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Gravitational and Space Research
Volume 12 (2024): Issue 1 (January 2024)
Open Access
Diacylglycerol kinase is downregulated in the Drosophila Seizure Mutant during Spaceflight
Fiona Samson
Fiona Samson
,
Aadya Bhat
Aadya Bhat
,
Zachary Sayyah
Zachary Sayyah
,
Sigrid Reinsch
Sigrid Reinsch
and
Elizabeth Blaber
Elizabeth Blaber
| Mar 21, 2024
Gravitational and Space Research
Volume 12 (2024): Issue 1 (January 2024)
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Article Category:
Research Note
Published Online:
Mar 21, 2024
Page range:
41 - 45
DOI:
https://doi.org/10.2478/gsr-2024-0002
Keywords
Diacylglycerol kinase
,
Longevity
,
Spaceflight
,
Drosophila
,
GeneLab Galaxy
© 2024 Fiona Samson et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1.
Statistical significance analysis. This histogram represents the statistical significance of the data based on p-value, specifically for the sei mutant flight and ground control comparison. If the p-value is less than 0.05, the data is significant. As the peak is closest to the origin, this graph indicates that this is an excellent data set for further analyses.
Figure 2.
The principal component analysis. PCA plot signifies the variance between the spaceflight and ground control groups. More variance in PC1 indicates a higher difference in the pattern of expression between ground controls and flight samples. This pattern is observed in the sei mutant flight and ground control sample comparisons.
Figure 3.
Identification of gene of interest. The volcano plot generated after DESeq 2 analysis for the sei mutant ground control and flight sample comparison is illustrated. The top twenty most significantly up or down-regulated genes are labeled on the plot. Note that rdgA, our gene of interest, is significantly downregulated.
Figure 4.
Gene Ontology Analysis. GoSeq pathway analysis indicated that proteolysis was a highly enriched biological process and serine-type endopeptidase activity was a highly enriched molecular function.