Kidney cell DNA damage caused by combined exposure to volatile anaesthetics and 1 Gy or 2 Gy radiotherapy dose in vivo

1Mazze RI, Cousins MJ, Barr GA. Renal effects and metabolism of isoflurane in man. Anesthesiology 1974;40:536–42. doi: 10.1097/00000542-197406000-00006 Mazze RI Cousins MJ Barr GA Renal effects and metabolism of isoflurane in man Anesthesiology 197440536 42 10.1097/00000542-197406000-000064829722Open DOISearch in Google Scholar

2Mazze RI, Calverley RK, Smith NT. Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers. Anesthesiology 1977;46:265–71. doi: 10.1097/00000542-19770400000007 Mazze RI Calverley RK Smith NT Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers Anesthesiology 197746265 71 10.1097/00000542-19770400000007Open DOISearch in Google Scholar

3Motayagheni N, Phan S, Eshraghi C, Nozari A, Atala A. A review of anesthetic effects on renal function: potential organ protection. Am J Nephrol 2017;46:380–9. doi: 10.1159/000482014 Motayagheni N Phan S Eshraghi C Nozari A Atala A A review of anesthetic effects on renal function: potential organ protection Am J Nephrol 201746380 9 10.1159/00048201429131005Open DOISearch in Google Scholar

4Fukazawa K, Lee HT. Volatile anesthetics and AKI: risks, mechanisms, and a potential therapeutic window. J Am Soc Nephrol 2014;25:884–92. doi: 10.1681/ASN.2013111215 Fukazawa K Lee HT Volatile anesthetics and AKI: risks, mechanisms, and a potential therapeutic window J Am Soc Nephrol 201425884–92 10.1681/ASN.2013111215400531724511126Open DOISearch in Google Scholar

5Dural O, Kanbak M, Ciliv G, Aypar U, Erdem K. Comparison of halothane, enflurane and isoflurane kidney effects through alanine aminopeptidase/urine creatinine values. Anaesth Intensive Care 1995;23:162–4. doi: 10.1177/0310057X9502300206 Dural O Kanbak M Ciliv G Aypar U Erdem K Comparison of halothane, enflurane and isoflurane kidney effects through alanine aminopeptidase/urine creatinine values Anaesth Intensive Care 199523162 4 10.1177/0310057X95023002067793585Open DOISearch in Google Scholar

6Neri M, Milazzo D, Ugolini D, Milić M, Campolongo A, Pasqualetti P, Bonassi S. Worldwide interest in the comet assay: a bibliometric study. Mutagenesis 2015;30:155–63. doi: 10.1093/mutage/geu061 Neri M Milazzo D Ugolini D Milić M Campolongo A Pasqualetti P Bonassi S Worldwide interest in the comet assay: a bibliometric study Mutagenesis 201530155 63 10.1093/mutage/geu06125527738Open DOISearch in Google Scholar

