<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1<italic>H</italic>)-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and thiourea. These thione derivatives were characterized by their analytical, physical, and spectroscopic data. In addition, the <italic>in vitro</italic> antibacterial activities of these pyrimidine derivatives were evaluated using Bauer-Kirby disc diffusion method.</p>
</abstract>

The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1H)-thione compounds using sodium hydroxide catalyzed three component condensation and cyclization reaction of substituted 6-methoxy-2-acetonapthone, various substituted benzaldehydes and thiourea. These thione derivatives were characterized by their analytical, physical, and spectroscopic data. In addition, the in vitro antibacterial activities of these pyrimidine derivatives were evaluated using Bauer-Kirby disc diffusion method.

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1<italic>H</italic>)-thiones

Ovidius University Annals of Chemistry

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1)-thiones

The objective of this study was to synthesize some novel substituted 4-(2-methoxynaphthalen-6-yl) pyrimidine- 2(1H)-thione compounds using sodium hydroxide...

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones

Online veröffentlicht: 07. Juni 2024

Seitenbereich: 36 - 42

Eingereicht: 04. Aug. 2023

Akzeptiert: 20. Apr. 2024

DOI: https://doi.org/10.2478/auoc-2024-0005

Schlüsselwörter
pyrimidinethiones, acetonaphthones, thiourea, NMR spectra, antibacterial activity

© 2024 Rajendran Venkatraman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Synthesis, spectral study and evaluation of antibacterial activity of some novel 4-(6-methoxynaphthalen-2-yl)-6-(substituted aryl)pyrimidine-2(1H)-thiones

Online veröffentlicht: 07. Juni 2024

Seitenbereich: 36 - 42

Eingereicht: 04. Aug. 2023

Akzeptiert: 20. Apr. 2024

DOI: https://doi.org/10.2478/auoc-2024-0005

Schlüsselwörterpyrimidinethiones, acetonaphthones, thiourea, NMR spectra, antibacterial activity

© 2024 Rajendran Venkatraman et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
pyrimidinethiones, acetonaphthones, thiourea, NMR spectra, antibacterial activity