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Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight

Fiona Samson

Fiona Samson

Troy High SchoolTroy, USA
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Samson, Fiona
, 
Aadya Bhat

Aadya Bhat

Eastlake High SchoolRedmond, USA
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Bhat, Aadya
, 
Zachary Sayyah

Zachary Sayyah

The Nueva SchoolHillsborough, USA
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Sayyah, Zachary
, 
Sigrid Reinsch

Sigrid Reinsch

Space Biosciences Division, NASA Ames Research CenterMoffett Field, USA
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Reinsch, Sigrid
 und 
Elizabeth Blaber

Elizabeth Blaber

  • Biomedical Engineering Department and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic InstituteTroy, USA
  • Blue Marble Space Institute of Science at NASA Ames Research CenterMoffett Field, USA
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Blaber, Elizabeth
  
21. März 2024
Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight's Cover Image
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Artikel-Kategorie: Research Note
Online veröffentlicht: 21. März 2024
Seitenbereich: 41 - 45
DOI: https://doi.org/10.2478/gsr-2024-0002
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© 2024 Fiona Samson et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1.

Statistical significance analysis. This histogram represents the statistical significance of the data based on p-value, specifically for the sei mutant flight and ground control comparison. If the p-value is less than 0.05, the data is significant. As the peak is closest to the origin, this graph indicates that this is an excellent data set for further analyses.
Statistical significance analysis. This histogram represents the statistical significance of the data based on p-value, specifically for the sei mutant flight and ground control comparison. If the p-value is less than 0.05, the data is significant. As the peak is closest to the origin, this graph indicates that this is an excellent data set for further analyses.

Figure 2.

The principal component analysis. PCA plot signifies the variance between the spaceflight and ground control groups. More variance in PC1 indicates a higher difference in the pattern of expression between ground controls and flight samples. This pattern is observed in the sei mutant flight and ground control sample comparisons.
The principal component analysis. PCA plot signifies the variance between the spaceflight and ground control groups. More variance in PC1 indicates a higher difference in the pattern of expression between ground controls and flight samples. This pattern is observed in the sei mutant flight and ground control sample comparisons.

Figure 3.

Identification of gene of interest. The volcano plot generated after DESeq 2 analysis for the sei mutant ground control and flight sample comparison is illustrated. The top twenty most significantly up or down-regulated genes are labeled on the plot. Note that rdgA, our gene of interest, is significantly downregulated.
Identification of gene of interest. The volcano plot generated after DESeq 2 analysis for the sei mutant ground control and flight sample comparison is illustrated. The top twenty most significantly up or down-regulated genes are labeled on the plot. Note that rdgA, our gene of interest, is significantly downregulated.

Figure 4.

Gene Ontology Analysis. GoSeq pathway analysis indicated that proteolysis was a highly enriched biological process and serine-type endopeptidase activity was a highly enriched molecular function.
Gene Ontology Analysis. GoSeq pathway analysis indicated that proteolysis was a highly enriched biological process and serine-type endopeptidase activity was a highly enriched molecular function.
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