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Mishra AP, Bajpai A, Rai AK. 1,4-Dihydropyridine: A dependable heterocyclic ring with the promising and the most anticipable therapeutic effects. Mini Rev Med Chem 2019;19:1219–54. doi: 10.2174/1389557519666190425184749 Mishra AP Bajpai A Rai AK . 1,4-Dihydropyridine: A dependable heterocyclic ring with the promising and the most anticipable therapeutic effects . Mini Rev Med Chem 2019 ; 19 : 1219 54 . doi: 10.2174/1389557519666190425184749 Open DOISearch in Google Scholar

Núñez-Vergara LJ, Salazar R, Camargo C, Carbajo J, Conde B, Navarrete-Encina PA, Squella JA. Oxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous medium. Bioorg Med Chem 2007;15:4318–26. doi: 10.1016/j.bmc.2007.03.042 Núñez-Vergara LJ Salazar R Camargo C Carbajo J Conde B Navarrete-Encina PA Squella JA . Oxidation of C4-hydroxyphenyl 1,4-dihydropyridines in dimethylsulfoxide and its reactivity towards alkylperoxyl radicals in aqueous medium . Bioorg Med Chem 2007 ; 15 : 4318 26 . doi: 10.1016/j.bmc.2007.03.042 Open DOISearch in Google Scholar

Ryabokon NI, Goncharova RI, Duburs G, Hancock R, Rzeszowska-Wolny J. Changes in poly(ADP-ribose) level modulate the kinetics of DNA strand break rejoining. Mutat Res 2008;637:173–81. doi: 10.1016/j.mrfmmm.2007.08.005 Ryabokon NI Goncharova RI Duburs G Hancock R Rzeszowska-Wolny J . Changes in poly(ADP-ribose) level modulate the kinetics of DNA strand break rejoining . Mutat Res 2008 ; 637 : 173 81 . doi: 10.1016/j.mrfmmm.2007.08.005 Open DOISearch in Google Scholar

Ryabokon NI, Goncharova RI, Duburs G, Rzeszowska-Wolny J. A 1,4-dihydropyridine derivative reduces DNA damage and stimulates DNA repair in human cells in vitro. Mutat Res 2005;587:52–8. doi: 10.1016/j.mrgentox.2005.07.009 Ryabokon NI Goncharova RI Duburs G Rzeszowska-Wolny J . A 1,4-dihydropyridine derivative reduces DNA damage and stimulates DNA repair in human cells in vitro . Mutat Res 2005 ; 587 : 52 8 . doi: 10.1016/j.mrgentox.2005.07.009 Open DOISearch in Google Scholar

Ryabokon NI, Nikitchenko NV, Dalivelya OV, Goncharova RI, Duburs G, Konopacka M, Rzeszowska-Wolny J. Modulation of cellular defense processes in human lymphocytes in vitro by a 1,4-dihydropyridine derivative. Mutat Res 2009;679:33–8. doi: 10.1016/j.mrgentox.2009.07.010 Ryabokon NI Nikitchenko NV Dalivelya OV Goncharova RI Duburs G Konopacka M Rzeszowska-Wolny J . Modulation of cellular defense processes in human lymphocytes in vitro by a 1,4-dihydropyridine derivative . Mutat Res 2009 ; 679 : 33 8 . doi: 10.1016/j.mrgentox.2009.07.010 Open DOISearch in Google Scholar

Pal S, Singh V, Das P, Choudhury LH. PEG-mediated one-pot multicomponent reactions for the efficient synthesis of functionalized dihydropyridines and their functional group dependent DNA cleavage activity. Bioorg Chem 2013;48:8–15. doi: 10.1016/j.bioorg.2013.03.003 Pal S Singh V Das P Choudhury LH . PEG-mediated one-pot multicomponent reactions for the efficient synthesis of functionalized dihydropyridines and their functional group dependent DNA cleavage activity . Bioorg Chem 2013 ; 48 : 8 15 . doi: 10.1016/j.bioorg.2013.03.003 Open DOISearch in Google Scholar

