HILP (High Impact, Low Probability) occurrences include CBRNE incidents (induced by terrorist acts or accidents). Nevertheless, since the probability of encountering chemical warfare threats increased in the actual global context, this work aims to highlight the most recent results obtained for the neutralization and removal of chemical warfare agents, by employing various types of nanoparticles and decontamination solutions. The performances of the decontamination solutions were evaluated by using GC-MS technique, which allows the quantification of the initial concentration of toxic agent, as well as the concentration of the remnant toxic agent, measured at various time intervals, until decontamination process was completed.