estrela, F. N., Braz, H. L. B., Jorge, R. J. B., Charlie-Silva, I., & Malafaia, G. (2021). Can use of hydroxychloroquine and azithromycin as a treatment of COVID-19 affect aquatic wildlife? A study conducted with neotropical tadpole. Sci. Total Environ., 780, 146553. https://doi. org/10.1016/J.SCITOTENV.2021.146553. da Luz T. M. Araújo A. P. da C. Estrela F. N. Braz H. L. B. Jorge R. J. B. Charlie-Silva I. Malafaia G. ( 2021 ). Can use of hydroxychloroquine and azithromycin as a treatment of COVID-19 affect aquatic wildlife? A study conducted with neotropical tadpole . Sci. Total Environ ., 780 , 146553 . https://doi. org/10.1016/J.SCITOTENV.2021.146553 . Search in Google Scholar

11 Tonnesen, H. H., Grislingaas, A. L., Woo, S. O., & Karlsen, J. (1988). Photochemical stability of antima-larial. I. Hydroxychloroquine. Int. J. Pharm., 43(3). https://doi.org/10.1016/0378-5173(88)90276-1. Tonnesen H. H. Grislingaas A. L. Woo S. O. Karlsen J. ( 1988 ). Photochemical stability of antima-larial. I. Hydroxychloroquine . Int. J. Pharm ., 43 ( 3 ). https://doi.org/10.1016/0378-5173(88)90276-1 . Search in Google Scholar

12 Kargar, F., Bemani, A., Sayadi, M. H., & Ahmad-pour, N. (2021). Synthesis of modified beta bismuth oxide by titanium oxide and highly efficient solar photocatalytic properties on hydroxychloroquine degradation and pathways. J. Photochem. Photobiol. A-Chemistry, 419, 113453. https://doi.org/10.1016/J. JPHOTOCHEM.2021.113453. Kargar F. Bemani A. Sayadi M. H. Ahmad-pour N. ( 2021 ). Synthesis of modified beta bismuth oxide by titanium oxide and highly efficient solar photocatalytic properties on hydroxychloroquine degradation and pathways . J. Photochem. Photobiol. A-Chemistry , 419 , 113453 . https://doi.org/10.1016/J. JPHOTOCHEM.2021.113453 . Search in Google Scholar

13 Dastborhan, M., Khataee, A., Arefi-Oskoui, S., & Yoon, Y. (2022). Synthesis of flower-like MoS2/CNTs nanocomposite as an efficient catalyst for the sonocat-alytic degradation of hydroxychloroquine. Ultrason. Sonochem., 87, 106058. https://doi.org/10.1016/J.ULTSONCH.2022.106058 Dastborhan M. Khataee A. Arefi-Oskoui S. Yoon Y. ( 2022 ). Synthesis of flower-like MoS2/CNTs nanocomposite as an efficient catalyst for the sonocat-alytic degradation of hydroxychloroquine . Ultrason. Sonochem ., 87 , 106058 . https://doi.org/10.1016/J. ULTSONCH.2022.106058 . Search in Google Scholar

14 Bensalah, N., Midassi, S., Ahmad, M. I., & Bedoui, A. (2020). Degradation of hydroxychloroquine by electrochemical advanced oxidation processes. Chem. Eng. J., 402, 126279. https://doi.org/10.1016/j.cej.2020.126279. Bensalah N. Midassi S. Ahmad M. I. Bedoui A. ( 2020 ). Degradation of hydroxychloroquine by electrochemical advanced oxidation processes . Chem. Eng. J ., 402 , 126279 . https://doi.org/10.1016/j. cej.2020.126279 . Search in Google Scholar

15 de Araújo, D. M., dos Santos, E. v., Martínez-Huitle, C. A., & de Battisti, A. (2022). Achieving electro-chemical-sustainable-based solutions for monitoring and treating hydroxychloroquine in real water matrix. Appl. Sci., 12(2), 699. https://doi.org/10.3390/ APP12020699. de Araújo D. M. dos Santos E. v. Martínez-Huitle C. A. de Battisti A. ( 2022 ). Achieving electro-chemical-sustainable-based solutions for monitoring and treating hydroxychloroquine in real water matrix . Appl. Sci ., 12 ( 2 ), 699 . https://doi.org/10.3390/ APP12020699 . Search in Google Scholar