7Milić M, Ceppi M, Bruzzone M, Azqueta A, Brunborg G, Godschalk R, Koppen G, Langie S, Møller P, Teixeira JP, Alija A, Anderson D, Andrade V, Andreoli C, Asllani F, Bangkoglu EE, Barančoková M, Basaran N, Boutet-Robinet E, Buschini A, Cavallo D, Costa Pereira C, Costa C, Costa S, Da Silva J, Del Bo C, Dimitrijević Srećković V, Djelić N, Dobrzyńska M, Duračková Z, Dvořáková M, Gajski G, Galati S, García Lima O, Giovannelli L, Goroshinskaya IA, Grindel A, Gutzkow KB, Hernández A, Hernández C, Holven KB, Ibero-Baraibar I, Ottestad I, Kadioglu E, Kažimirová A, Kuznetsova E, Ladeira C, Laffon B, Lamonaca P, Lebailly P, Louro H, Mandina Cardoso T, Marcon F, Marcos R, Moretti M, Moretti S, Najafzadeh M, Nemeth Z, Neri M, Novotna B, Orlow I, Paduchova Z, Pastor S, Perdry H, Spremo-Potparević B, Ramadhani D, Riso P, Rohr P, Rojas E, Rossner P, Safar A, Sardas S, Silva MJ, Sirota N, Smolkova B, Staruchova M, Stetina R, Stopper H, Surikova EI, Ulven SM, Ursini CL, Valdiglesias V, Valverde M, Vodicka P, Volkovova K, Wagner KH, Živković L, Dušinská M, Collins AR, Bonassi S. The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and effect of main confounders. Mutat Res Rev Mutat Res 2021;787:108371. doi: 10.1016/j.mrrev.2021.108371 Milić M Ceppi M Bruzzone M Azqueta A Brunborg G Godschalk R Koppen G Langie S Møller P Teixeira JP Alija A Anderson D Andrade V Andreoli C Asllani F Bangkoglu EE Barančoková M Basaran N Boutet-Robinet E Buschini A Cavallo D Costa Pereira C Costa C Costa S Da Silva J Del Bo C Dimitrijević Srećković V Djelić N Dobrzyńska M Duračková Z Dvořáková M Gajski G Galati S García Lima O Giovannelli L Goroshinskaya IA Grindel A Gutzkow KB Hernández A Hernández C Holven KB Ibero-Baraibar I Ottestad I Kadioglu E Kažimirová A Kuznetsova E Ladeira C Laffon B Lamonaca P Lebailly P Louro H Mandina Cardoso T Marcon F Marcos R Moretti M Moretti S Najafzadeh M Nemeth Z Neri M Novotna B Orlow I Paduchova Z Pastor S Perdry H Spremo-Potparević B Ramadhani D Riso P Rohr P Rojas E Rossner P Safar A Sardas S Silva MJ Sirota N Smolkova B Staruchova M Stetina R Stopper H Surikova EI Ulven SM Ursini CL Valdiglesias V Valverde M Vodicka P Volkovova K Wagner KH Živković L Dušinská M Collins AR Bonassi S The hCOMET project: International database comparison of results with the comet assay in human biomonitoring Baseline frequency of DNA damage and effect of main confounders. Mutat Res Rev Mutat Res 2021787108371 10.1016/j.mrrev.2021.108371852563234083035Open DOISearch in Google Scholar

8Collins A, Milic M, Bonassi S, Dusinska M. The comet assay in human biomonitoring: Technical and epidemiological perspectives. Mutat Res Genet Toxicol Environ Mutagen 2019;843:1–2. doi: 10.1016/j.mrgentox.2019.06.002 Collins A Milic M Bonassi S Dusinska M The comet assay in human biomonitoring: Technical and epidemiological perspectives Mutat Res Genet Toxicol Environ Mutagen 20198431 2 10.1016/j.mrgentox.2019.06.00231421730Open DOISearch in Google Scholar

9Brozovic G, Orsolic N, Rozgaj R, Kasuba V, Knezevic F, Knezevic AH, Benkovic V, Lisicic D, Borojevic N, Dikic D. DNA damage and repair after exposure to sevoflurane in vivo, evaluated in Swiss albino mice by the alkaline comet assay and micronucleus test. J Appl Genet 2010;51:79–86. doi: 10.1007/BF03195714 Brozovic G Orsolic N Rozgaj R Kasuba V Knezevic F Knezevic AH Benkovic V Lisicic D Borojevic N Dikic D DNA damage and repair after exposure to sevoflurane in vivo, evaluated in Swiss albino mice by the alkaline comet assay and micronucleus test J Appl Genet 20105179 86 10.1007/BF0319571420145304Open DOISearch in Google Scholar

10Milić M, Rozgaj R, Kašuba V, Jazbec AM, Hrelia P, Angelini S. Chapter 19: The influence of individual genome sensitivity in DNA damage repair assessment in chronic professional exposure to low doses of ionizing radiation. In: Chen C, editor. Selected topics in DNA repair, 2011 [displayed 28 Februray 2022]. Available at https://www.intechopen.com/chapters/22725 Milić M Rozgaj R Kašuba V Jazbec AM Hrelia P Angelini S Chapter 19: The influence of individual genome sensitivity in DNA damage repair assessment in chronic professional exposure to low doses of ionizing radiation Chen C Selected topics in DNA repair, 2011 [displayed 28 Februray 2022] Available at https://www.intechopen.com/chapters/2272510.5772/20814Search in Google Scholar

