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Ameliorative effects of Helianthus annuus against nephrotoxic, cardiac, and haematological disorders in alloxan-induced hyperglycaemia in albino rats

Samuel Okwudili Onoja

Samuel Okwudili Onoja

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Michael Okpara University of Agriculture UmudikeUmuahia Abia State, Nigeria
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Onoja, Samuel Okwudili
, 
Samuel Chukwuneke Udem

Samuel Chukwuneke Udem

Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria NsukkaEnugu State, Nigeria
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Udem, Samuel Chukwuneke
 und 
Aruh Ottah Anaga

Aruh Ottah Anaga

Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria NsukkaEnugu State, Nigeria
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Anaga, Aruh Ottah
  
23. Okt. 2018
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Online veröffentlicht: 23. Okt. 2018
Seitenbereich: 371 - 377
Eingereicht: 27. Apr. 2018
Akzeptiert: 17. Sept. 2018
DOI: https://doi.org/10.2478/jvetres-2018-0053
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© 2018 S.O. Onoja et al., published by Sciendo
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Introduction

The study evaluated the ameliorative effects of Helianthus annuus leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats.

Material and Methods

The cold maceration method with 80% methanol was used in the preparation of H. annuus extract. Thirty alloxan-induced hyperglycaemic rats were randomly assigned to five equal groups (A–E). Groups A and B received 5% tween-20 solution in water (5 mL/kg) and glibenclamide (2 mg/kg), respectively; while groups C, D, and E received 150, 300, and 600 mg/kg of the extract, respectively, per os once daily for 21 consecutive days. The levels of serum urea, creatinine, haematological indices, and histopathological changes in the kidneys and heart were evaluated 24 h after the last treatment on day 21.

Results

The extract and glibenclamide significantly (P < 0.05) reduced the levels of serum urea and urea : creatinine ratio in diabetic rats when compared with the vehicle treated group. The extract and glibenclamide also ameliorated haematological disorders and kidney and cardiac damage induced by alloxan.

Conclusion

H. annuus extract produced nephroprotective, cardioprotective, and haematoprotective effects and might prevent the advancement of diabetic complications such as diabetic nephropathy and cardiovascular diseases in diabetic patients.

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Englisch
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Biologie, Molekularbiologie, Mikrobiologie und Virologie, Biologie, andere, Medizin, Veterinärmedizin
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