| Age |
| Mean (SD) |
36.6 (12.0) |
41.4 (14.1) |
| Median (IQR) |
37.0 (27.0, 42.0) |
41.0 (29.0, 54.0) |
| Age, n (%) |
| 18-35 |
15 (44) |
31 (39) |
| 36-59 |
16 (47) |
39 (49) |
| >60 |
3 (9) |
9 (11) |
| Body mass index, n (%) |
| Underweight |
0 (0) |
1 (1) |
| Normal weight |
18 (53) |
48 (61) |
| Overweight |
16 (47) |
28 (35) |
| Obese |
0 |
2 (3) |
| Current treatment regimen, n (%) |
| On-demand |
10 (29) |
24 (30) |
| No recent FVIII treatmenta |
24 (71) |
55 (70) |
| Prophylaxis |
0 |
0 |
| ABR (all cause) |
| Bleeding reported, n (%) |
24 (71) |
67 (85) |
| Mean (SD) |
1.1 (0.9) |
2.9 (2.7) |
| Median (Q1, Q3) |
1.0 (0.0, 2.0) |
2.0 (1.0, 4.0) |
| ABR (spontaneous)b |
| Spontaneous bleeding reported, n (%) |
- |
57 (72) |
| Mean (SD) |
- |
0.88 (0.93) |
| Median (Q1, Q3) |
- |
0.6 (0, 1.2) |
| ABR, n (%) |
| 0 |
10 (29) |
12 (15) |
| 1 |
14 (41) |
14 (18) |
| >2 |
10 (29) |
53 (67) |
| Baseline factor level (overall) |
| Mean (SD) |
21.0 (10.3) |
3.5 (1.2) |
| Median (Q1, Q3, range) |
20 (11, 30, 5.01-40) |
4 (3, 5, 1-5) |
| Baseline factor level in those reporting a bleeding event |
| Mean (SD) |
21.3 (9.8) |
3.4 (1.3) |
| Median (Q1, Q3, range) |
20 (15, 27, 5.1-37) |
3.3 (2.3, 5, 1-5) |
| Target joints |
| Mean (SD) |
0.1 (0.3) |
0.3 (0.7) |
| Median (Q1, Q3) |
0 |
0 |
| Target joints, n (%) |
| 0 |
30 (88) |
62 (79) |
| 1 |
4 (12) |
11 (14) |
| >2 |
0 |
6 (8) |
| Problem joints |
| Mean (SD) |
0.1 (0.4) |
0.7 (0.8) |
| Median (Q1, Q3) |
0 |
1.0 (0.0, 1.0) |
| Problem joints, n (%) |
| 0 |
30 (88) |
39 (49) |
| 1 |
3 (9) |
26 (33) |
| >2 |
1 (3) |
14 (18) |
| Chronic pain level, n (%) |
| None |
22 (65) |
21 (27) |
| Mild pain |
11 (32) |
41 (52) |
| Moderate pain |
1 (3) |
17 (22) |
| Severe pain |
0 |
0 |
| Anxiety, n (%) |
4 (12) |
16 (20) |
| Depression, n (%) |
1 (3) |
12 (15) |
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