11Møller P, Knudsen LE, Loft S, Wallin H. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev 2000;9:1005–15. PMID: 11045781 Møller P Knudsen LE Loft S Wallin H The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors Cancer Epidemiol Biomarkers Prev 200091005 15 PMID: 11045781Search in Google Scholar

12Xiao C, He N, Liu Y, Wang Y, Liu Q. Research progress on biodosimeters of ionizing radiation damage. Rad Med Protec 2020;1:127–32. doi: 10.1016/j.radmp.2020.06.002 Xiao C He N Liu Y Wang Y Liu Q Research progress on biodosimeters of ionizing radiation damage Rad Med Protec 20201127 32 10.1016/j.radmp.2020.06.002Open DOISearch in Google Scholar

13Yılmaz S, Çalbayram NÇ. Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies. J Clin Anesth 2016;35:326–31. doi: 10.1016/j.jclinane.2016.08.029 Yılmaz S Çalbayram NÇ Exposure to anesthetic gases among operating room personnel and risk of genotoxicity: A systematic review of the human biomonitoring studies J Clin Anesth 201635326 31 10.1016/j.jclinane.2016.08.02927871551Open DOISearch in Google Scholar

14OECD Guidelines: Genetic toxicology Guidance Document Aug 31, 2015 [displayed 28 February 2022]. Available at https://www.oecd.org/chemicalsafety/testing/Genetic%20Toxicolog y%20 Guidance%20Document%20Aug%2031%202015.pdf OECD Guidelines: Genetic toxicology Guidance Document Aug 31, 2015 [displayed 28 February 2022] Available at https://www.oecd.org/chemicalsafety/testing/Genetic%20Toxicolog y%20 Guidance%20Document%20Aug%2031%202015.pdfSearch in Google Scholar

15IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Chemical Agents and Related Occupations. No. 100F. A review of human carcinogens. Lyon: IARC; 2012. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Chemical Agents and Related Occupations. No. 100F. A review of human carcinogens Lyon IARC; 2012Search in Google Scholar

16The Royal College of Radiologists. Radiology Dose Fractionation. 3^rd ed. London: The Royal College of Radiologist; 2019. The Royal College of Radiologists Radiology Dose Fractionation. 3^rd ed London The Royal College of Radiologist; 2019Search in Google Scholar

17Zakon o zaštiti životinja [Animal Protection Act, in Croatian]. Narodne novine 102/2017. Zakon o zaštiti životinja [Animal Protection Act, in Croatian] Narodne novine 102 2017Search in Google Scholar

18Pravilnik o zaštiti životinja koje se koriste u znanstvene svrhe [Ordinance on the protection of animals used for scientific purposes, in Croatian]. Narodne novine 55/2013; 39/2017. Pravilnik o zaštiti životinja koje se koriste u znanstvene svrhe [Ordinance on the protection of animals used for scientific purposes, in Croatian] Narodne novine 55 2013 39/2017Search in Google Scholar

19Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes [displayed 28 February 2022]. Available at https:// e u r- le x. e u r o p a . e u / Le x Ur i Se r v / Le x Ur i Se r v . do?uri=OJ:L:2010:276:0033:0079:en:PDF Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes [displayed 28 February 2022] Available at https:// e u r- le x. e u r o p a . e u / Le x Ur i Se r v / Le x Ur i Se r v . do?uri=OJ:L:2010:276:0033:0079:en:PDFSearch in Google Scholar