16 Ansarian, Z., Khataee, A., Arefi-Oskoui, S., Orooji, Y., & Lin, H. (2022). Ultrasound-assisted catalytic activation of peroxydisulfate on Ti3GeC2 MAX phase for efficient removal of hazardous pollutants. Mater. Today Chem., 24, 100818. https://doi.org/10.1016/J. MTCHEM.2022.100818. Ansarian Z. Khataee A. Arefi-Oskoui S. Orooji Y. Lin H. ( 2022 ). Ultrasound-assisted catalytic activation of peroxydisulfate on Ti3GeC2 MAX phase for efficient removal of hazardous pollutants . Mater. Today Chem ., 24 , 100818 . https://doi.org/10.1016/J.MTCHEM.2022.100818 . Search in Google Scholar

17 da Silva, P. L., Nippes, R. P., Macruz, P. D., Hegeto, F. L., & Olsen Scaliante, M. H. N. (2021). Photo-catalytic degradation of hydroxychloroquine using ZnO supported on clinoptilolite zeolite. Water Sci. Technol., 84 (3), 763–776. https://doi.org/10.2166/WST.2021.265. da Silva P. L. Nippes R. P. Macruz P. D. Hegeto F. L. Olsen Scaliante M. H. N. ( 2021 ). Photo-catalytic degradation of hydroxychloroquine using ZnO supported on clinoptilolite zeolite . Water Sci. Technol ., 84 ( 3 ), 763 – 776 . https://doi.org/10.2166/WST.2021.265 . Search in Google Scholar

18 el Amri, R., Elkacmi, R., Hasib, A., & Boudouch, O. (2022). Removal of hydroxychloroquine from an aqueous solution using living microalgae: Effect of operating parameters on removal efficiency and mechanisms. Water Environ. Res., 9, e10790–n/a. el Amri R. Elkacmi R. Hasib A. Boudouch O. ( 2022 ). Removal of hydroxychloroquine from an aqueous solution using living microalgae: Effect of operating parameters on removal efficiency and mechanisms . Water Environ. Res ., 9 , e10790 – n/a . Search in Google Scholar

19 Gümüş, D., & Gümüş, F. (2022). Removal of hy-droxychloroquine using engineered biochar from algal biodiesel industry waste: Characterization and design of experiment (DoE). Arabian Journal for Science and Engineering, 6, 7325–7334. Gümüş D. Gümüş F. ( 2022 ). Removal of hy-droxychloroquine using engineered biochar from algal biodiesel industry waste: Characterization and design of experiment (DoE) . Arabian Journal for Science and Engineering , 6 , 7325 – 7334 . Search in Google Scholar

20 Nippes, R. P., Macruz, P. D., Molina, L. C. A., & Scaliante, M. H. N. O. (2022). Hydroxychloroquine adsorption in aqueous medium using clinoptilolite zeolite. Water, Air and Soil Pollution, 233(8), 1–14. https://doi.org/10.1007/S11270-022-05787-3. Nippes R. P. Macruz P. D. Molina L. C. A. Scaliante M. H. N. O. ( 2022 ). Hydroxychloroquine adsorption in aqueous medium using clinoptilolite zeolite . Water, Air and Soil Pollution , 233 ( 8 ), 1 – 14 . https://doi.org/10.1007/S11270-022-05787-3 . Search in Google Scholar

21 Bendjeffal, H., Ziati, M., Aloui, A., Mamine, H., Meti-dji, T., Djebli, A., & Bouhedja, Y. (2021). Adsorption and removal of hydroxychloroquine from aqueous media using Algerian kaolin: Full factorial optimisation, kinetic, thermodynamic, and equilibrium studies. Int. J. Environ. Anal. Chem., 103(9), 1982–2003. https:// doi.org/10.1080/03067319.2021.1887162. Bendjeffal H. Ziati M. Aloui A. Mamine H. Meti-dji T. Djebli A. Bouhedja Y. ( 2021 ). Adsorption and removal of hydroxychloroquine from aqueous media using Algerian kaolin: Full factorial optimisation, kinetic, thermodynamic, and equilibrium studies . Int. J. Environ. Anal. Chem ., 103 ( 9 ), 1982 – 2003 . https:// doi.org/10.1080/03067319.2021.1887162 . Search in Google Scholar

