The interaction of female age and active male smoking has negative influence on success rates of the in vitro fertilization treatments
| 26. Aug. 2020
Über diesen Artikel
Article Category: Original Article
Online veröffentlicht: 26. Aug. 2020
Seitenbereich: 57 - 62
DOI: https://doi.org/10.2478/bjmg-2020-0005
Schlüsselwörter
© 2020 Petanovska Kostova E, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Demographic characteristics of patients in relation to male smoking status.
| Parameters | Male Non Smokers | Male Smokers | |
|---|---|---|---|
| Number of patients | 329 (46.87%) | 373 (53.13%) | |
| Males (age) (mean±SD) | 36.5±5.2 | 35.1±4.5 | 0.00015 A |
| Females (age) (mean±SD) | 31.5±3.9 | 32.2±4.4 | 0.027 A |
| Number of Female smokers (%) | 117 (35.56%) | 132 (35.39%) | 0.96 |
| Female BMI (mean±SD) | 24.3±4.05 | 24.6±3.90 | 0.36 |
parameters.
| Male Variables (mean±SD) | Male Non Smokers | Male Smokers | Mann-Whitney U Test | Significant |
|---|---|---|---|---|
| Number of retrieved oocytes (median) | 10.8±6.6 (10) | 11.1±16.9(10) | Z=0.17 | 0.86 |
| Number of mature oocytes (median) | 9.0±5.7 (8) | 9.2±15.9 (8) | Z=0.02 | 0.98 |
| Number of fertilized oocytes (median) | 6.8±4.2 (6) | 6.8±14.5 (6) | Z=0.4 | 0.67 |
| Fertilization rate | 0.8±0.2 | 0.8±0.2 | Z=0.19 | 0.85 |
| Number of excellent quality transferred embryos (median) | 2.3±0.7 (2) | 2.3±0.8 (3) | Z=0.9 | 0.35 |
| Number of transferred embryos (median) | 2.6±0.6 (3) | 2.6±0.7 (3) | Z=0.2 | 0.8 |
Clinical results in correlation to smoking status of male patients of all ages per embryo transfer.
| Clinical Parameters | Non Smokers In the group of non smokers we had one patient with late pregnancy loss at 18 weeks of pregnancy. | Smokers In the group of smokers, we had two patients with late pregnancy loss, one at 15 weeks of pregnancy and one at 17 weeks of pregnancy. We also had one patient with deliver a fetus mortus |
|---|---|---|
| Pregnancy rate | 173 (52.6) | 192(51.5) |
| Clinical pregnancy rate | 160 (48.6) | 164 (43.9) |
| Biochemical pregnancy rate | 13 (7.69) | 28 (13.4) |
| Ongoing pregnancy rate | 151 (45.9) | 134 (35.9) A |
| Live birth rate | 150 (45.6) | 131 (35.1) A |
| Early pregnancy loss rate | 9 (5.63) | 30 (18.3) A |
Binary logistic regression: Overall relative chance of live birth in IVF process according to male passive smoking status.
| Women’s Age | Male Smokers | OR (crude) | OR (adjusted for athernozoospermia) | |
|---|---|---|---|---|
| All ages | Non smokers (both partners) | 212 | ||
| Male passive smokers | 117 | 1.302 (0.828-2.047) | 1.260 (0.798-1.991) | |
| All ages | Non smokers (both partners) | 212 | ||
| Female passive smokers | 241 | 1.543 (1.441-1.653) | 1.599 (1.492-1.714) |
Binary logistic regression: Overall relative chance of clinical pregnancy in IVF process, according to male smoking status.
| Women’s Age | Male Smokers | OR (crude) | OR (adjusted for athernozoospermia) | OR (adjusted for female smokers) | |
|---|---|---|---|---|---|
| All ages | Non smokers | 329 | |||
| Smokers | 373 | 1.21 (0.89-1.62) | 1.22(0.91-1.64) | 1.201 (0.90-1.62) | |
| Women <35 years | Non smokers | 239 | |||
| Smokers | 234 | 0.96 (0.67-1.37) | 0.99 (0.69-1.42) | 0.96 (0.67-1.37) | |
| Non smokers | 90 | ||||
| Women >35 years | Smokers | 139 | 1.69 (0.97-2.93) | 1.63 (0.93-2.85) | 1.34 (0.75-2.37) |
Binary logistic regression model: Overall relative chance of live birth in ICSI process, according to male smoking status and age of the female.
| Variable | B | SE | Wald | Significant |
|---|---|---|---|---|
| Women (<35 years Referent category: age/women <35 years. | 0.82 | 0.17 | 21.8 | 0.000 |
| Men (non smokers Referent category: non smoker. | 0.36 | 0.16 | 5.23 | 0.022 |
| Constant | -0.06 | 0.12 | 0.27 | 0.601 |
Binary logistic regression: Overall relative chance of live birth in IVF process according to male smoking status.
| Women’s Age | Male Smokers | OR (crude) | OR (adjusted for athernozoospermia) | OR (adjusted for female smokers) | |
|---|---|---|---|---|---|
| Non smokers | 329 | ||||
| All ages | Smokers | 373 | 1.53 (1.13-2.07) | 1.56 (1.15-2.12) | 1.53 (1.13-2.07) |
| Women <35 years | Non smokers | 239 | |||
| Smokers | 234 | 1.15 (0.81-1.66 | 1.21 (0.84-1.75) | 1.16 (0.81-1.66) | |
| Non smokers | 90 | ||||
| Women >35 years | Smokers | 139 | 2.52 (1.39-4.56) | 2.42 (1.33-4.41) | 2.53 (1.40-4.59) |