20Kesimci E, Çoşkun E, Uğur G, Müderris T, İzdeş S, Karahalil, B. Can sevoflurane induce micronuclei formation in nasal epithelial cells of adult patients? Turk J Anaesthesiol Reanim 2017;45:264–9. doi: 10.5152/TJAR.2017.09475 Kesimci E Çoşkun E Uğur G Müderris T İzdeş S Karahalil B Can sevoflurane induce micronuclei formation in nasal epithelial cells of adult patients? Turk J Anaesthesiol Reanim 201745264 9 10.5152/TJAR.2017.09475565616029114410Open DOISearch in Google Scholar

21Narendran N, Luzhna L, Kovalchuk O. Sex difference of radiation response in occupational and accidental exposure. Front Genet 2019;10:260. doi: 10.3389/fgene.2019.00260 Narendran N Luzhna L Kovalchuk O Sex difference of radiation response in occupational and accidental exposure Front Genet 201910260 10.3389/fgene.2019.00260650915931130979Open DOISearch in Google Scholar

22Brozovic G, Orsolic N, Knezevic F, Horvat Knezevic A, Benkovic V, Vrdoljak DV, Saric A. Evaluation of DNA damage in vivo induced by combined application of cisplatin and sevoflurane. Eur J Anaesthesiol 2008;25:642–7. doi: 10.1017/S0265021508004171 Brozovic G Orsolic N Knezevic F Horvat Knezevic A Benkovic V Vrdoljak DV Saric A Evaluation of DNA damage in vivo induced by combined application of cisplatin and sevoflurane Eur J Anaesthesiol 200825642 7 10.1017/S026502150800417118400143Open DOISearch in Google Scholar

23Brozovic G, Orsolic N, Knezevic F, Horvat Knezevic A, Benkovic V, Sakic K, Borojevic N, Dikic D. The in vivo genotoxicity of cisplatin, isoflurane and halothane evaluated by alkaline comet assay in Swiss albino mice. J Appl Genet 2011;52:355–61. doi: 0.1007/s13353-011-0046-0 Brozovic G Orsolic N Knezevic F Horvat Knezevic A Benkovic V Sakic K Borojevic N Dikic D The in vivo genotoxicity of cisplatin, isoflurane and halothane evaluated by alkaline comet assay in Swiss albino mice J Appl Genet 201152355 61 0.1007/s13353-011-0046-010.1007/s13353-011-0046-021509577Search in Google Scholar

24Guedel AE. Inhalation Anesthesia: A Fundamental Guide. 2^nd ed. New York: Macmillan; 1951. Guedel AE Inhalation Anesthesia: A Fundamental Guide. 2^nd ed New York Macmillan; 1951Search in Google Scholar

25Brozović G, Oršolić N, Rozgaj R, Knežević F, Knežević AH, Maričić M, Krsnik D, Benković V. Sevoflurane and isoflurane genotoxicity in kidney cells of mice. Arh Hig Rada Toksikol 2017;68:228–35. doi: 10.1515/aiht-2017-68-2941 Brozović G Oršolić N Rozgaj R Knežević F Knežević AH Maričić M Krsnik D Benković V Sevoflurane and isoflurane genotoxicity in kidney cells of mice Arh Hig Rada Toksikol 201768228 35 10.1515/aiht-2017-68-294128976881Open DOISearch in Google Scholar

26Fish RE, Brown MJ, Danneman PJ, Karas AZ. Anesthesia and Analgesia in Laboratory Animals. 2^nd ed. London: Academic Press; 2008. p. 240–61. Fish RE Brown MJ Danneman PJ Karas AZ Anesthesia and Analgesia in Laboratory Animals. 2^nd ed London Academic Press 2008 240–61Search in Google Scholar

27Siddiqui BA, Kim PY. Anesthesia Stages. [Updated 7 March 2021]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [displayed 28 February 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK557596/ Siddiqui BA Kim PY Anesthesia Stages [Updated 7 March 2021 In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [displayed 28 February 2022]. Available at https://www.ncbi.nlm.nih.gov/books/NBK557596/Search in Google Scholar