22 Zaouak, A., Jebali, S., Chouchane, H., & Jelassi, H. (2022). Impact of gamma-irradiation on the degra-dation and mineralization of hydroxychloroquine aqueous solutions. Int. J. Environ. Sci. Technol., 20, 6815–6824. https://doi.org/10.1007/S13762-022-04360-z. Zaouak A. Jebali S. Chouchane H. Jelassi H. ( 2022 ). Impact of gamma-irradiation on the degra-dation and mineralization of hydroxychloroquine aqueous solutions . Int. J. Environ. Sci. Technol ., 20 , 6815 – 6824 . https://doi.org/10.1007/S13762-022-04360-z . Search in Google Scholar

23 Boujelbane, F., Nasr, K., Sadaoui, H., Bui, H. M., Gantri, F., & Mzoughi, N. (2022). Decomposition mechanism of hydroxychloroquine in aqueous solution by gamma irradiation. Chem. Pap., 76(3), 1777–1787. https://link.springer.com/article/10.1007/s11696-021-01969-1. Boujelbane F. Nasr K. Sadaoui H. Bui H. M. Gantri F. Mzoughi N. ( 2022 ). Decomposition mechanism of hydroxychloroquine in aqueous solution by gamma irradiation . Chem. Pap ., 76 ( 3 ), 1777 – 1787 . https://link.springer.com/article/10.1007/s11696-021-01969-1 . Search in Google Scholar

24 Han, B., Ko, J., Kim, J., Kim, Y., Chung, W., Maka-rov, I. E., Ponomarev, A. V., & Pikaev, A. K. (2002). Combined electron-beam and biological treatment of dyeing complex wastewater. Pilot plant experiments. Radiat. Phys. Chem., 64(1), 53–59. https://doi. org/10.1016/S0969-806X(01)00452-2. Han B. Ko J. Kim J. Kim Y. Chung W. Maka-rov I. E. Ponomarev A. V. Pikaev A. K. ( 2002 ). Combined electron-beam and biological treatment of dyeing complex wastewater. Pilot plant experiments . Radiat. Phys. Chem ., 64 ( 1 ), 53 – 59 . https://doi. org/10.1016/S0969-806X(01)00452-2 . Search in Google Scholar

25 Sharpe, P. H. G., & Sehested, K. (1989). The di-chromate dosimeter: A pulse-radiolysis study. Int. J. Radiat. Appl. Instrum. Pt. C-Radiat. Phys. Chem., 34(5), 763–768. https://doi.org/10.1016/1359-0197(89)90281-6. Sharpe P. H. G. Sehested K. ( 1989 ). The di-chromate dosimeter: A pulse-radiolysis study . Int. J. Radiat. Appl. Instrum. Pt. C-Radiat. Phys. Chem ., 34 ( 5 ), 763 – 768 . https://doi.org/10.1016/1359-0197(89)90281-6 . Search in Google Scholar

26 McLaughlin, W. L., Al-Sheikhly, M., Farahani, M., & Hussmann, M. H. (1990). A sensitive dichromate dosimeter for the dose range, 0.2–3 kGy. Int. J. Radiat. Appl. Instrum. Pt. C-Radiat. Phys. Chem., 35(4/6), 716–723. https://doi.org/10.1016/1359-0197(90)90303-Y. McLaughlin W. L. Al-Sheikhly M. Farahani M. Hussmann M. H. ( 1990 ). A sensitive dichromate dosimeter for the dose range, 0.2-3 kGy . Int. J. Radiat. Appl. Instrum. Pt. C-Radiat. Phys. Chem ., 35 ( 4/6 ), 716 – 723 . https://doi.org/10.1016/1359-0197(90)90303-Y . Search in Google Scholar

27 Šećerov, B., & Bačić, G. (2008). Comparison of dichro-mate and ethanol-chlorobenzene dosimeters in high dose radiation processing. Nukleonika, 53(3), 85–87. Šećerov B. Bačić G. ( 2008 ). Comparison of dichro-mate and ethanol-chlorobenzene dosimeters in high dose radiation processing . Nukleonika , 53 ( 3 ), 85 – 87 . Search in Google Scholar

