Epigenetics is Promising Direction in Modern Science

[1] Bird A. Perceptions of epigenetics. Nature. 2007;447(7143):396-8. DOI: 10.1038/nature05913.10.1038/nature05913 Search in Google Scholar

[2] Ashapkin VV, Kutueva LI, Vanyushin BF. The gene for domains rearranged methyltransferase (DRM2) in Arabidopsis thaliana plants is methylated at both cytosine and adenine residues. FEBS Lett. 2002;532(3):367-72. DOI: 10.1016/s0014-5793(02)03711-0.10.1016/S0014-5793(02)03711-0 Search in Google Scholar

[3] Chow J, Heard E. X inactivation and the complexities of silencing a sex chromosome. Current Opinion Cell Biol. 2009;21:359-66. DOI: 10.1016/j.ceb.2009.04.012.10.1016/j.ceb.2009.04.01219477626 Search in Google Scholar

[4] Singh RK, Prasad M. Delineating the epigenetic regulation of heat and drought response in plants. Critical Rev Biotechnol. 2021:1-4. DOI: 10.1080/07388551.2021.1946004.10.1080/07388551.2021.194600434289772 Search in Google Scholar

[5] Jiang W, Xia T, Liu C, Li J, Zhang W, Sun C. Remodeling the epigenetic landscape of cancer - Application potential of flavonoids in the prevention and treatment of cancer. Frontiers Oncol. 2021;11:2331. DOI: 10.3389/fonc.2021.705903.10.3389/fonc.2021.705903825597234235089 Search in Google Scholar

[6] Bartholdy B, Lajugie J, Yan Z, Zhang S, Mukhopadhyay R, Greally J. et al. Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation. Blood Adv. 2018;2(15):1833-52. DOI: 10.1182/bloodadvances.2018015651.10.1182/bloodadvances.2018015651609374130061308 Search in Google Scholar

[7] de Oliveira DT, Guerra-Sa R. Uncovering epigenetic landscape: a new path for biomarkers identification and drug development. Molecular Biol Reports. 2020;47:9097-122. DOI: 10.1007/s11033-020-05916-3.10.1007/s11033-020-05916-333089404 Search in Google Scholar

[8] Ehrlich M. DNA hypermethylation in disease: mechanisms and clinical relevance. J Epigenetics. 2019;14:1141-63. DOI: 10.1080/15592294.2019.1638701.10.1080/15592294.2019.1638701679169531284823 Search in Google Scholar

[9] Wilson AS, Power BE, Molloy PL. DNA hypomethylation and human diseases. Biochim Biophys Acta. 2007;1775:138-62. DOI: 10.1016/j.bbcan.2006.08.007.10.1016/j.bbcan.2006.08.00717045745 Search in Google Scholar

[10] Le Hellard S, Keller MC, Andreassen OA, Deary IJ, Glahn DC, Malhotra AK. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Mol Psychiatry. 2017;22(3):336-45. DOI: 10.1038/mp.2016.244.10.1038/mp.2016.244532227228093568 Search in Google Scholar

[11] Ashapkin VV, Kutueva LI, Vanyushin BF. Aging as an epigenetic phenomenon. Curr Genomics. 2017;18(5):385-407. DOI: 10.2174/1389202918666170412112130.10.2174/1389202918666170412112130563564529081695 Search in Google Scholar

[12] Ryabukha OI, Fedorenko VI. To the structural and functional preconditions of the emergence of thyroid pathology (literature review). Medicni Perspektivi. 2021;26(3):169-78. DOI: 10.26641/2307-0404.2021.3.242253.10.26641/2307-0404.2021.3.242253 Search in Google Scholar

[13] Ashapkin VV, Kutueva LI, Vanyushin BF. Epigenetic clock: Just a convenient marker or an active driver of aging? Adv Exp Med Biol. 2019;1178:175-206. DOI: 10.1007/978-3-030-25650-0_10.10.1007/978-3-030-25650-0_1031493228 Search in Google Scholar

[14] Gangisetty O, Cabrera MA, Murugan S. Impact of epigenetics in aging and age related neurodegenerative diseases. Front Biosci (Landmark Ed). 2018;23:1445-64. DOI: 10.2741/4654.10.2741/465429293444 Search in Google Scholar

[15] Korda Z, Pishva E, van den Hove DL. Epigenetics in Drug Discovery: Achievements and Challenges. In: Modern CNS Drug Discovery. Cham: Springer; 2021;57-75. DOI: 10.1007/978-3-030-62351-7_4.10.1007/978-3-030-62351-7_4 Search in Google Scholar