28Møller P, Azqueta A, Boutet-Robinet E, Koppen G, Bonassi S, Milić M, Gajski G, Costa S, Teixeira JP, Costa Pereira C, Dusinska M, Godschalk R, Brunborg G, Gutzkow KB, Giovannelli L, Cooke MS, Richling E, Laffon B, Valdiglesias V, Basaran N, Del Bo’ C, Zegura B, Novak M, Stopper H, Vodicka P, Vodenkova S, de Andrade VM, Sramkova M, Gabelova A, Collins A, Langie SAS. Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results. Nat Protoc 2020;15:3817–26. doi: 10.1038/s41596-020-0398-1 Møller P Azqueta A Boutet-Robinet E Koppen G Bonassi S Milić M Gajski G Costa S Teixeira JP Costa Pereira C Dusinska M Godschalk R Brunborg G Gutzkow KB Giovannelli L Cooke MS Richling E Laffon B Valdiglesias V Basaran N Del Bo’ C Zegura B Novak M Stopper H Vodicka P Vodenkova S de Andrade VM Sramkova M Gabelova A Collins A Langie SAS Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay procedures and results Nat Protoc 2020153817 26 10.1038/s41596-020-0398-1768843733106678Open DOISearch in Google Scholar

29Benković V, Marčina N, Horvat Knežević A, Rajevac V, Milić M, Kopjar N. Potential radioprotective properties of arbutin against ionising radiation on human leukocytes in vitro. Mutat Res Genet Toxicol Environ Mutagen 2021;872:503413. doi: 10.1016/j.mrgentox.2021.503413 Benković V Marčina N Horvat Knežević A Rajevac V Milić M Kopjar N Potential radioprotective properties of arbutin against ionising radiation on human leukocytes in vitro Mutat Res Genet Toxicol Environ Mutagen 2021872503413 10.1016/j.mrgentox.2021.50341334798933Open DOISearch in Google Scholar

30Jurica K, Benković V, Sikirić S, Brčić Karačonji I, Kopjar N. The effects of strawberry tree (Arbutus unedo L.) water leaf extract and arbutin upon kidney function and primary DNA damage in renal cells of rats. Nat Prod Res 2020;34:2354–7. doi: 10.1080/14786419.2018.1534106 Jurica K Benković V Sikirić S Brčić Karačonji I Kopjar N The effects of strawberry tree (Arbutus unedo L.) water leaf extract and arbutin upon kidney function and primary DNA damage in renal cells of rats Nat Prod Res 2020342354 7 10.1080/14786419.2018.153410630417709Open DOISearch in Google Scholar

31Nair GG, Nair CK. Protection of cellular DNA and membrane from γ-radiation-induced damages and enhancement in DNA repair by sesamol. Cancer Biother Radiopharm 2010;25:629–35. doi: 10.1089/cbr.2010.0803 Nair GG Nair CK Protection of cellular DNA and membrane from γ-radiation-induced damages and enhancement in DNA repair by sesamol Cancer Biother Radiopharm 201025629 35 10.1089/cbr.2010.080321204756Open DOISearch in Google Scholar

32Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, Pan C, Ten Haken RK, Schultheiss TE. Radiation-associated kidney injury. Int J Radiat Oncol Biol Phys 2010;76(3 Suppl):S108–15. doi: 10.1016/j.ijrobp.2009.02.089 Dawson LA Kavanagh BD Paulino AC Das SK Miften M Li XA Pan C Ten Haken RK Schultheiss TE Radiation-associated kidney injury Int J Radiat Oncol Biol Phys 201076 3 Suppl S108 15 10.1016/j.ijrobp.2009.02.08920171504Open DOISearch in Google Scholar

33Purohit RK, Chakrawati A, Bhartiya KM. Radiation and cadmium induced biochemical alterations in mouse kidney. Int J Radiat Res 2007;5:125–30. Purohit RK Chakrawati A Bhartiya KM Radiation and cadmium induced biochemical alterations in mouse kidney Int J Radiat Res 20075125 30Search in Google Scholar