28 Wojnárovits, L., & Takács, E. (2017). Wastewater treatment with ionizing radiation. J. Radioanal. Nucl. Chem., 311(2), 973–981. https://doi.org/10.1007/ s10967-016-4869-3 Wojnárovits L. Takács E. ( 2017 ). Wastewater treatment with ionizing radiation . J. Radioanal. Nucl. Chem ., 311 ( 2 ), 973 – 981 . https://doi.org/10.1007/ s10967-016-4869-3 Search in Google Scholar

29 Buxton, G. V., Greenstock, C. L., Helman, W. P., & Ross, A. B. (1988). Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (oOH/^O in aqueous solution. J. Phys. Chem. Ref. Data, 17(2), 513–886. https:// doi.org/10.1063/1.555805. Buxton G. V. Greenstock C. L. Helman W. P. Ross A. B. ( 1988 ). Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (·OH/·O^- in aqueous solution . J. Phys. Chem. Ref. Data , 17 ( 2 ), 513 – 886 . https:// doi.org/10.1063/1.555805 . Search in Google Scholar

30 Rath, M. C., Keny, S. J., Upadhyaya, H. P., & Adhikari, S. (2023). Free radical induced degradation and com-putational studies of hydroxychloroquine in aqueous solution. Radiat. Phys. Chem., 206, 110785. https:// doi.org/10.1016/j.radphyschem.2023.110785. Rath M. C. Keny S. J. Upadhyaya H. P. Adhikari S. ( 2023 ). Free radical induced degradation and com-putational studies of hydroxychloroquine in aqueous solution . Radiat. Phys. Chem ., 206 , 110785 . https:// doi.org/10.1016/j.radphyschem.2023.110785 . Search in Google Scholar

31 Bors, W., Golenser, J., Chevion, M., & Saran, M. (1991). Reductive and oxidative radical reactions of selected antimalarial drugs. Oxidative Damage & Repair, 1991, 234–240. https://doi.org/10.1016/ B978-0-08-041749-3.50046-2. Bors W. Golenser J. Chevion M. Saran M. ( 1991 ). Reductive and oxidative radical reactions of selected antimalarial drugs . Oxidative Damage & Repair , 1991 , 234 – 240 . https://doi.org/10.1016/ B978-0-08-041749-3.50046-2 . Search in Google Scholar

32 Kovács, K., Simon, Á., Balogh, G. T., Tóth, T., & Wojnàrovits, L. (2020). High-energy ionizing radi-ation-induced degradation of amodiaquine in dilute aqueous solution: radical reactions and kinetics. Free Radic. Res., 54(2/3), 185–194. https://doi.org/10.10 80/10715762.2020.1736579. Kovács K. Simon Á. Balogh G. T. Tóth T. Wojnàrovits L. ( 2020 ). High-energy ionizing radi-ation-induced degradation of amodiaquine in dilute aqueous solution: radical reactions and kinetics . Free Radic. Res ., 54 ( 2/3 ), 185 – 194 . https://doi.org/10.10 80/10715762.2020.1736579 . Search in Google Scholar

33 Rath, M. C., Keny, S. J., Upadhyaya, H. P., & Adhikari, S. (2023). Free radical induced degradation and com-putational studies of hydroxychloroquine in aqueous solution. Radiat. Phys. Chem., 206, 110785. https:// doi.org/10.1016/j.radphyschem.2023.110785. Rath M. C. Keny S. J. Upadhyaya H. P. Adhikari S. ( 2023 ). Free radical induced degradation and com-putational studies of hydroxychloroquine in aqueous solution . Radiat. Phys. Chem ., 206 , 110785 . https:// doi.org/10.1016/j.radphyschem.2023.110785 . Search in Google Scholar

34 Zaouak, A., Noomen, A., & Jelassi, H. (2021). Deg-radation mechanism of losartan in aqueous solutions under the effect of gamma radiation. Radiat. Phys. Chem., 184, 109435. https://doi.org/10.1016/j.rad-physchem.2021.109435. Zaouak A. Noomen A. Jelassi H. ( 2021 ). Deg-radation mechanism of losartan in aqueous solutions under the effect of gamma radiation . Radiat. Phys. Chem ., 184 , 109435 . https://doi.org/10.1016/j.rad-physchem.2021.109435 . Search in Google Scholar