[16] Oda M, Glass JL, Thompson RF, Mo Y, Olivier EN, Figueroa ME et al. High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers. Nucleic Acids Res. 2009;37:3829-39. DOI: 10.1093/nar/gkp260.10.1093/nar/gkp260270956019386619 Search in Google Scholar

[17] Yi SV, Goodisman MA. The impact of epigenetic information on genome evolution. Phil Trans Royal Soc B. 2021;376(1826):20200114. DOI: 10.1098/rstb.2020.0114.10.1098/rstb.2020.0114805997833866804 Search in Google Scholar

[18] Baribault C, Ehrlich KC, Ponnaluri VKC. Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription. Epigenetics. 2018;2:1-15. DOI: 10.1080/15592294.2018.1445900.10.1080/15592294.2018.1445900599715729498561 Search in Google Scholar

[19] Kundakovic M, Jiang Y, Kavanagh DH, Dincer A, Brown L, Pothula V, et al. Practical guidelines for high-resolution epigenomic profiling of nucleosomal histones in postmortem human brain tissue. Biol Psychiatry. 2017;81(2);162-70. DOI: 10.1016/j.Biopsych.2016.03.1048.10.1016/j.biopsych.2016.03.1048501789727113501 Search in Google Scholar

[20] Aref-Eshghi E, Rodenhiser DI, Schenkel LC. Genomic DNA methylation signatures enable concurrent diagnosis and clinical genetic variant classification in neurodevelopmental syndromes. Am J Hum Genet. 2018;102(1):156-74. DOI: 10.1016/j.ajhg.2017.12.008.10.1016/j.ajhg.2017.12.008577798329304373 Search in Google Scholar

[21] Mazzone R, Zwergel C, Artico M. The emerging role of epigenetics in human autoimmune disorders. Clin Epigenetics. 2019;11(1):34. DOI: 10.1186/s13148-019-0632-2.10.1186/s13148-019-0632-2639037330808407 Search in Google Scholar

[22] Evans LM, Tahmasbi R, Vrieze SI, Abecasis GR, Das S, Gazal S, et al. Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. Nat Genet. 2018; 50(5):737-45. DOI: 10.1038/s41588-018-0108-x.10.1038/s41588-018-0108-x593435029700474 Search in Google Scholar

[23] Collings CK, Anderson JN. Links between DNA methylation and nucleosome occupancy in the human genome. Epigenetics Chromatin. 2017;10(18):1-19. DOI: 10.1186/s13072-017-0125-5.10.1186/s13072-017-0125-5538734328413449 Search in Google Scholar

[24] Kane AE, Sinclair DA. Epigenetic changes during aging and their reprogramming potential. Crit Rev Biochem Mol Biol. 2019;54(1):61-83. DOI: 10.1080/10409238.2019.1570075.10.1080/10409238.2019.1570075642462230822165 Search in Google Scholar

[25] Ummarino S, Hausman C, Gaggi G, Rinaldi L, Bassal MA, Zhang Y, et al. NAD modulates DNA methylation and cell differentiation. Cells. 2021;10(11):2986:1-17. DOI: 10.3390/cells10112986.10.3390/cells10112986861646234831209 Search in Google Scholar

[26] Mochizuki K, Hariya N, Kubota T. Novel models of epigenetic gene regulation in the nutritional environment. Adv Exp Med Biol. 2018;1012:11-8. DOI: 10.1007/978-981-10-5526-3_2.10.1007/978-981-10-5526-3_229956190 Search in Google Scholar

[27] Hitchler MJ, Domann FE. The epigenetic and morphogenetic effects of molecular oxygen and its derived reactive species in development. Free Radic Biol Med. 2021;170:70-84. DOI: 10.1016/j.freeradbiomed.2021.01.008.10.1016/j.freeradbiomed.2021.01.008821708433450377 Search in Google Scholar

[28] Domann FE, Hitchler MJ. Aberrant redox biology and epigenetic reprogramming: Co-conspirators across multiple human diseases. Free Radic Biol Med. 2021;170:2-5. DOI: 10.1016/j.freeradbiomed.2021.04.020.10.1016/j.freeradbiomed.2021.04.020821731033932538 Search in Google Scholar

[29] Lamadema N, Burr S, Brewer AC. Dynamic regulation of epigenetic demethylation by oxygen availability and cellular redox. Free Radic Biol Med. 2019;131:282-98. DOI: 10.1016/j.freeradbiomed.2018.12.009.10.1016/j.freeradbiomed.2018.12.00930572012 Search in Google Scholar