34Canyilmaz E, Uslu GH, Bahat Z, Kandaz M, Mungan S, Haciislamoglu E, Mentese A, Yoney A. Comparison of the effects of melatonin and genistein on radiation-induced nephrotoxicity: Results of an experimental study. Biomed Rep 2016;4:45–50. doi: 10.3892/br.2015.547 Canyilmaz E Uslu GH Bahat Z Kandaz M Mungan S Haciislamoglu E Mentese A Yoney A Comparison of the effects of melatonin and genistein on radiation-induced nephrotoxicity: Results of an experimental study Biomed Rep 2016445 50 10.3892/br.2015.547472684626870332Open DOISearch in Google Scholar

35Kanter M, Topcu-Tarladacalisir Y, Uzal C. Role of amifostine on acute and late radiation nephrotoxicity: a histopathological study. In Vivo 2011;25:77–86. PMID: 21282738 Kanter M Topcu-Tarladacalisir Y Uzal C Role of amifostine on acute and late radiation nephrotoxicity: a histopathological study In Vivo 20112577 86 PMID: 21282738Search in Google Scholar

36Mansour HH, Abd El Azeem MG, Ismae NE. Protective effect of Moringa oleifera on gamma-radiation-induced hepatotoxicity and nephrotoxicity in rats. AJCPT 2014;2:495–508. Mansour HH Abd El Azeem MG Ismae NE Protective effect of Moringa oleifera on gamma-radiation-induced hepatotoxicity and nephrotoxicity in rats AJCPT 20142495 508Search in Google Scholar

37Mohamed HA, Nada AS, Hanafi N, Zaki HF, Kenawy SA. The renoprotective effect of gum arabic in gamma-irradiated and cisplatin treated rats. IJSRP 2015;5:1–11. Mohamed HA Nada AS Hanafi N Zaki HF Kenawy SA The renoprotective effect of gum arabic in gamma-irradiated and cisplatin treated rats IJSRP 201551 11Search in Google Scholar

38Schupp N, Stopper H, Heidland A. DNA damage in chronic kidney disease: evaluation of clinical biomarkers. Oxid Med Cell Longev 2016;2016:3592042. doi: 10.1155/2016/3592042 Schupp N Stopper H Heidland A DNA damage in chronic kidney disease: evaluation of clinical biomarkers Oxid Med Cell Longev 201620163592042 10.1155/2016/3592042489771927313827Open DOISearch in Google Scholar

39Bala S, Chugh NA, Bansal SC, Garg ML, Koul A. Radiomodulatory effects of Aloe vera on hepatic and renal tissues of X-ray irradiated mice. Mutat Res 2018;811:1–15. doi: 10.1016/j.mrfmmm.2018.07.001 Bala S Chugh NA Bansal SC Garg ML Koul A Radiomodulatory effects of Aloe vera on hepatic and renal tissues of X-ray irradiated mice Mutat Res 20188111 15 10.1016/j.mrfmmm.2018.07.00130014950Open DOISearch in Google Scholar

40Nair GG, Nair CK. Amelioration of γ-radiation induced genomic insult and oxidative stress in whole body irradiated Swiss albino mice by sesamol. Int J Low Radiat 2011;8:20–34. doi: 10.1504/IJLR.2011.040646 Nair GG Nair CK Amelioration of γ-radiation induced genomic insult and oxidative stress in whole body irradiated Swiss albino mice by sesamol Int J Low Radiat 2011820 34 10.1504/IJLR.2011.040646Open DOISearch in Google Scholar

41Davis PJ, Bosenberg A, Davidson A, Jimenez N, Kharasch E, Lynn AM, Tofovic SP, Woelfel S. Chapter 7: Pharmacology of pediatric anesthesia. In: Davis PJ, Cladis FP, Motoyama EK, editors. Smith’s anesthesia for infants and children. 8^th ed. Philadephia (PA): Elsevier Mosby; 2011. p. 179–261. Davis PJ Bosenberg A Davidson A Jimenez N Kharasch E Lynn AM Tofovic SP Woelfel S Chapter 7: Pharmacology of pediatric anesthesia Davis PJ Cladis FP Motoyama EK Smith’s anesthesia for infants and children. 8^th ed Philadephia (PA) Elsevier Mosby; 2011 179–26110.1016/B978-0-323-06612-9.00007-9Search in Google Scholar

