A Laboratory Method to Measure Skin Surface Staining by Cigarette Smoke, Tobacco Heating Products and E-Cigarettes

1 Schaller, J.-P., D. Keller, L. Poget, P. Pratte, E. Kaelin, D. McHugh, G. Cudazzo, D. Smart, A.R. Tricker, L. Gautier, M. Yerly, R. Reis Pires, S. Le Bouhellec, D. Ghosh, I. Hofer, E. Garcia, P. Vanscheeuwijck, and S. Maeder: Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aerosol; Regul. Toxicol. Pharmacol. 81, Suppl. 2 (2016) S27–S47. DOI: 10.1016/j.yrtph.2016.10.001 SchallerJ.-P. KellerD. PogetL. PratteP. KaelinE. McHughD. CudazzoG. SmartD. TrickerA.R. GautierL. YerlyM. Reis PiresR. Le BouhellecS. GhoshD. HoferI. GarciaE. VanscheeuwijckP. MaederS. Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical Composition, Genotoxicity, Cytotoxicity, and Physical Properties of the Aeroso Regul. Toxicol. Pharmacol. 81 Suppl. 2 2016 S27 S47 10.1016/j.yrtph.2016.10.001 Open DOISearch in Google Scholar

2 Forster, M., S. Fiebelkorn, C. Yurteri, D. Mariner, C. Liu, C. Wright, K. McAdam, J. Murphy, and C. Proctor: Assessment of Novel Tobacco Heating Product THP1.0. Part 3: Comprehensive Chemical Characterisation of Harmful and Potentially Harmful Aerosol Emissions; Regul. Toxicol. Pharmacol. 93 (2018) 14–33. DOI: 10.1016/j.yrtph.2017.10.006 ForsterM. FiebelkornS. YurteriC. MarinerD. LiuC. WrightC. McAdamK. MurphyJ. ProctorC. Assessment of Novel Tobacco Heating Product THP1.0. Part 3: Comprehensive Chemical Characterisation of Harmful and Potentially Harmful Aerosol Emissions Regul. Toxicol. Pharmacol. 93 2018 14 33 10.1016/j.yrtph.2017.10.006 Open DOISearch in Google Scholar

3 Baker, R.R. and C.J. Proctor: The Origins and Properties of Environmental Tobacco Smoke; Environ. Int. 16 (1990) 231–245. DOI: 10.1016/0160-4120(90)90117-O BakerR.R. ProctorC.J. The Origins and Properties of Environmental Tobacco Smoke Environ. Int. 16 1990 231 245 10.1016/0160-4120(90)90117-O Open DOISearch in Google Scholar

4 Rodgman, A. and T.A. Perfetti: The Chemical Components of Tobacco and Tobacco Smoke, 2^nd Edition; CRC Press, Boca Raton, FL, USA, 2013. RodgmanA. PerfettiT.A. The Chemical Components of Tobacco and Tobacco Smoke 2nd Edition CRC Press Boca Raton, FL, USA 2013 Search in Google Scholar

5 Noguchi, M., S. Tanaka, K. Watanabe, and A. Yamasaki: Correlation Between Odor Concentration and Volatile Organic Compounds (VOC) Composition of Environmental Tobacco Smoke (ETS); Int. J. Environ. Res. Public Health 13 (2016) 994. DOI: 10.3390/ijerph13100994 NoguchiM. TanakaS. WatanabeK. YamasakiA. Correlation Between Odor Concentration and Volatile Organic Compounds (VOC) Composition of Environmental Tobacco Smoke (ETS) Int. J. Environ. Res. Public Health 13 2016 994 10.3390/ijerph13100994508673327735848 Open DOISearch in Google Scholar

6 Dalrymple, A., T.C. Badrock, A. Terry, E.-J. Bean, M. Barber, P.J. Hall, S. Coburn, J. McAughey, and J. Murphy: Development of a Novel Method to Measure Material Surface Staining by Cigarette, E-Cigarette or Tobacco Heating Product Aerosols; Heliyon 6 (2020) e05012. DOI: 10.1016/j.heliyon.2020.e05012 DalrympleA. BadrockT.C. TerryA. BeanE.-J. BarberM. HallP.J. CoburnS. McAugheyJ. MurphyJ. Development of a Novel Method to Measure Material Surface Staining by Cigarette, E-Cigarette or Tobacco Heating Product Aerosols Heliyon 6 2020 e05012 10.1016/j.heliyon.2020.e05012751180632995648 Open DOISearch in Google Scholar