[30] Kumar SRM, Wang Y, Zhang X, Cheng H, Sun L, He S, et al. Redox components: key regulators of epigenetic modifications in plants. Int J Mol Sci. 2020;21(4):1419. DOI: 10.3390/ijms21041419.10.3390/ijms21041419707303032093110 Search in Google Scholar

[31] Kumar S., Chinnusamy V., Mohapatra T. Epigenetics of modified DNA bases: 5-Methylcytosine and beyond. Front Genet. 2018;9:640-54. DOI: 10.3389/fgene.2018.00640.10.3389/fgene.2018.00640 Search in Google Scholar

[32] Kumar S, Cheng X, Klimasauskas S. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994;22(1):1-10. DOI: 10.1093/nar/22.1.1.10.1093/nar/22.1.1 Search in Google Scholar

[33] Rocha MS, Castro R, Rivera I, Kok RM, Smulders YM, Jakobs C. Global DNA methylation: comparison of enzymatic- and non-enzymatic-based methods. Clinical Chem Lab Medicine. 2010;48:1793-8. DOI: 10.1515/CCLM.2010.346.10.1515/CCLM.2010.346 Search in Google Scholar

[34] Neri F, Incarnato D, Oliviero S. DNA methylation and demethylation dynamics. Oncotarget. 2015;6(33):34049-50. DOI: 10.18632/oncotarget.6039.10.18632/oncotarget.6039 Search in Google Scholar

[35] Ito K, Barnes PJ, Adcock IM. Histone acetylation and deacetylation. Methods Mol Med. 2000;44:309-19. DOI: 10.1385/1-59259-072-1:309.10.1385/1-59259-072-1:309 Search in Google Scholar

[36] Rossetto D, Avvakumov N, Côté J. Histone phosphorylation. Epigenetics. 2012;7(10):1098-108. DOI: 10.4161/epi.21975.10.4161/epi.21975 Search in Google Scholar

[37] Osta AE, Wolffe AP. DNA Methylation and histone deacetylation in the control of gene expression: Basic biochemistry to human development and disease. Gene Expr. 2000;9(1-2):63-75. DOI: 10.3727/000000001783992731.10.3727/000000001783992731 Search in Google Scholar

[38] Matzke MA, Matzke AJ. Homology dependent gene silencing in transgenic plants: what does it really tells us. Trends Genet. 1995;11(1):1-2. DOI: 10.1016/s0168-9525(00)88973-8.10.1016/S0168-9525(00)88973-8 Search in Google Scholar

[39] Santos JH. Mitochondria signaling to the epigenome: A novel role for an old organelle. Free Radic Biol Med. 2021;170:59-69. DOI: 10.1016/j.freeradbiomed.2020.11.016. PMID: 3327128210.1016/j.freeradbiomed.2020.11.016816695933271282 Search in Google Scholar

[40] Stefanowicz D, Ullah J, Lee K, Shaheen F, Olumese E, Fishbane N, et al. Epigenetic modifying enzyme expression in asthmatic airway epithelial cells and fibroblasts. BMC Pulm Med. 2017;17(1):1-11. DOI: 10.1186/s12890-017-0371-0.10.1186/s12890-017-0371-0528273828137284 Search in Google Scholar

[41] Coppedè F. One-carbon epigenetics and redox biology of neurodegeneration. Free Radic Biol Med. 2021;170:19-33. DOI: 10.1016/j.freeradbiomed.2020.12.002.10.1016/j.freeradbiomed.2020.12.00233307166 Search in Google Scholar

[42] Hamza M, Halayem S, Mrad R, Bourgou S, Charfi F, Belhadj A. Epigenetics' implication in autism spectrum disorders: A review. Encephale. 2017;43(4):374-81. DOI: 10.1016/j.encep.2016.07.00710.1016/j.encep.2016.07.00727692350 Search in Google Scholar

[43] Brewer AC. Physiological interrelationships between NADPH oxidases and chromatin remodeling. Free Radic Biol Med. 2021;170:109-15. DOI: 10.1016/j.freeradbiomed.2021.01.052.10.1016/j.freeradbiomed.2021.01.05233556461 Search in Google Scholar

[44] Xiao X, Liu X, Jiao B. Epigenetics: Recent advances and its role in the treatment of Alzheimer's disease. Front Neurol. 2020;11:538301. DOI: 10.3389/fneur.2020.538301.10.3389/fneur.2020.538301759452233178099 Search in Google Scholar

[45] Xu M, Zhu J, Liu XD, Luo MY, Xu NJ. Roles of physical exercise in neurodegeneration: reversal of epigenetic clock. Transl Neurodegener. 2021;10:30-45. DOI: 10.1186/s40035-021-00254-1.10.1186/s40035-021-00254-1836162334389067 Search in Google Scholar