Velena A, Zarkovic N, Troselj KG, Bisenieks E, Krauze A, Poikans J, Duburs G. 1,4-dihydropyridine derivatives: dihydronicotinamide analogues-model compounds targeting oxidative stress. Oxid Med Cell Longev 2016;2016:1892412. doi: 10.1155/2016/1892412 Velena A Zarkovic N Troselj KG Bisenieks E Krauze A Poikans J Duburs G . 1,4-dihydropyridine derivatives: dihydronicotinamide analogues-model compounds targeting oxidative stress . Oxid Med Cell Longev 2016 ; 2016 : 1892412 . doi: 10.1155/2016/1892412 Open DOISearch in Google Scholar

López-Alarcón C, Speisky H, Squella JA, Olea-Azar C, Camargo C, Núñez-Vergara LJ. Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite. Phar m Res 2004;21:1750–7. doi: 10.1023/B:PHAM.0000045224.97323.8b López-Alarcón C Speisky H Squella JA Olea-Azar C Camargo C Núñez-Vergara LJ . Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite . Phar m Res 2004 ; 21 : 1750 7 . doi: 10.1023/B:PHAM.0000045224.97323.8b Open DOISearch in Google Scholar

López-Alarcón C, Navarrete P, Camargo C, Squella JA, Núñez-VergaraLJ. Reactivity of 1,4-dihydropyridines toward alkyl, alkylperoxyl radicals, and ABTS radical cation. Chem Res Toxicol 2003;16:208–15. doi: 10.1021/tx025579o López-Alarcón C Navarrete P Camargo C Squella JA Núñez-Vergara LJ . Reactivity of 1,4-dihydropyridines toward alkyl, alkylperoxyl radicals, and ABTS radical cation . Chem Res Toxicol 2003 ; 16 : 208 15 . doi: 10.1021/tx025579o Open DOISearch in Google Scholar

Valenzuela V, Santander P, Camargo C, Squella JA, López-Alarcón C, Núñez-Vergara LJ. 1,4-dihydropyridines: reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation. Free Radic Res 2004;38:715–27. doi: 10.1080/10715760410001711486 Valenzuela V Santander P Camargo C Squella JA López-Alarcón C Núñez-Vergara LJ . 1,4-dihydropyridines: reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation . Free Radic Res 2004 ; 38 : 715 27 . doi: 10.1080/10715760410001711486 Open DOISearch in Google Scholar

Leonova E, Rostoka E, Baumane L, Borisovs V, Smelovs E, Bisenieks I, Brūvere I, Bisenieks E, Duburs G, Sjakste N. DNA-binding studies of a series of novel water-soluble derivatives of 1,4-dihydropyridine. Biopolym Cell 2018;34:129–42. doi: 10.7124/bc.000977 Leonova E Rostoka E Baumane L Borisovs V Smelovs E Bisenieks I Brūvere I Bisenieks E Duburs G Sjakste N . DNA-binding studies of a series of novel water-soluble derivatives of 1,4-dihydropyridine . Biopolym Cell 2018 ; 34 : 129 42 . doi: 10.7124/bc.000977 Open DOISearch in Google Scholar

Leonova E, Ošiņa K, Duburs G, Bisenieks E, Germini D, Vassetzky Y, Sjakste N. Metal ions modify DNA-protecting and mutagen-scavenging capacities of the AV-153 1,4-dihydropyridine. Mutat Res Genet Toxicol Environ Mutagen 2019;845:403077. doi: 10.1016/j.mrgentox.2019.06.007 Leonova E Ošiņa K Duburs G Bisenieks E Germini D Vassetzky Y Sjakste N . Metal ions modify DNA-protecting and mutagen-scavenging capacities of the AV-153 1,4-dihydropyridine . Mutat Res Genet Toxicol Environ Mutagen 2019 ; 845 : 403077 . doi: 10.1016/j.mrgentox.2019.06.007 Open DOISearch in Google Scholar

Ošiņa K, Leonova E, Isajevs S, Baumane L, Rostoka E, Sjakste T, Bisenieks E, Duburs G, Vīgante B, Sjakste N. Modifications of expression of genes and proteins involved in DNA repair and nitric oxide metabolism by carbatonides [disodium-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) derivatives] in intact and diabetic rats. Arh Hig Rada Toksikol 2017;68:212–27. doi: 10.1515/aiht-2017-68-2945 Ošiņa K Leonova E Isajevs S Baumane L Rostoka E Sjakste T Bisenieks E Duburs G Vīgante B Sjakste N . Modifications of expression of genes and proteins involved in DNA repair and nitric oxide metabolism by carbatonides [disodium-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) derivatives] in intact and diabetic rats . Arh Hig Rada Toksikol 2017 ; 68 : 212 27 . doi: 10.1515/aiht-2017-68-2945 Open DOISearch in Google Scholar

