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The efficiency of mycotoxin binding by sorbents in the in vitro model using a naturally contaminated animal feed

Adrianna Żybura

Adrianna Żybura

Department of Pharmacology and Toxicology, National Veterinary Research InstitutePuławy, Poland
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Żybura, Adrianna
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Piotr Jedziniak

Piotr Jedziniak

Department of Pharmacology and Toxicology, National Veterinary Research InstitutePuławy, Poland
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Jedziniak, Piotr
  
22. Mai 2024
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Online veröffentlicht: 22. Mai 2024
Seitenbereich: 233 - 240
Eingereicht: 19. Sept. 2023
Akzeptiert: 22. Apr. 2024
DOI: https://doi.org/10.2478/jvetres-2024-0023
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© 2024 Adrianna Żybura et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction

The productivity of domestic animals and the safety of food products derived from them are jeopardised by mycotoxins in animal feed. To control them, feed additives are used, which limit the absorption of mycotoxins in the gastrointestinal tract of animals by binding to them. The study aimed to evaluate the effectiveness of a new in vitro model in experiments on the binding of mycotoxins from buffers and contaminated feed and to confirm the effect of a single sorbent or mixture in binding them.

Material and Methods

Nine mineral sorbents were tested for their efficiency binding eight mycotoxins. Two in vitro experiments were conducted to indicate the mycotoxin-binding capacity of sorbents, each specifying a buffer with one of two different pH levels reflecting gastrointestinal conditions (pH 3.5 and 7.0). The first investigated the sorbent with only the buffer and mycotoxin standards, while the second did so with the sorbent, buffer and feed naturally contaminated with mycotoxins (deoxynivalenol, zearalenone, and ochratoxin A).

Results

The sorption was significantly lower in the trial with feed. In the first experiment at gastric pH (pH 3.5), activated charcoal bound deoxynivalenol and sepiolite bound zearalenone at 70% and 96%, respectively, whereas in the second experiment with feed, the binding was only 3% and 6%.

Conclusion

The study underlines the challenge of finding a feed additive that would work comprehensively, binding all mycotoxins regulated by law.
Sprache:
Englisch
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Fachgebiete der Zeitschrift:
Biologie, Molekularbiologie, Mikrobiologie und Virologie, Biologie, andere, Medizin, Veterinärmedizin
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