42Martin Jr JL, Njoku DB. Metabolism and toxicity of modern inhaled anaesthetics. In: Miller RD, editor. Miller’s anesthesia. 6^th ed. Philadelphia (PA): Elsevier; 2005. p. 231–72. Martin Jr JL Njoku DB Metabolism and toxicity of modern inhaled anaesthetics Miller RD Miller’s anesthesia. 6^th ed Philadelphia (PA) Elsevier 2005 231–72Search in Google Scholar

43Lee HT, Ota-Setlik A, Fu Y, Nasr SH, Emala CW. Differential protective effects of volatile anesthetics against renal ischemia– reperfusion injury in vivo. Anesthesiology 2004;101:1313–24. doi: 10.1097/00000542-200412000-00011 Lee HT Ota-Setlik A Fu Y Nasr SH Emala CW Differential protective effects of volatile anesthetics against renal ischemia– reperfusion injury in vivo Anesthesiology 20041011313 24 10.1097/00000542-200412000-0001115564938Open DOISearch in Google Scholar

44Lochhead KM, Kharasch ED, Zager RA. Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury. Am J Pathol 1997;150:2209–21. PMCID: PMC1858334 Lochhead KM Kharasch ED Zager RA Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury Am J Pathol 19971502209 21 PMCID: PMC1858334Search in Google Scholar

45Hanafi N, El Aaser A, Gabry M, Tohamy A, Ebrahim M. Effect of increase in antioxidants supplementation on kidney tissue of mice subjected to fractionated dose of γ-irradiation. EJHM 2007;26:22–30. doi: 10.12816/ejhm.2007.17777 Hanafi N El Aaser A Gabry M Tohamy A Ebrahim M Effect of increase in antioxidants supplementation on kidney tissue of mice subjected to fractionated dose of γ-irradiation EJHM 20072622 30 10.12816/ejhm.2007.17777Open DOISearch in Google Scholar

46Ji K, Wang Y, Du L, Xu C, Liu Y, He N, Wang J, Liu Q. Research progress on the biological effects of low-dose radiation in China. Dose Res pons e 2 0 1 9 ; 1 7 : 1 5 5 9 3 2 5 8 1 9 8 3 3 4 8 8 . do i : 10.1177/1559325819833488 Ji K Wang Y Du L Xu C Liu Y He N Wang J Liu Q Research progress on the biological effects of low-dose radiation in China Dose Res pons e 2 0 1 9 ; 1 7 : 1 5 5 9 3 2 5 8 1 9 8 3 3 4 8 8 . do i : 10.1177/155932581983348810.1177/1559325819833488639382830833876Search in Google Scholar

47Nogami M, Huang JT, James SJ, Lubinski JM, Nakamura LT. Mice chronically exposed to low dose ionizing radiation possess splenocytes with elevated levels of HSP70 mRNA, HSC70 and HSP72 and with an increased capacity to proliferate. Int J Radiat Biol 1994;63:775–83. doi: 10.1080/09553009314552181 Nogami M Huang JT James SJ Lubinski JM Nakamura LT Mice chronically exposed to low dose ionizing radiation possess splenocytes with elevated levels of HSP70 mRNA, HSC70 and HSP72 and with an increased capacity to proliferate Int J Radiat Biol 199463775 83 10.1080/095530093145521818100265Open DOISearch in Google Scholar

48Zois CE, Koukourakis MI. Radiation-induced autophagy in normal and cancer cells: towards novel cytoprotection and radio-sensitization policies? Autophagy. 2009;5:442–50. doi: 10.4161/auto.5.4.7667 Zois CE Koukourakis MI Radiation-induced autophagy in normal and cancer cells: towards novel cytoprotection and radio-sensitization policies? Autophagy 20095442 50 10.4161/auto.5.4.766719164950Open DOISearch in Google Scholar