7 Alandia-Roman, C.C., D.R. Cruvinel, A.B.S. Sousa, F.C.P. Pires-de-Souza, and H. Panzeri: Effect of Cigarette Smoke on Color Stability and Surface Roughness of Dental Composites; J. Dent. 41 (2013) e73–e79. DOI: 10.1016/j.jdent.2012.12.004 Alandia-RomanC.C. CruvinelD.R. SousaA.B.S. Pires-de-SouzaA.B.S. PanzeriH. Effect of Cigarette Smoke on Color Stability and Surface Roughness of Dental Composites J. Dent. 41 2013 e73 e79 10.1016/j.jdent.2012.12.00423270748 Open DOISearch in Google Scholar

8 Bergström, J.: Tobacco Smoking and Chronic Destructive Periodontal Disease; Odontology 92 (2004) 1–8. DOI: 10.1007/s10266-004-0043-4 BergströmJ. Tobacco Smoking and Chronic Destructive Periodontal Disease Odontology 92 2004 1 8 10.1007/s10266-004-0043-415490298 Open DOISearch in Google Scholar

9 Dalrymple, A., T.C. Badrock, A. Terry, M. Barber, P.J. Hall, D. Thorne, M.D. Gaca, S. Coburn, and C. Proctor: Assessment of Enamel Discoloration In Vitro Following Exposure to Cigarette Smoke and Emissions from Novel Vapor and Tobacco Heating Products; Am. J. Dent. 31 (2018) 227–233. DalrympleA. BadrockT.C. TerryA. BarberM. HallP.J. ThorneD. GacaM.D. CoburnS. ProctorC. Assessment of Enamel Discoloration In Vitro Following Exposure to Cigarette Smoke and Emissions from Novel Vapor and Tobacco Heating Products Am. J. Dent. 31 2018 227 233 Search in Google Scholar

10 Ortiz, A. and S.A. Grando: Smoking and the Skin; Int. J. Dermatol. 51 (2012) 250–262. DOI: 10.1111/j.1365-4632.2011.05205.x OrtizA. GrandoS.A. Smoking and the Skin Int. J. Dermatol. 51 2012 250 262 10.1111/j.1365-4632.2011.05205.x22348557 Open DOISearch in Google Scholar

11 Mallock, N., L. Böss, R. Burk, M. Danziger, T. Welsch, H. Hahn, H.L. Trieu, J. Hahn, E. Pieper, F. Henkler-Stephani, C. Hutzler, and A. Luch: Levels of Selected Analytes in the Emissions of “Heat Not Burn” Tobacco Products that are Relevant to Assess Human Health Risks; Arch. Toxicol. 92 (2018) 2145–2149. DOI: 10.1007/s00204-018-2215-y MallockN. BössL. BurkR. DanzigerM. WelschT. HahnH. TrieuH.L. HahnJ. PieperE. Henkler-StephaniF. HutzlerC. LuchA. Levels of Selected Analytes in the Emissions of “Heat Not Burn” Tobacco Products that are Relevant to Assess Human Health Risks Arch. Toxicol. 92 2018 2145 2149 10.1007/s00204-018-2215-y600245929730817 Open DOISearch in Google Scholar

12 Margham, J., K. McAdam, M. Forster, C. Liu, C. Wright, D. Mariner, and C. Proctor: Chemical Composition of an E-Cigarette Aerosol - A Quantitative Comparison with Cigarette Smoke; Chem. Res. Toxicol. 29 (2016) 1662–1678. DOI: 10.1021/acs.chemrestox.6b00188 MarghamJ. McAdamK. ForsterM. LiuC. WrightC. MarinerD. ProctorC. Chemical Composition of an E-Cigarette Aerosol - A Quantitative Comparison with Cigarette Smoke Chem. Res. Toxicol. 29 2016 1662 1678 10.1021/acs.chemrestox.6b0018827641760 Open DOISearch in Google Scholar