[46] Wang L, Yu CC, Liu XY, Deng XN, Tian Q, Du YJ. Epigenetic modulation of microglia function and phenotypes in neurodegenerative diseases. Neural Plast. 2021;2021:1-13. DOI: 10.1155/2021/9912686.10.1155/2021/9912686818109534194489 Search in Google Scholar

[47] Pierandrei S, Truglio G, Ceci F, Del Porto P, Bruno SM, Castellani S, et al. M. DNA methylation patterns correlate with the expression of SCNN1A, SCNN1B, and SCNN1G (epithelial sodium channel, ENaC) genes. Int J Mol Sci. 2021;22:3754. DOI: 10.3390/ijms22073754.10.3390/ijms22073754803845133916525 Search in Google Scholar

[48] Hogan R, Flamier A, Nardini E, Bernier G. The role of BMI1 in late-onset sporadic Alzheimer's disease. Genes (Basel). 2020;11:E825. DOI: 10.3390/genes11070825.10.3390/genes11070825739707432708145 Search in Google Scholar

[49] Murshid NM, Lubis FA, Makpol S. Epigenetic changes and its intervention in age-related neurodegenerative diseases. Cellular Molecular Neurobiol. 2020. DOI: 10.1007/s10571-020-00979-z.10.1007/s10571-020-00979-z33074454 Search in Google Scholar

[50] Titcombe P, Murray R, Hewitt M, Antoun E, Cooper C, Inskip HM, et al. Human non-CpG methylation patterns display both tissue-specific and inter-individual differences suggestive of underlying function. Epigenetics. 2021:1-12. DOI: 10.1080/15592294.2021.1950990.10.1080/15592294.2021.1950990923588734461806 Search in Google Scholar

[51] Coppedè F. One-carbon epigenetics and redox biology of neurodegeneration. Free Radical Biol Med. 2021;170:19-33. DOI: 10.1016/j.freeradbiomed.2020.12.002.10.1016/j.freeradbiomed.2020.12.00233307166 Search in Google Scholar

[52] Domann FE, Hitchler MJ. Introduction to the special issue on ‘epigenetics and redox signaling’. Free Radical Biol Med. 2021;170. DOI: 10.1016/j.freeradbiomed.2021.04.015.10.1016/j.freeradbiomed.2021.04.01533862159 Search in Google Scholar

[53] García-Giménez J-L. Garcés C, Romá-Mateo C, Pallardó FV. Oxidative stress-mediated alterations in histone post-translational modifications. Free Radical Biol Med. 2021;170:6-18. DOI: 10.1016/j.freeradbiomed.2021.02.027.10.1016/j.freeradbiomed.2021.02.02733689846 Search in Google Scholar

[54] Fernandez A, O'Leary C, O'Byrne KJ, Burgess J, Richard DJ, Suraweera A. Epigenetic mechanisms in DNA double strand break repair: A clinical review. Front Mol Biosci. 2021;8:685440. DOI: 10.3389/fmolb.2021.685440.10.3389/fmolb.2021.685440829279034307454 Search in Google Scholar

[55] Yang B, Chen Q. Cross-talk between oxidative stress and m⁶A RNA methylation in cancer. Oxid Med Cell Longev. 2021:1-26. DOI: 10.1155/2021/6545728.10.1155/2021/6545728841640034484567 Search in Google Scholar

[56] Börner JH, Rawashdeh O, Rami A. Exacerbated age-related hippocampal alterations of microglia morphology, β-amyloid and lipofuscin deposition and presenilin overexpression in per1^−/−-mice. Antioxidants (Basel). 2021;10(9):1330. DOI: 10.3390/antiox10091330.10.3390/antiox10091330846902134572962 Search in Google Scholar

[57] Ebrahimi SO, Reiisi S, Shareef S. miRNAs, oxidative stress, and cancer: A comprehensive and updated review. J Cell Physiol. 2020;235(11):8812-25. DOI: 10.1002/jcp.29724.10.1002/jcp.2972432394436 Search in Google Scholar

[58] Dionisio PA, Amaral JD, Rodrigues CMP. Oxidative stress and regulated cell death in Parkinson's disease. Ageing Res Rev. 2021;67. DOI: 10.1016/j.arr.2021.101263.10.1016/j.arr.2021.10126333540042 Search in Google Scholar

[59] Barbieri M. A new theory of development: the generation of complexity in ontogenesis. Phil Trans Royal Soc Math Phys Eng Sci. 2016:1-13. DOI: 10.1098/rsta.2015.0148.10.1098/rsta.2015.014826857661 Search in Google Scholar