Milkovic L, Vukovic T, Zarkovic N, Tatzber F, Bisenieks E, Kalme Z, Bruvere I, Ogle Z, Poikans J, Velena A, Duburs G. Antioxidative 1,4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro. Antioxidants (Basel) 2018;7(9):123. doi: 10.3390/antiox7090123 Milkovic L Vukovic T Zarkovic N Tatzber F Bisenieks E Kalme Z Bruvere I Ogle Z Poikans J Velena A Duburs G . Antioxidative 1,4-dihydropyridine derivatives modulate oxidative stress and growth of human osteoblast-like cells in vitro . Antioxidants (Basel) 2018 ; 7 ( 9 ): 123 . doi: 10.3390/antiox7090123 Open DOISearch in Google Scholar

Leonova E, Sokolovska J, Boucher JL, Isajevs S, Rostoka E, Baumane L, Sjakste T, Sjakste N. New 1,4-dihydropyridines down-regulate nitric oxide in animals with streptozotocin-induced diabetes mellitus and protect DNA against peroxynitrite action. Basic Clin Pharmacol Toxicol 2016;119:19–31. doi: 10.1111/bcpt.12542 Leonova E Sokolovska J Boucher JL Isajevs S Rostoka E Baumane L Sjakste T Sjakste N . New 1,4-dihydropyridines down-regulate nitric oxide in animals with streptozotocin-induced diabetes mellitus and protect DNA against peroxynitrite action . Basic Clin Pharmacol Toxicol 2016 ; 119 : 19 31 . doi: 10.1111/bcpt.12542 Open DOISearch in Google Scholar

Leonova E, Rostoka E, Sauvaigo S, Baumane L, Selga T, Sjakste N. Study of interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA-damaging molecules and its impact on DNA repair activity. PeerJ 2018;6:e4609. doi: 10.7717/peerj.4609 Leonova E Rostoka E Sauvaigo S Baumane L Selga T Sjakste N . Study of interaction of antimutagenic 1,4-dihydropyridine AV-153-Na with DNA-damaging molecules and its impact on DNA repair activity . PeerJ 2018 ; 6 : e4609 . doi: 10.7717/peerj.4609 Open DOISearch in Google Scholar

Briede J, Stivrina M, Vigante B, Stoldere D, Duburs G. Acute effect of antidiabetic 1,4-dihydropyridine compound cerebrocrast on cardiac function and glucose metabolism in theisolated, perfused normal rat heart. Cell Biochem Funct 2008;26:238–45. doi: 10.1002/cbf.1442 Briede J Stivrina M Vigante B Stoldere D Duburs G . Acute effect of antidiabetic 1,4-dihydropyridine compound cerebrocrast on cardiac function and glucose metabolism in theisolated, perfused normal rat heart . Cell Biochem Funct 2008 ; 26 : 238 45 . doi: 10.1002/cbf.1442 Open DOISearch in Google Scholar

Pupure J, Isajevs S, Gordjushina V, Taivans I, Rumaks J, Svirskis S, Kratovska A, Dzirkale Z, Pilipenko J, Duburs G, Klusa V. Distinct influence of atypical 1,4-dihydropyridine compounds in azidothymidine-induced neuro- and cardiotoxicity in mice ex vivo. Basic Clin Pharmacol Toxicol 2008;103:401–6. doi: 10.1111/j.1742-7843.2008.00221.x Pupure J Isajevs S Gordjushina V Taivans I Rumaks J Svirskis S Kratovska A Dzirkale Z Pilipenko J Duburs G Klusa V . Distinct influence of atypical 1,4-dihydropyridine compounds in azidothymidine-induced neuro- and cardiotoxicity in mice ex vivo . Basic Clin Pharmacol Toxicol 2008 ; 103 : 401 6 . doi: 10.1111/j.1742-7843.2008.00221.x Open DOISearch in Google Scholar