13 Tayyarah, R. and G.A. Long: Comparison of Select Analytes in Aerosol from E-Cigarettes with Smoke from Conventional Cigarettes and with Ambient Air; Regul. Toxicol. Pharmacol. 70 (2014) 704–710. DOI: 10.1016/j.yrtph.2014.10.010 TayyarahR. LongG.A. Comparison of Select Analytes in Aerosol from E-Cigarettes with Smoke from Conventional Cigarettes and with Ambient Air Regul. Toxicol. Pharmacol. 70 2014 704 710 10.1016/j.yrtph.2014.10.01025444997 Open DOISearch in Google Scholar

14 Committees on Toxicity, Carcinogenicity and Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COT, COC and COM): Statement on the Toxicological Evaluation of Novel Heat-Not-Burn Tobacco Products; 2017. Available at https://cot.food.gov.uk/sites/default/files/heat_not_burn_tobacco_statement.pdf (accessed October 19, 2020) Committees on Toxicity, Carcinogenicity and Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COT, COC and COM) Statement on the Toxicological Evaluation of Novel Heat-Not-Burn Tobacco Products 2017 Available at https://cot.food.gov.uk/sites/default/files/heat_not_burn_tobacco_statement.pdf (accessed October 19, 2020) Search in Google Scholar

15 Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT): Statement on the Potential Toxicological Risks from Electronic Nicotine (and Non-Nicotine) Delivery Systems (E(N)NDS - E-Cigarettes); 2020. Available at https://cot.food.gov.uk/sites/default/files/2020-09/COT%20E%28N%29NDS%20statement%202020-04.pdf (accessed September 17, 2020) Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) Statement on the Potential Toxicological Risks from Electronic Nicotine (and Non-Nicotine) Delivery Systems (E(N)NDS - E-Cigarettes) 2020 Available at https://cot.food.gov.uk/sites/default/files/2020-09/COT%20E%28N%29NDS%20statement%202020-04.pdf (accessed September 17, 2020) Search in Google Scholar

16 Food and Drug Administration (FDA): FDA Permits Sale of IQOS Tobacco Heating System Through Premarket Tobacco Product Application Pathway; 2019. Available at https://www.fda.gov/news-events/press-announcements/fda-permits-sale-iqos-tobacco-heating-system-through-premarket-tobacco-product-application-pathway (accessed October 19, 2020) Food and Drug Administration (FDA) FDA Permits Sale of IQOS Tobacco Heating System Through Premarket Tobacco Product Application Pathway 2019 Available at https://www.fda.gov/news-events/press-announcements/fda-permits-sale-iqos-tobacco-heating-system-through-premarket-tobacco-product-application-pathway (accessed October 19, 2020) Search in Google Scholar

17 McNeill, A., L.S. Brose, R. Calder, S.C. Hitchman, P. Hajek, and H. McRobbie: E-Cigarettes: An Evidence Update. A Report Commissioned by Public Health England; 2015. Available at https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/457102/Ecigarettes_an_evidence_update_A_report_commissioned_by_Public_Health_England_FINAL.pdf (accessed October 19, 2020) McNeillA. BroseL.S. CalderR. HitchmanS.C. HajekP. McRobbieH. E-Cigarettes: An Evidence Update. A Report Commissioned by Public Health England 2015 Available at https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/457102/Ecigarettes_an_evidence_update_A_report_commissioned_by_Public_Health_England_FINAL.pdf (accessed October 19, 2020) Search in Google Scholar

18 McNeill, A., L.S. Brose, R. Calder, L. Bauld, and D. Robson: Evidence Review of E-Cigarettes and Heated Tobacco Products. A Report Commissioned by Public Health England; 2018. Available at https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/684963/Evidence_review_of_e-cigarettes_and_heated_tobacco_products_2018.pdf (accessed October 19, 2020) McNeillA. BroseL.S. CalderR. BauldL. RobsonD. Evidence Review of E-Cigarettes and Heated Tobacco Products. A Report Commissioned by Public Health England 2018 Available at https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/684963/Evidence_review_of_e-cigarettes_and_heated_tobacco_products_2018.pdf (accessed October 19, 2020) Search in Google Scholar

