<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>Recently, genome editing tools have been extensively used in many biomedical sciences. The gene editing system is applied to modify the dnA sequences in the cellular system to comprehend their physiological response. A developing genome editing technology like clustered regularly short palindromic repeats (CRISPR) is widely used in medical sciences. CRISPR and CRISPR-associated protein 9 (CRISPR/Cas9) system is being exploited to edit any DNA mutations related to inherited ailments to investigate in animals (<italic>in vivo</italic>) and cell lines (<italic>in vitro</italic>). Remarkably, CRISPR/Cas9 could be employed to examine treatments of many human genetic diseases such as cystic fibrosis, tyrosinemia, phenylketonuria, muscular dystrophy, Parkinson’s disease, retinoschisis, hemophilia, β-thalassemia and atherosclerosis. Moreover, CRISPR/Cas9 was used for disease resistance such as tuberculosis, Johne’s diseases, chronic enteritis, and brucellosis in animals. Finally, this review discusses existing progress in treating hereditary diseases using CRISPR/Cas9 technology and the high points accompanying obstacles.</p>
</abstract>

Recently, genome editing tools have been extensively used in many biomedical sciences. The gene editing system is applied to modify the dnA sequences in the cellular system to comprehend their physiological response. A developing genome editing technology like clustered regularly short palindromic repeats (CRISPR) is widely used in medical sciences. CRISPR and CRISPR-associated protein 9 (CRISPR/Cas9) system is being exploited to edit any DNA mutations related to inherited ailments to investigate in animals (in vivo) and cell lines (in vitro). Remarkably, CRISPR/Cas9 could be employed to examine treatments of many human genetic diseases such as cystic fibrosis, tyrosinemia, phenylketonuria, muscular dystrophy, Parkinson’s disease, retinoschisis, hemophilia, β-thalassemia and atherosclerosis. Moreover, CRISPR/Cas9 was used for disease resistance such as tuberculosis, Johne’s diseases, chronic enteritis, and brucellosis in animals. Finally, this review discusses existing progress in treating hereditary diseases using CRISPR/Cas9 technology and the high points accompanying obstacles.

Applying the CRISPR/Cas9 for Treating Human and Animal Diseases – Comprehensive Review

Animal Production Department, Faculty of Agriculture

Laboratory Medicine Department, Faculty of Applied Medical Sciences

Genetics Department, Faculty of Agriculture

Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University

Department of Biology, College of Science

Poultry Department, Faculty of Agriculture

Annals of Animal Science

This work is licensed under the Creative Commons Attribution 4.0 International License.

Recently, genome editing tools have been extensively used in many biomedical sciences. The gene editing system is applied to modify the dnA sequences in the...

Applying the CRISPR/Cas9 for Treating Human and Animal Diseases – Comprehensive Review

Online veröffentlicht: 13. Nov. 2023

Seitenbereich: 979 - 992

Eingereicht: 05. Dez. 2022

Akzeptiert: 17. Jan. 2023

DOI: https://doi.org/10.2478/aoas-2023-0009

Schlüsselwörter
CRISPR/Cas9, genetic diseases, DNA sequences, disease-resistant animals

© 2023 Sameh A. Abdelnour et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Applying the CRISPR/Cas9 for Treating Human and Animal Diseases – Comprehensive Review

Online veröffentlicht: 13. Nov. 2023

Seitenbereich: 979 - 992

Eingereicht: 05. Dez. 2022

Akzeptiert: 17. Jan. 2023

DOI: https://doi.org/10.2478/aoas-2023-0009

SchlüsselwörterCRISPR/Cas9, genetic diseases, DNA sequences, disease-resistant animals

© 2023 Sameh A. Abdelnour et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

Schlüsselwörter
CRISPR/Cas9, genetic diseases, DNA sequences, disease-resistant animals