35 Wang, N., Zheng, T., Zhang, G., & Wang, P. (2016). A review on Fenton-like processes for organic wastewa-ter treatment. J. Environ. Chem. Eng., 4(1), 762–787. https://doi.org/10.1016/J.JECE.2015.12.016. Wang N. Zheng T. Zhang G. Wang P. ( 2016 ). A review on Fenton-like processes for organic wastewa-ter treatment . J. Environ. Chem. Eng ., 4 ( 1 ), 762 – 787 . https://doi.org/10.1016/J.JECE.2015.12.016 . Search in Google Scholar

36 Chu, L., & Wang, J. (2022). Treatment of oil-field produced wastewater by electron beam technology: Demulsification, disinfection and oil removal. J. Clean Prod., 378, 134532. https://doi.org/10.1016/J. JCLEPRO.2022.134532. Chu L. Wang J. ( 2022 ). Treatment of oil-field produced wastewater by electron beam technology: Demulsification, disinfection and oil removal . J. Clean Prod ., 378 , 134532 . https://doi.org/10.1016/J. JCLEPRO.2022.134532 . Search in Google Scholar

37 Wang, J., & Chu, L. (2016). Irradiation treatment of pharmaceutical and personal care products (PPCPs) in water and wastewater: An overview. Radiat. Phys. Chem., 125, 56–64. https://doi.org/10.1016/j.radphy-schem.2016.03.012. Wang J. Chu L. ( 2016 ). Irradiation treatment of pharmaceutical and personal care products (PPCPs) in water and wastewater: An overview . Radiat. Phys. Chem ., 125 , 56 – 64 . https://doi.org/10.1016/j.radphy-schem.2016.03.012 . Search in Google Scholar

38 Warhurst, D. C., Steele, J. C. P., Adagu, I. S., Craig, J. C., & Cullander, C. (2003). Hydroxychloro-quine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties. J. Antimicrob. Chemother., 52(2), 188–193. https://doi.org/10.1093/JAC/DKG319. Warhurst D. C. Steele J. C. P. Adagu I. S. Craig J. C. Cullander C. ( 2003 ). Hydroxychloro-quine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties . J. Antimicrob. Chemother ., 52 ( 2 ), 188 – 193 . https://doi.org/10.1093/JAC/DKG319 . Search in Google Scholar

39 Klouda, C. B., & Stone, W. L. (2020). Oxidative stress, proton fluxes, and chloroquine/hydroxychloroquine treatment for COVID-19. Antioxidants, 9(9), 894. https://doi.org/10.3390/antiox9090894. Klouda C. B. Stone W. L. ( 2020 ). Oxidative stress, proton fluxes, and chloroquine/hydroxychloroquine treatment for COVID-19 . Antioxidants , 9 ( 9 ), 894 . https://doi.org/10.3390/antiox9090894 . Search in Google Scholar

40 Catrinel, I. A., Mlak-Marginean, M., Savin, M., & Daescu, M. (2022). The influence of the aqueous composition over degradation of hydroxychloroquine. UPB Sci. Bull. B, 84(3), 63–76. Catrinel I. A. Mlak-Marginean M. Savin M. Daescu M. ( 2022 ). The influence of the aqueous composition over degradation of hydroxychloroquine . UPB Sci . Bull. B , 84 ( 3 ), 63 – 76 . Search in Google Scholar

41 Tominaga, F. K., Dos Santos Batista, A. P., Silva Costa Teixeira, A. C., & Borrely, S. I. (2018). Degradation of diclofenac by electron beam irradiaton: Toxicitiy removal, by-products identification and effect of an-other pharmaceutical compound. J. Environ. Chem. Eng., 6(4), 4605–4611. https://doi.org/10.1016/j. jece.2018.06.065. Tominaga F. K. Dos Santos Batista A. P. Silva Costa Teixeira A. C. Borrely S. I. ( 2018 ). Degradation of diclofenac by electron beam irradiaton: Toxicitiy removal, by-products identification and effect of an-other pharmaceutical compound . J. Environ. Chem. Eng ., 6 ( 4 ), 4605 – 4611 . https://doi.org/10.1016/j. jece.2018.06.065 . Search in Google Scholar