19 International Organization for Standardization (ISO): ISO 3402:1999 – Tobacco and Tobacco Products – Atmosphere for Conditioning and Testing; 1999. Available at https://www.iso.org/standard/28324.html (accessed October 19, 2020) International Organization for Standardization (ISO) ISO 3402:1999 – Tobacco and Tobacco Products – Atmosphere for Conditioning and Testing 1999 Available at https://www.iso.org/standard/28324.html (accessed October 19, 2020) Search in Google Scholar

20 Combes, R., K. Scott, I. Crooks, D. Dillon, C. Meredith, K. McAdam, and C. Proctor: The In Vitro Cytotoxicity and Genotoxicity of Cigarette Smoke Particulate Matter with Reduced Toxicant Yields; Toxicol. In Vitro 27 (2013) 1533–1541. DOI: 10.1016/j.tiv.2013.03.005 CombesR. ScottK. CrooksI. DillonD. MeredithC. McAdamK. ProctorC. The In Vitro Cytotoxicity and Genotoxicity of Cigarette Smoke Particulate Matter with Reduced Toxicant Yields Toxicol. In Vitro 27 2013 1533 1541 10.1016/j.tiv.2013.03.00523542039 Open DOISearch in Google Scholar

21 Thorne, D., I. Crooks, M. Hollings, A. Seymour, C. Meredith, and M. Gaca: The Mutagenic Assessment of an Electronic-Cigarette and Reference Cigarette Smoke Using the Ames Assay in Strains TA98 and TA100; Mutat. Res. 812 (2016) 29–38. DOI: 10.1016/j.mrgentox.2016.10.005 ThorneD. CrooksI. HollingsM. SeymourA. MeredithC. GacaM. The Mutagenic Assessment of an Electronic-Cigarette and Reference Cigarette Smoke Using the Ames Assay in Strains TA98 and TA100 Mutat. Res. 812 2016 29 38 10.1016/j.mrgentox.2016.10.00527908385 Open DOISearch in Google Scholar

22 de Souza Araujo Wasilewski, M., M.K. Takahashi, G.A. Kirsten, and E.M. de Souza: Effect of Cigarette Smoke and Whiskey on the Color Stability of Dental Composites; Am. J. Dent. 23 (2010) 4–8. de Souza Araujo WasilewskiM. TakahashiM.K. KirstenG.A. de SouzaE.M. Effect of Cigarette Smoke and Whiskey on the Color Stability of Dental Composites Am. J. Dent. 23 2010 4 8 Search in Google Scholar

23 Adamson, J., C. Kanitscheider, K. Prasad, O.M. Camacho, E. Beyerlein, Y.K. Bhagavan, C. Proctor, and J. Murphy: Results from a 2018 Cross-Sectional Survey in Tokyo, Osaka and Sendai to Assess Tobacco and Nicotine Product Usage after the Introduction of Heated Tobacco Products (HTPs) in Japan; Harm. Reduct. J. 17 (2020) 32. DOI: 10.1186/s12954-020-00374-3 AdamsonJ. KanitscheiderC. PrasadK. CamachoO.M. BeyerleinE. BhagavanY.K. ProctorC. MurphyJ. Results from a 2018 Cross-Sectional Survey in Tokyo, Osaka and Sendai to Assess Tobacco and Nicotine Product Usage after the Introduction of Heated Tobacco Products (HTPs) in Japan Harm. Reduct. J 17 2020 32 10.1186/s12954-020-00374-3724964832450856 Open DOISearch in Google Scholar

24 Summerfield, A., F. Meurens, and M.E. Ricklin: The Immunology of the Porcine Skin and its Value as a Model for Human Skin; Mol. Immunol. 66 (2015) 14–21. DOI: 10.1016/j.molimm.2014.10.023 SummerfieldA. MeurensF. RicklinM.E. The Immunology of the Porcine Skin and its Value as a Model for Human Skin Mol. Immunol. 66 2015 14 21 10.1016/j.molimm.2014.10.02325466611 Open DOISearch in Google Scholar

