Incidence and prevention of post-immunisation bleeding complications in people with haemophilia at a treatment centre in India

Figure 1.

Figure 2.

Figure 3.

Immunisation schedule criteria established by the Ministry of Health and Family Welfare, India [8]

VACCINE	TIME TO ADMINISTER	DOSE	ROUTE	SITE	INTRODUCTION TIME IN INDIA (MHFW)
HBV	At birth	0.5ml	Intramuscular	Anterolateral side of mid-thigh	2002
HBV 1,2,3	6 weeks, 10 weeks, 14 weeks	0.5ml	Intramuscular	Anterolateral side of mid-thigh	1970s
DTwP/DTaP 1,2,3	6 weeks, 10 weeks, 14 weeks	0.5ml	Intramuscular	Anterolateral side of mid-thigh
Hib	6 weeks, 10 weeks, 14 weeks	0.5ml	Intramuscular	Anterolateral side of mid-thigh	2008
DTwP/DTaP booster 1	16-18 months	0.5ml	Intramuscular	Anterolateral side of mid-thigh	1970
DTwP/DTaP booster 2	4-6 years	0.5ml	Intramuscular	Upper arm
TT	10 years and 16 years	0.5ml	Intramuscular	Upper arm	1970

Frequency and percentage distribution of demographic characteristics of study participants (n=65)

VARIABLE	FREQUENCY (F)	PERCENTAGE (%)
Age (years)
<10	22	33.8
11-20	22	33.8
>21	21	32.3
Education
No schooling	7	10.7
Primary	12	18.4
Secondary	19	29.2
Higher secondary	9	13.8
University	18	27.6
Age at diagnosis (years)
0-2	46	70.7
3-5	8	12.3
Over 5	11	16.9
Type of haemophilia
Haemophilia A	55	84.6
Haemophilia B	10	15.3
Disease severity
Mild	3	4.6
Moderate	15	23
Severe	47	72.3
Family history of haemophilia
Yes	30	46.1
No	35	53.8

Frequency and percentage distribution of prophylactic measures to prevent complications after vaccination

ITEM	FREQUENCY (N)	PERCENTAGE (%)
Have you/your child received vaccination? (n=79)
Yes	65	82.2
No	14	17.7
Did you have any bleeding complications after the vaccination? (n=65)
Yes	15	23.1
No	50	76.9
If yes, how was it managed? (n=15)
Factor injection	9	13.8
Icepack and compression	6	9.2
Did you receive any clotting factor replacement therapy before your vaccination? (n=65)
Yes	37	56.9
No	28	43.1
Route of administration of first vaccination? (n=65)
Subcutaneous	54	83.1
Intramuscular	11	16.9