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Buraka E, Chen CY, Gavare M, Grube M, Makarenkova G, Nikolajeva V, Bisenieks I, Brūvere I, Bisenieks E, Duburs G, Sjakste N. DNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine. Chem Biol Interact 2014;220:200–7. doi: 10.1016/j.cbi.2014.06.027 Buraka E Chen CY Gavare M Grube M Makarenkova G Nikolajeva V Bisenieks I Brūvere I Bisenieks E Duburs G Sjakste N . DNA-binding studies of AV-153, an antimutagenic and DNA repair-stimulating derivative of 1,4-dihydropiridine . Chem Biol Interact 2014 ; 220 : 200 7 . doi: 10.1016/j.cbi.2014.06.027 Open DOISearch in Google Scholar

Leonova E, Shvirksts K, Borisovs V, Smelovs E, Sokolovska J, Bisenieks E, Duburs G, Grube M, Sjakste N. Spectroscopic and electrochemical study of interactions between DNA and different salts of 1,4-dihydropyridine AV-153. PeerJ 2020;8:e10061. doi: 10.7717/peerj.10061 Leonova E Shvirksts K Borisovs V Smelovs E Sokolovska J Bisenieks E Duburs G Grube M Sjakste N . Spectroscopic and electrochemical study of interactions between DNA and different salts of 1,4-dihydropyridine AV-153 . PeerJ 2020 ; 8 : e10061 . doi: 10.7717/peerj.10061 Open DOISearch in Google Scholar

Fernandes MAS, Santos MS, Vicente JAF, Moreno AJM, Velena A, Duburs G, Oliveira CR. Effects of 1,4-dihydropyridine derivatives (cerebrocrast, gammapyrone, glutapyrone, and diethone) on mitochondrial bioenergetics and oxidative stress: a comparative study. Mitochondrion 2003;3:47–59. doi: 10.1016/S1567-7249(03)00060-6 Fernandes MAS Santos MS Vicente JAF Moreno AJM Velena A Duburs G Oliveira CR . Effects of 1,4-dihydropyridine derivatives (cerebrocrast, gammapyrone, glutapyrone, and diethone) on mitochondrial bioenergetics and oxidative stress: a comparative study . Mitochondrion 2003 ; 3 : 47 59 . doi: 10.1016/S1567-7249(03)00060-6 Open DOISearch in Google Scholar

Aghaei R, Mazloum-Ardakani M, Abdollahi-Alibeik M, Moshtaghioun SM, Rezaeipoor-Anari A, Haghighijoo Z, Zamani L. A new electrochemical biosensor based on telomeric G-quadruplex DNA: In silico and experimental study of dihydropyridine derivatives potential effect on telomerase inhibition. J Electroanal Chem 2017;796:24–32. doi: 10.1016/j.jelechem.2017.04.055 Aghaei R Mazloum-Ardakani M Abdollahi-Alibeik M Moshtaghioun SM Rezaeipoor-Anari A Haghighijoo Z Zamani L . A new electrochemical biosensor based on telomeric G-quadruplex DNA: In silico and experimental study of dihydropyridine derivatives potential effect on telomerase inhibition . J Electroanal Chem 2017 ; 796 : 24 32 . doi: 10.1016/j.jelechem.2017.04.055 Open DOISearch in Google Scholar

Shahzad S, Dogan-Topal B, Karadurmus L, Caglayan MG, Tok TT, Uslu B, Shah A, Ozkan SA: Electrochemical, spectroscopic and molecular docking studies on the interaction of calcium channel blockers with dsDNA. Bioelectrochemistry 2019;127:12–20. doi: 10.1016/j.bioelechem.2018.12.007 Shahzad S Dogan-Topal B Karadurmus L Caglayan MG Tok TT Uslu B Shah A Ozkan SA . Electrochemical, spectroscopic and molecular docking studies on the interaction of calcium channel blockers with dsDNA . Bioelectrochemistry 2019 ; 127 : 12 20 . doi: 10.1016/j.bioelechem.2018.12.007 Open DOISearch in Google Scholar

Leonova E, Dislere K, Rostoka E, Baumane L, Bisenieks E, Duburs G, Sjakste N. Study of impact of a 1,4-DHP derivative glutapyrone on DNA using in vitro tests. Proc Latvian Acad Sci 2023;77(1):49–52. Leonova E Dislere K Rostoka E Baumane L Bisenieks E Duburs G Sjakste N . Study of impact of a 1,4-DHP derivative glutapyrone on DNA using in vitro tests . Proc Latvian Acad Sci 2023 ; 77 ( 1 ): 49 52 . Search in Google Scholar

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