Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives: a brief review
, , , , , , , , und | 04. Apr. 2023
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Article Category: Review
Online veröffentlicht: 04. Apr. 2023
Seitenbereich: 1 - 7
Eingereicht: 01. Jan. 2023
Akzeptiert: 01. März 2023
DOI: https://doi.org/10.2478/aiht-2023-74-3707
© 2023 Elina Leonova et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
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Figure 3
Comparison of some properties of studied 1,4-DHP derivatives (11, 12, 15, 20, 25)
| 1,4-DHP derivative | DNA binding constant (UV/VIS spectroscopy) (M-1) | Stern-Volmer binding constant (EtBr extrusion) (M-1) | DNA binding constant (spectrofluorimetry) (M-1) | Effect on hydroxyl radical production (EPR; %) | Peroxynitrite decomposition time compared to control | Decrease in DNA damage in HeLa cells by peroxynitrite after pre-incubation with 10 nmol/L of a 1,4-DHP (%) |
|---|---|---|---|---|---|---|
| AV-153-Na | 7.21328×104 | 9.4×104 | 4.40×105 | 96.8 | 0.75 | 50 |
| AV-153-Ca | 1.7×105 | 4.04×105 | 3.44 | 57 | ||
| AV-153-Mg | 2.3×105 | 5.43×105 | 7.52 | NS | ||
| AV-153-Li | 9.9×104 | 3.32×105 | 3.48 | NS | ||
| AV-153-K | 8.7×104 | 2.70×105 | 3.13 | 19 | ||
| AV-153-Rb | 8.9×104 | 3.07×105 | 3.00 | 14 | ||
| AV-154-Na | No binding | 98.7 | 0.29 | NS | ||
| Carbatone | 1.09×102 | 100 | N/A | |||
| Metcarbatone | 0.82×102 | 3.8×102 | 31.4 | |||
| Etcarbatone | 0.54×102 | 9.5×102 | 98.3 | |||
| Propcarbatone | 1.11×102 | 86.4 | ||||
| Styrylcarbatone | 1.9×103 | ? | 1.4×104 | 106 | ||
| Glutapyrone | No binding | 27 | ||||
| Cerebrocrast | 2.2×103 | 8.61 | 29 | |||
| Etaftorone | 2.25 | 27 |
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| Fenoftorone | 2.28 |