25 Zatz, J.L.: Scratching the Surface: Rationale and Approaches to Skin Permeation; in: Skin Permeation Fundamentals and Application, edited by J. Zatz, Allured Publishing Corporation, Wheaton, IL, USA, 1993, pp. 11–31. ZatzJ.L. Scratching the Surface: Rationale and Approaches to Skin Permeation in: Skin Permeation Fundamentals and Application edited by ZatzJ. Allured Publishing Corporation Wheaton, IL, USA 1993 11 31 Search in Google Scholar

26 Thorne, D., D. Breheny, C. Proctor, and M. Gaca: Assessment of Novel Tobacco Heating Product THP1.0. Part 7: Comparative In Vitro Toxicological Evaluation; Regul. Toxicol. Pharmacol. 93 (2018) 71–83. DOI: 10.1016/j.yrtph.2017.08.017 ThorneD. BrehenyD. ProctorC. GacaM. Assessment of Novel Tobacco Heating Product THP1.0. Part 7: Comparative In Vitro Toxicological Evaluation Regul. Toxicol. Pharmacol. 93 2018 71 83 10.1016/j.yrtph.2017.08.01729080850 Open DOISearch in Google Scholar

27 Prieux, R., M. Eeman, B. Rothen-Rutishauser, and G. Valacchi: Mimicking Cigarette Smoke Exposure to Assess Cutaneous Toxicity; Toxicol. In Vitro 62 (2020) 104664. DOI: 10.1016/j.tiv.2019.104664 PrieuxR. EemanM. Rothen-RutishauserB. ValacchiG. Mimicking Cigarette Smoke Exposure to Assess Cutaneous Toxicity Toxicol. In Vitro 62 2020 104664 10.1016/j.tiv.2019.10466431669394 Open DOISearch in Google Scholar

28 Soeur, J., J.-P. Belaïdi, C. Chollet, L. Denat, A. Dimitrov, C. Jones, P. Perez, M. Zanini, O. Zobiri, S. Mezzache, D. Erdmann, G. Lereaux, J. Eilstein, and L. Marrot: Photo-Pollution Stress in Skin: Traces of Pollutants (PAH and Particulate Matter) Impair Redox Homeostasis in Keratinocytes Exposed to UVA1; J. Dermatol. Sci. 86 (2017) 162–169. DOI: 10.1016/j.jdermsci.2017.01.007 SoeurJ. BelaïdiJ.-P. CholletC. DenatL. DimitrovA. JonesC. PerezP. ZaniniM. ZobiriO. MezzacheS. ErdmannD. LereauxG. EilsteinJ. MarrotL. Photo-Pollution Stress in Skin: Traces of Pollutants (PAH and Particulate Matter) Impair Redox Homeostasis in Keratinocytes Exposed to UVA1 J. Dermatol. Sci. 86 2017 162 169 10.1016/j.jdermsci.2017.01.00728153538 Open DOISearch in Google Scholar

29 Health Canada: Determination of “Tar”, Nicotine and Carbon Monoxide in Mainstream Tobacco Smoke; 1999. Available at https://healthycanadians.gc.ca/en/open-information/tobacco/t100/nicotine (accessed October 19, 2020) Health Canada Determination of “Tar”, Nicotine and Carbon Monoxide in Mainstream Tobacco Smoke 1999 Available at https://healthycanadians.gc.ca/en/open-information/tobacco/t100/nicotine (accessed October 19, 2020) Search in Google Scholar

30 Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA): CORESTA Recommended Method No. 81. Routine Analytical Machine for E-Cigarette Aerosol Generation and Collection – Definitions and Standard Conditions; 2015. Available at https://www.coresta.org/sites/default/files/technical_documents/main/CRM_81.pdf (accessed October 19, 2020) Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) CORESTA Recommended Method No. 81. Routine Analytical Machine for E-Cigarette Aerosol Generation and Collection – Definitions and Standard Conditions 2015 Available at https://www.coresta.org/sites/default/files/technical_documents/main/CRM_81.pdf (accessed October 19, 2020) Search in Google Scholar