<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of the present study is to evaluate the total phenolic contents, antioxidant and anti-proliferative activities of the <italic>n</italic>-BuOH extract of <italic>Centaurea maroccana</italic> (BECM). The total phenolic and flavonoid of the butanolic extract of the plant were assessed by using Folin-Ciocalteau and aluminium chloride colorimetric assays, respectively, and the quantitative estimation of total flavonoids and phenols revealed the richness of the extract in these compounds. Antioxidant activity was evaluated using standard lab colorimetric methods, while the anti-proliferative activity was evaluated using sulforhodamine B (SRB) assay against C6 (<italic>Rattus norvegicus</italic> brain glioma) and HT29 (<italic>Homo sapiens</italic> colorectal adenocarcinoma) cell lines. The <italic>n</italic>-butanolic extract of <italic>Centaurea maroccana</italic> showed a strong antioxidant activity through DPPH, ABTS<sup>•+</sup>, DMSO alkalin, Reducing power, β-Carotene-linoleic acid and CUPRAC assays. Furthermore, the anti-proliferative activity against C6 and HT29 of <italic>Centaurea maroccana</italic> exhibited a high effect by the decrease in viability of both cancer cell lines. Our results suggest a possible use of <italic>Centaurea maroccana</italic> as a source of natural antioxidant and chemo-preventive agents against cancer.</p></abstract>

The aim of the present study is to evaluate the total phenolic contents, antioxidant and anti-proliferative activities of the n-BuOH extract of Centaurea maroccana (BECM). The total phenolic and flavonoid of the butanolic extract of the plant were assessed by using Folin-Ciocalteau and aluminium chloride colorimetric assays, respectively, and the quantitative estimation of total flavonoids and phenols revealed the richness of the extract in these compounds. Antioxidant activity was evaluated using standard lab colorimetric methods, while the anti-proliferative activity was evaluated using sulforhodamine B (SRB) assay against C6 (Rattus norvegicus brain glioma) and HT29 (Homo sapiens colorectal adenocarcinoma) cell lines. The n-butanolic extract of Centaurea maroccana showed a strong antioxidant activity through DPPH, ABTS•+, DMSO alkalin, Reducing power, β-Carotene-linoleic acid and CUPRAC assays. Furthermore, the anti-proliferative activity against C6 and HT29 of Centaurea maroccana exhibited a high effect by the decrease in viability of both cancer cell lines. Our results suggest a possible use of Centaurea maroccana as a source of natural antioxidant and chemo-preventive agents against cancer.

Antioxidant and antiproliferative activities of the <italic>n</italic>-butanol extract of <italic>Centaurea maroccana</italic> Ball aerial parts

Laboratory of Biology and Environment, Faculty of Sciences of Nature and Life

Department of Molecular Biology and Genetics

Faculty of Arts and Sciences, Department of Chemistry

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antioxidant and antiproliferative activities of the -butanol extract of  Ball aerial parts

The aim of the present study is to evaluate the total phenolic contents, antioxidant and anti-proliferative activities of the n-BuOH extract of Centaurea...

Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts

Online veröffentlicht: 22. März 2021

Seitenbereich: 5 - 11

Eingereicht: 08. Mai 2020

Akzeptiert: 10. Okt. 2020

DOI: https://doi.org/10.2478/cipms-2021-0002

Schlüsselwörter
phenolic contents, antioxidant activity, anti-proliferative activity

© 2021 Imen Aissous et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antioxidant and antiproliferative activities of the n-butanol extract of Centaurea maroccana Ball aerial parts

Online veröffentlicht: 22. März 2021

Seitenbereich: 5 - 11

Eingereicht: 08. Mai 2020

Akzeptiert: 10. Okt. 2020

DOI: https://doi.org/10.2478/cipms-2021-0002

Schlüsselwörterphenolic contents, antioxidant activity, anti-proliferative activity

© 2021 Imen Aissous et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Schlüsselwörter
phenolic contents, antioxidant activity, anti-proliferative activity